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Inflammation assessment in patients with arthritis using a novel in vivo fluorescence optical imaging technology

Background Indocyanine green (ICG)-enhanced fluorescence optical imaging (FOI) is an established technology for imaging of inflammation in animal models. In experimental models of arthritis, FOI findings corresponded to histologically proven synovitis. This is the first comparative study of FOI with... Full description

Journal Title: Annals of the Rheumatic Diseases 2012-04, Vol.71 (4), p.504-510
Main Author: Werner, Stephanie G
Other Authors: Langer, Hans-Eckhard , Ohrndorf, Sarah , Bahner, Malte , Schott, Peter , Schwenke, Carsten , Schirner, Michael , Bastian, Hans , Lind-Albrecht, Gudrun , Kurtz, Bernward , Burmester, Gerd R , Backhaus, Marina
Format: Electronic Article Electronic Article
Language: English
Subjects:
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Publisher: London: BMJ Publishing Group Ltd and European League Against Rheumatism
ID: ISSN: 0003-4967
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title: Inflammation assessment in patients with arthritis using a novel in vivo fluorescence optical imaging technology
format: Article
creator:
  • Werner, Stephanie G
  • Langer, Hans-Eckhard
  • Ohrndorf, Sarah
  • Bahner, Malte
  • Schott, Peter
  • Schwenke, Carsten
  • Schirner, Michael
  • Bastian, Hans
  • Lind-Albrecht, Gudrun
  • Kurtz, Bernward
  • Burmester, Gerd R
  • Backhaus, Marina
subjects:
  • 1506
  • Adult
  • Aged
  • Aged, 80 and over
  • Agreements
  • Arthritis
  • Arthritis - diagnosis
  • Arthritis - diagnostic imaging
  • Arthritis, Psoriatic - diagnosis
  • Arthritis, Psoriatic - diagnostic imaging
  • Arthritis, Rheumatoid - diagnosis
  • Arthritis, Rheumatoid - diagnostic imaging
  • Biological and medical sciences
  • Case-Control Studies
  • Clinical
  • Clinical and Epidemiological Research
  • Coloring Agents
  • Comparative analysis
  • Confidence intervals
  • Diagnosis
  • Diagnostic imaging
  • Diagnostic Imaging - methods
  • Disease
  • Diseases of the osteoarticular system
  • Epidemiological Research
  • Female
  • Fluorescence
  • Fluorescence microscopy
  • Hand Joints - diagnostic imaging
  • Hand Joints - pathology
  • Hands
  • Humans
  • Image Interpretation, Computer-Assisted - methods
  • Indocyanine Green
  • Inflammation
  • Integrated software
  • Laboratories
  • Magnetic Resonance Imaging - methods
  • Male
  • Medical sciences
  • Methods
  • Microscopy, Fluorescence - methods
  • Middle Aged
  • Miscellaneous. Osteoarticular involvement in other diseases
  • NMR
  • Nuclear magnetic resonance
  • Patients
  • Sensitivity and Specificity
  • Statistical analysis
  • Studies
  • Synovitis - diagnosis
  • Synovitis - diagnostic imaging
  • Ultrasonic imaging
  • Ultrasonography
  • Usage
  • Young Adult
ispartof: Annals of the Rheumatic Diseases, 2012-04, Vol.71 (4), p.504-510
description: Background Indocyanine green (ICG)-enhanced fluorescence optical imaging (FOI) is an established technology for imaging of inflammation in animal models. In experimental models of arthritis, FOI findings corresponded to histologically proven synovitis. This is the first comparative study of FOI with other imaging modalities in humans with arthritis. Methods 252 FOI examinations (Xiralite system, mivenion GmbH, Berlin, Germany; ICG bolus of 0.1 mg/kg/body weight, sequence of 360 images, one image per second) were compared with clinical examination (CE), ultrasonography (US) and MRI of patients with arthritis of the hands. Results In an FOI sequence, three phases could be distinguished (P1–P3). With MRI as reference, FOI had a sensitivity of 76% and a specificity of 54%, while the specificity of phase 1 was 94%. FOI had agreement rates up to 88% versus CE, 64% versus greyscale US, 88% versus power Doppler US and 83% versus MRI, depending on the compared phase and parameter. FOI showed a higher rate of positive results compared to CE, US and MRI. In individual patients, FOI correlated significantly (p
language: eng
source:
identifier: ISSN: 0003-4967
fulltext: no_fulltext
issn:
  • 0003-4967
  • 1468-2060
url: Link


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titleInflammation assessment in patients with arthritis using a novel in vivo fluorescence optical imaging technology
