schliessen

Filtern

 

Bibliotheken

Cover Image

Predictors of Low Clopidogrel Adherence Following Percutaneous Coronary Intervention

Few data are available on factors associated with low adherence or early clopidogrel discontinuation after percutaneous coronary intervention (PCI). Patients (n = 284) were evaluated before hospital discharge after PCI to identify factors associated with low adherence to clopidogrel 30 days later. A... Full description

Journal Title: The American journal of cardiology 2011, Vol.108 (6), p.822-827
Main Author: Muntner, Paul, PhD
Other Authors: Mann, Devin M., MD , Woodward, Mark, PhD , Choi, James W., MD , Stoler, Robert C., MD , Shimbo, Daichi, MD , Farkouh, Michael E., MD , Kim, Michael C., MD
Format: Electronic Article Electronic Article
Language: English
Subjects:
Abridged Index Medicus
Angioplasty
Angioplasty, Balloon, Coronary
Article
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiovascular
cardiovascular diseases
Clopidgrel
Coronary Disease - drug therapy
Coronary Disease - therapy
Diseases of the cardiovascular system
Drug dosages
Female
Humans
Male
Medical sciences
Medication Adherence
Middle Aged
New York
operative
Patient compliance
percutaneous coronary intervention
Platelet Aggregation Inhibitors - administration & dosage
Predictive Value of Tests
Prescription drugs
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Risk Factors
surgical procedures
Surveys and Questionnaires
Texas
Ticlopidine - administration & dosage
Ticlopidine - analogs & derivatives
Treatment Outcome
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 0002-9149
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3586559
title: Predictors of Low Clopidogrel Adherence Following Percutaneous Coronary Intervention
format: Article
creator:
  • Muntner, Paul, PhD
  • Mann, Devin M., MD
  • Woodward, Mark, PhD
  • Choi, James W., MD
  • Stoler, Robert C., MD
  • Shimbo, Daichi, MD
  • Farkouh, Michael E., MD
  • Kim, Michael C., MD
subjects:
  • Abridged Index Medicus
  • Angioplasty
  • Angioplasty, Balloon, Coronary
  • Article
  • Biological and medical sciences
  • Cardiology
  • Cardiology. Vascular system
  • Cardiovascular
  • cardiovascular diseases
  • Clopidgrel
  • Coronary Disease - drug therapy
  • Coronary Disease - therapy
  • Diseases of the cardiovascular system
  • Drug dosages
  • Female
  • Humans
  • Male
  • Medical sciences
  • Medication Adherence
  • Middle Aged
  • New York
  • operative
  • Patient compliance
  • percutaneous coronary intervention
  • Platelet Aggregation Inhibitors - administration & dosage
  • Predictive Value of Tests
  • Prescription drugs
  • Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
  • Risk Factors
  • surgical procedures
  • Surveys and Questionnaires
  • Texas
  • Ticlopidine - administration & dosage
  • Ticlopidine - analogs & derivatives
  • Treatment Outcome
ispartof: The American journal of cardiology, 2011, Vol.108 (6), p.822-827
description: Few data are available on factors associated with low adherence or early clopidogrel discontinuation after percutaneous coronary intervention (PCI). Patients (n = 284) were evaluated before hospital discharge after PCI to identify factors associated with low adherence to clopidogrel 30 days later. Adherence to daily medications before PCI was assessed using the 8-item Morisky Medication Adherence Scale (MMAS-8) and categorized as low (score
