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Insulin resistance, beta cell dysfunction and visceral adiposity as predictors of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study

Aims/hypothesis Central obesity, insulin resistance and beta cell dysfunction are independent risk factors for incident type 2 diabetes, although few studies have used detailed measures of these disorders. Our objective was to study the association of directly measured visceral and subcutaneous adip... Full description

Journal Title: Diabetologia 2009, Vol.52 (10), p.2079-2086
Main Author: Hanley, A. J. G
Other Authors: Wagenknecht, L. E , Norris, J. M , Bryer-Ash, M , Chen, Y. I , Anderson, A. M , Bergman, R , Haffner, S. M
Format: Electronic Article Electronic Article
Language: English
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Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 0012-186X
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title: Insulin resistance, beta cell dysfunction and visceral adiposity as predictors of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study
format: Article
creator:
  • Hanley, A. J. G
  • Wagenknecht, L. E
  • Norris, J. M
  • Bryer-Ash, M
  • Chen, Y. I
  • Anderson, A. M
  • Bergman, R
  • Haffner, S. M
subjects:
  • Adipose tissues
  • Adiposity - physiology
  • Adult
  • African Americans
  • Article
  • Atherosclerosis
  • Atherosclerosis (general aspects, experimental research)
  • Biological and medical sciences
  • Blood and lymphatic vessels
  • Cardiology. Vascular system
  • Cell research
  • Cholesterol
  • Dextrose
  • Diabetes
  • Diabetes Mellitus, Type 2 - epidemiology
  • Diabetes Mellitus, Type 2 - ethnology
  • Diabetes Mellitus, Type 2 - etiology
  • Diabetes. Impaired glucose tolerance
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Epidemiology
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Female
  • Glucose
  • Glucose metabolism
  • Hispanic Americans
  • Human Physiology
  • Humans
  • Insulin - metabolism
  • Insulin - physiology
  • Insulin resistance
  • Insulin Resistance - physiology
  • Insulin secretion
  • Insulin sensitivity
  • Insulin-Secreting Cells - metabolism
  • Insulin-Secreting Cells - pathology
  • Internal Medicine
  • Intra-Abdominal Fat - pathology
  • Male
  • Medical colleges
  • Medical genetics
  • Medical sciences
  • Medicine
  • Medicine & Public Health
  • Medicine, Preventive
  • Metabolic Diseases
  • Middle Aged
  • Pancreatic beta cells
  • Preventive health services
  • Prospective studies
  • Public health
  • Risk factors
  • Sex Factors
  • Triglycerides
  • Type 2 diabetes
  • Visceral adipose tissue
ispartof: Diabetologia, 2009, Vol.52 (10), p.2079-2086
description: Aims/hypothesis Central obesity, insulin resistance and beta cell dysfunction are independent risk factors for incident type 2 diabetes, although few studies have used detailed measures of these disorders. Our objective was to study the association of directly measured visceral and subcutaneous adipose tissue (VAT, SAT), insulin sensitivity ( S I ) and the acute insulin response (AIR) with incident type 2 diabetes. Methods Participants were 1,230 Hispanic-Americans and African-Americans in the Insulin Resistance Atherosclerosis Study (IRAS) Family Study who were free of type 2 diabetes at baseline (2000–2002). S I and AIR were determined from frequently sampled IVGTTs with minimal model analysis. VAT and SAT were determined by computed tomography. Impaired fasting glucose and type 2 diabetes were defined according to American Diabetes Association criteria. Results Incident type 2 diabetes was diagnosed in 90 participants after 5 years. After adjustment for age, sex, ethnicity, centre, impaired fasting glucose, triacylglycerol, HDL-cholesterol and systolic BP, both S I and AIR were inversely associated with type 2 diabetes ( S I , OR 0.53, 95% CI 0.39–0.73; AIR, OR 0.22, 95% CI 0.14–0.34 per SD; both p  
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titleInsulin resistance, beta cell dysfunction and visceral adiposity as predictors of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study
creatorHanley, A. J. G ; Wagenknecht, L. E ; Norris, J. M ; Bryer-Ash, M ; Chen, Y. I ; Anderson, A. M ; Bergman, R ; Haffner, S. M
creatorcontribHanley, A. J. G ; Wagenknecht, L. E ; Norris, J. M ; Bryer-Ash, M ; Chen, Y. I ; Anderson, A. M ; Bergman, R ; Haffner, S. M
