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Antiretroviral drug susceptibility among HIV-infected adults failing antiretroviral therapy in Rakai, Uganda

Objective: To analyze antiretroviral drug susceptibility in HIV–infected adults failing first- and second-line antiretroviral treatment (ART) in Rakai, Uganda. Methods: Samples obtained from participants at baseline (pre-treatment), at the time of failure on first-line ART and second-line ART were a... Full description

Journal Title: AIDS research and human retroviruses 2012, Vol.28 (ja), p.1739-1744
Main Author: Reynolds, Steven James
Other Authors: Laeyendecker, Oliver , Nakigozi, Gertrude , Gallant, Joel , Huang, Wei , Hudelson, Sarah E , Quinn, Thomas C , Newell, Kevin , Serwadda, David , Gray, Ronald H , Wawer, Maria J , Eshleman, Susan
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: New Rochelle, NY: Liebert
ID: ISSN: 0889-2229
Zum Text:
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title: Antiretroviral drug susceptibility among HIV-infected adults failing antiretroviral therapy in Rakai, Uganda
format: Article
creator:
  • Reynolds, Steven James
  • Laeyendecker, Oliver
  • Nakigozi, Gertrude
  • Gallant, Joel
  • Huang, Wei
  • Hudelson, Sarah E
  • Quinn, Thomas C
  • Newell, Kevin
  • Serwadda, David
  • Gray, Ronald H
  • Wawer, Maria J
  • Eshleman, Susan
subjects:
  • Adolescent
  • Adult
  • AIDS/HIV
  • Anti-Retroviral Agents - administration & dosage
  • antiretroviral therapy
  • Antiretroviral Therapy, Highly Active - methods
  • Antiviral agents
  • Biological and medical sciences
  • Drug resistance
  • Drug Resistance, Viral
  • Drugs
  • Epidemiology
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Genotype
  • HIV - drug effects
  • HIV - genetics
  • HIV - isolation & purification
  • HIV Infections - drug therapy
  • HIV Infections - virology
  • HIV Protease - genetics
  • HIV Reverse Transcriptase - genetics
  • Human immunodeficiency virus
  • Human viral diseases
  • Humans
  • Infectious diseases
  • Lamivudine
  • Male
  • Medical sciences
  • Microbial Sensitivity Tests
  • Microbiology
  • Miscellaneous
  • Molecular Sequence Data
  • Mutation
  • Mutation, Missense
  • non-nucleoside reverse transcriptase inhibitors
  • nucleosides
  • Proteinase inhibitors
  • Retrovirus
  • Sequence Analysis, DNA
  • Treatment Failure
  • Uganda
  • Viral diseases
  • Viral diseases of the lymphoid tissue and the blood. Aids
  • Virology
  • Young Adult
ispartof: AIDS research and human retroviruses, 2012, Vol.28 (ja), p.1739-1744
description: Objective: To analyze antiretroviral drug susceptibility in HIV–infected adults failing first- and second-line antiretroviral treatment (ART) in Rakai, Uganda. Methods: Samples obtained from participants at baseline (pre-treatment), at the time of failure on first-line ART and second-line ART were analyzed using genotypic and phenotypic assays for antiretroviral drug resistance. Results: Test results were obtained from 73 samples from 38 individuals (31 baseline samples, 36 first-line failure samples, and six second-line failure samples). Four (13%) of the 31 baseline samples had mutations associated with resistance to nucleoside or non-nucleoside reverse transcriptase inhibitors (NRTIs and NNRTIs, respectively). Among the 36 first-line failure samples, 31 (86%) had NNRTI resistance mutations and 29 (81%) had lamivudine resistance mutations; only 8 (22%) had other NRTI resistance mutations. None of the six individuals failing a second-line protease inhibitor (PI)-based regimen had PI resistance mutations. Six (16%) of the participants had discordant genotypic and phenotypic test results. Conclusions: Genotypic resistance to drugs included in first-line ART regimens was detected prior to treatment and among participants failing first-line ART. PI resistance was not detected in individuals failing second-line ART. Surveillance for transmitted and acquired drug resistance remains a priority for scale-up of ART.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0889-2229
fulltext: fulltext
issn:
  • 0889-2229
  • 1931-8405
url: Link


