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Age at menarche and risk of type 2 diabetes among African-American and white women in the Atherosclerosis Risk in Communities (ARIC) study

Aims/hypothesis We examined race differences in the association between age at menarche and type 2 diabetes before and after adjustment for adiposity. Methods We analysed baseline and 9-year follow-up data from 8,491 women ( n  = 2,505 African-American, mean age 53.3 years; n  = 5,986 white, mean ag... Full description

Journal Title: Diabetologia 2012-07-04, Vol.55 (9), p.2371-2380
Main Author: Dreyfus, J. G
Other Authors: Lutsey, P. L , Huxley, R , Pankow, J. S , Selvin, E , Fernández-Rhodes, L , Franceschini, N , Demerath, E. W
Format: Electronic Article Electronic Article
Language: English
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Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 0012-186X
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3690318
title: Age at menarche and risk of type 2 diabetes among African-American and white women in the Atherosclerosis Risk in Communities (ARIC) study
format: Article
creator:
  • Dreyfus, J. G
  • Lutsey, P. L
  • Huxley, R
  • Pankow, J. S
  • Selvin, E
  • Fernández-Rhodes, L
  • Franceschini, N
  • Demerath, E. W
subjects:
  • Adiposity
  • African Americans - statistics & numerical data
  • Age of Onset
  • Aged
  • Article
  • Atherosclerosis
  • Atherosclerosis (general aspects, experimental research)
  • Atherosclerosis - epidemiology
  • Atherosclerosis - ethnology
  • Atherosclerosis - prevention & control
  • Biological and medical sciences
  • Blood and lymphatic vessels
  • Cardiology. Vascular system
  • Child
  • Community Health Services
  • Diabetes mellitus
  • Diabetes Mellitus, Type 2 - epidemiology
  • Diabetes Mellitus, Type 2 - ethnology
  • Diabetes Mellitus, Type 2 - prevention & control
  • Diabetes. Impaired glucose tolerance
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Epidemiology
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • European Continental Ancestry Group - statistics & numerical data
  • Female
  • Follow-Up Studies
  • Growth and development
  • Human Physiology
  • Humans
  • Internal Medicine
  • Medical sciences
  • Medicine
  • Medicine & Public Health
  • Menarche
  • Menarche - ethnology
  • Metabolic Diseases
  • Middle Aged
  • Obesity
  • Obesity - epidemiology
  • Obesity - ethnology
  • Obesity - prevention & control
  • Prospective Studies
  • Puberty
  • Risk factor
  • Risk Factors
  • Type 2 diabetes
  • United States - epidemiology
  • Women
ispartof: Diabetologia, 2012-07-04, Vol.55 (9), p.2371-2380
description: Aims/hypothesis We examined race differences in the association between age at menarche and type 2 diabetes before and after adjustment for adiposity. Methods We analysed baseline and 9-year follow-up data from 8,491 women ( n  = 2,505 African-American, mean age 53.3 years; n  = 5,986 white, mean age 54.0 years) in the Atherosclerosis Risk in Communities (ARIC) study. Stratifying by race, we used logistic regression to estimate the OR for prevalent diabetes at baseline, and Cox proportional hazard models to estimate the HR for incident diabetes over follow-up according to age at menarche category (8–11, 12, 13, 14 and 15–18 years). Results Adjusting for age and centre, we found that early age at menarche (8–11 vs 13 years) was associated with diabetes for white, but not African-American women in both the prevalent (white OR 1.72, 95% CI 1.32, 2.25; African-American OR 1.13, 95% CI 0.84, 1.51; interaction p  = 0.043) and incident models (white HR 1.43, 95% CI 1.08, 1.89; African-American HR 1.20, 95% CI 0.87, 1.67; interaction p  = 0.527). Adjustment for adiposity and lifestyle confounders attenuated associations for prevalent (white OR 1.41, 95% CI 1.05, 1.89; African-American OR 0.94, 95% CI 0.68, 1.30; interaction p  = 0.093) and incident diabetes (white HR 1.22, 95% CI 0.92, 1.63; African-American HR 1.11, 95% CI 0.80, 1.56; interaction p  = 0.554). Conclusions/interpretation Early menarche was associated with type 2 diabetes in white women, and adulthood adiposity attenuated the relationship. We did not find a similar association in African-American women. Our findings suggest that there may be race/ethnic differences in the influence of developmental factors in the aetiology of type 2 diabetes, which merit further investigation.
