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Determinants of asthma after severe respiratory syncytial virus bronchiolitis

Background The development of asthma after respiratory syncytial virus (RSV) bronchiolitis has been demonstrated in case-control studies, although the determinants of post-RSV asthma remain undefined. Objectives We sought to evaluate the potential determinants of physician-diagnosed asthma after sev... Full description

Journal Title: Journal of allergy and clinical immunology 2012, Vol.130 (1), p.91-100.e3
Main Author: Bacharier, Leonard B., MD
Other Authors: Cohen, Rebecca, MD , Schweiger, Toni, RN , Yin-DeClue, Huiquing, PhD , Christie, Chandrika, MA , Zheng, Jie, MS , Schechtman, Kenneth B., PhD , Strunk, Robert C., MD , Castro, Mario, MD, MPH
Format: Electronic Article Electronic Article
Language: English
Subjects:
Age
Quelle: Alma/SFX Local Collection
Publisher: New York, NY: Mosby, Inc
ID: ISSN: 0091-6749
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3612548
title: Determinants of asthma after severe respiratory syncytial virus bronchiolitis
format: Article
creator:
  • Bacharier, Leonard B., MD
  • Cohen, Rebecca, MD
  • Schweiger, Toni, RN
  • Yin-DeClue, Huiquing, PhD
  • Christie, Chandrika, MA
  • Zheng, Jie, MS
  • Schechtman, Kenneth B., PhD
  • Strunk, Robert C., MD
  • Castro, Mario, MD, MPH
subjects:
  • Abridged Index Medicus
  • Age
  • Allergens - immunology
  • Allergies
  • Allergy and Immunology
  • Animals
  • Article
  • Asthma
  • Asthma - diagnosis
  • Asthma - epidemiology
  • Asthma - etiology
  • Biological and medical sciences
  • Bronchiolitis
  • Bronchiolitis, Viral - complications
  • Bronchiolitis, Viral - epidemiology
  • Bronchiolitis, Viral - physiopathology
  • Bronchiolitis, Viral - virology
  • CCL5
  • Chemokine CCL5 - genetics
  • Chemokine CCL5 - metabolism
  • Child
  • Child, Preschool
  • Children & youth
  • Chronic obstructive pulmonary disease, asthma
  • Cohort Studies
  • Colds
  • Dogs
  • Epithelial Cells - metabolism
  • Families & family life
  • Family medical history
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Fundamental immunology
  • Hospitalization
  • Humans
  • Immunopathology
  • Infant
  • Infections
  • Male
  • Medical colleges
  • Medical sciences
  • Nasal Cavity - cytology
  • Pneumology
  • Prevalence
  • prospective cohort
  • Prospective Studies
  • Respiratory agents
  • Respiratory syncytial virus
  • Respiratory Syncytial Virus Infections - complications
  • Respiratory Syncytial Virus Infections - epidemiology
  • Respiratory Syncytial Virus Infections - physiopathology
  • Respiratory Syncytial Virus Infections - virology
  • Respiratory Syncytial Virus, Human - pathogenicity
  • Respiratory tract diseases
  • Risk Factors
  • Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
  • Severity of Illness Index
  • Studies
  • Virus diseases
ispartof: Journal of allergy and clinical immunology, 2012, Vol.130 (1), p.91-100.e3
description: Background The development of asthma after respiratory syncytial virus (RSV) bronchiolitis has been demonstrated in case-control studies, although the determinants of post-RSV asthma remain undefined. Objectives We sought to evaluate the potential determinants of physician-diagnosed asthma after severe RSV bronchiolitis during infancy. Methods We enrolled 206 children during an initial episode of severe RSV bronchiolitis at 12 months of age or less in a prospective cohort study and followed these children for up to 6 years. In a subset of 81 children, we analyzed CCL5 (RANTES) mRNA expression in upper airway epithelial cells. Results Forty-eight percent of children had physician-diagnosed