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Molecular mechanisms of diabetic cardiomyopathy

In recent years, diabetes mellitus has become an epidemic and now represents one of the most prevalent disorders. Cardiovascular complications are the major cause of mortality and morbidity in diabetic patients. While ischaemic events dominate the cardiac complications of diabetes, it is widely reco... Full description

Journal Title: Diabetologia 2014, Vol.57 (4), p.660-671
Main Author: Bugger, Heiko
Other Authors: Abel, E. Dale
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0012-186X
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3969857
title: Molecular mechanisms of diabetic cardiomyopathy
format: Article
creator:
  • Bugger, Heiko
  • Abel, E. Dale
subjects:
  • Analysis
  • Animal models
  • Animals
  • Article
  • Autophagy
  • Biological and medical sciences
  • Cardiology. Vascular system
  • Cardiomyopathy
  • Diabetes
  • Diabetes Mellitus, Type 1 - complications
  • Diabetes Mellitus, Type 1 - metabolism
  • Diabetes Mellitus, Type 1 - pathology
  • Diabetes Mellitus, Type 2 - complications
  • Diabetes Mellitus, Type 2 - metabolism
  • Diabetes Mellitus, Type 2 - pathology
  • Diabetes. Impaired glucose tolerance
  • Diabetic Cardiomyopathies - etiology
  • Diabetic Cardiomyopathies - metabolism
  • Diabetic Cardiomyopathies - pathology
  • Diabetics
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Fibrosis
  • Genetically modified organisms
  • Health aspects
  • Heart
  • Heart diseases
  • Heart failure
  • Heart Failure - etiology
  • Heart Failure - metabolism
  • Heart Failure - pathology
  • Heart failure, cardiogenic pulmonary edema, cardiac enlargement
  • Human Physiology
  • Humans
  • Hypertension
  • Inflammation
  • Internal Medicine
  • Lipotoxicity
  • Medical sciences
  • Medicine
  • Medicine & Public Health
  • Metabolic Diseases
  • Metabolism
  • Myocarditis. Cardiomyopathies
  • Physiological aspects
  • Review
  • Type 2 diabetes
ispartof: Diabetologia, 2014, Vol.57 (4), p.660-671
description: In recent years, diabetes mellitus has become an epidemic and now represents one of the most prevalent disorders. Cardiovascular complications are the major cause of mortality and morbidity in diabetic patients. While ischaemic events dominate the cardiac complications of diabetes, it is widely recognised that the risk for developing heart failure is also increased in the absence of overt myocardial ischaemia and hypertension or is accelerated in the presence of these comorbidities. These diabetes-associated changes in myocardial structure and function have been called diabetic cardiomyopathy. Numerous molecular mechanisms have been proposed to contribute to the development of diabetic cardiomyopathy following analysis of various animal models of type 1 or type 2 diabetes and in genetically modified mouse models. The steady increase in reports presenting novel mechanistic data on this subject expands the list of potential underlying mechanisms. The current review provides an update on molecular alterations that may contribute to the structural and functional alterations in the diabetic heart.
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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descriptionIn recent years, diabetes mellitus has become an epidemic and now represents one of the most prevalent disorders. Cardiovascular complications are the major cause of mortality and morbidity in diabetic patients. While ischaemic events dominate the cardiac complications of diabetes, it is widely recognised that the risk for developing heart failure is also increased in the absence of overt myocardial ischaemia and hypertension or is accelerated in the presence of these comorbidities. These diabetes-associated changes in myocardial structure and function have been called diabetic cardiomyopathy. Numerous molecular mechanisms have been proposed to contribute to the development of diabetic cardiomyopathy following analysis of various animal models of type 1 or type 2 diabetes and in genetically modified mouse models. The steady increase in reports presenting novel mechanistic data on this subject expands the list of potential underlying mechanisms. The current review provides an update on molecular alterations that may contribute to the structural and functional alterations in the diabetic heart.