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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descriptionAims/hypothesis We examined race differences in the association between age at menarche and type 2 diabetes before and after adjustment for adiposity. Methods We analysed baseline and 9-year follow-up data from 8,491 women ( n  = 2,505 African-American, mean age 53.3 years; n  = 5,986 white, mean age 54.0 years) in the Atherosclerosis Risk in Communities (ARIC) study. Stratifying by race, we used logistic regression to estimate the OR for prevalent diabetes at baseline, and Cox proportional hazard models to estimate the HR for incident diabetes over follow-up according to age at menarche category (8–11, 12, 13, 14 and 15–18 years). Results Adjusting for age and centre, we found that early age at menarche (8–11 vs 13 years) was associated with diabetes for white, but not African-American women in both the prevalent (white OR 1.72, 95% CI 1.32, 2.25; African-American OR 1.13, 95% CI 0.84, 1.51; interaction p  = 0.043) and incident models (white HR 1.43, 95% CI 1.08, 1.89; African-American HR 1.20, 95% CI 0.87, 1.67; interaction p  = 0.527). Adjustment for adiposity and lifestyle confounders attenuated associations for prevalent (white OR 1.41, 95% CI 1.05, 1.89; African-American OR 0.94, 95% CI 0.68, 1.30; interaction p  = 0.093) and incident diabetes (white HR 1.22, 95% CI 0.92, 1.63; African-American HR 1.11, 95% CI 0.80, 1.56; interaction p  = 0.554). Conclusions/interpretation Early menarche was associated with type 2 diabetes in white women, and adulthood adiposity attenuated the relationship. We did not find a similar association in African-American women. Our findings suggest that there may be race/ethnic differences in the influence of developmental factors in the aetiology of type 2 diabetes, which merit further investigation.
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descriptionAims/hypothesis We examined race differences in the association between age at menarche and type 2 diabetes before and after adjustment for adiposity. Methods We analysed baseline and 9-year follow-up data from 8,491 women ( n  = 2,505 African-American, mean age 53.3 years; n  = 5,986 white, mean age 54.0 years) in the Atherosclerosis Risk in Communities (ARIC) study. Stratifying by race, we used logistic regression to estimate the OR for prevalent diabetes at baseline, and Cox proportional hazard models to estimate the HR for incident diabetes over follow-up according to age at menarche category (8–11, 12, 13, 14 and 15–18 years). Results Adjusting for age and centre, we found that early age at menarche (8–11 vs 13 years) was associated with diabetes for white, but not African-American women in both the prevalent (white OR 1.72, 95% CI 1.32, 2.25; African-American OR 1.13, 95% CI 0.84, 1.51; interaction p  = 0.043) and incident models (white HR 1.43, 95% CI 1.08, 1.89; African-American HR 1.20, 95% CI 0.87, 1.67; interaction p  = 0.527). Adjustment for adiposity and lifestyle confounders attenuated associations for prevalent (white OR 1.41, 95% CI 1.05, 1.89; African-American OR 0.94, 95% CI 0.68, 1.30; interaction p  = 0.093) and incident diabetes (white HR 1.22, 95% CI 0.92, 1.63; African-American HR 1.11, 95% CI 0.80, 1.56; interaction p  = 0.554). Conclusions/interpretation Early menarche was associated with type 2 diabetes in white women, and adulthood adiposity attenuated the relationship. We did not find a similar association in African-American women. Our findings suggest that there may be race/ethnic differences in the influence of developmental factors in the aetiology of type 2 diabetes, which merit further investigation.
