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A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic -Raman nanoparticle

The difficulty in delineating brain tumor margins is a major obstacle in the path toward better outcomes for patients with brain tumors. Current imaging methods are often limited by inadequate sensitivity, specificity and spatial resolution. Here we show that a unique triple-modality magnetic resona... Full description

Journal Title: Nature medicine 2012-04-15, Vol.18 (5), p.829-834
Main Author: Kircher, Moritz F
Other Authors: de la Zerda, Adam , Jokerst, Jesse V , Zavaleta, Cristina L , Kempen, Paul J , Mittra, Erik , Pitter, Ken , Huang, Ruimin , Campos, Carl , Habte, Frezghi , Sinclair, Robert , Brennan, Cameron W , Mellinghoff, Ingo K , Holland, Eric C , Gambhir, Sanjiv S
Format: Electronic Article Electronic Article
Language: English
Subjects:
MRI
Publisher: United States: Nature Publishing Group
ID: ISSN: 1078-8956
Link: https://www.ncbi.nlm.nih.gov/pubmed/22504484
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title: A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic -Raman nanoparticle
format: Article
creator:
  • Kircher, Moritz F
  • de la Zerda, Adam
  • Jokerst, Jesse V
  • Zavaleta, Cristina L
  • Kempen, Paul J
  • Mittra, Erik
  • Pitter, Ken
  • Huang, Ruimin
  • Campos, Carl
  • Habte, Frezghi
  • Sinclair, Robert
  • Brennan, Cameron W
  • Mellinghoff, Ingo K
  • Holland, Eric C
  • Gambhir, Sanjiv S
subjects:
  • Animals
  • Article
  • Brain cancer
  • Brain Neoplasms - diagnosis
  • Brain Neoplasms - pathology
  • Brain Neoplasms - surgery
  • brain tumor
  • Brain tumors
  • cancer
  • Care and treatment
  • contrast agent
  • Diagnosis
  • gold
  • Humans
  • in vivo
  • Magnetic resonance imaging
  • Magnetic Resonance Imaging - methods
  • Medical imaging
  • Metal Nanoparticles - chemistry
  • Methods
  • Mice
  • molecular imaging
  • Molecular Imaging - methods
  • MRI
  • multimodality
  • nanoparticle
  • Nanoparticles
  • Neuroimaging
  • Photoacoustic
  • Photoacoustic Techniques - methods
  • Raman
  • SERS
  • silica
  • Spectrum Analysis, Raman - methods
  • surgery
  • tumor margin
  • Tumors
  • Usage
ispartof: Nature medicine, 2012-04-15, Vol.18 (5), p.829-834
description: The difficulty in delineating brain tumor margins is a major obstacle in the path toward better outcomes for patients with brain tumors. Current imaging methods are often limited by inadequate sensitivity, specificity and spatial resolution. Here we show that a unique triple-modality magnetic resonance imaging-photoacoustic imaging-Raman imaging nanoparticle (termed here MPR nanoparticle) can accurately help delineate the margins of brain tumors in living mice both preoperatively and intraoperatively. The MPRs were detected by all three modalities with at least a picomolar sensitivity both in vitro and in living mice. Intravenous injection of MPRs into glioblastoma-bearing mice led to MPR accumulation and retention by the tumors, with no MPR accumulation in the surrounding healthy tissue, allowing for a noninvasive tumor delineation using all three modalities through the intact skull. Raman imaging allowed for guidance of intraoperative tumor resection, and a histological correlation validated that Raman imaging was accurately delineating the brain tumor margins. This new triple-modality-nanoparticle approach has promise for enabling more accurate brain tumor imaging and resection.
language: eng
source:
identifier: ISSN: 1078-8956
fulltext: no_fulltext
issn:
  • 1078-8956
  • 1546-170X
url: Link