language: eng
source:
identifier: ISSN: 0002-9149
fulltext: no_fulltext
issn:
  • 0002-9149
  • 1879-1913
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.4228764
LOCALfalse
PrimoNMBib
record
control
sourceidgale_pubme
recordidTN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3586559
sourceformatXML
sourcesystemPC
galeidA266066742
sourcerecordidA266066742
originalsourceidFETCH-LOGICAL-1682t-3a02aadb40d7c29d211f70866e353f5e82aaac0ec2f72d9efd4f74a86000f3b10
addsrcrecordideNqFU1Fv0zAYjBCIlcFPAEVIiKcW20nsWEhDVcXYpEpMYjxbrv25c0ntYqed9u_5opbC-jLlwUp8d7nvfC6Kt5RMKKH802qi1yujk50wQumE1BNS1c-KEW2FHFNJq-fFiBDCxpLW8qx4lfMKXylt-MvijFFRU07JqLi9SWC96WPKZXTlPN6Xsy5uvI3LBF05tXeQIBgoL2PXxXsfluUNJLPtdYC4zeUsphh0eiivQw9pB6H3MbwuXjjdZXhzWM-Ln5dfb2dX4_n3b9ez6XxMecv6caUJ09ouamKFYdIySp0gLedQNZVroMVdbQgY5gSzEpytnah1y3EQVy0oOS8u9rqb7WIN1uDfk-7UJvk1WlJRe_V4J_g7tYw7VTUtbxqJAld7gbiBoH2CR1wboFfRKsaFaig4yQSVTAunjXZCNq2TxBohRMstSn08eEnx9xZyr9Y-G-i6fVCqbUVDOKMcke9PkKu4TQGDGkCskrQhCJrsQUvdgfLBRRzA4GNh7U0M4Dx-nzLOCeeiZkho9gSTYs4J3HEUStTQGLVSh8aooTGK1Aobg7x3_2d4ZP2tCAI-HAA6G925pIPx-R-uxixxLsR9PjFgfK-HOqBz3z1p48ueDdiXnYeksvFD8SyeiumVjf5JhYsTBdP54NHyL3iAfMyYqswUUT-GyzHcDYqaQkhO_gCUigoq
sourcetypeOpen Access Repository
isCDItrue
recordtypearticle
pqid887239150
display
typearticle
titlePredictors of Low Clopidogrel Adherence Following Percutaneous Coronary Intervention
creatorMuntner, Paul, PhD ; Mann, Devin M., MD ; Woodward, Mark, PhD ; Choi, James W., MD ; Stoler, Robert C., MD ; Shimbo, Daichi, MD ; Farkouh, Michael E., MD ; Kim, Michael C., MD
creatorcontribMuntner, Paul, PhD ; Mann, Devin M., MD ; Woodward, Mark, PhD ; Choi, James W., MD ; Stoler, Robert C., MD ; Shimbo, Daichi, MD ; Farkouh, Michael E., MD ; Kim, Michael C., MD
descriptionFew data are available on factors associated with low adherence or early clopidogrel discontinuation after percutaneous coronary intervention (PCI). Patients (n = 284) were evaluated before hospital discharge after PCI to identify factors associated with low adherence to clopidogrel 30 days later. Adherence to daily medications before PCI was assessed using the 8-item Morisky Medication Adherence Scale (MMAS-8) and categorized as low (score <6), medium (score 6 to <8), or high (score 8). Low adherence to clopidogrel was defined as MMAS-8 score <6 (n = 21) or having discontinued clopidogrel (n = 11), which was ascertained during a 30-day interview after PCI. At 30 days after PCI, 11% of patients had low adherence to clopidogrel. Odds ratios (95% confidence intervals [CIs]) for low adherence to clopidogrel were 3.78 (1.09 to 13.1), 3.06 (1.36 to 6.87), 2.46 (0.97 to 6.27), and 3.36 (0.99 to 11.4) for patients who before PCI reported taking smaller doses of medication because of cost, had difficulty filling prescriptions, had difficulty reaching their primary physician, and were not comfortable asking their doctor for instructions, respectively. Odds ratios (95% CIs) for low clopidogrel adherence after PCI in patients with medium and low versus high adherence to daily medications before PCI were 6.13 (1.34 to 28.2) and 10.9 (2.46 to 48.7), respectively. The c-statistic associated with MMAS-8 scores before PCI for discriminating low clopidogrel adherence at 30 days after PCI was 0.733 (95% CI 0.650 to 0.852). In conclusion, adherence to daily medications before PCI may be a useful indicator for identifying patients who will have low clopidogrel adherence after PCI.
