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Cardiovascular disease risk scores in identifying future frailty: the Whitehall II prospective cohort study

Objectives To examine the capacity of existing cardiovascular disease (CVD) risk algorithms widely used in primary care, to predict frailty. Design Prospective cohort study. Risk algorithms at baseline (1997–1999) were the Framingham CVD, coronary heart disease and stroke risk scores, and the System... Full description

Journal Title: Heart 2013, Vol.99 (10), p.737-742
Main Author: Bouillon, Kim
Other Authors: Batty, G David , Hamer, Mark , Sabia, Severine , Shipley, Martin J , Britton, Annie , Singh-Manoux, Archana , Kivimäki, Mika
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: BMJ Publishing Group Ltd and British Cardiovascular Society
ID: ISSN: 1355-6037
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3632981
title: Cardiovascular disease risk scores in identifying future frailty: the Whitehall II prospective cohort study
format: Article
creator:
  • Bouillon, Kim
  • Batty, G David
  • Hamer, Mark
  • Sabia, Severine
  • Shipley, Martin J
  • Britton, Annie
  • Singh-Manoux, Archana
  • Kivimäki, Mika
subjects:
  • 1506
  • Abridged Index Medicus
  • Aged
  • Algorithms
  • Cardiac Rehabilitation
  • Cardiovascular disease
  • Cardiovascular Diseases
  • Cardiovascular Diseases - epidemiology
  • Disability Evaluation
  • Epidemiology
  • Female
  • Follow
  • Follow-Up Studies
  • Frail Elderly
  • Frail Elderly - statistics & numerical data
  • Frailty
  • Health risk assessment
  • Humans
  • Life Sciences
  • London
  • London - epidemiology
  • Male
  • Management
  • methods
  • Middle Aged
  • Morbidity
  • Morbidity - trends
  • Motor Activity
  • Primary health care
  • Prognosis
  • Prospective Studies
  • Quality of Life
  • rehabilitation
  • Risk Assessment
  • Risk Assessment - methods
  • Risk Factors
  • Santé publique et épidémiologie
  • statistics & numerical data
  • Studies
  • trends
  • Up Studies
ispartof: Heart, 2013, Vol.99 (10), p.737-742
description: Objectives To examine the capacity of existing cardiovascular disease (CVD) risk algorithms widely used in primary care, to predict frailty. Design Prospective cohort study. Risk algorithms at baseline (1997–1999) were the Framingham CVD, coronary heart disease and stroke risk scores, and the Systematic Coronary Risk Evaluation. Setting Civil Service departments in London, UK. Participants 3895 participants (73% men) aged 45–69 years and free of CVD at baseline. Main outcome measure Status of frailty at the end of follow-up (2007–2009), based on the following indicators: self-reported exhaustion, low physical activity, slow walking speed, low grip strength and weight loss. Results At the end of the follow-up, 2.8% (n=108) of the sample was classified as frail. All four CVD risk scores were associated with future risk of developing frailty, with ORs per one SD increment in the score ranging from 1.35 (95% CI 1.21 to 1.51) for the Framingham stroke score to 1.42 (1.23 to 1.62) for the Framingham CVD score. These associations remained after excluding incident CVD cases. For comparison, the corresponding ORs for the risk scores and incident cardiovascular events varied between 1.36 (1.15 to 1.61) and 1.64 (1.50 to 1.80) depending on the risk algorithm. Conclusions The use of CVD risk scores in clinical practice may also have utility for frailty prediction.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1355-6037
fulltext: fulltext
issn:
  • 1355-6037
  • 1468-201X
url: Link


