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Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA)

Background Patients with rheumatoid arthritis (RA) are at increased risk of developing comorbid conditions. Objectives To evaluate the prevalence of comorbidities and compare their management in RA patients from different countries worldwide. Methods Study design: international, cross-sectional. Pat... Full description

Journal Title: Annals of the Rheumatic Diseases 2014-01, Vol.73 (1), p.62-68
Main Author: Dougados, Maxime
Other Authors: Soubrier, Martin , Antunez, Anna , Balint, Peter , Balsa, Alejandro , Buch, Maya H , Casado, Gustavo , Detert, Jacqueline , El-zorkany, Bassel , Emery, Paul , Hajjaj-Hassouni, Najia , Harigai, Masayoshi , Luo, Shue-Fen , Kurucz, Reka , Maciel, Gabriel , Mola, Emilio Martin , Montecucco, Carlo Maurizio , McInnes, Iain , Radner, Helga , Smolen, Josef S , Song, Yeong-Wook , Vonkeman, Harald Erwin , Winthrop, Kevin , Kay, Jonathan
Format: Electronic Article Electronic Article
Language: English
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Publisher: England: BMJ Publishing Group Ltd
ID: ISSN: 0003-4967
Link: https://www.ncbi.nlm.nih.gov/pubmed/24095940
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title: Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA)
format: Article
creator:
  • Dougados, Maxime
  • Soubrier, Martin
  • Antunez, Anna
  • Balint, Peter
  • Balsa, Alejandro
  • Buch, Maya H
  • Casado, Gustavo
  • Detert, Jacqueline
  • El-zorkany, Bassel
  • Emery, Paul
  • Hajjaj-Hassouni, Najia
  • Harigai, Masayoshi
  • Luo, Shue-Fen
  • Kurucz, Reka
  • Maciel, Gabriel
  • Mola, Emilio Martin
  • Montecucco, Carlo Maurizio
  • McInnes, Iain
  • Radner, Helga
  • Smolen, Josef S
  • Song, Yeong-Wook
  • Vonkeman, Harald Erwin
  • Winthrop, Kevin
  • Kay, Jonathan
subjects:
  • 1506
  • Adult
  • Aged
  • Arthritis, Rheumatoid - epidemiology
  • Arthritis, Rheumatoid - therapy
  • Cardiovascular Disease
  • Cardiovascular Diseases - epidemiology
  • Cardiovascular Diseases - therapy
  • Care and treatment
  • Clinical
  • Clinical and Epidemiological Research
  • Comorbidity
  • Complications and side effects
  • Cross-Sectional Studies
  • Epidemiological Research
  • Epidemiology
  • Female
  • Gastrointestinal Diseases - epidemiology
  • Gastrointestinal Diseases - therapy
  • Global Health
  • Humans
  • Infections - epidemiology
  • Infections - therapy
  • Internationality
  • Lipids
  • Lung Diseases - epidemiology
  • Lung Diseases - therapy
  • Male
  • Mental Disorders - epidemiology
  • Mental Disorders - therapy
  • Middle Aged
  • Neoplasms - epidemiology
  • Neoplasms - therapy
  • Observational studies
  • Osteoporosis - epidemiology
  • Osteoporosis - therapy
  • Prevalence
  • Rheumatoid Arthritis
  • Risk Factors
  • Severity of Illness Index
  • Usage
  • Vaccination
ispartof: Annals of the Rheumatic Diseases, 2014-01, Vol.73 (1), p.62-68
description: Background Patients with rheumatoid arthritis (RA) are at increased risk of developing comorbid conditions. Objectives To evaluate the prevalence of comorbidities and compare their management in RA patients from different countries worldwide. Methods Study design: international, cross-sectional. Patients: consecutive RA patients. Data collected: demographics, disease characteristics (activity, severity, treatment), comorbidities (cardiovascular, infections, cancer, gastrointestinal, pulmonary, osteoporosis and psychiatric disorders). Results Of 4586 patients recruited in 17 participating countries, 3920 were analysed (age, 56±13 years; disease duration, 10±9 years (mean±SD); female gender, 82%; DAS28 (Disease Activity Score using 28 joints)–erythrocyte sedimentation rate, 3.7±1.6 (mean±SD); Health Assessment Questionnaire, 1.0±0.7 (mean±SD); past or current methotrexate use, 89%; past or current use of biological agents, 39%. The most frequently associated diseases (past or current) were: depression, 15%; asthma, 6.6%; cardiovascular events (myocardial infarction, stroke), 6%; solid malignancies (excluding basal cell carcinoma), 4.5%; chronic obstructive pulmonary disease, 3.5%. High intercountry variability was observed for both the prevalence of comorbidities and the proportion of subjects complying with recommendations for preventing and managing comorbidities. The systematic evaluation of comorbidities in this study detected abnormalities in vital signs, such as elevated blood pressure in 11.2%, and identified conditions that manifest as laboratory test abnormalities, such as hyperglycaemia in 3.3% and hyperlipidaemia in 8.3%. Conclusions Among RA patients, there is a high prevalence of comorbidities and their risk factors. In this multinational sample, variability among countries was wide, not only in prevalence but also in compliance with recommendations for preventing and managing these comorbidities. Systematic measurement of vital signs and laboratory testing detects otherwise unrecognised comorbid conditions.