identifier
0ISSN: 0002-9149
1EISSN: 1879-1913
2DOI: 10.1016/j.amjcard.2011.04.034
3PMID: 21741610
4CODEN: AJCDAG
languageeng
publisherNew York, NY: Elsevier Inc
subjectAbridged Index Medicus ; Angioplasty ; Angioplasty, Balloon, Coronary ; Article ; Biological and medical sciences ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; cardiovascular diseases ; Clopidgrel ; Coronary Disease - drug therapy ; Coronary Disease - therapy ; Diseases of the cardiovascular system ; Drug dosages ; Female ; Humans ; Male ; Medical sciences ; Medication Adherence ; Middle Aged ; New York ; operative ; Patient compliance ; percutaneous coronary intervention ; Platelet Aggregation Inhibitors - administration & dosage ; Predictive Value of Tests ; Prescription drugs ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Risk Factors ; surgical procedures ; Surveys and Questionnaires ; Texas ; Ticlopidine - administration & dosage ; Ticlopidine - analogs & derivatives ; Treatment Outcome
ispartofThe American journal of cardiology, 2011, Vol.108 (6), p.822-827
rights
0Elsevier Inc.
12011 Elsevier Inc.
22015 INIST-CNRS
3Copyright © 2011 Elsevier Inc. All rights reserved.
4COPYRIGHT 2011 Elsevier B.V.
5Copyright Elsevier Sequoia S.A. Sep 15, 2011
62011 Excerpta Medica, Inc. All rights reserved. 2011
lds50peer_reviewed
oafree_for_read
citedbyFETCH-LOGICAL-1682t-3a02aadb40d7c29d211f70866e353f5e82aaac0ec2f72d9efd4f74a86000f3b10
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24586621$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21741610$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Muntner, Paul, PhD
1Mann, Devin M., MD
2Woodward, Mark, PhD
3Choi, James W., MD
4Stoler, Robert C., MD
5Shimbo, Daichi, MD
6Farkouh, Michael E., MD
7Kim, Michael C., MD
title
0Predictors of Low Clopidogrel Adherence Following Percutaneous Coronary Intervention
1The American journal of cardiology
addtitleAm J Cardiol
descriptionFew data are available on factors associated with low adherence or early clopidogrel discontinuation after percutaneous coronary intervention (PCI). Patients (n = 284) were evaluated before hospital discharge after PCI to identify factors associated with low adherence to clopidogrel 30 days later. Adherence to daily medications before PCI was assessed using the 8-item Morisky Medication Adherence Scale (MMAS-8) and categorized as low (score <6), medium (score 6 to <8), or high (score 8). Low adherence to clopidogrel was defined as MMAS-8 score <6 (n = 21) or having discontinued clopidogrel (n = 11), which was ascertained during a 30-day interview after PCI. At 30 days after PCI, 11% of patients had low adherence to clopidogrel. Odds ratios (95% confidence intervals [CIs]) for low adherence to clopidogrel were 3.78 (1.09 to 13.1), 3.06 (1.36 to 6.87), 2.46 (0.97 to 6.27), and 3.36 (0.99 to 11.4) for patients who before PCI reported taking smaller doses of medication because of cost, had difficulty filling prescriptions, had difficulty reaching their primary physician, and were not comfortable asking their doctor for instructions, respectively. Odds ratios (95% CIs) for low clopidogrel adherence after PCI in patients with medium and low versus high adherence to daily medications before PCI were 6.13 (1.34 to 28.2) and 10.9 (2.46 to 48.7), respectively. The c-statistic associated with MMAS-8 scores before PCI for discriminating low clopidogrel adherence at 30 days after PCI was 0.733 (95% CI 0.650 to 0.852). In conclusion, adherence to daily medications before PCI may be a useful indicator for identifying patients who will have low clopidogrel adherence after PCI.
