schliessen

Filtern

 

Bibliotheken

Male circumcision reduces penile high-risk human papillomavirus viral load in a randomised clinical trial in Rakai, Uganda

Objectives Male circumcision reduces penile high-risk human papillomavirus (HR-HPV) prevalence in randomised trials. The goal of this study was to examine the effect of circumcision on HPV viral load among HPV-infected men in a randomised trial of male circumcision. Methods In a randomised trial to... Full description

Journal Title: Sexually transmitted infections 2013-05, Vol.89 (3), p.262-266
Main Author: Wilson, Lauren E
Other Authors: Gravitt, Patti , Tobian, Aaron A R , Kigozi, Godfrey , Serwadda, David , Nalugoda, Fred , Watya, Stephen , Wawer, Maria J , Gray, Ronald H
Format: Electronic Article Electronic Article
Language: English
Subjects:
Hpv
Publisher: London: BMJ Publishing Group Ltd
ID: ISSN: 1368-4973
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3706631
title: Male circumcision reduces penile high-risk human papillomavirus viral load in a randomised clinical trial in Rakai, Uganda
format: Article
creator:
  • Wilson, Lauren E
  • Gravitt, Patti
  • Tobian, Aaron A R
  • Kigozi, Godfrey
  • Serwadda, David
  • Nalugoda, Fred
  • Watya, Stephen
  • Wawer, Maria J
  • Gray, Ronald H
subjects:
  • Adolescent
  • Adult
  • Africa
  • Analysis
  • Article
  • Biological and medical sciences
  • Circumcision
  • Circumcision, Male
  • Clinical trials
  • Epidemiology. Vaccinations
  • General aspects
  • Genotype
  • Hpv
  • Human immunodeficiency virus
  • Human infectious diseases. Experimental studies and models
  • Human papillomavirus
  • Humans
  • Infectious diseases
  • Male
  • Medical sciences
  • Middle Aged
  • Molecular Epidemiology
  • Papillomaviridae - classification
  • Papillomaviridae - genetics
  • Papillomaviridae - isolation & purification
  • Papillomavirus infections
  • Papillomavirus Infections - prevention & control
  • Papillomavirus Infections - virology
  • Penile Diseases - prevention & control
  • Penile Diseases - virology
  • Real-Time Polymerase Chain Reaction
  • Risk factors
  • Treatment Outcome
  • Uganda
  • Usage
  • Viral Load
  • Virus Shedding
  • Young Adult
ispartof: Sexually transmitted infections, 2013-05, Vol.89 (3), p.262-266
description: Objectives Male circumcision reduces penile high-risk human papillomavirus (HR-HPV) prevalence in randomised trials. The goal of this study was to examine the effect of circumcision on HPV viral load among HPV-infected men in a randomised trial of male circumcision. Methods In a randomised trial to assess the efficacy of circumcision on HIV acquisition in Rakai, Uganda, HIV-negative men were randomised to immediate (intervention) or delayed (control) circumcision and followed over 24 months. We performed quantitative-PCR HPV viral load assays on penile swabs which tested positive by Linear Array (LA) for six HR-HPV genotypes and estimated viral load in the remaining types by LA signal strength. Results At 24 months, circumcision intervention arm men infected with one of the six selected HR-HPV genotypes had a lower viral load and significantly reduced HR-HPV high LA band intensity (PRR=0.61, 95% CI 0.43 to 0.86) compared to infected men in the control arm of the trial. The decreased viral load associated with circumcision was seen among HPV infections acquired after enrolment but not among infections that persisted from trial enrolment to 24 months (p=0.80). Conclusions The decreased penile HR-HPV shedding observed among HPV-infected circumcised men may help to explain the protective association observed between circumcision and reduced acquisition of HR-HPV in female partners.
