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Pathfinding of Corticothalamic Axons Relies on a Rendezvous with Thalamic Projections

Major outputs of the neocortex are conveyed by corticothalamic axons (CTAs), which form reciprocal connections with thalamocortical axons, and corticosubcerebral axons (CSAs) headed to more caudal parts of the nervous system. Previous findings establish that transcriptional programs define cortical... Full description

Journal Title: Neuron (Cambridge Mass.), 2013-02-06, Vol.77 (3), p.472-484
Main Author: Deck, Marie
Other Authors: Lokmane, Ludmilla , Chauvet, Sophie , Mailhes, Caroline , Keita, Maryama , Niquille, Mathieu , Yoshida, Michio , Yoshida, Yutaka , Lebrand, Cécile , Mann, Fanny , Grove, Elizabeth A , Garel, Sonia
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0896-6273
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title: Pathfinding of Corticothalamic Axons Relies on a Rendezvous with Thalamic Projections
format: Article
creator:
  • Deck, Marie
  • Lokmane, Ludmilla
  • Chauvet, Sophie
  • Mailhes, Caroline
  • Keita, Maryama
  • Niquille, Mathieu
  • Yoshida, Michio
  • Yoshida, Yutaka
  • Lebrand, Cécile
  • Mann, Fanny
  • Grove, Elizabeth A
  • Garel, Sonia
subjects:
  • Age Factors
  • Animals
  • Article
  • axon guidance
  • Axons
  • Axons - physiology
  • Binding Protein
  • Binding Proteins
  • Body Patterning
  • Body Patterning - genetics
  • Calbindin 2
  • Calcium
  • Calcium-Binding Protein, Vitamin D-Dependent
  • Cellular Biology
  • Cerebral Cortex
  • Cerebral Cortex - cytology
  • Cerebral Cortex - physiology
  • Contactin 2
  • Contactin 2 - metabolism
  • corticothalamic
  • cytology
  • Dependent
  • Developmental
  • Developmental biology
  • DNA-Binding Proteins
  • DNA-Binding Proteins - metabolism
  • Embryo
  • Embryo, Mammalian
  • Experiments
  • Gene Expression Regulation
  • Gene Expression Regulation, Developmental
  • Gene Expression Regulation, Developmental - genetics
  • genetics
  • Glycoproteins
  • Glycoproteins - genetics
  • handshake
  • Homeodomain Proteins
  • Homeodomain Proteins - genetics
  • Inbred C57BL
  • Laboratories
  • Leukocyte L1 Antigen Complex
  • Leukocyte L1 Antigen Complex - metabolism
  • Life Sciences
  • Luminescent Proteins
  • Luminescent Proteins - genetics
  • Luminescent Proteins - metabolism
  • Mammalian
  • Membrane Glycoproteins
  • Membrane Glycoproteins - genetics
  • Membrane Proteins
  • Membrane Proteins - genetics
  • metabolism
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Nerve Tissue Proteins
  • Nerve Tissue Proteins - genetics
  • Nerve Tissue Proteins - metabolism
  • nervous system
  • Neural Pathways
  • Neural Pathways - physiology
  • Neurons
  • Neuroscience(all)
  • Nuclear Proteins
  • Nuclear Proteins - metabolism
  • physiology
  • PlexinD1
  • POU Domain Factors
  • POU Domain Factors - genetics
  • reciprocal connections
  • Repressor Proteins
  • Repressor Proteins - metabolism
  • S100 Calcium Binding Protein G - metabolism
  • Sema3E
  • Studies
  • tau Proteins
  • tau Proteins - genetics
  • thalamocortical
  • Thalamus
  • Thalamus - cytology
  • Thalamus - physiology
  • Thyroid Nuclear Factor 1
  • Transcription Factors
  • Transcription Factors - genetics
  • Transcription Factors - metabolism
  • Transgenic
  • Tumor Suppressor Proteins
  • Tumor Suppressor Proteins - metabolism
  • Vitamin D
  • waiting period
  • Wnt3A Protein
  • Wnt3A Protein - genetics
ispartof: Neuron (Cambridge, Mass.), 2013-02-06, Vol.77 (3), p.472-484
description: Major outputs of the neocortex are conveyed by corticothalamic axons (CTAs), which form reciprocal connections with thalamocortical axons, and corticosubcerebral axons (CSAs) headed to more caudal parts of the nervous system. Previous findings establish that transcriptional programs define cortical neuron identity and suggest that CTAs and thalamic axons may guide each other, but the mechanisms governing CTA versus CSA pathfinding remain elusive. Here, we show that thalamocortical axons are required to guide pioneer CTAs away from a default CSA-like trajectory. This process relies on a hold in the progression of cortical axons, or waiting period, during which thalamic projections navigate toward cortical axons. At the molecular level, Sema3E/PlexinD1 signaling in pioneer cortical neurons mediates a “waiting signal” required to orchestrate the mandatory meeting with reciprocal thalamic axons. Our study reveals that temporal control of axonal progression contributes to spatial pathfinding of cortical projections and opens perspectives on brain wiring. ► Corticothalamic and corticosubcerebral axons follow distinct subpallial trajectories ► Thalamic projections guide corticothalamic axons ► Meeting with thalamic axons relies on a waiting period of pioneer cortical axons ► PlexinD1/Sema3E signaling controls the waiting period Reciprocal connections between the thalamus and neocortex are established during development. Deck et al. show that the pathfinding of corticothalamic projections relies on an encounter with reciprocal thalamocortical axons. This encounter is timely controlled by PlexinD1/Sema3E signaling.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0896-6273