asthma before the seventh birthday. Independent determinants significantly associated with increased risk for physician-diagnosed asthma by the seventh birthday included maternal asthma (odds ratio [OR], 5.2; 95% CI, 1.7-15.9; P  = .004), exposure to high levels of dog allergen (OR, 3.2; 95% CI, 1.3-7.7; P  = .012), aeroallergen sensitivity at age 3 years (OR, 10.7; 95% CI, 2.1-55.0; P  = .005), recurrent wheezing during the first 3 years of life (OR, 7.3; 95% CI, 1.2-43.3; P  = .028), and CCL5 expression in nasal epithelia during acute RSV infection (OR, 3.8; 95% CI, 1.2-2.4; P  < .001). White children (OR, 0.19; 95% CI, 0.04-0.93; P  = .041) and children attending day care (OR, 0.18; 95% CI, 0.04-0.84; P  = .029) had a decreased risk of physician-diagnosed asthma. Conclusions Approximately 50% of children who experience severe RSV bronchiolitis have a subsequent asthma diagnosis. The presence of increased CCL5 levels in nasal epithelia at the time of bronchiolitis or the development of allergic sensitization by age 3 years are associated with increased likelihood of subsequent asthma.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0091-6749
fulltext: fulltext
issn:
  • 0091-6749
  • 1097-6825
url: Link


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titleDeterminants of asthma after severe respiratory syncytial virus bronchiolitis
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creatorBacharier, Leonard B., MD ; Cohen, Rebecca, MD ; Schweiger, Toni, RN ; Yin-DeClue, Huiquing, PhD ; Christie, Chandrika, MA ; Zheng, Jie, MS ; Schechtman, Kenneth B., PhD ; Strunk, Robert C., MD ; Castro, Mario, MD, MPH
creatorcontribBacharier, Leonard B., MD ; Cohen, Rebecca, MD ; Schweiger, Toni, RN ; Yin-DeClue, Huiquing, PhD ; Christie, Chandrika, MA ; Zheng, Jie, MS ; Schechtman, Kenneth B., PhD ; Strunk, Robert C., MD ; Castro, Mario, MD, MPH
descriptionBackground The development of asthma after respiratory syncytial virus (RSV) bronchiolitis has been demonstrated in case-control studies, although the determinants of post-RSV asthma remain undefined. Objectives We sought to evaluate the potential determinants of physician-diagnosed asthma after severe RSV bronchiolitis during infancy. Methods We enrolled 206 children during an initial episode of severe RSV bronchiolitis at 12 months of age or less in a prospective cohort study and followed these children for up to 6 years. In a subset of 81 children, we analyzed CCL5 (RANTES) mRNA expression in upper airway epithelial cells. Results Forty-eight percent of children had physician-diagnosed asthma before the seventh birthday. Independent determinants significantly associated with increased risk for physician-diagnosed asthma by the seventh birthday included maternal asthma (odds ratio [OR], 5.2; 95% CI, 1.7-15.9; P  = .004), exposure to high levels of dog allergen (OR, 3.2; 95% CI, 1.3-7.7; P  = .012), aeroallergen sensitivity at age 3 years (OR, 10.7; 95% CI, 2.1-55.0; P  = .005), recurrent wheezing during the first 3 years of life (OR, 7.3; 95% CI, 1.2-43.3; P  = .028), and CCL5 expression in nasal epithelia during acute RSV infection (OR, 3.8; 95% CI, 1.2-2.4; P  < .001). White children (OR, 0.19; 95% CI, 0.04-0.93; P  = .041) and children attending day care (OR, 0.18; 95% CI, 0.04-0.84; P  = .029) had a decreased risk of physician-diagnosed asthma. Conclusions Approximately 50% of children who experience severe RSV bronchiolitis have a subsequent asthma diagnosis. The presence of increased CCL5 levels in nasal epithelia at the time of bronchiolitis or the development of allergic sensitization by age 3 years are associated with increased likelihood of subsequent asthma.
