schliessen

Filtern

 

Bibliotheken

Peripheral Type I Interferon Receptor Correlated with Oxidative Stress in Chronic Hepatitis B Virus Infection

Type I interferon receptor (IFNAR) has been involved in the progression of chronic hepatitis B (CHB). Oxidative stress is also associated with hepatitis B virus (HBV) infection and might contribute to the structure and function of protein synthesis including the IFNAR family. This study was aimed to... Full description

Journal Title: Journal of interferon & cytokine research 2013-08-01, Vol.33 (8), p.45-414
Main Author: Zhao, Jing
Other Authors: Fan, Yu-Chen , Sun, Feng-Kai , Zhao, Ze-Hua , Wang, Li-Yuan , Hu, Lei-Hua , Yin, Yan-Ping , Li, Tao , Gao, Shuai , Wang, Kai
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Mary Ann Liebert, Inc
ID: ISSN: 1079-9907
Link: https://www.ncbi.nlm.nih.gov/pubmed/23663046
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3741434
title: Peripheral Type I Interferon Receptor Correlated with Oxidative Stress in Chronic Hepatitis B Virus Infection
format: Article
creator:
  • Zhao, Jing
  • Fan, Yu-Chen
  • Sun, Feng-Kai
  • Zhao, Ze-Hua
  • Wang, Li-Yuan
  • Hu, Lei-Hua
  • Yin, Yan-Ping
  • Li, Tao
  • Gao, Shuai
  • Wang, Kai
subjects:
  • Adult
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Flow Cytometry
  • Gene Expression
  • Glutathione - blood
  • Glutathione Peroxidase - blood
  • Glutathione Transferase - blood
  • Hepatitis B, Chronic - blood
  • Hepatitis B, Chronic - genetics
  • Hepatitis B, Chronic - metabolism
  • Humans
  • Liver Cirrhosis - blood
  • Liver Cirrhosis - genetics
  • Liver Cirrhosis - metabolism
  • Lymphocytes - metabolism
  • Male
  • Malondialdehyde - blood
  • Middle Aged
  • Monocytes - metabolism
  • Oxidative Stress
  • Receptor, Interferon alpha-beta - blood
  • Receptor, Interferon alpha-beta - genetics
  • Receptor, Interferon alpha-beta - metabolism
  • Research Reports
  • Reverse Transcriptase Polymerase Chain Reaction
  • Xanthine Oxidase - blood
ispartof: Journal of interferon & cytokine research, 2013-08-01, Vol.33 (8), p.45-414
description: Type I interferon receptor (IFNAR) has been involved in the progression of chronic hepatitis B (CHB). Oxidative stress is also associated with hepatitis B virus (HBV) infection and might contribute to the structure and function of protein synthesis including the IFNAR family. This study was aimed to determine the possible associations between oxidative stress and peripheral IFNAR expression in chronic HBV infection. Fifty-four CHB patients and 31 liver cirrhosis (LC) patients were consecutively collected, as well as 11 healthy subjects as controls. Expression levels of IFNAR1 and IFNAR2 in peripheral blood lymphocytes and monocytes were measured by flow cytometry. IFNAR1 and IFNAR2c mRNA were detected by real-time reverse transcription–polymerase chain reaction. Levels of plasma-soluble IFNAR and oxidative stress parameters, including xanthine oxidase (XOD), malondialdehyde (MDA), glutathione (GSH), glutathione S-transferase (GST), and glutathione peroxidase (GSH-Px) were detected by enzyme linked immunosorbent assay (ELISA). The frequencies of IFNAR1 and IFNAR2 in lymphocytes and monocytes were significantly increased in CHB and LC patients than in healthy controls. Expression levels of IFNAR1 and IFNAR2c mRNA and plasma-soluble IFNAR level in CHB and LC patients were upregulated compared with healthy controls. Mean fluorescence intensity (MFI) of IFNAR2 in monocytes of CHB patients was higher than that in LC patients. Levels of plasma XOD, MDA, and GST were significantly increased in CHB and LC patients compared with healthy controls. Meanwhile, GSH and GSH-Px in CHB and LC patients were decreased than that in healthy controls. Furthermore, plasma MDA, GSH, and GST levels in CHB patients were higher than that in LC patients. In CHB patients, plasma GST level was negatively correlated with MFI of IFNAR2 in lymphocytes. Our results suggested that oxidative stress play an important role in the regulation of IFNAR in chronic HBV infection.