creatorWerner, Stephanie G ; Langer, Hans-Eckhard ; Ohrndorf, Sarah ; Bahner, Malte ; Schott, Peter ; Schwenke, Carsten ; Schirner, Michael ; Bastian, Hans ; Lind-Albrecht, Gudrun ; Kurtz, Bernward ; Burmester, Gerd R ; Backhaus, Marina
creatorcontribWerner, Stephanie G ; Langer, Hans-Eckhard ; Ohrndorf, Sarah ; Bahner, Malte ; Schott, Peter ; Schwenke, Carsten ; Schirner, Michael ; Bastian, Hans ; Lind-Albrecht, Gudrun ; Kurtz, Bernward ; Burmester, Gerd R ; Backhaus, Marina
descriptionBackground Indocyanine green (ICG)-enhanced fluorescence optical imaging (FOI) is an established technology for imaging of inflammation in animal models. In experimental models of arthritis, FOI findings corresponded to histologically proven synovitis. This is the first comparative study of FOI with other imaging modalities in humans with arthritis. Methods 252 FOI examinations (Xiralite system, mivenion GmbH, Berlin, Germany; ICG bolus of 0.1 mg/kg/body weight, sequence of 360 images, one image per second) were compared with clinical examination (CE), ultrasonography (US) and MRI of patients with arthritis of the hands. Results In an FOI sequence, three phases could be distinguished (P1–P3). With MRI as reference, FOI had a sensitivity of 76% and a specificity of 54%, while the specificity of phase 1 was 94%. FOI had agreement rates up to 88% versus CE, 64% versus greyscale US, 88% versus power Doppler US and 83% versus MRI, depending on the compared phase and parameter. FOI showed a higher rate of positive results compared to CE, US and MRI. In individual patients, FOI correlated significantly (p<0.05) with disease activity (Disease Activity Score 28, r=0.41), US (r=0.40) and RAMRIS (Rheumatoid Arthritis MRI Score) (r=0.56). FOI was normal in 97.8% of joints of controls. Conclusion ICG-enhanced FOI is a new technology offering sensitive imaging detection of inflammatory changes in subjects with arthritis. FOI was more sensitive than CE and had good agreement with CE, US in power Doppler mode and MRI, while showing more positive results than these. An adequate interpretation of an FOI sequence requires a separate evaluation of all phases. For the detection of synovitis and tenosynovitis, FOI appears to be as informative as 1.5 T MRI and US.
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publisherLondon: BMJ Publishing Group Ltd and European League Against Rheumatism
subject1506 ; Adult ; Aged ; Aged, 80 and over ; Agreements ; Arthritis ; Arthritis - diagnosis ; Arthritis - diagnostic imaging ; Arthritis, Psoriatic - diagnosis ; Arthritis, Psoriatic - diagnostic imaging ; Arthritis, Rheumatoid - diagnosis ; Arthritis, Rheumatoid - diagnostic imaging ; Biological and medical sciences ; Case-Control Studies ; Clinical ; Clinical and Epidemiological Research ; Coloring Agents ; Comparative analysis ; Confidence intervals ; Diagnosis ; Diagnostic imaging ; Diagnostic Imaging - methods ; Disease ; Diseases of the osteoarticular system ; Epidemiological Research ; Female ; Fluorescence ; Fluorescence microscopy ; Hand Joints - diagnostic imaging ; Hand Joints - pathology ; Hands ; Humans ; Image Interpretation, Computer-Assisted - methods ; Indocyanine Green ; Inflammation ; Integrated software ; Laboratories ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Methods ; Microscopy, Fluorescence - methods ; Middle Aged ; Miscellaneous. Osteoarticular involvement in other diseases ; NMR ; Nuclear magnetic resonance ; Patients ; Sensitivity and Specificity ; Statistical analysis ; Studies ; Synovitis - diagnosis ; Synovitis - diagnostic imaging ; Ultrasonic imaging ; Ultrasonography ; Usage ; Young Adult
ispartofAnnals of the Rheumatic Diseases, 2012-04, Vol.71 (4), p.504-510
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4Schott, Peter
5Schwenke, Carsten
6Schirner, Michael
7Bastian, Hans
8Lind-Albrecht, Gudrun
9Kurtz, Bernward
10Burmester, Gerd R
11Backhaus, Marina
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0Inflammation assessment in patients with arthritis using a novel in vivo fluorescence optical imaging technology
1Annals of the Rheumatic Diseases
addtitleAnn Rheum Dis