subject
0Abridged Index Medicus
1Angioplasty
2Angioplasty, Balloon, Coronary
3Article
4Biological and medical sciences
5Cardiology
6Cardiology. Vascular system
7Cardiovascular
8cardiovascular diseases
9Clopidgrel
10Coronary Disease - drug therapy
11Coronary Disease - therapy
12Diseases of the cardiovascular system
13Drug dosages
14Female
15Humans
16Male
17Medical sciences
18Medication Adherence
19Middle Aged
20New York
21operative
22Patient compliance
23percutaneous coronary intervention
24Platelet Aggregation Inhibitors - administration & dosage
25Predictive Value of Tests
26Prescription drugs
27Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
28Risk Factors
29surgical procedures
30Surveys and Questionnaires
31Texas
32Ticlopidine - administration & dosage
33Ticlopidine - analogs & derivatives
34Treatment Outcome
issn
00002-9149
11879-1913
fulltextfalse
rsrctypearticle
creationdate2011
recordtypearticle
recordideNqFU1Fv0zAYjBCIlcFPAEVIiKcW20nsWEhDVcXYpEpMYjxbrv25c0ntYqed9u_5opbC-jLlwUp8d7nvfC6Kt5RMKKH802qi1yujk50wQumE1BNS1c-KEW2FHFNJq-fFiBDCxpLW8qx4lfMKXylt-MvijFFRU07JqLi9SWC96WPKZXTlPN6Xsy5uvI3LBF05tXeQIBgoL2PXxXsfluUNJLPtdYC4zeUsphh0eiivQw9pB6H3MbwuXjjdZXhzWM-Ln5dfb2dX4_n3b9ez6XxMecv6caUJ09ouamKFYdIySp0gLedQNZVroMVdbQgY5gSzEpytnah1y3EQVy0oOS8u9rqb7WIN1uDfk-7UJvk1WlJRe_V4J_g7tYw7VTUtbxqJAld7gbiBoH2CR1wboFfRKsaFaig4yQSVTAunjXZCNq2TxBohRMstSn08eEnx9xZyr9Y-G-i6fVCqbUVDOKMcke9PkKu4TQGDGkCskrQhCJrsQUvdgfLBRRzA4GNh7U0M4Dx-nzLOCeeiZkho9gSTYs4J3HEUStTQGLVSh8aooTGK1Aobg7x3_2d4ZP2tCAI-HAA6G925pIPx-R-uxixxLsR9PjFgfK-HOqBz3z1p48ueDdiXnYeksvFD8SyeiumVjf5JhYsTBdP54NHyL3iAfMyYqswUUT-GyzHcDYqaQkhO_gCUigoq
startdate2011
enddate2011
creator
0Muntner, Paul, PhD
1Mann, Devin M., MD
2Woodward, Mark, PhD
3Choi, James W., MD
4Stoler, Robert C., MD
5Shimbo, Daichi, MD
6Farkouh, Michael E., MD
7Kim, Michael C., MD
general
0Elsevier Inc
1Elsevier
2Elsevier B.V
3Elsevier Limited
scope
0IQODW
1CGR
2CUY
3CVF
4ECM
5EIF
6NPM
7AAYXX
8CITATION
9BSHEE
107QO
117TS
128FD
13FR3
14K9.