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subjectAbridged Index Medicus ; Age ; Allergens - immunology ; Allergies ; Allergy and Immunology ; Animals ; Article ; Asthma ; Asthma - diagnosis ; Asthma - epidemiology ; Asthma - etiology ; Biological and medical sciences ; Bronchiolitis ; Bronchiolitis, Viral - complications ; Bronchiolitis, Viral - epidemiology ; Bronchiolitis, Viral - physiopathology ; Bronchiolitis, Viral - virology ; CCL5 ; Chemokine CCL5 - genetics ; Chemokine CCL5 - metabolism ; Child ; Child, Preschool ; Children & youth ; Chronic obstructive pulmonary disease, asthma ; Cohort Studies ; Colds ; Dogs ; Epithelial Cells - metabolism ; Families & family life ; Family medical history ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Hospitalization ; Humans ; Immunopathology ; Infant ; Infections ; Male ; Medical colleges ; Medical sciences ; Nasal Cavity - cytology ; Pneumology ; Prevalence ; prospective cohort ; Prospective Studies ; Respiratory agents ; Respiratory syncytial virus ; Respiratory Syncytial Virus Infections - complications ; Respiratory Syncytial Virus Infections - epidemiology ; Respiratory Syncytial Virus Infections - physiopathology ; Respiratory Syncytial Virus Infections - virology ; Respiratory Syncytial Virus, Human - pathogenicity ; Respiratory tract diseases ; Risk Factors ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Severity of Illness Index ; Studies ; Virus diseases
ispartofJournal of allergy and clinical immunology, 2012, Vol.130 (1), p.91-100.e3
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0American Academy of Allergy, Asthma & Immunology
12012 American Academy of Allergy, Asthma & Immunology
22015 INIST-CNRS
3Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
4COPYRIGHT 2012 Elsevier B.V.
5Copyright Elsevier Limited Jul 2012
62012 American Academy of Allergy, Asthma & Immunology 2012
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0Bacharier, Leonard B., MD
1Cohen, Rebecca, MD
2Schweiger, Toni, RN
3Yin-DeClue, Huiquing, PhD
4Christie, Chandrika, MA
5Zheng, Jie, MS
6Schechtman, Kenneth B., PhD
7Strunk, Robert C., MD
8Castro, Mario, MD, MPH
title
0Determinants of asthma after severe respiratory syncytial virus bronchiolitis
1Journal of allergy and clinical immunology
addtitleJ Allergy Clin Immunol
descriptionBackground The development of asthma after respiratory syncytial virus (RSV) bronchiolitis has been demonstrated in case-control studies, although the determinants of post-RSV asthma remain undefined. Objectives We sought to evaluate the potential determinants of physician-diagnosed asthma after severe RSV bronchiolitis during infancy. Methods We enrolled 206 children during an initial episode of severe RSV bronchiolitis at 12 months of age or less in a prospective cohort study and followed these children for up to 6 years. In a subset of 81 children, we analyzed CCL5 (RANTES) mRNA expression in upper airway epithelial cells. Results Forty-eight percent of children had physician-diagnosed asthma before the seventh birthday. Independent determinants significantly associated with increased risk for physician-diagnosed asthma by the seventh birthday included maternal asthma (odds ratio [OR], 5.2; 95% CI, 1.7-15.9; P  = .004), exposure to high levels of dog allergen (OR, 3.2; 95% CI, 1.3-7.7; P  = .012), aeroallergen sensitivity at age 3 years (OR, 10.7; 95% CI, 2.1-55.0; P  = .005), recurrent wheezing during the first 3 years of life (OR, 7.3; 95% CI, 1.2-43.3; P  = .028), and CCL5 expression in nasal epithelia during acute RSV infection (OR, 3.8; 95% CI, 1.2-2.4; P  < .001). White children (OR, 0.19; 95% CI, 0.04-0.93; P  = .041) and children attending day care (OR, 0.18; 95% CI, 0.04-0.84; P  = .029) had a decreased risk of physician-diagnosed asthma. Conclusions Approximately 50% of children who experience severe RSV bronchiolitis have a subsequent asthma diagnosis. The presence of increased CCL5 levels in nasal epithelia at the time of bronchiolitis or the development of allergic sensitization by age 3 years are associated with increased likelihood of subsequent asthma.