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1African Americans - statistics & numerical data
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6Atherosclerosis (general aspects, experimental research)
7Atherosclerosis - epidemiology
8Atherosclerosis - ethnology
9Atherosclerosis - prevention & control
10Biological and medical sciences
11Blood and lymphatic vessels
12Cardiology. Vascular system
13Child
14Community Health Services
15Diabetes mellitus
16Diabetes Mellitus, Type 2 - epidemiology
17Diabetes Mellitus, Type 2 - ethnology
18Diabetes Mellitus, Type 2 - prevention & control
19Diabetes. Impaired glucose tolerance
20Endocrine pancreas. Apud cells (diseases)
21Endocrinopathies
22Epidemiology
23Etiopathogenesis. Screening. Investigations. Target tissue resistance
24European Continental Ancestry Group - statistics & numerical data
25Female
26Follow-Up Studies
27Growth and development
28Human Physiology
29Humans
30Internal Medicine
31Medical sciences
32Medicine
33Medicine & Public Health
34Menarche
35Menarche - ethnology
36Metabolic Diseases
37Middle Aged
38Obesity
39Obesity - epidemiology
40Obesity - ethnology
41Obesity - prevention & control
42Prospective Studies
43Puberty
44Risk factor
45Risk Factors
46Type 2 diabetes
47United States - epidemiology
48Women
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titleAge at menarche and risk of type 2 diabetes among African-American and white women in the Atherosclerosis Risk in Communities (ARIC) study
authorDreyfus, J. G ; Lutsey, P. L ; Huxley, R ; Pankow, J. S ; Selvin, E ; Fernández-Rhodes, L ; Franceschini, N ; Demerath, E. W
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1African Americans - statistics & numerical data
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5Atherosclerosis
6Atherosclerosis (general aspects, experimental research)
7Atherosclerosis - epidemiology
8Atherosclerosis - ethnology
9Atherosclerosis - prevention & control
10Biological and medical sciences
11Blood and lymphatic vessels
12Cardiology. Vascular system
13Child
14Community Health Services
15Diabetes mellitus
16Diabetes Mellitus, Type 2 - epidemiology
17Diabetes Mellitus, Type 2 - ethnology
18Diabetes Mellitus, Type 2 - prevention & control
19Diabetes. Impaired glucose tolerance
20Endocrine pancreas. Apud cells (diseases)
21Endocrinopathies
22Epidemiology
23Etiopathogenesis. Screening. Investigations. Target tissue resistance
24European Continental Ancestry Group - statistics & numerical data
25Female
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28Human Physiology
29Humans
30Internal Medicine
31Medical sciences
32Medicine
33Medicine & Public Health
34Menarche
35Menarche - ethnology
36Metabolic Diseases
37Middle Aged
38Obesity
39Obesity - epidemiology
40Obesity - ethnology
41Obesity - prevention & control
42Prospective Studies
43Puberty
44Risk factor
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46Type 2 diabetes
47United States - epidemiology
48Women
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abstractAims/hypothesis We examined race differences in the association between age at menarche and type 2 diabetes before and after adjustment for adiposity. Methods We analysed baseline and 9-year follow-up data from 8,491 women ( n  = 2,505 African-American, mean age 53.3 years; n  = 5,986 white, mean age 54.0 years) in the Atherosclerosis Risk in Communities (ARIC) study. Stratifying by race, we used logistic regression to estimate the OR for prevalent diabetes at baseline, and Cox proportional hazard models to estimate the HR for incident diabetes over follow-up according to age at menarche category (8–11, 12, 13, 14 and 15–18 years). Results Adjusting for age and centre, we found that early age at menarche (8–11 vs 13 years) was associated with diabetes for white, but not African-American women in both the prevalent (white OR 1.72, 95% CI 1.32, 2.25; African-American OR 1.13, 95% CI 0.84, 1.51; interaction p  = 0.043) and incident models (white HR 1.43, 95% CI 1.08, 1.89; African-American HR 1.20, 95% CI 0.87, 1.67; interaction p  = 0.527). Adjustment for adiposity and lifestyle confounders attenuated associations for prevalent (white OR 1.41, 95% CI 1.05, 1.89; African-American OR 0.94, 95% CI 0.68, 1.30; interaction p  = 0.093) and incident diabetes (white HR 1.22, 95% CI 0.92, 1.63; African-American HR 1.11, 95% CI 0.80, 1.56; interaction p  = 0.554). Conclusions/interpretation Early menarche was associated with type 2 diabetes in white women, and adulthood adiposity attenuated the relationship. We did not find a similar association in African-American women. Our findings suggest that there may be race/ethnic differences in the influence of developmental factors in the aetiology of type 2 diabetes, which merit further investigation.
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