language: eng
source:
identifier: ISSN: 1079-9907
fulltext: no_fulltext
issn:
  • 1079-9907
  • 1557-7465
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.3483784
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_pubme
recordidTN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3741434
sourceformatXML
sourcesystemPC
sourcerecordid3040505581
originalsourceidFETCH-LOGICAL-1533t-acc8703c58c1e5796a1ae69b119674e5b7d95a16a6e5c81d3366df3d987f0e910
addsrcrecordideNqFkkGLFDEQhYMo7jp69CoBL156TDqdpHMRdFBnYGFFV68hna52MvQkbZJZ3X9vmhkXd0E8JVCvPl5VPYSeU7KkpFWvdy4ua0LrJaGcPUDnlHNZyUbwh-VPpKqUIvIMPUlpRwgRba0eo7OaCcFII87R_hNEN20hmhFf3UyAN3jjM8QBYvD4M1iYcoh4FWKE0WTo8U-Xt_jyl-tNdteAv-QIKWHn8WpbWpzFa5hKKbuE3-FvLh5SIQ5gswv-KXo0mDHBs9O7QF8_vL9arauLy4-b1duLqszAcmWsbSVhlreWApdKGGpAqI5SJWQDvJO94oYKI4DblvasjNMPrFetHAgoShbozZE7Hbo99BZ8LgPqKbq9iTc6GKfvVrzb6u_hWjPZ0IY1BbA-AsIE3rgId3p7D1mHXtdCatEoCwCNHSTnVtaSmq5TUAtrjFS9KahXJy8x_DhAynrvkoVxNB7CIWnalPMJSdvZ9st70l04RF82VVS0lYzO4gWqjiobQ0oRhltvlOg5E7pkQs-Z0HMmiv7F38u4Vf8JQRGwe0DrspnvVXbjxn9iT10zzHg_Ougg5v-Y-Q12AtUe
sourcetypeOpen Access Repository
isCDItrue
recordtypearticle
pqid1418731142
display
typearticle
titlePeripheral Type I Interferon Receptor Correlated with Oxidative Stress in Chronic Hepatitis B Virus Infection
creatorZhao, Jing ; Fan, Yu-Chen ; Sun, Feng-Kai ; Zhao, Ze-Hua ; Wang, Li-Yuan ; Hu, Lei-Hua ; Yin, Yan-Ping ; Li, Tao ; Gao, Shuai ; Wang, Kai
creatorcontribZhao, Jing ; Fan, Yu-Chen ; Sun, Feng-Kai ; Zhao, Ze-Hua ; Wang, Li-Yuan ; Hu, Lei-Hua ; Yin, Yan-Ping ; Li, Tao ; Gao, Shuai ; Wang, Kai
descriptionType I interferon receptor (IFNAR) has been involved in the progression of chronic hepatitis B (CHB). Oxidative stress is also associated with hepatitis B virus (HBV) infection and might contribute to the structure and function of protein synthesis including the IFNAR family. This study was aimed to determine the possible associations between oxidative stress and peripheral IFNAR expression in chronic HBV infection. Fifty-four CHB patients and 31 liver cirrhosis (LC) patients were consecutively collected, as well as 11 healthy subjects as controls. Expression levels of IFNAR1 and IFNAR2 in peripheral blood lymphocytes and monocytes were measured by flow cytometry. IFNAR1 and IFNAR2c mRNA were detected by real-time reverse transcription–polymerase chain reaction. Levels of plasma-soluble IFNAR and oxidative stress parameters, including xanthine oxidase (XOD), malondialdehyde (MDA), glutathione (GSH), glutathione S-transferase (GST), and glutathione peroxidase (GSH-Px) were detected by enzyme linked immunosorbent assay (ELISA). The frequencies of IFNAR1 and IFNAR2 in lymphocytes and monocytes were significantly increased in CHB and LC patients than in healthy controls. Expression levels of IFNAR1 and IFNAR2c mRNA and plasma-soluble IFNAR level in CHB and LC patients were upregulated compared with healthy controls. Mean fluorescence intensity (MFI) of IFNAR2 in monocytes of CHB