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descriptionObjectives To examine the capacity of existing cardiovascular disease (CVD) risk algorithms widely used in primary care, to predict frailty. Design Prospective cohort study. Risk algorithms at baseline (1997–1999) were the Framingham CVD, coronary heart disease and stroke risk scores, and the Systematic Coronary Risk Evaluation. Setting Civil Service departments in London, UK. Participants 3895 participants (73% men) aged 45–69 years and free of CVD at baseline. Main outcome measure Status of frailty at the end of follow-up (2007–2009), based on the following indicators: self-reported exhaustion, low physical activity, slow walking speed, low grip strength and weight loss. Results At the end of the follow-up, 2.8% (n=108) of the sample was classified as frail. All four CVD risk scores were associated with future risk of developing frailty, with ORs per one SD increment in the score ranging from 1.35 (95% CI 1.21 to 1.51) for the Framingham stroke score to 1.42 (1.23 to 1.62) for the Framingham CVD score. These associations remained after excluding incident CVD cases. For comparison, the corresponding ORs for the risk scores and incident cardiovascular events varied between 1.36 (1.15 to 1.61) and 1.64 (1.50 to 1.80) depending on the risk algorithm. Conclusions The use of CVD risk scores in clinical practice may also have utility for frailty prediction.
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languageeng
publisherEngland: BMJ Publishing Group Ltd and British Cardiovascular Society
subject1506 ; Abridged Index Medicus ; Aged ; Algorithms ; Cardiac Rehabilitation ; Cardiovascular disease ; Cardiovascular Diseases ; Cardiovascular Diseases - epidemiology ; Disability Evaluation ; Epidemiology ; Female ; Follow ; Follow-Up Studies ; Frail Elderly ; Frail Elderly - statistics & numerical data ; Frailty ; Health risk assessment ; Humans ; Life Sciences ; London ; London - epidemiology ; Male ; Management ; methods ; Middle Aged ; Morbidity ; Morbidity - trends ; Motor Activity ; Primary health care ; Prognosis ; Prospective Studies ; Quality of Life ; rehabilitation ; Risk Assessment ; Risk Assessment - methods ; Risk Factors ; Santé publique et épidémiologie ; statistics & numerical data ; Studies ; trends ; Up Studies
ispartofHeart, 2013, Vol.99 (10), p.737-742
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3Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions 2013
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descriptionObjectives To examine the capacity of existing cardiovascular disease (CVD) risk algorithms widely used in primary care, to predict frailty. Design Prospective cohort study. Risk algorithms at baseline (1997–1999) were the Framingham CVD, coronary heart disease and stroke risk scores, and the Systematic Coronary Risk Evaluation. Setting Civil Service departments in London, UK. Participants 3895 participants (73% men) aged 45–69 years and free of CVD at baseline. Main outcome measure Status of frailty at the end of follow-up (2007–2009), based on the following indicators: self-reported exhaustion, low physical activity, slow walking speed, low grip strength and weight loss. Results At the end of the follow-up, 2.8% (n=108) of the sample was classified as frail. All four CVD risk scores were associated with future risk of developing frailty, with ORs per one SD increment in the score ranging from 1.35 (95% CI 1.21 to 1.51) for the Framingham stroke score to 1.42 (1.23 to 1.62) for the Framingham CVD score. These associations remained after excluding incident CVD cases. For comparison, the corresponding ORs for the risk scores and incident cardiovascular events varied between 1.36 (1.15 to 1.61) and 1.64 (1.50 to 1.80) depending on the risk algorithm. Conclusions The use of CVD risk scores in clinical practice may also have utility for frailty prediction.
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abstractObjectives To examine the capacity of existing cardiovascular disease (CVD) risk algorithms widely used in primary care, to predict frailty. Design Prospective cohort study. Risk algorithms at baseline (1997–1999) were the Framingham CVD, coronary heart disease and stroke risk scores, and the Systematic Coronary Risk Evaluation. Setting Civil Service departments in London, UK. Participants 3895 participants (73% men) aged 45–69 years and free of CVD at baseline. Main outcome measure Status of frailty at the end of follow-up (2007–2009), based on the following indicators: self-reported exhaustion, low physical activity, slow walking speed, low grip strength and weight loss. Results At the end of the follow-up, 2.8% (n=108) of the sample was classified as frail. All four CVD risk scores were associated with future risk of developing frailty, with ORs per one SD increment in the score ranging from 1.35 (95% CI 1.21 to 1.51) for the Framingham stroke score to 1.42 (1.23 to 1.62) for the Framingham CVD score. These associations remained after excluding incident CVD cases. For comparison, the corresponding ORs for the risk scores and incident cardiovascular events varied between 1.36 (1.15 to 1.61) and 1.64 (1.50 to 1.80) depending on the risk algorithm. Conclusions The use of CVD risk scores in clinical practice may also have utility for frailty prediction.
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