15P64
167X8
17BOBZL
18CLFQK
195PM
sort
creationdate2011
titlePredictors of Low Clopidogrel Adherence Following Percutaneous Coronary Intervention
authorMuntner, Paul, PhD ; Mann, Devin M., MD ; Woodward, Mark, PhD ; Choi, James W., MD ; Stoler, Robert C., MD ; Shimbo, Daichi, MD ; Farkouh, Michael E., MD ; Kim, Michael C., MD
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1682t-3a02aadb40d7c29d211f70866e353f5e82aaac0ec2f72d9efd4f74a86000f3b10
rsrctypearticles
prefilterarticles
languageeng
creationdate2011
topic
0Abridged Index Medicus
1Angioplasty
2Angioplasty, Balloon, Coronary
3Article
4Biological and medical sciences
5Cardiology
6Cardiology. Vascular system
7Cardiovascular
8cardiovascular diseases
9Clopidgrel
10Coronary Disease - drug therapy
11Coronary Disease - therapy
12Diseases of the cardiovascular system
13Drug dosages
14Female
15Humans
16Male
17Medical sciences
18Medication Adherence
19Middle Aged
20New York
21operative
22Patient compliance
23percutaneous coronary intervention
24Platelet Aggregation Inhibitors - administration & dosage
25Predictive Value of Tests
26Prescription drugs
27Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
28Risk Factors
29surgical procedures
30Surveys and Questionnaires
31Texas
32Ticlopidine - administration & dosage
33Ticlopidine - analogs & derivatives
34Treatment Outcome
toplevelpeer_reviewed
creatorcontrib
0Muntner, Paul, PhD
1Mann, Devin M., MD
2Woodward, Mark, PhD
3Choi, James W., MD
4Stoler, Robert C., MD
5Shimbo, Daichi, MD
6Farkouh, Michael E., MD
7Kim, Michael C., MD
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8Academic OneFile (A&I only)
9Biotechnology Research Abstracts
10Physical Education Index
11Technology Research Database
12Engineering Research Database
13ProQuest Health & Medical Complete (Alumni)
14Biotechnology and BioEngineering Abstracts
15MEDLINE - Academic
16OpenAIRE (Open Access)
17OpenAIRE
18PubMed Central (Full Participant titles)
jtitleThe American journal of cardiology
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Muntner, Paul, PhD
1Mann, Devin M., MD
2Woodward, Mark, PhD
3Choi, James W., MD
4Stoler, Robert C., MD
5Shimbo, Daichi, MD
6Farkouh, Michael E., MD
7Kim, Michael C., MD
formatjournal
genrearticle
ristypeJOUR
atitlePredictors of Low Clopidogrel Adherence Following Percutaneous Coronary Intervention
jtitleThe American journal of cardiology
addtitleAm J Cardiol
date2011
risdate2011
volume108
issue6
spage822
epage827
pages822-827
issn0002-9149
eissn1879-1913
codenAJCDAG
abstractFew data are available on factors associated with low adherence or early clopidogrel discontinuation after percutaneous coronary intervention (PCI). Patients (n = 284) were evaluated before hospital discharge after PCI to identify factors associated with low adherence to clopidogrel 30 days later. Adherence to daily medications before PCI was assessed using the 8-item Morisky Medication Adherence Scale (MMAS-8) and categorized as low (score <6), medium (score 6 to <8), or high (score 8). Low adherence to clopidogrel was defined as MMAS-8 score <6 (n = 21) or having discontinued clopidogrel (n = 11), which was ascertained during a 30-day interview after PCI. At 30 days after PCI, 11% of patients had low adherence to clopidogrel. Odds ratios (95% confidence intervals [CIs]) for low adherence to clopidogrel were 3.78 (1.09 to 13.1), 3.06 (1.36 to 6.87), 2.46 (0.97 to 6.27), and 3.36 (0.99 to 11.4) for patients who before PCI reported taking smaller doses of medication because of cost, had difficulty filling prescriptions, had difficulty reaching their primary physician, and were not comfortable asking their doctor for instructions, respectively. Odds ratios (95% CIs) for low clopidogrel adherence after PCI in patients with medium and low versus high adherence to daily medications before PCI were 6.13 (1.34 to 28.2) and 10.9 (2.46 to 48.7), respectively. The c-statistic associated with MMAS-8 scores before PCI for discriminating low clopidogrel adherence at 30 days after PCI was 0.733 (95% CI 0.650 to 0.852). In conclusion, adherence to daily medications before PCI may be a useful indicator for identifying patients who will have low clopidogrel adherence after PCI.
copNew York, NY
pubElsevier Inc
pmid21741610
doi10.1016/j.amjcard.2011.04.034
oafree_for_read