patients was higher than that in LC patients. Levels of plasma XOD, MDA, and GST were significantly increased in CHB and LC patients compared with healthy controls. Meanwhile, GSH and GSH-Px in CHB and LC patients were decreased than that in healthy controls. Furthermore, plasma MDA, GSH, and GST levels in CHB patients were higher than that in LC patients. In CHB patients, plasma GST level was negatively correlated with MFI of IFNAR2 in lymphocytes. Our results suggested that oxidative stress play an important role in the regulation of IFNAR in chronic HBV infection.
identifier
0ISSN: 1079-9907
1EISSN: 1557-7465
2DOI: 10.1089/jir.2012.0153
3PMID: 23663046
languageeng
publisherUnited States: Mary Ann Liebert, Inc
subjectAdult ; Enzyme-Linked Immunosorbent Assay ; Female ; Flow Cytometry ; Gene Expression ; Glutathione - blood ; Glutathione Peroxidase - blood ; Glutathione Transferase - blood ; Hepatitis B, Chronic - blood ; Hepatitis B, Chronic - genetics ; Hepatitis B, Chronic - metabolism ; Humans ; Liver Cirrhosis - blood ; Liver Cirrhosis - genetics ; Liver Cirrhosis - metabolism ; Lymphocytes - metabolism ; Male ; Malondialdehyde - blood ; Middle Aged ; Monocytes - metabolism ; Oxidative Stress ; Receptor, Interferon alpha-beta - blood ; Receptor, Interferon alpha-beta - genetics ; Receptor, Interferon alpha-beta - metabolism ; Research Reports ; Reverse Transcriptase Polymerase Chain Reaction ; Xanthine Oxidase - blood
ispartofJournal of interferon & cytokine research, 2013-08-01, Vol.33 (8), p.45-414
rights
02013, Mary Ann Liebert, Inc.
1(©) Copyright 2013, Mary Ann Liebert, Inc.
2Copyright 2013, Mary Ann Liebert, Inc. 2013
lds50peer_reviewed
oafree_for_read
citedbyFETCH-LOGICAL-1533t-acc8703c58c1e5796a1ae69b119674e5b7d95a16a6e5c81d3366df3d987f0e910
citesFETCH-LOGICAL-1533t-acc8703c58c1e5796a1ae69b119674e5b7d95a16a6e5c81d3366df3d987f0e910
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23663046$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Zhao, Jing
1Fan, Yu-Chen
2Sun, Feng-Kai
3Zhao, Ze-Hua
4Wang, Li-Yuan
5Hu, Lei-Hua
6Yin, Yan-Ping
7Li, Tao
8Gao, Shuai
9Wang, Kai
title
0Peripheral Type I Interferon Receptor Correlated with Oxidative Stress in Chronic Hepatitis B Virus Infection
1Journal of interferon & cytokine research
addtitleJ Interferon Cytokine Res
descriptionType I interferon receptor (IFNAR) has been involved in the progression of chronic hepatitis B (CHB). Oxidative stress is also associated with hepatitis B virus (HBV) infection and might contribute to the structure and function of protein synthesis including the IFNAR family. This study was aimed to determine the possible associations between oxidative stress and peripheral IFNAR expression in chronic HBV infection. Fifty-four CHB patients and 31 liver cirrhosis (LC) patients were consecutively collected, as well as 11 healthy subjects as controls. Expression levels of IFNAR1 and IFNAR2 in peripheral blood lymphocytes and monocytes were measured by