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subjectAnalysis ; Animal models ; Animals ; Article ; Autophagy ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiomyopathy ; Diabetes ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - metabolism ; Diabetes Mellitus, Type 1 - pathology ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes Mellitus, Type 2 - pathology ; Diabetes. Impaired glucose tolerance ; Diabetic Cardiomyopathies - etiology ; Diabetic Cardiomyopathies - metabolism ; Diabetic Cardiomyopathies - pathology ; Diabetics ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fibrosis ; Genetically modified organisms ; Health aspects ; Heart ; Heart diseases ; Heart failure ; Heart Failure - etiology ; Heart Failure - metabolism ; Heart Failure - pathology ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Human Physiology ; Humans ; Hypertension ; Inflammation ; Internal Medicine ; Lipotoxicity ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolism ; Myocarditis. Cardiomyopathies ; Physiological aspects ; Review ; Type 2 diabetes
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descriptionIn recent years, diabetes mellitus has become an epidemic and now represents one of the most prevalent disorders. Cardiovascular complications are the major cause of mortality and morbidity in diabetic patients. While ischaemic events dominate the cardiac complications of diabetes, it is widely recognised that the risk for developing heart failure is also increased in the absence of overt myocardial ischaemia and hypertension or is accelerated in the presence of these comorbidities. These diabetes-associated changes in myocardial structure and function have been called diabetic cardiomyopathy. Numerous molecular mechanisms have been proposed to contribute to the development of diabetic cardiomyopathy following analysis of various animal models of type 1 or type 2 diabetes and in genetically modified mouse models. The steady increase in reports presenting novel mechanistic data on this subject expands the list of potential underlying mechanisms. The current review provides an update on molecular alterations that may contribute to the structural and functional alterations in the diabetic heart.
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4Autophagy
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6Cardiology. Vascular system
7Cardiomyopathy
8Diabetes
9Diabetes Mellitus, Type 1 - complications
10Diabetes Mellitus, Type 1 - metabolism
11Diabetes Mellitus, Type 1 - pathology
12Diabetes Mellitus, Type 2 - complications
13Diabetes Mellitus, Type 2 - metabolism
14Diabetes Mellitus, Type 2 - pathology
15Diabetes. Impaired glucose tolerance
16Diabetic Cardiomyopathies - etiology
17Diabetic Cardiomyopathies - metabolism
18Diabetic Cardiomyopathies - pathology
19Diabetics
20Endocrine pancreas. Apud cells (diseases)
21Endocrinopathies
22Etiopathogenesis. Screening. Investigations. Target tissue resistance
23Fibrosis
24Genetically modified organisms
25Health aspects
26Heart
27Heart diseases
28Heart failure
29Heart Failure - etiology
30Heart Failure - metabolism
31Heart Failure - pathology
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36Inflammation
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41Medicine & Public Health
42Metabolic Diseases
43Metabolism
44Myocarditis. Cardiomyopathies
45Physiological aspects
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30Heart Failure - metabolism
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35Hypertension
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38Lipotoxicity
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42Metabolic Diseases
43Metabolism
44Myocarditis. Cardiomyopathies
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abstractIn recent years, diabetes mellitus has become an epidemic and now represents one of the most prevalent disorders. Cardiovascular complications are the major cause of mortality and morbidity in diabetic patients. While ischaemic events dominate the cardiac complications of diabetes, it is widely recognised that the risk for developing heart failure is also increased in the absence of overt myocardial ischaemia and hypertension or is accelerated in the presence of these comorbidities. These diabetes-associated changes in myocardial structure and function have been called diabetic cardiomyopathy. Numerous molecular mechanisms have been proposed to contribute to the development of diabetic cardiomyopathy following analysis of various animal models of type 1 or type 2 diabetes and in genetically modified mouse models. The steady increase in reports presenting novel mechanistic data on this subject expands the list of potential underlying mechanisms. The current review provides an update on molecular alterations that may contribute to the structural and functional alterations in the diabetic heart.
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