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Mesenchymal cells of the intestinal lamina propria

The mesenchymal elements of the intestinal lamina propria reviewed here are the myofibroblasts, fibroblasts, mural cells (pericytes) of the vasculature, bone marrow-derived stromal stem cells, smooth muscle of the muscularis mucosae, and smooth muscle surrounding the lymphatic lacteals. These cells... Full description

Journal Title: Annual review of physiology 2011, Vol.73 (1), p.213-237
Main Author: Powell, D W
Other Authors: Pinchuk, I V , Saada, J I , Chen, Xin , Mifflin, R C
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Annual Reviews, Inc
ID: ISSN: 0066-4278
Link: https://www.ncbi.nlm.nih.gov/pubmed/21054163
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3754809
title: Mesenchymal cells of the intestinal lamina propria
format: Article
creator:
  • Powell, D W
  • Pinchuk, I V
  • Saada, J I
  • Chen, Xin
  • Mifflin, R C
subjects:
  • Animals
  • Article
  • Biomarkers - metabolism
  • Bone marrow
  • Cell Differentiation - physiology
  • colorectal cancer
  • Cytology
  • Epithelial-Mesenchymal Transition - physiology
  • Female
  • Fibroblasts
  • Genetic aspects
  • Hedgehog Proteins - physiology
  • Humans
  • Immune system
  • Immunity, Innate - physiology
  • Immunology
  • Intestine, Small
  • Intestines - anatomy & histology
  • Intestines - immunology
  • Intestines - physiology
  • Lymphatic system
  • Male
  • Mesenchymal Stromal Cells - physiology
  • Mesoderm - anatomy & histology
  • Mesoderm - immunology
  • Mesoderm - physiology
  • Mice
  • mucosal immunology
  • Mucous Membrane - anatomy & histology
  • Mucous Membrane - immunology
  • Mucous Membrane - physiology
  • Muscular system
  • muscularis mucosae
  • myofibroblast
  • Myofibroblasts - physiology
  • Pericytes - physiology
  • Physiological aspects
  • Physiology
  • Research
  • Signal Transduction - physiology
  • stem cell niche
  • Stem cells
  • Stromal Cells - immunology
  • Stromal Cells - physiology
ispartof: Annual review of physiology, 2011, Vol.73 (1), p.213-237
description: The mesenchymal elements of the intestinal lamina propria reviewed here are the myofibroblasts, fibroblasts, mural cells (pericytes) of the vasculature, bone marrow-derived stromal stem cells, smooth muscle of the muscularis mucosae, and smooth muscle surrounding the lymphatic lacteals. These cells share similar marker molecules, origins, and coordinated biological functions previously ascribed solely to subepithelial myofibroblasts. We review the functional anatomy of intestinal mesenchymal cells and describe what is known about their origin in the embryo and their replacement in adults. As part of their putative role in intestinal mucosal morphogenesis, we consider the intestinal stem cell niche. Lastly, we review emerging information about myofibroblasts as nonprofessional immune cells that may be important as an alarm system for the gut and as a participant in peripheral immune tolerance.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0066-4278
fulltext: fulltext
issn:
  • 0066-4278
  • 1545-1585
url: Link


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descriptionThe mesenchymal elements of the intestinal lamina propria reviewed here are the myofibroblasts, fibroblasts, mural cells (pericytes) of the vasculature, bone marrow-derived stromal stem cells, smooth muscle of the muscularis mucosae, and smooth muscle surrounding the lymphatic lacteals. These cells share similar marker molecules, origins, and coordinated biological functions previously ascribed solely to subepithelial myofibroblasts. We review the functional anatomy of intestinal mesenchymal cells and describe what is known about their origin in the embryo and their replacement in adults. As part of their putative role in intestinal mucosal morphogenesis, we consider the intestinal stem cell niche. Lastly, we review emerging information about myofibroblasts as nonprofessional immune cells that may be important as an alarm system for the gut and as a participant in peripheral immune tolerance.
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languageeng
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subjectAnimals ; Article ; Biomarkers - metabolism ; Bone marrow ; Cell Differentiation - physiology ; colorectal cancer ; Cytology ; Epithelial-Mesenchymal Transition - physiology ; Female ; Fibroblasts ; Genetic aspects ; Hedgehog Proteins - physiology ; Humans ; Immune system ; Immunity, Innate - physiology ; Immunology ; Intestine, Small ; Intestines - anatomy & histology ; Intestines - immunology ; Intestines - physiology ; Lymphatic system ; Male ; Mesenchymal Stromal Cells - physiology ; Mesoderm - anatomy & histology ; Mesoderm - immunology ; Mesoderm - physiology ; Mice ; mucosal immunology ; Mucous Membrane - anatomy & histology ; Mucous Membrane - immunology ; Mucous Membrane - physiology ; Muscular system ; muscularis mucosae ; myofibroblast ; Myofibroblasts - physiology ; Pericytes - physiology ; Physiological aspects ; Physiology ; Research ; Signal Transduction - physiology ; stem cell niche ; Stem cells ; Stromal Cells - immunology ; Stromal Cells - physiology
ispartofAnnual review of physiology, 2011, Vol.73 (1), p.213-237
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descriptionThe mesenchymal elements of the intestinal lamina propria reviewed here are the myofibroblasts, fibroblasts, mural cells (pericytes) of the vasculature, bone marrow-derived stromal stem cells, smooth muscle of the muscularis mucosae, and smooth muscle surrounding the lymphatic lacteals. These cells share similar marker molecules, origins, and coordinated biological functions previously ascribed solely to subepithelial myofibroblasts. We review the functional anatomy of intestinal mesenchymal cells and describe what is known about their origin in the embryo and their replacement in adults. As part of their putative role in intestinal mucosal morphogenesis, we consider the intestinal stem cell niche. Lastly, we review emerging information about myofibroblasts as nonprofessional immune cells that may be important as an alarm system for the gut and as a participant in peripheral immune tolerance.
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abstractThe mesenchymal elements of the intestinal lamina propria reviewed here are the myofibroblasts, fibroblasts, mural cells (pericytes) of the vasculature, bone marrow-derived stromal stem cells, smooth muscle of the muscularis mucosae, and smooth muscle surrounding the lymphatic lacteals. These cells share similar marker molecules, origins, and coordinated biological functions previously ascribed solely to subepithelial myofibroblasts. We review the functional anatomy of intestinal mesenchymal cells and describe what is known about their origin in the embryo and their replacement in adults. As part of their putative role in intestinal mucosal morphogenesis, we consider the intestinal stem cell niche. Lastly, we review emerging information about myofibroblasts as nonprofessional immune cells that may be important as an alarm system for the gut and as a participant in peripheral immune tolerance.
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