flow cytometry. IFNAR1 and IFNAR2c mRNA were detected by real-time reverse transcription–polymerase chain reaction. Levels of plasma-soluble IFNAR and oxidative stress parameters, including xanthine oxidase (XOD), malondialdehyde (MDA), glutathione (GSH), glutathione S-transferase (GST), and glutathione peroxidase (GSH-Px) were detected by enzyme linked immunosorbent assay (ELISA). The frequencies of IFNAR1 and IFNAR2 in lymphocytes and monocytes were significantly increased in CHB and LC patients than in healthy controls. Expression levels of IFNAR1 and IFNAR2c mRNA and plasma-soluble IFNAR level in CHB and LC patients were upregulated compared with healthy controls. Mean fluorescence intensity (MFI) of IFNAR2 in monocytes of CHB patients was higher than that in LC patients. Levels of plasma XOD, MDA, and GST were significantly increased in CHB and LC patients compared with healthy controls. Meanwhile, GSH and GSH-Px in CHB and LC patients were decreased than that in healthy controls. Furthermore, plasma MDA, GSH, and GST levels in CHB patients were higher than that in LC patients. In CHB patients, plasma GST level was negatively correlated with MFI of IFNAR2 in lymphocytes. Our results suggested that oxidative stress play an important role in the regulation of IFNAR in chronic HBV infection.
subject
0Adult
1Enzyme-Linked Immunosorbent Assay
2Female
3Flow Cytometry
4Gene Expression
5Glutathione - blood
6Glutathione Peroxidase - blood
7Glutathione Transferase - blood
8Hepatitis B, Chronic - blood
9Hepatitis B, Chronic - genetics
10Hepatitis B, Chronic - metabolism
11Humans
12Liver Cirrhosis - blood
13Liver Cirrhosis - genetics
14Liver Cirrhosis - metabolism
15Lymphocytes - metabolism
16Male
17Malondialdehyde - blood
18Middle Aged
19Monocytes - metabolism
20Oxidative Stress
21Receptor, Interferon alpha-beta - blood
22Receptor, Interferon alpha-beta - genetics
23Receptor, Interferon alpha-beta - metabolism
24Research Reports
25Reverse Transcriptase Polymerase Chain Reaction
26Xanthine Oxidase - blood
issn
01079-9907
11557-7465
fulltextfalse
rsrctypearticle
creationdate2013
recordtypearticle
recordideNqFkkGLFDEQhYMo7jp69CoBL156TDqdpHMRdFBnYGFFV68hna52MvQkbZJZ3X9vmhkXd0E8JVCvPl5VPYSeU7KkpFWvdy4ua0LrJaGcPUDnlHNZyUbwh-VPpKqUIvIMPUlpRwgRba0eo7OaCcFII87R_hNEN20hmhFf3UyAN3jjM8QBYvD4M1iYcoh4FWKE0WTo8U-Xt_jyl-tNdteAv-QIKWHn8WpbWpzFa5hKKbuE3-FvLh5SIQ5gswv-KXo0mDHBs9O7QF8_vL9arauLy4-b1duLqszAcmWsbSVhlreWApdKGGpAqI5SJWQDvJO94oYKI4DblvasjNMPrFetHAgoShbozZE7Hbo99BZ8LgPqKbq9iTc6GKfvVrzb6u_hWjPZ0IY1BbA-AsIE3rgId3p7D1mHXtdCatEoCwCNHSTnVtaSmq5TUAtrjFS9KahXJy8x_DhAynrvkoVxNB7CIWnalPMJSdvZ9st70l04RF82VVS0lYzO4gWqjiobQ0oRhltvlOg5E7pkQs-Z0HMmiv7F38u4Vf8JQRGwe0DrspnvVXbjxn9iT10zzHg_Ougg5v-Y-Q12AtUe
startdate20130801
enddate20130801
creator
0Zhao, Jing
1Fan, Yu-Chen
2Sun, Feng-Kai
3Zhao, Ze-Hua
4Wang, Li-Yuan
5Hu, Lei-Hua
6Yin, Yan-Ping
7Li, Tao
8Gao, Shuai
9Wang, Kai
generalMary Ann Liebert, Inc
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
83V.
