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The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines

Highlights ► As part of the “inflammaging” process, innate immune processes may not only be ineffective, they may result in harmful inflammatory responses to infection. ► Increased levels of “bGrzB” activity associated with CMV, may be a common thread between immune dysfunction and the risk for card... Full description

Journal Title: Vaccine 2012, Vol.30 (12), p.2060-2067
Main Author: McElhaney, Janet E
Other Authors: Zhou, Xin , Talbot, H. Keipp , Soethout, Ernst , Bleackley, R. Chris , Granville, David J , Pawelec, Graham
Format: Electronic Article Electronic Article
Language: English
Subjects:
CMV
Quelle: Alma/SFX Local Collection
Publisher: Netherlands: Elsevier Ltd
ID: ISSN: 0264-410X
Link: https://www.ncbi.nlm.nih.gov/pubmed/22289511
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title: The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines
format: Article
creator:
  • McElhaney, Janet E
  • Zhou, Xin
  • Talbot, H. Keipp
  • Soethout, Ernst
  • Bleackley, R. Chris
  • Granville, David J
  • Pawelec, Graham
subjects:
  • Aged
  • Aging
  • Aging - immunology
  • Allergy and Immunology
  • Article
  • CD8 antigen
  • Chronic illnesses
  • CMV
  • Cytokines - blood
  • Cytomegalovirus
  • Cytomegalovirus infections
  • Cytomegalovirus Infections - epidemiology
  • Cytomegalovirus Infections - immunology
  • Elderly
  • Frailty
  • gamma -Interferon
  • Geriatrics
  • Granzyme B
  • Health aspects
  • Hospitalization
  • Humans
  • Immune response (cell-mediated)
  • Immunopathogenesis
  • Immunosenescence
  • Infection
  • Inflammation
  • Influenza
  • Influenza vaccine
  • Influenza vaccines
  • Influenza Vaccines - administration & dosage
  • Influenza Vaccines - immunology
  • Influenza virus
  • Influenza, Human - mortality
  • Influenza, Human - prevention & control
  • Interleukin 1
  • Interleukin 10
  • Interleukin 6
  • Lung
  • Lymphocytes T
  • Medical research
  • Mortality
  • Older adults
  • Older people
  • Peripheral blood mononuclear cells
  • Public health
  • Senescence
  • Serum levels
  • T-Lymphocytes - immunology
  • Transforming growth factor- beta
  • Tumor necrosis factor- alpha
  • Vaccines
ispartof: Vaccine, 2012, Vol.30 (12), p.2060-2067
description: Highlights ► As part of the “inflammaging” process, innate immune processes may not only be ineffective, they may result in harmful inflammatory responses to infection. ► Increased levels of “bGrzB” activity associated with CMV, may be a common thread between immune dysfunction and the risk for cardiovascular complications of influenza. ► The IFN-γ:IL-10 ratio and GrzB activity in influenza-challenged PBMC can be used as biomarkers to firmly establish vaccine-mediated protection/failure. ► Adding specific adjuvants may further enhance vaccine responses even in the face of a suboptimal immune system. ► Reliance on antibody titers as a sole predictor of vaccine efficacy is a major barrier to the development of more effective influenza vaccines, which remains an unmet need.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0264-410X
fulltext: fulltext
issn:
  • 0264-410X
  • 1873-2518
url: Link


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titleThe unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines
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descriptionHighlights ► As part of the “inflammaging” process, innate immune processes may not only be ineffective, they may result in harmful inflammatory responses to infection. ► Increased levels of “bGrzB” activity associated with CMV, may be a common thread between immune dysfunction and the risk for cardiovascular complications of influenza. ► The IFN-γ:IL-10 ratio and GrzB activity in influenza-challenged PBMC can be used as biomarkers to firmly establish vaccine-mediated protection/failure. ► Adding specific adjuvants may further enhance vaccine responses even in the face of a suboptimal immune system. ► Reliance on antibody titers as a sole predictor of vaccine efficacy is a major barrier to the development of more effective influenza vaccines, which remains an unmet need.
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subjectAged ; Aging ; Aging - immunology ; Allergy and Immunology ; Article ; CD8 antigen ; Chronic illnesses ; CMV ; Cytokines - blood ; Cytomegalovirus ; Cytomegalovirus infections ; Cytomegalovirus Infections - epidemiology ; Cytomegalovirus Infections - immunology ; Elderly ; Frailty ; gamma -Interferon ; Geriatrics ; Granzyme B ; Health aspects ; Hospitalization ; Humans ; Immune response (cell-mediated) ; Immunopathogenesis ; Immunosenescence ; Infection ; Inflammation ; Influenza ; Influenza vaccine ; Influenza vaccines ; Influenza Vaccines - administration & dosage ; Influenza Vaccines - immunology ; Influenza virus ; Influenza, Human - mortality ; Influenza, Human - prevention & control ; Interleukin 1 ; Interleukin 10 ; Interleukin 6 ; Lung ; Lymphocytes T ; Medical research ; Mortality ; Older adults ; Older people ; Peripheral blood mononuclear cells ; Public health ; Senescence ; Serum levels ; T-Lymphocytes - immunology ; Transforming growth factor- beta ; Tumor necrosis factor- alpha ; Vaccines
ispartofVaccine, 2012, Vol.30 (12), p.2060-2067
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descriptionHighlights ► As part of the “inflammaging” process, innate immune processes may not only be ineffective, they may result in harmful inflammatory responses to infection. ► Increased levels of “bGrzB” activity associated with CMV, may be a common thread between immune dysfunction and the risk for cardiovascular complications of influenza. ► The IFN-γ:IL-10 ratio and GrzB activity in influenza-challenged PBMC can be used as biomarkers to firmly establish vaccine-mediated protection/failure. ► Adding specific adjuvants may further enhance vaccine responses even in the face of a suboptimal immune system. ► Reliance on antibody titers as a sole predictor of vaccine efficacy is a major barrier to the development of more effective influenza vaccines, which remains an unmet need.
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titleThe unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines
authorMcElhaney, Janet E ; Zhou, Xin ; Talbot, H. Keipp ; Soethout, Ernst ; Bleackley, R. Chris ; Granville, David J ; Pawelec, Graham
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abstractHighlights ► As part of the “inflammaging” process, innate immune processes may not only be ineffective, they may result in harmful inflammatory responses to infection. ► Increased levels of “bGrzB” activity associated with CMV, may be a common thread between immune dysfunction and the risk for cardiovascular complications of influenza. ► The IFN-γ:IL-10 ratio and GrzB activity in influenza-challenged PBMC can be used as biomarkers to firmly establish vaccine-mediated protection/failure. ► Adding specific adjuvants may further enhance vaccine responses even in the face of a suboptimal immune system. ► Reliance on antibody titers as a sole predictor of vaccine efficacy is a major barrier to the development of more effective influenza vaccines, which remains an unmet need.
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