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0Abridged Index Medicus
1Age
2Allergens - immunology
3Allergies
4Allergy and Immunology
5Animals
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7Asthma
8Asthma - diagnosis
9Asthma - epidemiology
10Asthma - etiology
11Biological and medical sciences
12Bronchiolitis
13Bronchiolitis, Viral - complications
14Bronchiolitis, Viral - epidemiology
15Bronchiolitis, Viral - physiopathology
16Bronchiolitis, Viral - virology
17CCL5
18Chemokine CCL5 - genetics
19Chemokine CCL5 - metabolism
20Child
21Child, Preschool
22Children & youth
23Chronic obstructive pulmonary disease, asthma
24Cohort Studies
25Colds
26Dogs
27Epithelial Cells - metabolism
28Families & family life
29Family medical history
30Female
31Fundamental and applied biological sciences. Psychology
32Fundamental immunology
33Hospitalization
34Humans
35Immunopathology
36Infant
37Infections
38Male
39Medical colleges
40Medical sciences
41Nasal Cavity - cytology
42Pneumology
43Prevalence
44prospective cohort
45Prospective Studies
46Respiratory agents
47Respiratory syncytial virus
48Respiratory Syncytial Virus Infections - complications
49Respiratory Syncytial Virus Infections - epidemiology
50Respiratory Syncytial Virus Infections - physiopathology
51Respiratory Syncytial Virus Infections - virology
52Respiratory Syncytial Virus, Human - pathogenicity
53Respiratory tract diseases
54Risk Factors
55Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
56Severity of Illness Index
57Studies
58Virus diseases
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titleDeterminants of asthma after severe respiratory syncytial virus bronchiolitis
authorBacharier, Leonard B., MD ; Cohen, Rebecca, MD ; Schweiger, Toni, RN ; Yin-DeClue, Huiquing, PhD ; Christie, Chandrika, MA ; Zheng, Jie, MS ; Schechtman, Kenneth B., PhD ; Strunk, Robert C., MD ; Castro, Mario, MD, MPH
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2Allergens - immunology
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9Asthma - epidemiology
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50Respiratory Syncytial Virus Infections - physiopathology
51Respiratory Syncytial Virus Infections - virology
52Respiratory Syncytial Virus, Human - pathogenicity
53Respiratory tract diseases
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abstractBackground The development of asthma after respiratory syncytial virus (RSV) bronchiolitis has been demonstrated in case-control studies, although the determinants of post-RSV asthma remain undefined. Objectives We sought to evaluate the potential determinants of physician-diagnosed asthma after severe RSV bronchiolitis during infancy. Methods We enrolled 206 children during an initial episode of severe RSV bronchiolitis at 12 months of age or less in a prospective cohort study and followed these children for up to 6 years. In a subset of 81 children, we analyzed CCL5 (RANTES) mRNA expression in upper airway epithelial cells. Results Forty-eight percent of children had physician-diagnosed asthma before the seventh birthday. Independent determinants significantly associated with increased risk for physician-diagnosed asthma by the seventh birthday included maternal asthma (odds ratio [OR], 5.2; 95% CI, 1.7-15.9; P  = .004), exposure to high levels of dog allergen (OR, 3.2; 95% CI, 1.3-7.7; P  = .012), aeroallergen sensitivity at age 3 years (OR, 10.7; 95% CI, 2.1-55.0; P  = .005), recurrent wheezing during the first 3 years of life (OR, 7.3; 95% CI, 1.2-43.3; P  = .028), and CCL5 expression in nasal epithelia during acute RSV infection (OR, 3.8; 95% CI, 1.2-2.4; P  < .001). White children (OR, 0.19; 95% CI, 0.04-0.93; P  = .041) and children attending day care (OR, 0.18; 95% CI, 0.04-0.84; P  = .029) had a decreased risk of physician-diagnosed asthma. Conclusions Approximately 50% of children who experience severe RSV bronchiolitis have a subsequent asthma diagnosis. The presence of increased CCL5 levels in nasal epithelia at the time of bronchiolitis or the development of allergic sensitization by age 3 years are associated with increased likelihood of subsequent asthma.
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