descriptionAims/hypothesis Central obesity, insulin resistance and beta cell dysfunction are independent risk factors for incident type 2 diabetes, although few studies have used detailed measures of these disorders. Our objective was to study the association of directly measured visceral and subcutaneous adipose tissue (VAT, SAT), insulin sensitivity ( S I ) and the acute insulin response (AIR) with incident type 2 diabetes. Methods Participants were 1,230 Hispanic-Americans and African-Americans in the Insulin Resistance Atherosclerosis Study (IRAS) Family Study who were free of type 2 diabetes at baseline (2000–2002). S I and AIR were determined from frequently sampled IVGTTs with minimal model analysis. VAT and SAT were determined by computed tomography. Impaired fasting glucose and type 2 diabetes were defined according to American Diabetes Association criteria. Results Incident type 2 diabetes was diagnosed in 90 participants after 5 years. After adjustment for age, sex, ethnicity, centre, impaired fasting glucose, triacylglycerol, HDL-cholesterol and systolic BP, both S I and AIR were inversely associated with type 2 diabetes ( S I , OR 0.53, 95% CI 0.39–0.73; AIR, OR 0.22, 95% CI 0.14–0.34 per SD; both p  < 0.001), while both VAT and SAT were positively associated with type 2 diabetes (VAT, OR 1.68, 95% CI 1.22–2.33; SAT, OR 1.49, 95% CI 1.13–1.99; both p  < 0.01). In a model including all four factors, S I and AIR ( S I , OR 0.55, 95% CI 0.37–0.80; AIR, OR 0.21, 95% CI 0.13–0.33; both p  < 0.01) were significant predictors of type 2 diabetes, although associations with VAT and SAT were no longer significant. A significant sex × VAT interaction indicated a stronger association of VAT with type 2 diabetes in women than in men. Conclusions/interpretation Insulin resistance, beta cell dysfunction and VAT predicted incident type 2 diabetes, with evidence of a stronger association of VAT with type 2 diabetes among women.
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languageeng
publisherBerlin/Heidelberg: Springer-Verlag
subjectAdipose tissues ; Adiposity - physiology ; Adult ; African Americans ; Article ; Atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cell research ; Cholesterol ; Dextrose ; Diabetes ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - ethnology ; Diabetes Mellitus, Type 2 - etiology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Epidemiology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Glucose ; Glucose metabolism ; Hispanic Americans ; Human Physiology ; Humans ; Insulin - metabolism ; Insulin - physiology ; Insulin resistance ; Insulin Resistance - physiology ; Insulin secretion ; Insulin sensitivity ; Insulin-Secreting Cells - metabolism ; Insulin-Secreting Cells - pathology ; Internal Medicine ; Intra-Abdominal Fat - pathology ; Male ; Medical colleges ; Medical genetics ; Medical sciences ; Medicine ; Medicine & Public Health ; Medicine, Preventive ; Metabolic Diseases ; Middle Aged ; Pancreatic beta cells ; Preventive health services ; Prospective studies ; Public health ; Risk factors ; Sex Factors ; Triglycerides ; Type 2 diabetes ; Visceral adipose tissue
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2Norris, J. M
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7Haffner, S. M
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0Insulin resistance, beta cell dysfunction and visceral adiposity as predictors of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study
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descriptionAims/hypothesis Central obesity, insulin resistance and beta cell dysfunction are independent risk factors for incident type 2 diabetes, although few studies have used detailed measures of these disorders. Our objective was to study the association of directly measured visceral and subcutaneous adipose tissue (VAT, SAT), insulin sensitivity ( S I ) and the acute insulin response (AIR) with incident type 2 diabetes. Methods Participants were 1,230 Hispanic-Americans and African-Americans in the Insulin Resistance Atherosclerosis Study (IRAS) Family Study who were free of type 2 diabetes at baseline (2000–2002). S I and AIR were determined from frequently sampled IVGTTs with minimal model analysis. VAT and SAT were determined by computed tomography. Impaired fasting glucose and type 2 diabetes were defined according to American Diabetes Association criteria. Results Incident type 2 diabetes was diagnosed in 90 participants after 5 years. After adjustment for age, sex, ethnicity, centre, impaired fasting glucose, triacylglycerol, HDL-cholesterol and systolic BP, both S I and AIR were inversely associated with type 2 diabetes ( S I , OR 0.53, 95% CI 0.39–0.73; AIR, OR 0.22, 95% CI 0.14–0.34 per SD; both p  < 0.001), while both VAT and SAT were positively associated with type 2 diabetes (VAT, OR 1.68, 95% CI 1.22–2.33; SAT, OR 1.49, 95% CI 1.13–1.99; both p  < 0.01). In a model including all four factors, S I and AIR ( S I , OR 0.55, 95% CI 0.37–0.80; AIR, OR 0.21, 95% CI 0.13–0.33; both p  < 0.01) were significant predictors of type 2 diabetes, although associations with VAT and SAT were no longer significant. A significant sex × VAT interaction indicated a stronger association of VAT with type 2 diabetes in women than in men. Conclusions/interpretation Insulin resistance, beta cell dysfunction and VAT predicted incident type 2 diabetes, with evidence of a stronger association of VAT with type 2 diabetes among women.
