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Bacillithiol is an antioxidant thiol produced in Bacilli

Glutathione is a nearly ubiquitous, low-molecular-mass thiol and antioxidant, but it is conspicuously absent from most Gram-positive bacteria. We identify here the structure of bacillithiol, a newly described and abundant thiol produced by Bacillus species, Staphylococcus aureus and Deinococcus radi... Full description

Journal Title: Nature chemical biology 2009-09, Vol.5 (9), p.625-627
Main Author: Fahey, Robert C
Other Authors: Newton, Gerald L , Rawat, Mamta , La Clair, James J , Jothivasan, Vishnu Karthik , Budiarto, Tanya , Hamilton, Chris J , Claiborne, Al , Helmann, John D
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Nature Publishing Group
ID: ISSN: 1552-4450
Link: https://www.ncbi.nlm.nih.gov/pubmed/19578333
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3510479
title: Bacillithiol is an antioxidant thiol produced in Bacilli
format: Article
creator:
  • Fahey, Robert C
  • Newton, Gerald L
  • Rawat, Mamta
  • La Clair, James J
  • Jothivasan, Vishnu Karthik
  • Budiarto, Tanya
  • Hamilton, Chris J
  • Claiborne, Al
  • Helmann, John D
subjects:
  • Antioxidants
  • Antioxidants - chemistry
  • Antioxidants - isolation & purification
  • Antioxidants - pharmacology
  • Article
  • Bacillus
  • Bacteria
  • Biochemistry
  • Cysteine - analogs & derivatives
  • Cysteine - chemistry
  • Cysteine - isolation & purification
  • Cysteine - pharmacology
  • Deinococcus - metabolism
  • Deinococcus radiodurans
  • Glucosamine - analogs & derivatives
  • Glucosamine - chemistry
  • Glucosamine - isolation & purification
  • Glucosamine - pharmacology
  • Glutathione - chemistry
  • Glutathione - pharmacology
  • Models, Molecular
  • Molecular biology
  • Molecular Structure
  • Staphylococcus aureus
  • Staphylococcus aureus - metabolism
  • Sulfhydryl Compounds - chemistry
  • Sulfhydryl Compounds - isolation & purification
  • Sulfhydryl Compounds - pharmacology
ispartof: Nature chemical biology, 2009-09, Vol.5 (9), p.625-627
description: Glutathione is a nearly ubiquitous, low-molecular-mass thiol and antioxidant, but it is conspicuously absent from most Gram-positive bacteria. We identify here the structure of bacillithiol, a newly described and abundant thiol produced by Bacillus species, Staphylococcus aureus and Deinococcus radiodurans. Bacillithiol is the α-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid and most probably functions as an antioxidant. Bacillithiol, like the structurally similar mycothiol, may serve as a substitute for glutathione.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1552-4450
fulltext: fulltext
issn:
  • 1552-4450
  • 1548-7105
  • 1552-4469
url: Link


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descriptionGlutathione is a nearly ubiquitous, low-molecular-mass thiol and antioxidant, but it is conspicuously absent from most Gram-positive bacteria. We identify here the structure of bacillithiol, a newly described and abundant thiol produced by Bacillus species, Staphylococcus aureus and Deinococcus radiodurans. Bacillithiol is the α-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid and most probably functions as an antioxidant. Bacillithiol, like the structurally similar mycothiol, may serve as a substitute for glutathione.
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abstractGlutathione is a nearly ubiquitous, low-molecular-mass thiol and antioxidant, but it is conspicuously absent from most Gram-positive bacteria. We identify here the structure of bacillithiol, a newly described and abundant thiol produced by Bacillus species, Staphylococcus aureus and Deinococcus radiodurans. Bacillithiol is the α-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid and most probably functions as an antioxidant. Bacillithiol, like the structurally similar mycothiol, may serve as a substitute for glutathione.
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