97QL
107T5
117T7
127TM
137U9
147X7
157XB
1688A
1788E
1888I
198C1
208FD
218FE
228FH
238FI
248FJ
258FK
26ABUWG
27AZQEC
28BBNVY
29BENPR
30BHPHI
31C1K
32DWQXO
33FR3
34FYUFA
35GHDGH
36GNUQQ
37H94
38HCIFZ
39K9.
40LK8
41M0S
42M1P
43M2P
44M7N
45M7P
46P64
47PQEST
48PQQKQ
49PQUKI
50PRINS
51Q9U
527X8
53BOBZL
54CLFQK
555PM
sort
creationdate20130801
titlePeripheral Type I Interferon Receptor Correlated with Oxidative Stress in Chronic Hepatitis B Virus Infection
authorZhao, Jing ; Fan, Yu-Chen ; Sun, Feng-Kai ; Zhao, Ze-Hua ; Wang, Li-Yuan ; Hu, Lei-Hua ; Yin, Yan-Ping ; Li, Tao ; Gao, Shuai ; Wang, Kai
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1533t-acc8703c58c1e5796a1ae69b119674e5b7d95a16a6e5c81d3366df3d987f0e910
rsrctypearticles
prefilterarticles
languageeng
creationdate2013
topic
0Adult
1Enzyme-Linked Immunosorbent Assay
2Female
3Flow Cytometry
4Gene Expression
5Glutathione - blood
6Glutathione Peroxidase - blood
7Glutathione Transferase - blood
8Hepatitis B, Chronic - blood
9Hepatitis B, Chronic - genetics
10Hepatitis B, Chronic - metabolism
11Humans
12Liver Cirrhosis - blood
13Liver Cirrhosis - genetics
14Liver Cirrhosis - metabolism
15Lymphocytes - metabolism
16Male
17Malondialdehyde - blood
18Middle Aged
19Monocytes - metabolism
20Oxidative Stress
21Receptor, Interferon alpha-beta - blood
22Receptor, Interferon alpha-beta - genetics
23Receptor, Interferon alpha-beta - metabolism
24Research Reports
25Reverse Transcriptase Polymerase Chain Reaction
26Xanthine Oxidase - blood
toplevelpeer_reviewed
creatorcontrib
0Zhao, Jing
1Fan, Yu-Chen
2Sun, Feng-Kai
3Zhao, Ze-Hua
4Wang, Li-Yuan
5Hu, Lei-Hua
6Yin, Yan-Ping
7Li, Tao
8Gao, Shuai
9Wang, Kai
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7ProQuest Central (Corporate)
8Bacteriology Abstracts (Microbiology B)
9Immunology Abstracts
10Industrial and Applied Microbiology Abstracts (Microbiology A)
11Nucleic Acids Abstracts
12Virology and AIDS Abstracts
13Health & Medical Collection
14ProQuest Central (purchase pre-March 2016)
15Biology Database (Alumni Edition)
16Medical Database (Alumni Edition)
17Science Database (Alumni Edition)
18Public Health Database
19Technology Research Database
20ProQuest SciTech Collection
21ProQuest Natural Science Collection
22Hospital Premium Collection
23Hospital Premium Collection (Alumni Edition)
24ProQuest Central (Alumni) (purchase pre-March 2016)
25ProQuest Central (Alumni Edition)
26ProQuest Central Essentials
27Biological Science Collection
28ProQuest Central
29Natural Science Collection
30Environmental Sciences and Pollution Management
31ProQuest Central Korea
32Engineering Research Database
33Health Research Premium Collection
34Health Research Premium Collection (Alumni)
35ProQuest Central Student
36AIDS and Cancer Research Abstracts
37SciTech Premium Collection
38ProQuest Health & Medical Complete (Alumni)
39ProQuest Biological Science Collection
40Health & Medical Collection (Alumni Edition)
41Medical Database
42Science Database