language: eng
source:
identifier: ISSN: 0003-4967
fulltext: no_fulltext
issn:
  • 0003-4967
  • 1468-2060
url: Link


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titlePrevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA)
creatorDougados, Maxime ; Soubrier, Martin ; Antunez, Anna ; Balint, Peter ; Balsa, Alejandro ; Buch, Maya H ; Casado, Gustavo ; Detert, Jacqueline ; El-zorkany, Bassel ; Emery, Paul ; Hajjaj-Hassouni, Najia ; Harigai, Masayoshi ; Luo, Shue-Fen ; Kurucz, Reka ; Maciel, Gabriel ; Mola, Emilio Martin ; Montecucco, Carlo Maurizio ; McInnes, Iain ; Radner, Helga ; Smolen, Josef S ; Song, Yeong-Wook ; Vonkeman, Harald Erwin ; Winthrop, Kevin ; Kay, Jonathan
creatorcontribDougados, Maxime ; Soubrier, Martin ; Antunez, Anna ; Balint, Peter ; Balsa, Alejandro ; Buch, Maya H ; Casado, Gustavo ; Detert, Jacqueline ; El-zorkany, Bassel ; Emery, Paul ; Hajjaj-Hassouni, Najia ; Harigai, Masayoshi ; Luo, Shue-Fen ; Kurucz, Reka ; Maciel, Gabriel ; Mola, Emilio Martin ; Montecucco, Carlo Maurizio ; McInnes, Iain ; Radner, Helga ; Smolen, Josef S ; Song, Yeong-Wook ; Vonkeman, Harald Erwin ; Winthrop, Kevin ; Kay, Jonathan
descriptionBackground Patients with rheumatoid arthritis (RA) are at increased risk of developing comorbid conditions. Objectives To evaluate the prevalence of comorbidities and compare their management in RA patients from different countries worldwide. Methods Study design: international, cross-sectional. Patients: consecutive RA patients. Data collected: demographics, disease characteristics (activity, severity, treatment), comorbidities (cardiovascular, infections, cancer, gastrointestinal, pulmonary, osteoporosis and psychiatric disorders). Results Of 4586 patients recruited in 17 participating countries, 3920 were analysed (age, 56±13 years; disease duration, 10±9 years (mean±SD); female gender, 82%; DAS28 (Disease Activity Score using 28 joints)–erythrocyte sedimentation rate, 3.7±1.6 (mean±SD); Health Assessment Questionnaire, 1.0±0.7 (mean±SD); past or current methotrexate use, 89%; past or current use of biological agents, 39%. The most frequently associated diseases (past or current) were: depression, 15%; asthma, 6.6%; cardiovascular events (myocardial infarction, stroke), 6%; solid malignancies (excluding basal cell carcinoma), 4.5%; chronic obstructive pulmonary disease, 3.5%. High intercountry variability was observed for both the prevalence of comorbidities and the proportion of subjects complying with recommendations for preventing and managing comorbidities. The systematic evaluation of comorbidities in this study detected abnormalities in vital signs, such as elevated blood pressure in 11.2%, and identified conditions that manifest as laboratory test abnormalities, such as hyperglycaemia in 3.3% and hyperlipidaemia in 8.3%. Conclusions Among RA patients, there is a high prevalence of comorbidities and their risk factors. In this multinational sample, variability among countries was wide, not only in prevalence but also in compliance with recommendations for preventing and managing these comorbidities. Systematic measurement of vital signs and laboratory testing detects otherwise unrecognised comorbid conditions.
