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EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment

Cancer-preventive effects of tea polyphenols, especially epigallocatechin-3-gallate (EGCG), have been demonstrated by epidemiological, preclinical, and clinical studies. Green tea polyphenols such as EGCG have the potential to affect multiple biological pathways, including gene expression, growth fa... Full description

Journal Title: Advances in Clinical Chemistry 2011, Vol.53, p.155-177
Main Author: Chen, Di
Other Authors: Wan, Sheng Biao , Yang, Huanjie , Yuan, Jian , Chan, Tak Hang , Dou, Q. Ping
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Science & Technology
ID: ISSN: 0065-2423
Link: https://www.ncbi.nlm.nih.gov/pubmed/21404918
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3304302
title: EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment
format: Article
creator:
  • Chen, Di
  • Wan, Sheng Biao
  • Yang, Huanjie
  • Yuan, Jian
  • Chan, Tak Hang
  • Dou, Q. Ping
subjects:
  • Analogs
  • Anticarcinogenic Agents - chemistry
  • Anticarcinogenic Agents - therapeutic use
  • Article
  • beverages
  • Cancer prevention
  • Cancer treatment
  • Catechin - analogs & derivatives
  • Catechin - chemistry
  • Catechin - therapeutic use
  • complex mixtures
  • DNA Damage
  • DNA Methylation
  • Flavonoids - chemistry
  • Flavonoids - therapeutic use
  • food
  • Humans
  • Molecular targets
  • Neoplasms - drug therapy
  • Neoplasms - prevention & control
  • Phenols - chemistry
  • Phenols - therapeutic use
  • Polyphenols
  • Prodrugs
  • Prodrugs - chemistry
  • Prodrugs - pharmacology
  • Proteasome Inhibitors
  • Structure-Activity Relationship
  • Tea - chemistry
  • Tea polyphenols
ispartof: Advances in Clinical Chemistry, 2011, Vol.53, p.155-177
description: Cancer-preventive effects of tea polyphenols, especially epigallocatechin-3-gallate (EGCG), have been demonstrated by epidemiological, preclinical, and clinical studies. Green tea polyphenols such as EGCG have the potential to affect multiple biological pathways, including gene expression, growth factor-mediated pathways, the mitogen-activated protein kinase-dependent pathway, and the ubiquitin/proteasome degradation pathway. Therefore, identification of the molecular targets of EGCG should greatly facilitate a better understanding of the mechanisms underlying its anticancer and cancer-preventive activities. Performing structure-activity relationship (SAR) studies could also greatly enhance the discovery of novel tea polyphenol analogs as potential anticancer and cancer-preventive agents. In this chapter, we review the relevant literature as it relates to the effects of natural and synthetic green tea polyphenols and EGCG analogs on human cancer cells and their potential molecular targets as well as their antitumor effects. We also discuss the implications of green tea polyphenols in cancer prevention.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0065-2423
fulltext: fulltext
issn:
  • 0065-2423
  • 2162-9471
url: Link


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descriptionCancer-preventive effects of tea polyphenols, especially epigallocatechin-3-gallate (EGCG), have been demonstrated by epidemiological, preclinical, and clinical studies. Green tea polyphenols such as EGCG have the potential to affect multiple biological pathways, including gene expression, growth factor-mediated pathways, the mitogen-activated protein kinase-dependent pathway, and the ubiquitin/proteasome degradation pathway. Therefore, identification of the molecular targets of EGCG should greatly facilitate a better understanding of the mechanisms underlying its anticancer and cancer-preventive activities. Performing structure-activity relationship (SAR) studies could also greatly enhance the discovery of novel tea polyphenol analogs as potential anticancer and cancer-preventive agents. In this chapter, we review the relevant literature as it relates to the effects of natural and synthetic green tea polyphenols and EGCG analogs on human cancer cells and their potential molecular targets as well as their antitumor effects. We also discuss the implications of green tea polyphenols in cancer prevention.
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subjectAnalogs ; Anticarcinogenic Agents - chemistry ; Anticarcinogenic Agents - therapeutic use ; Article ; beverages ; Cancer prevention ; Cancer treatment ; Catechin - analogs & derivatives ; Catechin - chemistry ; Catechin - therapeutic use ; complex mixtures ; DNA Damage ; DNA Methylation ; Flavonoids - chemistry ; Flavonoids - therapeutic use ; food ; Humans ; Molecular targets ; Neoplasms - drug therapy ; Neoplasms - prevention & control ; Phenols - chemistry ; Phenols - therapeutic use ; Polyphenols ; Prodrugs ; Prodrugs - chemistry ; Prodrugs - pharmacology ; Proteasome Inhibitors ; Structure-Activity Relationship ; Tea - chemistry ; Tea polyphenols
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descriptionCancer-preventive effects of tea polyphenols, especially epigallocatechin-3-gallate (EGCG), have been demonstrated by epidemiological, preclinical, and clinical studies. Green tea polyphenols such as EGCG have the potential to affect multiple biological pathways, including gene expression, growth factor-mediated pathways, the mitogen-activated protein kinase-dependent pathway, and the ubiquitin/proteasome degradation pathway. Therefore, identification of the molecular targets of EGCG should greatly facilitate a better understanding of the mechanisms underlying its anticancer and cancer-preventive activities. Performing structure-activity relationship (SAR) studies could also greatly enhance the discovery of novel tea polyphenol analogs as potential anticancer and cancer-preventive agents. In this chapter, we review the relevant literature as it relates to the effects of natural and synthetic green tea polyphenols and EGCG analogs on human cancer cells and their potential molecular targets as well as their antitumor effects. We also discuss the implications of green tea polyphenols in cancer prevention.
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abstractCancer-preventive effects of tea polyphenols, especially epigallocatechin-3-gallate (EGCG), have been demonstrated by epidemiological, preclinical, and clinical studies. Green tea polyphenols such as EGCG have the potential to affect multiple biological pathways, including gene expression, growth factor-mediated pathways, the mitogen-activated protein kinase-dependent pathway, and the ubiquitin/proteasome degradation pathway. Therefore, identification of the molecular targets of EGCG should greatly facilitate a better understanding of the mechanisms underlying its anticancer and cancer-preventive activities. Performing structure-activity relationship (SAR) studies could also greatly enhance the discovery of novel tea polyphenol analogs as potential anticancer and cancer-preventive agents. In this chapter, we review the relevant literature as it relates to the effects of natural and synthetic green tea polyphenols and EGCG analogs on human cancer cells and their potential molecular targets as well as their antitumor effects. We also discuss the implications of green tea polyphenols in cancer prevention.
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