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The Intestinal Absorption of Folates

The properties of intestinal folate absorption were documented decades ago. However, it was only recently that the proton-coupled folate transporter (PCFT) was identified and its critical role in folate transport across the apical brush-border membrane of the proximal small intestine established by... Full description

Journal Title: Annual review of physiology 2014, Vol.76 (1), p.251-274
Main Author: Visentin, Michele
Other Authors: Diop-Bove, Ndeye , Zhao, Rongbao , Goldman, I David
Format: Electronic Article Electronic Article
Language: English
Subjects:
RFC
Quelle: Alma/SFX Local Collection
Publisher: United States: Annual Reviews, Inc
ID: ISSN: 0066-4278
Link: https://www.ncbi.nlm.nih.gov/pubmed/24512081
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3982215
title: The Intestinal Absorption of Folates
format: Article
creator:
  • Visentin, Michele
  • Diop-Bove, Ndeye
  • Zhao, Rongbao
  • Goldman, I David
subjects:
  • Animals
  • Article
  • Biological transport, Active
  • Enterohepatic Circulation - physiology
  • folate absorption
  • folates
  • Folic acid
  • Folic Acid - metabolism
  • Folic Acid Deficiency - genetics
  • Folic Acid Deficiency - metabolism
  • Gene expression
  • HCP1
  • Health aspects
  • Humans
  • Intestinal Absorption - genetics
  • Intestinal Absorption - physiology
  • intestinal folate transport
  • Intestine, Large - metabolism
  • Intestine, Small - metabolism
  • Ions
  • Malabsorption Syndromes - genetics
  • Malabsorption Syndromes - metabolism
  • Medical research
  • Medicine, Experimental
  • Membranes
  • methotrexate
  • Mice
  • Molecules
  • Mutation
  • PCFT
  • pemetrexed
  • Physiological aspects
  • Proton-Coupled Folate Transporter - genetics
  • Proton-Coupled Folate Transporter - metabolism
  • Research
  • RFC
  • Rodents
  • transport
ispartof: Annual review of physiology, 2014, Vol.76 (1), p.251-274
description: The properties of intestinal folate absorption were documented decades ago. However, it was only recently that the proton-coupled folate transporter (PCFT) was identified and its critical role in folate transport across the apical brush-border membrane of the proximal small intestine established by the loss-of-function mutations identified in the PCFT gene in subjects with hereditary folate malabsorption and, more recently, by the Pcft-null mouse. This article reviews the current understanding of the properties of PCFT-mediated transport and how they differ from those of the reduced folate carrier. Other processes that contribute to the transport of folates across the enterocyte, along with the contribution of the enterohepatic circulation, are considered. Important unresolved issues are addressed, including the mechanism of intestinal folate absorption in the absence of PCFT and regulation of PCFT gene expression. The impact of a variety of ions, organic molecules, and drugs on PCFT-mediated folate transport is described.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0066-4278
fulltext: fulltext
issn:
  • 0066-4278
  • 1545-1585
url: Link


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descriptionThe properties of intestinal folate absorption were documented decades ago. However, it was only recently that the proton-coupled folate transporter (PCFT) was identified and its critical role in folate transport across the apical brush-border membrane of the proximal small intestine established by the loss-of-function mutations identified in the PCFT gene in subjects with hereditary folate malabsorption and, more recently, by the Pcft-null mouse. This article reviews the current understanding of the properties of PCFT-mediated transport and how they differ from those of the reduced folate carrier. Other processes that contribute to the transport of folates across the enterocyte, along with the contribution of the enterohepatic circulation, are considered. Important unresolved issues are addressed, including the mechanism of intestinal folate absorption in the absence of PCFT and regulation of PCFT gene expression. The impact of a variety of ions, organic molecules, and drugs on PCFT-mediated folate transport is described.
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languageeng
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subjectAnimals ; Article ; Biological transport, Active ; Enterohepatic Circulation - physiology ; folate absorption ; folates ; Folic acid ; Folic Acid - metabolism ; Folic Acid Deficiency - genetics ; Folic Acid Deficiency - metabolism ; Gene expression ; HCP1 ; Health aspects ; Humans ; Intestinal Absorption - genetics ; Intestinal Absorption - physiology ; intestinal folate transport ; Intestine, Large - metabolism ; Intestine, Small - metabolism ; Ions ; Malabsorption Syndromes - genetics ; Malabsorption Syndromes - metabolism ; Medical research ; Medicine, Experimental ; Membranes ; methotrexate ; Mice ; Molecules ; Mutation ; PCFT ; pemetrexed ; Physiological aspects ; Proton-Coupled Folate Transporter - genetics ; Proton-Coupled Folate Transporter - metabolism ; Research ; RFC ; Rodents ; transport
ispartofAnnual review of physiology, 2014, Vol.76 (1), p.251-274
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descriptionThe properties of intestinal folate absorption were documented decades ago. However, it was only recently that the proton-coupled folate transporter (PCFT) was identified and its critical role in folate transport across the apical brush-border membrane of the proximal small intestine established by the loss-of-function mutations identified in the PCFT gene in subjects with hereditary folate malabsorption and, more recently, by the Pcft-null mouse. This article reviews the current understanding of the properties of PCFT-mediated transport and how they differ from those of the reduced folate carrier. Other processes that contribute to the transport of folates across the enterocyte, along with the contribution of the enterohepatic circulation, are considered. Important unresolved issues are addressed, including the mechanism of intestinal folate absorption in the absence of PCFT and regulation of PCFT gene expression. The impact of a variety of ions, organic molecules, and drugs on PCFT-mediated folate transport is described.
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7Folic Acid - metabolism
8Folic Acid Deficiency - genetics
9Folic Acid Deficiency - metabolism
10Gene expression
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14Intestinal Absorption - genetics
15Intestinal Absorption - physiology
16intestinal folate transport
17Intestine, Large - metabolism
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19Ions
20Malabsorption Syndromes - genetics
21Malabsorption Syndromes - metabolism
22Medical research
23Medicine, Experimental
24Membranes
25methotrexate
26Mice
27Molecules
28Mutation
29PCFT
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31Physiological aspects
32Proton-Coupled Folate Transporter - genetics
33Proton-Coupled Folate Transporter - metabolism
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35RFC
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abstractThe properties of intestinal folate absorption were documented decades ago. However, it was only recently that the proton-coupled folate transporter (PCFT) was identified and its critical role in folate transport across the apical brush-border membrane of the proximal small intestine established by the loss-of-function mutations identified in the PCFT gene in subjects with hereditary folate malabsorption and, more recently, by the Pcft-null mouse. This article reviews the current understanding of the properties of PCFT-mediated transport and how they differ from those of the reduced folate carrier. Other processes that contribute to the transport of folates across the enterocyte, along with the contribution of the enterohepatic circulation, are considered. Important unresolved issues are addressed, including the mechanism of intestinal folate absorption in the absence of PCFT and regulation of PCFT gene expression. The impact of a variety of ions, organic molecules, and drugs on PCFT-mediated folate transport is described.
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pmid24512081
doi10.1146/annurev-physiol-020911-153251
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