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Infrared Matrix-Assisted Laser Desorption Electrospray Ionization (IR-MALDESI) Imaging Source Coupled to a FT-ICR Mass Spectrometer

Mass spectrometry imaging (MSI) allows for the direct monitoring of the abundance and spatial distribution of chemical compounds over the surface of a tissue sample. This technology has opened the field of mass spectrometry to numerous innovative applications over the past 15 years. First used with... Full description

Journal Title: Journal of the American Society for Mass Spectrometry 2012-12-04, Vol.24 (1), p.92-100
Main Author: Robichaud, Guillaume
Other Authors: Barry, Jeremy A , Garrard, Kenneth P , Muddiman, David C
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: New York: Springer-Verlag
ID: ISSN: 1044-0305
Link: https://www.ncbi.nlm.nih.gov/pubmed/23208743
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3689149
title: Infrared Matrix-Assisted Laser Desorption Electrospray Ionization (IR-MALDESI) Imaging Source Coupled to a FT-ICR Mass Spectrometer
format: Article
creator:
  • Robichaud, Guillaume
  • Barry, Jeremy A
  • Garrard, Kenneth P
  • Muddiman, David C
subjects:
  • Abundance
  • Analytical Chemistry
  • Animals
  • Article
  • Atmospheric Pressure
  • Bioinformatics
  • Biotechnology
  • Brain Chemistry
  • Chemical compounds
  • Chemistry
  • Chemistry and Materials Science
  • Desorption
  • Fourier Analysis
  • Imaging
  • Infrared lasers
  • Ionization
  • Ions
  • Lipids - analysis
  • Lipids - chemistry
  • Lung - chemistry
  • Mass spectrometry
  • Mice
  • Molecular Imaging - methods
  • Myocardium - chemistry
  • Organic Chemistry
  • Oversampling
  • Pixels
  • Pressure
  • Proteomics
  • Research Article
  • Scanning
  • Scientific imaging
  • Spatial distribution
  • Spatial resolution
  • Spectrometry, Mass, Electrospray Ionization - methods
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
  • Spectroscopy
ispartof: Journal of the American Society for Mass Spectrometry, 2012-12-04, Vol.24 (1), p.92-100
description: Mass spectrometry imaging (MSI) allows for the direct monitoring of the abundance and spatial distribution of chemical compounds over the surface of a tissue sample. This technology has opened the field of mass spectrometry to numerous innovative applications over the past 15 years. First used with SIMS and MALDI MS that operate under vacuum, interest has grown for mass spectrometry ionization sources that allow for effective imaging but where the analysis can be performed at ambient pressure with minimal or no sample preparation. We introduce here a versatile source for MALDESI imaging analysis coupled to a hybrid LTQ-FT-ICR mass spectrometer. The imaging source offers single shot or multi-shot capability per pixel with full control over the laser repetition rate and mass spectrometer scanning cycle. Scanning rates can be as fast as 1 pixel/second and a spatial resolution of 45 μm was achieved with oversampling. Design and integration of a versatile IR-MALDESI imaging source offering multi-shot capability with a commercial FT-ICR mass spectrometer
language: eng
source:
identifier: ISSN: 1044-0305
fulltext: no_fulltext
issn:
  • 1044-0305
  • 1879-1123
url: Link


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titleInfrared Matrix-Assisted Laser Desorption Electrospray Ionization (IR-MALDESI) Imaging Source Coupled to a FT-ICR Mass Spectrometer
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descriptionMass spectrometry imaging (MSI) allows for the direct monitoring of the abundance and spatial distribution of chemical compounds over the surface of a tissue sample. This technology has opened the field of mass spectrometry to numerous innovative applications over the past 15 years. First used with SIMS and MALDI MS that operate under vacuum, interest has grown for mass spectrometry ionization sources that allow for effective imaging but where the analysis can be performed at ambient pressure with minimal or no sample preparation. We introduce here a versatile source for MALDESI imaging analysis coupled to a hybrid LTQ-FT-ICR mass spectrometer. The imaging source offers single shot or multi-shot capability per pixel with full control over the laser repetition rate and mass spectrometer scanning cycle. Scanning rates can be as fast as 1 pixel/second and a spatial resolution of 45 μm was achieved with oversampling. Design and integration of a versatile IR-MALDESI imaging source offering multi-shot capability with a commercial FT-ICR mass spectrometer
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subjectAbundance ; Analytical Chemistry ; Animals ; Article ; Atmospheric Pressure ; Bioinformatics ; Biotechnology ; Brain Chemistry ; Chemical compounds ; Chemistry ; Chemistry and Materials Science ; Desorption ; Fourier Analysis ; Imaging ; Infrared lasers ; Ionization ; Ions ; Lipids - analysis ; Lipids - chemistry ; Lung - chemistry ; Mass spectrometry ; Mice ; Molecular Imaging - methods ; Myocardium - chemistry ; Organic Chemistry ; Oversampling ; Pixels ; Pressure ; Proteomics ; Research Article ; Scanning ; Scientific imaging ; Spatial distribution ; Spatial resolution ; Spectrometry, Mass, Electrospray Ionization - methods ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods ; Spectroscopy
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titleInfrared Matrix-Assisted Laser Desorption Electrospray Ionization (IR-MALDESI) Imaging Source Coupled to a FT-ICR Mass Spectrometer
authorRobichaud, Guillaume ; Barry, Jeremy A ; Garrard, Kenneth P ; Muddiman, David C
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atitleInfrared Matrix-Assisted Laser Desorption Electrospray Ionization (IR-MALDESI) Imaging Source Coupled to a FT-ICR Mass Spectrometer
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abstractMass spectrometry imaging (MSI) allows for the direct monitoring of the abundance and spatial distribution of chemical compounds over the surface of a tissue sample. This technology has opened the field of mass spectrometry to numerous innovative applications over the past 15 years. First used with SIMS and MALDI MS that operate under vacuum, interest has grown for mass spectrometry ionization sources that allow for effective imaging but where the analysis can be performed at ambient pressure with minimal or no sample preparation. We introduce here a versatile source for MALDESI imaging analysis coupled to a hybrid LTQ-FT-ICR mass spectrometer. The imaging source offers single shot or multi-shot capability per pixel with full control over the laser repetition rate and mass spectrometer scanning cycle. Scanning rates can be as fast as 1 pixel/second and a spatial resolution of 45 μm was achieved with oversampling. Design and integration of a versatile IR-MALDESI imaging source offering multi-shot capability with a commercial FT-ICR mass spectrometer
copNew York
pubSpringer-Verlag
pmid23208743
doi10.1007/s13361-012-0505-9
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