language: eng
source:
identifier: ISSN: 1368-4973
fulltext: no_fulltext
issn:
  • 1368-4973
  • 1472-3263
  • 1472-3263
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.4351306
LOCALfalse
PrimoNMBib
record
control
sourceidgale_pubme
recordidTN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3706631
sourceformatXML
sourcesystemPC
galeidA543625415
sourcerecordidA543625415
originalsourceidFETCH-LOGICAL-1733t-d1e584bed4ea945d8118e9b60e659ca9addc5191e7f3b1ee87c5c687d8c41a420
addsrcrecordideNqNkm1r1EAQx4Motla_gUhABF-YNvuc9IVQzocK9QFtfbvs7U7utk2y525Sqp_eOdJebSlUApuE-c1_Zmf-WfaclLuEMLmX4GKIpk8FLQktSlFKxh5k24QrWjAq2UP8ZrIqeK3YVvYkpdOyLKUS9eNsizJCKONkO_vz2bSQWx_t2FmffOjzCG60kPIV9B5jS79YFtGns3w5dqbPV2bl2zZ05tzHMeV4mjZvg3G573OTY0sudD6By23re28xOkSPJ4a_mzPj3-QnC4TM0-xRY9oEzy7fO9nJh_fHs8Pi6OvHT7ODo4IoxobCERAVn4PjYGouXEVIBfVcliBFbU1tnLOC1ARUw-YEoFJWWFkpV1lODKflTvZ20l2N8w6chR7n1upV9J2Jv3UwXt-M9H6pF-FcM1VKyQgKHE4CAUdifIQbua6HQQenqVRa0YZAyYBZw-eSSmqkklByy51Z_6LU68teYvg1Qho0jspC25oewpg0EYJgSYHrvBdlVClaqapC9OUt9DSMscehaqIqImspcPcbaoEr175vAt7WrkX1geBMUsHJuuzuHRQ-DjpvQw8NmuJmwos7EvS_AJ8AG0NKEZrN-Eip11bWV1bWayvrycrXutNyNklX3kXg1SVgErqsQQV08DWnqKrKmiO3f6u-9YMZ0OpY1Lf3dVFMyT4NcLERN_FMS8WU0F9-zvSP2Tf57viY6CPk9yZ-3p3-3z3_Ame_Lbg
sourcetypeOpen Access Repository
isCDItrue
recordtypearticle
pqid1781696500
display
typearticle
titleMale circumcision reduces penile high-risk human papillomavirus viral load in a randomised clinical trial in Rakai, Uganda
creatorWilson, Lauren E ; Gravitt, Patti ; Tobian, Aaron A R ; Kigozi, Godfrey ; Serwadda, David ; Nalugoda, Fred ; Watya, Stephen ; Wawer, Maria J ; Gray, Ronald H
creatorcontribWilson, Lauren E ; Gravitt, Patti ; Tobian, Aaron A R ; Kigozi, Godfrey ; Serwadda, David ; Nalugoda, Fred ; Watya, Stephen ; Wawer, Maria J ; Gray, Ronald H
descriptionObjectives Male circumcision reduces penile high-risk human papillomavirus (HR-HPV) prevalence in randomised trials. The goal of this study was to examine the effect of circumcision on HPV viral load among HPV-infected men in a randomised trial of male circumcision. Methods In a randomised trial to assess the efficacy of circumcision on HIV acquisition in Rakai, Uganda, HIV-negative men were randomised to immediate (intervention) or delayed (control) circumcision and followed over 24 months. We performed quantitative-PCR HPV viral load assays on penile swabs which tested positive by Linear Array (LA) for six HR-HPV genotypes and estimated viral load in the remaining types by LA signal strength. Results At 24 months, circumcision intervention arm men infected with one of the six selected HR-HPV genotypes had a lower viral load and significantly reduced HR-HPV high LA band intensity (PRR=0.61, 95% CI 0.43 to 0.86) compared to infected men in the control arm of the trial. The decreased viral load associated with circumcision was seen among HPV infections acquired after enrolment but not among infections that persisted from trial enrolment to 24 months (p=0.80). Conclusions The decreased penile HR-HPV shedding observed among HPV-infected circumcised men may help to explain the protective association observed between circumcision and reduced acquisition of HR-HPV in female partners.