fulltext: fulltext
issn:
  • 0896-6273
  • 1097-4199
url: Link


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titlePathfinding of Corticothalamic Axons Relies on a Rendezvous with Thalamic Projections
sourceAlma/SFX Local Collection
creatorDeck, Marie ; Lokmane, Ludmilla ; Chauvet, Sophie ; Mailhes, Caroline ; Keita, Maryama ; Niquille, Mathieu ; Yoshida, Michio ; Yoshida, Yutaka ; Lebrand, Cécile ; Mann, Fanny ; Grove, Elizabeth A ; Garel, Sonia
creatorcontribDeck, Marie ; Lokmane, Ludmilla ; Chauvet, Sophie ; Mailhes, Caroline ; Keita, Maryama ; Niquille, Mathieu ; Yoshida, Michio ; Yoshida, Yutaka ; Lebrand, Cécile ; Mann, Fanny ; Grove, Elizabeth A ; Garel, Sonia
descriptionMajor outputs of the neocortex are conveyed by corticothalamic axons (CTAs), which form reciprocal connections with thalamocortical axons, and corticosubcerebral axons (CSAs) headed to more caudal parts of the nervous system. Previous findings establish that transcriptional programs define cortical neuron identity and suggest that CTAs and thalamic axons may guide each other, but the mechanisms governing CTA versus CSA pathfinding remain elusive. Here, we show that thalamocortical axons are required to guide pioneer CTAs away from a default CSA-like trajectory. This process relies on a hold in the progression of cortical axons, or waiting period, during which thalamic projections navigate toward cortical axons. At the molecular level, Sema3E/PlexinD1 signaling in pioneer cortical neurons mediates a “waiting signal” required to orchestrate the mandatory meeting with reciprocal thalamic axons. Our study reveals that temporal control of axonal progression contributes to spatial pathfinding of cortical projections and opens perspectives on brain wiring. ► Corticothalamic and corticosubcerebral axons follow distinct subpallial trajectories ► Thalamic projections guide corticothalamic axons ► Meeting with thalamic axons relies on a waiting period of pioneer cortical axons ► PlexinD1/Sema3E signaling controls the waiting period Reciprocal connections between the thalamus and neocortex are established during development. Deck et al. show that the pathfinding of corticothalamic projections relies on an encounter with reciprocal thalamocortical axons. This encounter is timely controlled by PlexinD1/Sema3E signaling.
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languageeng
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subjectAge Factors ; Animals ; Article ; axon guidance ; Axons ; Axons - physiology ; Binding Protein ; Binding Proteins ; Body Patterning ; Body Patterning - genetics ; Calbindin 2 ; Calcium ; Calcium-Binding Protein, Vitamin D-Dependent ; Cellular Biology ; Cerebral Cortex ; Cerebral Cortex - cytology ; Cerebral Cortex - physiology ; Contactin 2 ; Contactin 2 - metabolism ; corticothalamic ; cytology ; Dependent ; Developmental ; Developmental biology ; DNA-Binding Proteins ; DNA-Binding Proteins - metabolism ; Embryo ; Embryo, Mammalian ; Experiments ; Gene Expression Regulation ; Gene Expression Regulation, Developmental ; Gene Expression Regulation, Developmental - genetics ; genetics ; Glycoproteins ; Glycoproteins - genetics ; handshake ; Homeodomain Proteins ; Homeodomain Proteins - genetics ; Inbred C57BL ; Laboratories ; Leukocyte L1 Antigen Complex ; Leukocyte L1 Antigen Complex - metabolism ; Life Sciences ; Luminescent Proteins ; Luminescent Proteins - genetics ; Luminescent Proteins - metabolism ; Mammalian ; Membrane Glycoproteins ; Membrane Glycoproteins - genetics ; Membrane Proteins ; Membrane Proteins - genetics ; metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Nerve Tissue Proteins ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - metabolism ; nervous system ; Neural Pathways ; Neural Pathways - physiology ; Neurons ; Neuroscience(all) ; Nuclear Proteins ; Nuclear Proteins - metabolism ; physiology ; PlexinD1 ; POU Domain Factors ; POU Domain Factors - genetics ; reciprocal connections ; Repressor Proteins ; Repressor Proteins - metabolism ; S100 Calcium Binding Protein G - metabolism ; Sema3E ; Studies ; tau Proteins ; tau Proteins - genetics ; thalamocortical ; Thalamus ; Thalamus - cytology ; Thalamus - physiology ; Thyroid Nuclear Factor 1 ; Transcription Factors ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Transgenic ; Tumor Suppressor Proteins ; Tumor Suppressor Proteins - metabolism ; Vitamin D ; waiting period ; Wnt3A Protein ; Wnt3A Protein - genetics