descriptionBackground Indocyanine green (ICG)-enhanced fluorescence optical imaging (FOI) is an established technology for imaging of inflammation in animal models. In experimental models of arthritis, FOI findings corresponded to histologically proven synovitis. This is the first comparative study of FOI with other imaging modalities in humans with arthritis. Methods 252 FOI examinations (Xiralite system, mivenion GmbH, Berlin, Germany; ICG bolus of 0.1 mg/kg/body weight, sequence of 360 images, one image per second) were compared with clinical examination (CE), ultrasonography (US) and MRI of patients with arthritis of the hands. Results In an FOI sequence, three phases could be distinguished (P1–P3). With MRI as reference, FOI had a sensitivity of 76% and a specificity of 54%, while the specificity of phase 1 was 94%. FOI had agreement rates up to 88% versus CE, 64% versus greyscale US, 88% versus power Doppler US and 83% versus MRI, depending on the compared phase and parameter. FOI showed a higher rate of positive results compared to CE, US and MRI. In individual patients, FOI correlated significantly (p<0.05) with disease activity (Disease Activity Score 28, r=0.41), US (r=0.40) and RAMRIS (Rheumatoid Arthritis MRI Score) (r=0.56). FOI was normal in 97.8% of joints of controls. Conclusion ICG-enhanced FOI is a new technology offering sensitive imaging detection of inflammatory changes in subjects with arthritis. FOI was more sensitive than CE and had good agreement with CE, US in power Doppler mode and MRI, while showing more positive results than these. An adequate interpretation of an FOI sequence requires a separate evaluation of all phases. For the detection of synovitis and tenosynovitis, FOI appears to be as informative as 1.5 T MRI and US.
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titleInflammation assessment in patients with arthritis using a novel in vivo fluorescence optical imaging technology
authorWerner, Stephanie G ; Langer, Hans-Eckhard ; Ohrndorf, Sarah ; Bahner, Malte ; Schott, Peter ; Schwenke, Carsten ; Schirner, Michael ; Bastian, Hans ; Lind-Albrecht, Gudrun ; Kurtz, Bernward ; Burmester, Gerd R ; Backhaus, Marina
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10Arthritis, Rheumatoid - diagnosis
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13Case-Control Studies
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15Clinical and Epidemiological Research
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17Comparative analysis
18Confidence intervals
19Diagnosis
20Diagnostic imaging
21Diagnostic Imaging - methods
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abstractBackground Indocyanine green (ICG)-enhanced fluorescence optical imaging (FOI) is an established technology for imaging of inflammation in animal models. In experimental models of arthritis, FOI findings corresponded to histologically proven synovitis. This is the first comparative study of FOI with other imaging modalities in humans with arthritis. Methods 252 FOI examinations (Xiralite system, mivenion GmbH, Berlin, Germany; ICG bolus of 0.1 mg/kg/body weight, sequence of 360 images, one image per second) were compared with clinical examination (CE), ultrasonography (US) and MRI of patients with arthritis of the hands. Results In an FOI sequence, three phases could be distinguished (P1–P3). With MRI as reference, FOI had a sensitivity of 76% and a specificity of 54%, while the specificity of phase 1 was 94%. FOI had agreement rates up to 88% versus CE, 64% versus greyscale US, 88% versus power Doppler US and 83% versus MRI, depending on the compared phase and parameter. FOI showed a higher rate of positive results compared to CE, US and MRI. In individual patients, FOI correlated significantly (p<0.05) with disease activity (Disease Activity Score 28, r=0.41), US (r=0.40) and RAMRIS (Rheumatoid Arthritis MRI Score) (r=0.56). FOI was normal in 97.8% of joints of controls. Conclusion ICG-enhanced FOI is a new technology offering sensitive imaging detection of inflammatory changes in subjects with arthritis. FOI was more sensitive than CE and had good agreement with CE, US in power Doppler mode and MRI, while showing more positive results than these. An adequate interpretation of an FOI sequence requires a separate evaluation of all phases. For the detection of synovitis and tenosynovitis, FOI appears to be as informative as 1.5 T MRI and US.
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