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The complementary roles of dynamic contrast-enhanced MRI and 18F-fluorodeoxyglucose PET/CT for imaging of carotid atherosclerosis

Purpose Inflammation and neovascularization in vulnerable atherosclerotic plaques are key features for severe clinical events. Dynamic contrast-enhanced (DCE) MRI and FDG PET are two noninvasive imaging techniques capable of quantifying plaque neovascularization and inflammatory infiltrate, respecti... Full description

Journal Title: European journal of nuclear medicine and molecular imaging 2013-08-14, Vol.40 (12), p.1884-1893
Main Author: Calcagno, Claudia
Other Authors: Ramachandran, Sarayu , Izquierdo-Garcia, David , Mani, Venkatesh , Millon, Antoine , Rosenbaum, David , Tawakol, Ahmed , Woodward, Mark , Bucerius, Jan , Moshier, Erin , Godbold, James , Kallend, David , Farkouh, Michael E , Fuster, Valentin , Rudd, James H. F , Fayad, Zahi A
Format: Electronic Article Electronic Article
Language: English
Subjects:
PET
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 1619-7070
Link: https://www.ncbi.nlm.nih.gov/pubmed/23942908
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title: The complementary roles of dynamic contrast-enhanced MRI and 18F-fluorodeoxyglucose PET/CT for imaging of carotid atherosclerosis
format: Article
creator:
  • Calcagno, Claudia
  • Ramachandran, Sarayu
  • Izquierdo-Garcia, David
  • Mani, Venkatesh
  • Millon, Antoine
  • Rosenbaum, David
  • Tawakol, Ahmed
  • Woodward, Mark
  • Bucerius, Jan
  • Moshier, Erin
  • Godbold, James
  • Kallend, David
  • Farkouh, Michael E
  • Fuster, Valentin
  • Rudd, James H. F
  • Fayad, Zahi A
subjects:
  • Article
  • atherosclerosis
  • Cardiology
  • Carotid Artery Diseases - diagnosis
  • Carotid Artery Diseases - diagnostic imaging
  • Contrast Media
  • DCE-MRI
  • Female
  • Fluorodeoxyglucose F18
  • Humans
  • Imaging
  • inflammation
  • Magnetic Resonance Imaging
  • Male
  • Medicine
  • Medicine & Public Health
  • Middle Aged
  • Multimodal Imaging
  • neovascularization
  • Nuclear Medicine
  • Oncology
  • Original Article
  • Orthopedics
  • PET
  • Positron-Emission Tomography
  • Radiology
  • Tomography, X-Ray Computed
ispartof: European journal of nuclear medicine and molecular imaging, 2013-08-14, Vol.40 (12), p.1884-1893
description: Purpose Inflammation and neovascularization in vulnerable atherosclerotic plaques are key features for severe clinical events. Dynamic contrast-enhanced (DCE) MRI and FDG PET are two noninvasive imaging techniques capable of quantifying plaque neovascularization and inflammatory infiltrate, respectively. However, their mutual role in defining plaque vulnerability and their possible overlap has not been thoroughly investigated. We studied the relationship between DCE-MRI and 18 F-FDG PET data from the carotid arteries of 40 subjects with coronary heart disease (CHD) or CHD risk equivalent, as a substudy of the dal-PLAQUE trial (NCT00655473). Methods The dal-PLAQUE trial was a multicenter study that evaluated dalcetrapib, a cholesteryl ester transfer protein modulator. Subjects underwent anatomical MRI, DCE-MRI and 18 F-FDG PET. Only baseline imaging and biomarker data (before randomization) from dal-PLAQUE were used as part of this substudy. Our primary goal was to evaluate the relationship between DCE-MRI and 18 F-FDG PET data. As secondary endpoints, we evaluated the relationship between (a) PET data and whole-vessel anatomical MRI data, and (b) DCE-MRI and matching anatomical MRI data. All correlations were estimated using a mixed linear model. Results We found a significant inverse relationship between several perfusion indices by DCE-MRI and 18 F-FDG uptake by PET. Regarding our secondary endpoints, there was a significant relationship between plaque burden measured by anatomical MRI with several perfusion indices by DCE-MRI and 18 F-FDG uptake by PET. No relationship was found between plaque composition by anatomical MRI and DCE-MRI or 18 F-FDG PET metrics. Conclusion In this study we observed a significant, weak inverse relationship between inflammation measured as 18 F-FDG uptake by PET and plaque perfusion by DCE-MRI. Our findings suggest that there may be a complex relationship between plaque inflammation and microvascularization during the different stages of plaque development. 18 F-FDG PET and DCE-MRI may have complementary roles in future clinical practice in identifying subjects at high risk of cardiovascular events.