43Algology Mycology and Protozoology Abstracts (Microbiology C)
44Biological Science Database
45Biotechnology and BioEngineering Abstracts
46ProQuest One Academic Eastern Edition
47ProQuest One Academic
48ProQuest One Academic UKI Edition
49ProQuest Central China
50ProQuest Central Basic
51MEDLINE - Academic
52OpenAIRE (Open Access)
53OpenAIRE
54PubMed Central (Full Participant titles)
jtitleJournal of interferon & cytokine research
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Zhao, Jing
1Fan, Yu-Chen
2Sun, Feng-Kai
3Zhao, Ze-Hua
4Wang, Li-Yuan
5Hu, Lei-Hua
6Yin, Yan-Ping
7Li, Tao
8Gao, Shuai
9Wang, Kai
formatjournal
genrearticle
ristypeJOUR
atitlePeripheral Type I Interferon Receptor Correlated with Oxidative Stress in Chronic Hepatitis B Virus Infection
jtitleJournal of interferon & cytokine research
addtitleJ Interferon Cytokine Res
date2013-08-01
risdate2013
volume33
issue8
spage45
epage414
pages45-414
issn1079-9907
eissn1557-7465
abstractType I interferon receptor (IFNAR) has been involved in the progression of chronic hepatitis B (CHB). Oxidative stress is also associated with hepatitis B virus (HBV) infection and might contribute to the structure and function of protein synthesis including the IFNAR family. This study was aimed to determine the possible associations between oxidative stress and peripheral IFNAR expression in chronic HBV infection. Fifty-four CHB patients and 31 liver cirrhosis (LC) patients were consecutively collected, as well as 11 healthy subjects as controls. Expression levels of IFNAR1 and IFNAR2 in peripheral blood lymphocytes and monocytes were measured by flow cytometry. IFNAR1 and IFNAR2c mRNA were detected by real-time reverse transcription–polymerase chain reaction. Levels of plasma-soluble IFNAR and oxidative stress parameters, including xanthine oxidase (XOD), malondialdehyde (MDA), glutathione (GSH), glutathione S-transferase (GST), and glutathione peroxidase (GSH-Px) were detected by enzyme linked immunosorbent assay (ELISA). The frequencies of IFNAR1 and IFNAR2 in lymphocytes and monocytes were significantly increased in CHB and LC patients than in healthy controls. Expression levels of IFNAR1 and IFNAR2c mRNA and plasma-soluble IFNAR level in CHB and LC patients were upregulated compared with healthy controls. Mean fluorescence intensity (MFI) of IFNAR2 in monocytes of CHB patients was higher than that in LC patients. Levels of plasma XOD, MDA, and GST were significantly increased in CHB and LC patients compared with healthy controls. Meanwhile, GSH and GSH-Px in CHB and LC patients were decreased than that in healthy controls. Furthermore, plasma MDA, GSH, and GST levels in CHB patients were higher than that in LC patients. In CHB patients, plasma GST level was negatively correlated with MFI of IFNAR2 in lymphocytes. Our results suggested that oxidative stress play an important role in the regulation of IFNAR in chronic HBV infection.
copUnited States
pubMary Ann Liebert, Inc
pmid23663046
doi10.1089/jir.2012.0153
oafree_for_read