ispartofNeuron (Cambridge, Mass.), 2013-02-06, Vol.77 (3), p.472-484
rights
02013 Elsevier Inc.
1Copyright © 2013 Elsevier Inc. All rights reserved.
2COPYRIGHT 2013 Elsevier B.V.
3Copyright Elsevier Limited Feb 6, 2013
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0Deck, Marie
1Lokmane, Ludmilla
2Chauvet, Sophie
3Mailhes, Caroline
4Keita, Maryama
5Niquille, Mathieu
6Yoshida, Michio
7Yoshida, Yutaka
8Lebrand, Cécile
9Mann, Fanny
10Grove, Elizabeth A
11Garel, Sonia
title
0Pathfinding of Corticothalamic Axons Relies on a Rendezvous with Thalamic Projections
1Neuron (Cambridge, Mass.)
addtitleNeuron
descriptionMajor outputs of the neocortex are conveyed by corticothalamic axons (CTAs), which form reciprocal connections with thalamocortical axons, and corticosubcerebral axons (CSAs) headed to more caudal parts of the nervous system. Previous findings establish that transcriptional programs define cortical neuron identity and suggest that CTAs and thalamic axons may guide each other, but the mechanisms governing CTA versus CSA pathfinding remain elusive. Here, we show that thalamocortical axons are required to guide pioneer CTAs away from a default CSA-like trajectory. This process relies on a hold in the progression of cortical axons, or waiting period, during which thalamic projections navigate toward cortical axons. At the molecular level, Sema3E/PlexinD1 signaling in pioneer cortical neurons mediates a “waiting signal” required to orchestrate the mandatory meeting with reciprocal thalamic axons. Our study reveals that temporal control of axonal progression contributes to spatial pathfinding of cortical projections and opens perspectives on brain wiring. ► Corticothalamic and corticosubcerebral axons follow distinct subpallial trajectories ► Thalamic projections guide corticothalamic axons ► Meeting with thalamic axons relies on a waiting period of pioneer cortical axons ► PlexinD1/Sema3E signaling controls the waiting period Reciprocal connections between the thalamus and neocortex are established during development. Deck et al. show that the pathfinding of corticothalamic projections relies on an encounter with reciprocal thalamocortical axons. This encounter is timely controlled by PlexinD1/Sema3E signaling.
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0Age Factors
1Animals
2Article
3axon guidance
4Axons
5Axons - physiology
6Binding Protein
7Binding Proteins
8Body Patterning
9Body Patterning - genetics
10Calbindin 2
11Calcium
12Calcium-Binding Protein, Vitamin D-Dependent
13Cellular Biology
14Cerebral Cortex
15Cerebral Cortex - cytology
16Cerebral Cortex - physiology
17Contactin 2
18Contactin 2 - metabolism
19corticothalamic
20cytology
21Dependent
22Developmental
23Developmental biology
24DNA-Binding Proteins
25DNA-Binding Proteins - metabolism
26Embryo
27Embryo, Mammalian
28Experiments
29Gene Expression Regulation
30Gene Expression Regulation, Developmental
31Gene Expression Regulation, Developmental - genetics
32genetics
33Glycoproteins
34Glycoproteins - genetics
35handshake
36Homeodomain Proteins
37Homeodomain Proteins - genetics
38Inbred C57BL
39Laboratories
40Leukocyte L1 Antigen Complex
41Leukocyte L1 Antigen Complex - metabolism
42Life Sciences
43Luminescent Proteins
44Luminescent Proteins - genetics
45Luminescent Proteins - metabolism
46Mammalian
47Membrane Glycoproteins
48Membrane Glycoproteins - genetics
49Membrane Proteins
50Membrane Proteins - genetics
51metabolism
52Mice
53Mice, Inbred C57BL
54Mice, Transgenic
55Nerve Tissue Proteins
56Nerve Tissue Proteins - genetics
57Nerve Tissue Proteins - metabolism
58nervous system
59Neural Pathways
60Neural Pathways - physiology
61Neurons
62Neuroscience(all)
63Nuclear Proteins
64Nuclear Proteins - metabolism
65physiology
66PlexinD1
67POU Domain Factors
68POU Domain Factors - genetics
69reciprocal connections
70Repressor Proteins
71Repressor Proteins - metabolism
72S100 Calcium Binding Protein G - metabolism
73Sema3E
74Studies
75tau Proteins
76tau Proteins - genetics
77thalamocortical
78Thalamus
79Thalamus - cytology
80Thalamus - physiology
81Thyroid Nuclear Factor 1
82Transcription Factors
83Transcription Factors - genetics
84Transcription Factors - metabolism
85Transgenic
86Tumor Suppressor Proteins
87Tumor Suppressor Proteins - metabolism
88Vitamin D
89waiting period
90Wnt3A Protein
91Wnt3A Protein - genetics
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1Lokmane, Ludmilla