language: eng
source:
identifier: ISSN: 1619-7070
fulltext: no_fulltext
issn:
  • 1619-7070
  • 1619-7089
url: Link


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titleThe complementary roles of dynamic contrast-enhanced MRI and 18F-fluorodeoxyglucose PET/CT for imaging of carotid atherosclerosis
creatorCalcagno, Claudia ; Ramachandran, Sarayu ; Izquierdo-Garcia, David ; Mani, Venkatesh ; Millon, Antoine ; Rosenbaum, David ; Tawakol, Ahmed ; Woodward, Mark ; Bucerius, Jan ; Moshier, Erin ; Godbold, James ; Kallend, David ; Farkouh, Michael E ; Fuster, Valentin ; Rudd, James H. F ; Fayad, Zahi A
creatorcontribCalcagno, Claudia ; Ramachandran, Sarayu ; Izquierdo-Garcia, David ; Mani, Venkatesh ; Millon, Antoine ; Rosenbaum, David ; Tawakol, Ahmed ; Woodward, Mark ; Bucerius, Jan ; Moshier, Erin ; Godbold, James ; Kallend, David ; Farkouh, Michael E ; Fuster, Valentin ; Rudd, James H. F ; Fayad, Zahi A
descriptionPurpose Inflammation and neovascularization in vulnerable atherosclerotic plaques are key features for severe clinical events. Dynamic contrast-enhanced (DCE) MRI and FDG PET are two noninvasive imaging techniques capable of quantifying plaque neovascularization and inflammatory infiltrate, respectively. However, their mutual role in defining plaque vulnerability and their possible overlap has not been thoroughly investigated. We studied the relationship between DCE-MRI and 18 F-FDG PET data from the carotid arteries of 40 subjects with coronary heart disease (CHD) or CHD risk equivalent, as a substudy of the dal-PLAQUE trial (NCT00655473). Methods The dal-PLAQUE trial was a multicenter study that evaluated dalcetrapib, a cholesteryl ester transfer protein modulator. Subjects underwent anatomical MRI, DCE-MRI and 18 F-FDG PET. Only baseline imaging and biomarker data (before randomization) from dal-PLAQUE were used as part of this substudy. Our primary goal was to evaluate the relationship between DCE-MRI and 18 F-FDG PET data. As secondary endpoints, we evaluated the relationship between (a) PET data and whole-vessel anatomical MRI data, and (b) DCE-MRI and matching anatomical MRI data. All correlations were estimated using a mixed linear model. Results We found a significant inverse relationship between several perfusion indices by DCE-MRI and 18 F-FDG uptake by PET. Regarding our secondary endpoints, there was a significant relationship between plaque burden measured by anatomical MRI with several perfusion indices by DCE-MRI and 18 F-FDG uptake by PET. No relationship was found between plaque composition by anatomical MRI and DCE-MRI or 18 F-FDG PET metrics. Conclusion In this study we observed a significant, weak inverse relationship between inflammation measured as 18 F-FDG uptake by PET and plaque perfusion by DCE-MRI. Our findings suggest that there may be a complex relationship between plaque inflammation and microvascularization during the different stages of plaque development. 18 F-FDG PET and DCE-MRI may have complementary roles in future clinical practice in identifying subjects at high risk of cardiovascular events.