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descriptionThe difficulty in delineating brain tumor margins is a major obstacle in the path toward better outcomes for patients with brain tumors. Current imaging methods are often limited by inadequate sensitivity, specificity and spatial resolution. Here we show that a unique triple-modality magnetic resonance imaging-photoacoustic imaging-Raman imaging nanoparticle (termed here MPR nanoparticle) can accurately help delineate the margins of brain tumors in living mice both preoperatively and intraoperatively. The MPRs were detected by all three modalities with at least a picomolar sensitivity both in vitro and in living mice. Intravenous injection of MPRs into glioblastoma-bearing mice led to MPR accumulation and retention by the tumors, with no MPR accumulation in the surrounding healthy tissue, allowing for a noninvasive tumor delineation using all three modalities through the intact skull. Raman imaging allowed for guidance of intraoperative tumor resection, and a histological correlation validated that Raman imaging was accurately delineating the brain tumor margins. This new triple-modality-nanoparticle approach has promise for enabling more accurate brain tumor imaging and resection.
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subjectAnimals ; Article ; Brain cancer ; Brain Neoplasms - diagnosis ; Brain Neoplasms - pathology ; Brain Neoplasms - surgery ; brain tumor ; Brain tumors ; cancer ; Care and treatment ; contrast agent ; Diagnosis ; gold ; Humans ; in vivo ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Medical imaging ; Metal Nanoparticles - chemistry ; Methods ; Mice ; molecular imaging ; Molecular Imaging - methods ; MRI ; multimodality ; nanoparticle ; Nanoparticles ; Neuroimaging ; Photoacoustic ; Photoacoustic Techniques - methods ; Raman ; SERS ; silica ; Spectrum Analysis, Raman - methods ; surgery ; tumor margin ; Tumors ; Usage
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descriptionThe difficulty in delineating brain tumor margins is a major obstacle in the path toward better outcomes for patients with brain tumors. Current imaging methods are often limited by inadequate sensitivity, specificity and spatial resolution. Here we show that a unique triple-modality magnetic resonance imaging-photoacoustic imaging-Raman imaging nanoparticle (termed here MPR nanoparticle) can accurately help delineate the margins of brain tumors in living mice both preoperatively and intraoperatively. The MPRs were detected by all three modalities with at least a picomolar sensitivity both in vitro and in living mice. Intravenous injection of MPRs into glioblastoma-bearing mice led to MPR accumulation and retention by the tumors, with no MPR accumulation in the surrounding healthy tissue, allowing for a noninvasive tumor delineation using all three modalities through the intact skull. Raman imaging allowed for guidance of intraoperative tumor resection, and a histological correlation validated that Raman imaging was accurately delineating the brain tumor margins. This new triple-modality-nanoparticle approach has promise for enabling more accurate brain tumor imaging and resection.
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titleA brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic -Raman nanoparticle
authorKircher, Moritz F ; de la Zerda, Adam ; Jokerst, Jesse V ; Zavaleta, Cristina L ; Kempen, Paul J ; Mittra, Erik ; Pitter, Ken ; Huang, Ruimin ; Campos, Carl ; Habte, Frezghi ; Sinclair, Robert ; Brennan, Cameron W ; Mellinghoff, Ingo K ; Holland, Eric C ; Gambhir, Sanjiv S
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abstractThe difficulty in delineating brain tumor margins is a major obstacle in the path toward better outcomes for patients with brain tumors. Current imaging methods are often limited by inadequate sensitivity, specificity and spatial resolution. Here we show that a unique triple-modality magnetic resonance imaging-photoacoustic imaging-Raman imaging nanoparticle (termed here MPR nanoparticle) can accurately help delineate the margins of brain tumors in living mice both preoperatively and intraoperatively. The MPRs were detected by all three modalities with at least a picomolar sensitivity both in vitro and in living mice. Intravenous injection of MPRs into glioblastoma-bearing mice led to MPR accumulation and retention by the tumors, with no MPR accumulation in the surrounding healthy tissue, allowing for a noninvasive tumor delineation using all three modalities through the intact skull. Raman imaging allowed for guidance of intraoperative tumor resection, and a histological correlation validated that Raman imaging was accurately delineating the brain tumor margins. This new triple-modality-nanoparticle approach has promise for enabling more accurate brain tumor imaging and resection.
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