2Chauvet, Sophie
3Mailhes, Caroline
4Keita, Maryama
5Niquille, Mathieu
6Yoshida, Michio
7Yoshida, Yutaka
8Lebrand, Cécile
9Mann, Fanny
10Grove, Elizabeth A
11Garel, Sonia
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titlePathfinding of Corticothalamic Axons Relies on a Rendezvous with Thalamic Projections
authorDeck, Marie ; Lokmane, Ludmilla ; Chauvet, Sophie ; Mailhes, Caroline ; Keita, Maryama ; Niquille, Mathieu ; Yoshida, Michio ; Yoshida, Yutaka ; Lebrand, Cécile ; Mann, Fanny ; Grove, Elizabeth A ; Garel, Sonia
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6Binding Protein
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9Body Patterning - genetics
10Calbindin 2
11Calcium
12Calcium-Binding Protein, Vitamin D-Dependent
13Cellular Biology
14Cerebral Cortex
15Cerebral Cortex - cytology
16Cerebral Cortex - physiology
17Contactin 2
18Contactin 2 - metabolism
19corticothalamic
20cytology
21Dependent
22Developmental
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24DNA-Binding Proteins
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30Gene Expression Regulation, Developmental
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33Glycoproteins
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35handshake
36Homeodomain Proteins
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38Inbred C57BL
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43Luminescent Proteins
44Luminescent Proteins - genetics
45Luminescent Proteins - metabolism
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47Membrane Glycoproteins
48Membrane Glycoproteins - genetics
49Membrane Proteins
50Membrane Proteins - genetics
51metabolism
52Mice
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54Mice, Transgenic
55Nerve Tissue Proteins
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57Nerve Tissue Proteins - metabolism
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62Neuroscience(all)
63Nuclear Proteins
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65physiology
66PlexinD1
67POU Domain Factors
68POU Domain Factors - genetics
69reciprocal connections
70Repressor Proteins
71Repressor Proteins - metabolism
72S100 Calcium Binding Protein G - metabolism
73Sema3E
74Studies
75tau Proteins
76tau Proteins - genetics
77thalamocortical
78Thalamus
79Thalamus - cytology
80Thalamus - physiology
81Thyroid Nuclear Factor 1
82Transcription Factors
83Transcription Factors - genetics
84Transcription Factors - metabolism
85Transgenic
86Tumor Suppressor Proteins
87Tumor Suppressor Proteins - metabolism
88Vitamin D
89waiting period
90Wnt3A Protein
91Wnt3A Protein - genetics
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7Yoshida, Yutaka
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abstractMajor outputs of the neocortex are conveyed by corticothalamic axons (CTAs), which form reciprocal connections with thalamocortical axons, and corticosubcerebral axons (CSAs) headed to more caudal parts of the nervous system. Previous findings establish that transcriptional programs define cortical neuron identity and suggest that CTAs and thalamic axons may guide each other, but the mechanisms governing CTA versus CSA pathfinding remain elusive. Here, we show that thalamocortical axons are required to guide pioneer CTAs away from a default CSA-like trajectory. This process relies on a hold in the progression of cortical axons, or waiting period, during which thalamic projections navigate toward cortical axons. At the molecular level, Sema3E/PlexinD1 signaling in pioneer cortical neurons mediates a “waiting signal” required to orchestrate the mandatory meeting with reciprocal thalamic axons. Our study reveals that temporal control of axonal progression contributes to spatial pathfinding of cortical projections and opens perspectives on brain wiring. ► Corticothalamic and corticosubcerebral axons follow distinct subpallial trajectories ► Thalamic projections guide corticothalamic axons ► Meeting with thalamic axons relies on a waiting period of pioneer cortical axons ► PlexinD1/Sema3E signaling controls the waiting period Reciprocal connections between the thalamus and neocortex are established during development. Deck et al. show that the pathfinding of corticothalamic projections relies on an encounter with reciprocal thalamocortical axons. This encounter is timely controlled by PlexinD1/Sema3E signaling.
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