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subjectArticle ; atherosclerosis ; Cardiology ; Carotid Artery Diseases - diagnosis ; Carotid Artery Diseases - diagnostic imaging ; Contrast Media ; DCE-MRI ; Female ; Fluorodeoxyglucose F18 ; Humans ; Imaging ; inflammation ; Magnetic Resonance Imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multimodal Imaging ; neovascularization ; Nuclear Medicine ; Oncology ; Original Article ; Orthopedics ; PET ; Positron-Emission Tomography ; Radiology ; Tomography, X-Ray Computed
ispartofEuropean journal of nuclear medicine and molecular imaging, 2013-08-14, Vol.40 (12), p.1884-1893
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1Ramachandran, Sarayu
2Izquierdo-Garcia, David
3Mani, Venkatesh
4Millon, Antoine
5Rosenbaum, David
6Tawakol, Ahmed
7Woodward, Mark
8Bucerius, Jan
9Moshier, Erin
10Godbold, James
11Kallend, David
12Farkouh, Michael E
13Fuster, Valentin
14Rudd, James H. F
15Fayad, Zahi A
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descriptionPurpose Inflammation and neovascularization in vulnerable atherosclerotic plaques are key features for severe clinical events. Dynamic contrast-enhanced (DCE) MRI and FDG PET are two noninvasive imaging techniques capable of quantifying plaque neovascularization and inflammatory infiltrate, respectively. However, their mutual role in defining plaque vulnerability and their possible overlap has not been thoroughly investigated. We studied the relationship between DCE-MRI and 18 F-FDG PET data from the carotid arteries of 40 subjects with coronary heart disease (CHD) or CHD risk equivalent, as a substudy of the dal-PLAQUE trial (NCT00655473). Methods The dal-PLAQUE trial was a multicenter study that evaluated dalcetrapib, a cholesteryl ester transfer protein modulator. Subjects underwent anatomical MRI, DCE-MRI and 18 F-FDG PET. Only baseline imaging and biomarker data (before randomization) from dal-PLAQUE were used as part of this substudy. Our primary goal was to evaluate the relationship between DCE-MRI and 18 F-FDG PET data. As secondary endpoints, we evaluated the relationship between (a) PET data and whole-vessel anatomical MRI data, and (b) DCE-MRI and matching anatomical MRI data. All correlations were estimated using a mixed linear model. Results We found a significant inverse relationship between several perfusion indices by DCE-MRI and 18 F-FDG uptake by PET. Regarding our secondary endpoints, there was a significant relationship between plaque burden measured by anatomical MRI with several perfusion indices by DCE-MRI and 18 F-FDG uptake by PET. No relationship was found between plaque composition by anatomical MRI and DCE-MRI or 18 F-FDG PET metrics. Conclusion In this study we observed a significant, weak inverse relationship between inflammation measured as 18 F-FDG uptake by PET and plaque perfusion by DCE-MRI. Our findings suggest that there may be a complex relationship between plaque inflammation and microvascularization during the different stages of plaque development. 18 F-FDG PET and DCE-MRI may have complementary roles in future clinical practice in identifying subjects at high risk of cardiovascular events.
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20Oncology
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9Moshier, Erin
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titleThe complementary roles of dynamic contrast-enhanced MRI and 18F-fluorodeoxyglucose PET/CT for imaging of carotid atherosclerosis
authorCalcagno, Claudia ; Ramachandran, Sarayu ; Izquierdo-Garcia, David ; Mani, Venkatesh ; Millon, Antoine ; Rosenbaum, David ; Tawakol, Ahmed ; Woodward, Mark ; Bucerius, Jan ; Moshier, Erin ; Godbold, James ; Kallend, David ; Farkouh, Michael E ; Fuster, Valentin ; Rudd, James H. F ; Fayad, Zahi A
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7Woodward, Mark
8Bucerius, Jan
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abstractPurpose Inflammation and neovascularization in vulnerable atherosclerotic plaques are key features for severe clinical events. Dynamic contrast-enhanced (DCE) MRI and FDG PET are two noninvasive imaging techniques capable of quantifying plaque neovascularization and inflammatory infiltrate, respectively. However, their mutual role in defining plaque vulnerability and their possible overlap has not been thoroughly investigated. We studied the relationship between DCE-MRI and 18 F-FDG PET data from the carotid arteries of 40 subjects with coronary heart disease (CHD) or CHD risk equivalent, as a substudy of the dal-PLAQUE trial (NCT00655473). Methods The dal-PLAQUE trial was a multicenter study that evaluated dalcetrapib, a cholesteryl ester transfer protein modulator. Subjects underwent anatomical MRI, DCE-MRI and 18 F-FDG PET. Only baseline imaging and biomarker data (before randomization) from dal-PLAQUE were used as part of this substudy. Our primary goal was to evaluate the relationship between DCE-MRI and 18 F-FDG PET data. As secondary endpoints, we evaluated the relationship between (a) PET data and whole-vessel anatomical MRI data, and (b) DCE-MRI and matching anatomical MRI data. All correlations were estimated using a mixed linear model. Results We found a significant inverse relationship between several perfusion indices by DCE-MRI and 18 F-FDG uptake by PET. Regarding our secondary endpoints, there was a significant relationship between plaque burden measured by anatomical MRI with several perfusion indices by DCE-MRI and 18 F-FDG uptake by PET. No relationship was found between plaque composition by anatomical MRI and DCE-MRI or 18 F-FDG PET metrics. Conclusion In this study we observed a significant, weak inverse relationship between inflammation measured as 18 F-FDG uptake by PET and plaque perfusion by DCE-MRI. Our findings suggest that there may be a complex relationship between plaque inflammation and microvascularization during the different stages of plaque development. 18 F-FDG PET and DCE-MRI may have complementary roles in future clinical practice in identifying subjects at high risk of cardiovascular events.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
pmid23942908
doi10.1007/s00259-013-2518-4
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