identifier
0ISSN: 1368-4973
1ISSN: 1472-3263
2EISSN: 1472-3263
3DOI: 10.1136/sextrans-2012-050633
4PMID: 23112341
languageeng
publisherLondon: BMJ Publishing Group Ltd
subjectAdolescent ; Adult ; Africa ; Analysis ; Article ; Biological and medical sciences ; Circumcision ; Circumcision, Male ; Clinical trials ; Epidemiology. Vaccinations ; General aspects ; Genotype ; Hpv ; Human immunodeficiency virus ; Human infectious diseases. Experimental studies and models ; Human papillomavirus ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Molecular Epidemiology ; Papillomaviridae - classification ; Papillomaviridae - genetics ; Papillomaviridae - isolation & purification ; Papillomavirus infections ; Papillomavirus Infections - prevention & control ; Papillomavirus Infections - virology ; Penile Diseases - prevention & control ; Penile Diseases - virology ; Real-Time Polymerase Chain Reaction ; Risk factors ; Treatment Outcome ; Uganda ; Usage ; Viral Load ; Virus Shedding ; Young Adult
ispartofSexually transmitted infections, 2013-05, Vol.89 (3), p.262-266
rights
0Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions
12014 INIST-CNRS
2Copyright: 2013 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions
3Copyright Article author (or their employer) 2012. Produced by BMJ Publishing Group Ltd under licence. 2012
lds50peer_reviewed
oafree_for_read
citedbyFETCH-LOGICAL-1733t-d1e584bed4ea945d8118e9b60e659ca9addc5191e7f3b1ee87c5c687d8c41a420
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27278094$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23112341$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Wilson, Lauren E
1Gravitt, Patti
2Tobian, Aaron A R
3Kigozi, Godfrey
4Serwadda, David
5Nalugoda, Fred
6Watya, Stephen
7Wawer, Maria J
8Gray, Ronald H
title
0Male circumcision reduces penile high-risk human papillomavirus viral load in a randomised clinical trial in Rakai, Uganda
1Sexually transmitted infections
addtitleSex Transm Infect
descriptionObjectives Male circumcision reduces penile high-risk human papillomavirus (HR-HPV) prevalence in randomised trials. The goal of this study was to examine the effect of circumcision on HPV viral load among HPV-infected men in a randomised trial of male circumcision. Methods In a randomised trial to assess the efficacy of circumcision on HIV acquisition in Rakai, Uganda, HIV-negative men were randomised to immediate (intervention) or delayed (control) circumcision and followed over 24 months. We performed quantitative-PCR HPV viral load assays on penile swabs which tested positive by Linear Array (LA) for six HR-HPV genotypes and estimated viral load in the remaining types by LA signal strength. Results At 24 months, circumcision intervention arm men infected with one of the six selected HR-HPV genotypes had a lower viral load and significantly reduced HR-HPV high LA band intensity (PRR=0.61, 95% CI 0.43 to 0.86) compared to infected men in the control arm of the trial. The decreased viral load associated with circumcision was seen among HPV infections acquired after enrolment but not among infections that persisted from trial enrolment to 24 months (p=0.80). Conclusions The decreased penile HR-HPV shedding observed among HPV-infected circumcised men may help to explain the protective association observed between circumcision and reduced acquisition of HR-HPV in female partners.