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10Cell research
11Cholesterol
12Dextrose
13Diabetes
14Diabetes Mellitus, Type 2 - epidemiology
15Diabetes Mellitus, Type 2 - ethnology
16Diabetes Mellitus, Type 2 - etiology
17Diabetes. Impaired glucose tolerance
18Endocrine pancreas. Apud cells (diseases)
19Endocrinopathies
20Epidemiology
21Etiopathogenesis. Screening. Investigations. Target tissue resistance
22Female
23Glucose
24Glucose metabolism
25Hispanic Americans
26Human Physiology
27Humans
28Insulin - metabolism
29Insulin - physiology
30Insulin resistance
31Insulin Resistance - physiology
32Insulin secretion
33Insulin sensitivity
34Insulin-Secreting Cells - metabolism
35Insulin-Secreting Cells - pathology
36Internal Medicine
37Intra-Abdominal Fat - pathology
38Male
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40Medical genetics
41Medical sciences
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43Medicine & Public Health
44Medicine, Preventive
45Metabolic Diseases
46Middle Aged
47Pancreatic beta cells
48Preventive health services
49Prospective studies
50Public health
51Risk factors
52Sex Factors
53Triglycerides
54Type 2 diabetes
55Visceral adipose tissue
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titleInsulin resistance, beta cell dysfunction and visceral adiposity as predictors of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study
authorHanley, A. J. G ; Wagenknecht, L. E ; Norris, J. M ; Bryer-Ash, M ; Chen, Y. I ; Anderson, A. M ; Bergman, R ; Haffner, S. M
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1Adiposity - physiology
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3African Americans
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5Atherosclerosis
6Atherosclerosis (general aspects, experimental research)
7Biological and medical sciences
8Blood and lymphatic vessels
9Cardiology. Vascular system
10Cell research
11Cholesterol
12Dextrose
13Diabetes
14Diabetes Mellitus, Type 2 - epidemiology
15Diabetes Mellitus, Type 2 - ethnology
16Diabetes Mellitus, Type 2 - etiology
17Diabetes. Impaired glucose tolerance
18Endocrine pancreas. Apud cells (diseases)
19Endocrinopathies
20Epidemiology
21Etiopathogenesis. Screening. Investigations. Target tissue resistance
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23Glucose
24Glucose metabolism
25Hispanic Americans
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45Metabolic Diseases
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49Prospective studies
50Public health
51Risk factors
52Sex Factors
53Triglycerides
54Type 2 diabetes
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abstractAims/hypothesis Central obesity, insulin resistance and beta cell dysfunction are independent risk factors for incident type 2 diabetes, although few studies have used detailed measures of these disorders. Our objective was to study the association of directly measured visceral and subcutaneous adipose tissue (VAT, SAT), insulin sensitivity ( S I ) and the acute insulin response (AIR) with incident type 2 diabetes. Methods Participants were 1,230 Hispanic-Americans and African-Americans in the Insulin Resistance Atherosclerosis Study (IRAS) Family Study who were free of type 2 diabetes at baseline (2000–2002). S I and AIR were determined from frequently sampled IVGTTs with minimal model analysis. VAT and SAT were determined by computed tomography. Impaired fasting glucose and type 2 diabetes were defined according to American Diabetes Association criteria. Results Incident type 2 diabetes was diagnosed in 90 participants after 5 years. After adjustment for age, sex, ethnicity, centre, impaired fasting glucose, triacylglycerol, HDL-cholesterol and systolic BP, both S I and AIR were inversely associated with type 2 diabetes ( S I , OR 0.53, 95% CI 0.39–0.73; AIR, OR 0.22, 95% CI 0.14–0.34 per SD; both p  < 0.001), while both VAT and SAT were positively associated with type 2 diabetes (VAT, OR 1.68, 95% CI 1.22–2.33; SAT, OR 1.49, 95% CI 1.13–1.99; both p  < 0.01). In a model including all four factors, S I and AIR ( S I , OR 0.55, 95% CI 0.37–0.80; AIR, OR 0.21, 95% CI 0.13–0.33; both p  < 0.01) were significant predictors of type 2 diabetes, although associations with VAT and SAT were no longer significant. A significant sex × VAT interaction indicated a stronger association of VAT with type 2 diabetes in women than in men. Conclusions/interpretation Insulin resistance, beta cell dysfunction and VAT predicted incident type 2 diabetes, with evidence of a stronger association of VAT with type 2 diabetes among women.
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