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subject1506 ; Adult ; Aged ; Arthritis, Rheumatoid - epidemiology ; Arthritis, Rheumatoid - therapy ; Cardiovascular Disease ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - therapy ; Care and treatment ; Clinical ; Clinical and Epidemiological Research ; Comorbidity ; Complications and side effects ; Cross-Sectional Studies ; Epidemiological Research ; Epidemiology ; Female ; Gastrointestinal Diseases - epidemiology ; Gastrointestinal Diseases - therapy ; Global Health ; Humans ; Infections - epidemiology ; Infections - therapy ; Internationality ; Lipids ; Lung Diseases - epidemiology ; Lung Diseases - therapy ; Male ; Mental Disorders - epidemiology ; Mental Disorders - therapy ; Middle Aged ; Neoplasms - epidemiology ; Neoplasms - therapy ; Observational studies ; Osteoporosis - epidemiology ; Osteoporosis - therapy ; Prevalence ; Rheumatoid Arthritis ; Risk Factors ; Severity of Illness Index ; Usage ; Vaccination
ispartofAnnals of the Rheumatic Diseases, 2014-01, Vol.73 (1), p.62-68
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3Balint, Peter
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5Buch, Maya H
6Casado, Gustavo
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8El-zorkany, Bassel
9Emery, Paul
10Hajjaj-Hassouni, Najia
11Harigai, Masayoshi
12Luo, Shue-Fen
13Kurucz, Reka
14Maciel, Gabriel
15Mola, Emilio Martin
16Montecucco, Carlo Maurizio
17McInnes, Iain
18Radner, Helga
19Smolen, Josef S
20Song, Yeong-Wook
21Vonkeman, Harald Erwin
22Winthrop, Kevin
23Kay, Jonathan
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descriptionBackground Patients with rheumatoid arthritis (RA) are at increased risk of developing comorbid conditions. Objectives To evaluate the prevalence of comorbidities and compare their management in RA patients from different countries worldwide. Methods Study design: international, cross-sectional. Patients: consecutive RA patients. Data collected: demographics, disease characteristics (activity, severity, treatment), comorbidities (cardiovascular, infections, cancer, gastrointestinal, pulmonary, osteoporosis and psychiatric disorders). Results Of 4586 patients recruited in 17 participating countries, 3920 were analysed (age, 56±13 years; disease duration, 10±9 years (mean±SD); female gender, 82%; DAS28 (Disease Activity Score using 28 joints)–erythrocyte sedimentation rate, 3.7±1.6 (mean±SD); Health Assessment Questionnaire, 1.0±0.7 (mean±SD); past or current methotrexate use, 89%; past or current use of biological agents, 39%. The most frequently associated diseases (past or current) were: depression, 15%; asthma, 6.6%; cardiovascular events (myocardial infarction, stroke), 6%; solid malignancies (excluding basal cell carcinoma), 4.5%; chronic obstructive pulmonary disease, 3.5%. High intercountry variability was observed for both the prevalence of comorbidities and the proportion of subjects complying with recommendations for preventing and managing comorbidities. The systematic evaluation of comorbidities in this study detected abnormalities in vital signs, such as elevated blood pressure in 11.2%, and identified conditions that manifest as laboratory test abnormalities, such as hyperglycaemia in 3.3% and hyperlipidaemia in 8.3%. Conclusions Among RA patients, there is a high prevalence of comorbidities and their risk factors. In this multinational sample, variability among countries was wide, not only in prevalence but also in compliance with recommendations for preventing and managing these comorbidities. Systematic measurement of vital signs and laboratory testing detects otherwise unrecognised comorbid conditions.
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titlePrevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA)
authorDougados, Maxime ; Soubrier, Martin ; Antunez, Anna ; Balint, Peter ; Balsa, Alejandro ; Buch, Maya H ; Casado, Gustavo ; Detert, Jacqueline ; El-zorkany, Bassel ; Emery, Paul ; Hajjaj-Hassouni, Najia ; Harigai, Masayoshi ; Luo, Shue-Fen ; Kurucz, Reka ; Maciel, Gabriel ; Mola, Emilio Martin ; Montecucco, Carlo Maurizio ; McInnes, Iain ; Radner, Helga ; Smolen, Josef S ; Song, Yeong-Wook ; Vonkeman, Harald Erwin ; Winthrop, Kevin ; Kay, Jonathan
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5Cardiovascular Disease
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7Cardiovascular Diseases - therapy
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12Complications and side effects
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33Observational studies
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36Prevalence
37Rheumatoid Arthritis
38Risk Factors
39Severity of Illness Index
40Usage
41Vaccination
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abstractBackground Patients with rheumatoid arthritis (RA) are at increased risk of developing comorbid conditions. Objectives To evaluate the prevalence of comorbidities and compare their management in RA patients from different countries worldwide. Methods Study design: international, cross-sectional. Patients: consecutive RA patients. Data collected: demographics, disease characteristics (activity, severity, treatment), comorbidities (cardiovascular, infections, cancer, gastrointestinal, pulmonary, osteoporosis and psychiatric disorders). Results Of 4586 patients recruited in 17 participating countries, 3920 were analysed (age, 56±13 years; disease duration, 10±9 years (mean±SD); female gender, 82%; DAS28 (Disease Activity Score using 28 joints)–erythrocyte sedimentation rate, 3.7±1.6 (mean±SD); Health Assessment Questionnaire, 1.0±0.7 (mean±SD); past or current methotrexate use, 89%; past or current use of biological agents, 39%. The most frequently associated diseases (past or current) were: depression, 15%; asthma, 6.6%; cardiovascular events (myocardial infarction, stroke), 6%; solid malignancies (excluding basal cell carcinoma), 4.5%; chronic obstructive pulmonary disease, 3.5%. High intercountry variability was observed for both the prevalence of comorbidities and the proportion of subjects complying with recommendations for preventing and managing comorbidities. The systematic evaluation of comorbidities in this study detected abnormalities in vital signs, such as elevated blood pressure in 11.2%, and identified conditions that manifest as laboratory test abnormalities, such as hyperglycaemia in 3.3% and hyperlipidaemia in 8.3%. Conclusions Among RA patients, there is a high prevalence of comorbidities and their risk factors. In this multinational sample, variability among countries was wide, not only in prevalence but also in compliance with recommendations for preventing and managing these comorbidities. Systematic measurement of vital signs and laboratory testing detects otherwise unrecognised comorbid conditions.
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