subject
0Adolescent
1Adult
2Africa
3Analysis
4Article
5Biological and medical sciences
6Circumcision
7Circumcision, Male
8Clinical trials
9Epidemiology. Vaccinations
10General aspects
11Genotype
12Hpv
13Human immunodeficiency virus
14Human infectious diseases. Experimental studies and models
15Human papillomavirus
16Humans
17Infectious diseases
18Male
19Medical sciences
20Middle Aged
21Molecular Epidemiology
22Papillomaviridae - classification
23Papillomaviridae - genetics
24Papillomaviridae - isolation & purification
25Papillomavirus infections
26Papillomavirus Infections - prevention & control
27Papillomavirus Infections - virology
28Penile Diseases - prevention & control
29Penile Diseases - virology
30Real-Time Polymerase Chain Reaction
31Risk factors
32Treatment Outcome
33Uganda
34Usage
35Viral Load
36Virus Shedding
37Young Adult
issn
01368-4973
11472-3263
21472-3263
fulltextfalse
rsrctypearticle
creationdate2013
recordtypearticle
recordideNqNkm1r1EAQx4Motla_gUhABF-YNvuc9IVQzocK9QFtfbvs7U7utk2y525Sqp_eOdJebSlUApuE-c1_Zmf-WfaclLuEMLmX4GKIpk8FLQktSlFKxh5k24QrWjAq2UP8ZrIqeK3YVvYkpdOyLKUS9eNsizJCKONkO_vz2bSQWx_t2FmffOjzCG60kPIV9B5jS79YFtGns3w5dqbPV2bl2zZ05tzHMeV4mjZvg3G573OTY0sudD6By23re28xOkSPJ4a_mzPj3-QnC4TM0-xRY9oEzy7fO9nJh_fHs8Pi6OvHT7ODo4IoxobCERAVn4PjYGouXEVIBfVcliBFbU1tnLOC1ARUw-YEoFJWWFkpV1lODKflTvZ20l2N8w6chR7n1upV9J2Jv3UwXt-M9H6pF-FcM1VKyQgKHE4CAUdifIQbua6HQQenqVRa0YZAyYBZw-eSSmqkklByy51Z_6LU68teYvg1Qho0jspC25oewpg0EYJgSYHrvBdlVClaqapC9OUt9DSMscehaqIqImspcPcbaoEr175vAt7WrkX1geBMUsHJuuzuHRQ-DjpvQw8NmuJmwos7EvS_AJ8AG0NKEZrN-Eip11bWV1bWayvrycrXutNyNklX3kXg1SVgErqsQQV08DWnqKrKmiO3f6u-9YMZ0OpY1Lf3dVFMyT4NcLERN_FMS8WU0F9-zvSP2Tf57viY6CPk9yZ-3p3-3z3_Ame_Lbg
startdate201305
enddate201305
creator
0Wilson, Lauren E
1Gravitt, Patti
2Tobian, Aaron A R
3Kigozi, Godfrey
4Serwadda, David
5Nalugoda, Fred
6Watya, Stephen
7Wawer, Maria J
8Gray, Ronald H
general
0BMJ Publishing Group Ltd
1BMJ Publishing Group
2BMJ Publishing Group LTD
scope
0BSCLL
1IQODW
2CGR
3CUY
4CVF
5ECM
6EIF
7NPM
8AAYXX
9CITATION
10BKMMT
11BSHEE
123V.
137X7
147XB
1588E
1688I
178AF
188FI
198FJ
208FK
21ABUWG
22AZQEC
23BENPR
24BTHHO
25DWQXO
26FYUFA
27GHDGH
28GNUQQ
29HCIFZ
30K9.
31M0S
32M1P
33M2P
34PQEST
35PQQKQ
36PQUKI
37Q9U
387X8
397U9
40H94
41BOBZL
42CLFQK
435PM
sort
creationdate201305
titleMale circumcision reduces penile high-risk human papillomavirus viral load in a randomised clinical trial in Rakai, Uganda
authorWilson, Lauren E ; Gravitt, Patti ; Tobian, Aaron A R ; Kigozi, Godfrey ; Serwadda, David ; Nalugoda, Fred ; Watya, Stephen ; Wawer, Maria J ; Gray, Ronald H
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1733t-d1e584bed4ea945d8118e9b60e659ca9addc5191e7f3b1ee87c5c687d8c41a420
rsrctypearticles
prefilterarticles
languageeng
creationdate2013
topic
0Adolescent
1Adult
2Africa
3Analysis
4Article
5Biological and medical sciences
6Circumcision
7Circumcision, Male
8Clinical trials
9Epidemiology. Vaccinations
10General aspects
11Genotype
12Hpv
13Human immunodeficiency virus
14Human infectious diseases. Experimental studies and models
15Human papillomavirus
16Humans
17Infectious diseases
18Male
19Medical sciences
20Middle Aged
21Molecular Epidemiology
22Papillomaviridae - classification
23Papillomaviridae - genetics
24Papillomaviridae - isolation & purification
25Papillomavirus infections
26Papillomavirus Infections - prevention & control
27Papillomavirus Infections - virology
28Penile Diseases - prevention & control
29Penile Diseases - virology
30Real-Time Polymerase Chain Reaction
31Risk factors