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titleAntiretroviral drug susceptibility among HIV-infected adults failing antiretroviral therapy in Rakai, Uganda
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creatorReynolds, Steven James ; Laeyendecker, Oliver ; Nakigozi, Gertrude ; Gallant, Joel ; Huang, Wei ; Hudelson, Sarah E ; Quinn, Thomas C ; Newell, Kevin ; Serwadda, David ; Gray, Ronald H ; Wawer, Maria J ; Eshleman, Susan
creatorcontribReynolds, Steven James ; Laeyendecker, Oliver ; Nakigozi, Gertrude ; Gallant, Joel ; Huang, Wei ; Hudelson, Sarah E ; Quinn, Thomas C ; Newell, Kevin ; Serwadda, David ; Gray, Ronald H ; Wawer, Maria J ; Eshleman, Susan
descriptionObjective: To analyze antiretroviral drug susceptibility in HIV–infected adults failing first- and second-line antiretroviral treatment (ART) in Rakai, Uganda. Methods: Samples obtained from participants at baseline (pre-treatment), at the time of failure on first-line ART and second-line ART were analyzed using genotypic and phenotypic assays for antiretroviral drug resistance. Results: Test results were obtained from 73 samples from 38 individuals (31 baseline samples, 36 first-line failure samples, and six second-line failure samples). Four (13%) of the 31 baseline samples had mutations associated with resistance to nucleoside or non-nucleoside reverse transcriptase inhibitors (NRTIs and NNRTIs, respectively). Among the 36 first-line failure samples, 31 (86%) had NNRTI resistance mutations and 29 (81%) had lamivudine resistance mutations; only 8 (22%) had other NRTI resistance mutations. None of the six individuals failing a second-line protease inhibitor (PI)-based regimen had PI resistance mutations. Six (16%) of the participants had discordant genotypic and phenotypic test results. Conclusions: Genotypic resistance to drugs included in first-line ART regimens was detected prior to treatment and among participants failing first-line ART. PI resistance was not detected in individuals failing second-line ART. Surveillance for transmitted and acquired drug resistance remains a priority for scale-up of ART.
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subjectAdolescent ; Adult ; AIDS/HIV ; Anti-Retroviral Agents - administration & dosage ; antiretroviral therapy ; Antiretroviral Therapy, Highly Active - methods ; Antiviral agents ; Biological and medical sciences ; Drug resistance ; Drug Resistance, Viral ; Drugs ; Epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; Genotype ; HIV - drug effects ; HIV - genetics ; HIV - isolation & purification ; HIV Infections - drug therapy ; HIV Infections - virology ; HIV Protease - genetics ; HIV Reverse Transcriptase - genetics ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Lamivudine ; Male ; Medical sciences ; Microbial Sensitivity Tests ; Microbiology ; Miscellaneous ; Molecular Sequence Data ; Mutation ; Mutation, Missense ; non-nucleoside reverse transcriptase inhibitors ; nucleosides ; Proteinase inhibitors ; Retrovirus ; Sequence Analysis, DNA ; Treatment Failure ; Uganda ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Virology ; Young Adult
ispartofAIDS research and human retroviruses, 2012, Vol.28 (ja), p.1739-1744
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2Nakigozi, Gertrude
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5Hudelson, Sarah E
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7Newell, Kevin
8Serwadda, David
9Gray, Ronald H
10Wawer, Maria J
11Eshleman, Susan
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descriptionObjective: To analyze antiretroviral drug susceptibility in HIV–infected adults failing first- and second-line antiretroviral treatment (ART) in Rakai, Uganda. Methods: Samples obtained from participants at baseline (pre-treatment), at the time of failure on first-line ART and second-line ART were analyzed using genotypic and phenotypic assays for antiretroviral drug resistance. Results: Test results were obtained from 73 samples from 38 individuals (31 baseline samples, 36 first-line failure samples, and six second-line failure samples). Four (13%) of the 31 baseline samples had mutations associated with resistance to nucleoside or non-nucleoside reverse transcriptase inhibitors (NRTIs and NNRTIs, respectively). Among the 36 first-line failure samples, 31 (86%) had NNRTI resistance mutations and 29 (81%) had lamivudine resistance mutations; only 8 (22%) had other NRTI resistance mutations. None of the six individuals failing a second-line protease inhibitor (PI)-based regimen had PI resistance mutations. Six (16%) of the participants had discordant genotypic and phenotypic test results. Conclusions: Genotypic resistance to drugs included in first-line ART regimens was detected prior to treatment and among participants failing first-line ART. PI resistance was not detected in individuals failing second-line ART. Surveillance for transmitted and acquired drug resistance remains a priority for scale-up of ART.
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0Adolescent
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2AIDS/HIV
3Anti-Retroviral Agents - administration & dosage
4antiretroviral therapy
5Antiretroviral Therapy, Highly Active - methods
6Antiviral agents
7Biological and medical sciences
8Drug resistance
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10Drugs
11Epidemiology
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13Fundamental and applied biological sciences. Psychology
14Genotype
15HIV - drug effects
16HIV - genetics
17HIV - isolation & purification
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21HIV Reverse Transcriptase - genetics
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37Proteinase inhibitors
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39Sequence Analysis, DNA
40Treatment Failure
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42Viral diseases
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45Young Adult
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titleAntiretroviral drug susceptibility among HIV-infected adults failing antiretroviral therapy in Rakai, Uganda
authorReynolds, Steven James ; Laeyendecker, Oliver ; Nakigozi, Gertrude ; Gallant, Joel ; Huang, Wei ; Hudelson, Sarah E ; Quinn, Thomas C ; Newell, Kevin ; Serwadda, David ; Gray, Ronald H ; Wawer, Maria J ; Eshleman, Susan
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21HIV Reverse Transcriptase - genetics
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45Young Adult
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8Serwadda, David
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abstractObjective: To analyze antiretroviral drug susceptibility in HIV–infected adults failing first- and second-line antiretroviral treatment (ART) in Rakai, Uganda. Methods: Samples obtained from participants at baseline (pre-treatment), at the time of failure on first-line ART and second-line ART were analyzed using genotypic and phenotypic assays for antiretroviral drug resistance. Results: Test results were obtained from 73 samples from 38 individuals (31 baseline samples, 36 first-line failure samples, and six second-line failure samples). Four (13%) of the 31 baseline samples had mutations associated with resistance to nucleoside or non-nucleoside reverse transcriptase inhibitors (NRTIs and NNRTIs, respectively). Among the 36 first-line failure samples, 31 (86%) had NNRTI resistance mutations and 29 (81%) had lamivudine resistance mutations; only 8 (22%) had other NRTI resistance mutations. None of the six individuals failing a second-line protease inhibitor (PI)-based regimen had PI resistance mutations. Six (16%) of the participants had discordant genotypic and phenotypic test results. Conclusions: Genotypic resistance to drugs included in first-line ART regimens was detected prior to treatment and among participants failing first-line ART. PI resistance was not detected in individuals failing second-line ART. Surveillance for transmitted and acquired drug resistance remains a priority for scale-up of ART.
copNew Rochelle, NY
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pmid22443282
doi10.1089/AID.2011.0352
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