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Impact of HIV Subtype on Performance of the Limiting Antigen-Avidity Enzyme Immunoassay, the Bio-Rad Avidity Assay, and the BED Capture Immunoassay in Rakai, Uganda

Previous studies demonstrated that individuals with subtype D HIV infection who had been infected for 2 or more years were frequently misclassified as assay positive using cross-sectional incidence assays. Samples from 510 subjects (212 subtype A, 298 subtype D) who were infected for 2.2 to 14.5 yea... Full description

Journal Title: AIDS research and human retroviruses 2014-04-01, Vol.30 (4), p.339-344
Main Author: Longosz, Andrew F
Other Authors: Serwadda, David , Nalugoda, Fred , Kigozi, Godfrey , Franco, Veronica , Gray, Ronald H , Quinn, Thomas C , Eshleman, Susan H , Laeyendecker, Oliver
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Mary Ann Liebert, Inc
ID: ISSN: 0889-2229
Link: https://www.ncbi.nlm.nih.gov/pubmed/24083837
Zum Text:
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title: Impact of HIV Subtype on Performance of the Limiting Antigen-Avidity Enzyme Immunoassay, the Bio-Rad Avidity Assay, and the BED Capture Immunoassay in Rakai, Uganda
format: Article
creator:
  • Longosz, Andrew F
  • Serwadda, David
  • Nalugoda, Fred
  • Kigozi, Godfrey
  • Franco, Veronica
  • Gray, Ronald H
  • Quinn, Thomas C
  • Eshleman, Susan H
  • Laeyendecker, Oliver
subjects:
  • Adolescent
  • Adult
  • AIDS/HIV
  • Antibody Affinity
  • chemical
  • Cohort Studies
  • Epidemiological Monitoring
  • Epidemiology
  • Female
  • Genotype
  • HIV - classification
  • HIV - genetics
  • HIV - immunology
  • HIV Antibodies - blood
  • HIV Antigens - immunology
  • HIV Infections - diagnosis
  • HIV Infections - immunology
  • Human immunodeficiency virus
  • Humans
  • Immunoassay - methods
  • Male
  • Mass Screening - methods
  • Middle Aged
  • pharmacologic phenomena
  • Retrovirus
  • Uganda
  • Young Adult
ispartof: AIDS research and human retroviruses, 2014-04-01, Vol.30 (4), p.339-344
description: Previous studies demonstrated that individuals with subtype D HIV infection who had been infected for 2 or more years were frequently misclassified as assay positive using cross-sectional incidence assays. Samples from 510 subjects (212 subtype A, 298 subtype D) who were infected for 2.2 to 14.5 years (median 5.4 years) and were not virally suppressed were tested using an LAg-Avidity enzyme immunoassay (LAg-Avidity EIA), Bio-Rad Avidity assay, and BED capture enzyme immunoassay (BED-CEIA). The performance of these three assays was evaluated using various assay cutoff values [LAg-Avidity EIA:
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0889-2229
fulltext: fulltext
issn:
  • 0889-2229
  • 1931-8405
url: Link


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subjectAdolescent ; Adult ; AIDS/HIV ; Antibody Affinity ; chemical ; Cohort Studies ; Epidemiological Monitoring ; Epidemiology ; Female ; Genotype ; HIV - classification ; HIV - genetics ; HIV - immunology ; HIV Antibodies - blood ; HIV Antigens - immunology ; HIV Infections - diagnosis ; HIV Infections - immunology ; Human immunodeficiency virus ; Humans ; Immunoassay - methods ; Male ; Mass Screening - methods ; Middle Aged ; pharmacologic phenomena ; Retrovirus ; Uganda ; Young Adult
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