32Treatment Outcome
33Uganda
34Usage
35Viral Load
36Virus Shedding
37Young Adult
toplevelpeer_reviewed
creatorcontrib
0Wilson, Lauren E
1Gravitt, Patti
2Tobian, Aaron A R
3Kigozi, Godfrey
4Serwadda, David
5Nalugoda, Fred
6Watya, Stephen
7Wawer, Maria J
8Gray, Ronald H
collection
0Istex
1Pascal-Francis
2Medline
3MEDLINE
4MEDLINE (Ovid)
5MEDLINE
6MEDLINE
7PubMed
8CrossRef
9Gale General OneFile (A&I only)
10Academic OneFile (A&I only)
11ProQuest Central (Corporate)
12Health & Medical Collection
13ProQuest Central (purchase pre-March 2016)
14Medical Database (Alumni Edition)
15Science Database (Alumni Edition)
16STEM Database
17Hospital Premium Collection
18Hospital Premium Collection (Alumni Edition)
19ProQuest Central (Alumni) (purchase pre-March 2016)
20ProQuest Central (Alumni Edition)
21ProQuest Central Essentials
22ProQuest Central
23BMJ Journals
24ProQuest Central Korea
25Health Research Premium Collection
26Health Research Premium Collection (Alumni)
27ProQuest Central Student
28SciTech Premium Collection
29ProQuest Health & Medical Complete (Alumni)
30Health & Medical Collection (Alumni Edition)
31Medical Database
32Science Database
33ProQuest One Academic Eastern Edition
34ProQuest One Academic
35ProQuest One Academic UKI Edition
36ProQuest Central Basic
37MEDLINE - Academic
38Virology and AIDS Abstracts
39AIDS and Cancer Research Abstracts
40OpenAIRE (Open Access)
41OpenAIRE
42PubMed Central (Full Participant titles)
jtitleSexually transmitted infections
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Wilson, Lauren E
1Gravitt, Patti
2Tobian, Aaron A R
3Kigozi, Godfrey
4Serwadda, David
5Nalugoda, Fred
6Watya, Stephen
7Wawer, Maria J
8Gray, Ronald H
formatjournal
genrearticle
ristypeJOUR
atitleMale circumcision reduces penile high-risk human papillomavirus viral load in a randomised clinical trial in Rakai, Uganda
jtitleSexually transmitted infections
addtitleSex Transm Infect
date2013-05
risdate2013
volume89
issue3
spage262
epage266
pages262-266
issn
01368-4973
11472-3263
eissn1472-3263
abstractObjectives Male circumcision reduces penile high-risk human papillomavirus (HR-HPV) prevalence in randomised trials. The goal of this study was to examine the effect of circumcision on HPV viral load among HPV-infected men in a randomised trial of male circumcision. Methods In a randomised trial to assess the efficacy of circumcision on HIV acquisition in Rakai, Uganda, HIV-negative men were randomised to immediate (intervention) or delayed (control) circumcision and followed over 24 months. We performed quantitative-PCR HPV viral load assays on penile swabs which tested positive by Linear Array (LA) for six HR-HPV genotypes and estimated viral load in the remaining types by LA signal strength. Results At 24 months, circumcision intervention arm men infected with one of the six selected HR-HPV genotypes had a lower viral load and significantly reduced HR-HPV high LA band intensity (PRR=0.61, 95% CI 0.43 to 0.86) compared to infected men in the control arm of the trial. The decreased viral load associated with circumcision was seen among HPV infections acquired after enrolment but not among infections that persisted from trial enrolment to 24 months (p=0.80). Conclusions The decreased penile HR-HPV shedding observed among HPV-infected circumcised men may help to explain the protective association observed between circumcision and reduced acquisition of HR-HPV in female partners.
copLondon
pubBMJ Publishing Group Ltd
pmid23112341
doi10.1136/sextrans-2012-050633
oafree_for_read