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Male circumcision and Mycoplasma genitalium infection in female partners: a randomised trial in Rakai, Uganda

Objective Previous randomised trial data have demonstrated that male circumcision reduces Mycoplasma genitalium prevalence in men. We assessed whether male circumcision also reduces M genitalium infection in female partners of circumcised men. Methods HIV-negative men were enrolled and randomised to... Full description

Journal Title: Sexually transmitted infections 2014-03, Vol.90 (2), p.150-154
Main Author: Tobian, Aaron A R
Other Authors: Gaydos, Charlotte , Gray, Ronald H , Kigozi, Godfrey , Serwadda, David , Quinn, Nicole , Grabowski, Mary K , Musoke, Richard , Ndyanabo, Anthony , Nalugoda, Fred , Wawer, Maria J , Quinn, Thomas C
Format: Electronic Article Electronic Article
Language: English
Subjects:
HIV
Publisher: London: BMJ Publishing Group
ID: ISSN: 1368-4973
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4018720
title: Male circumcision and Mycoplasma genitalium infection in female partners: a randomised trial in Rakai, Uganda
format: Article
creator:
  • Tobian, Aaron A R
  • Gaydos, Charlotte
  • Gray, Ronald H
  • Kigozi, Godfrey
  • Serwadda, David
  • Quinn, Nicole
  • Grabowski, Mary K
  • Musoke, Richard
  • Ndyanabo, Anthony
  • Nalugoda, Fred
  • Wawer, Maria J
  • Quinn, Thomas C
subjects:
  • Adolescent
  • Adult
  • Article
  • Biological and medical sciences
  • Circumcision
  • Circumcision, Male
  • Demographic aspects
  • Epidemiology. Vaccinations
  • Female
  • General aspects
  • Health aspects
  • HIV
  • HIV Infections - epidemiology
  • HIV Infections - prevention & control
  • Human infectious diseases. Experimental studies and models
  • Humans
  • Incidence
  • Infectious diseases
  • Male
  • Male circumcision
  • Medical sciences
  • Middle Aged
  • Molecular Diagnostic Techniques
  • mycoplasma genitalium
  • Mycoplasma genitalium - isolation & purification
  • Mycoplasma infections
  • Mycoplasma Infections - epidemiology
  • Mycoplasma Infections - microbiology
  • Mycoplasma Infections - prevention & control
  • Poisson Distribution
  • Prevention
  • Risk Factors
  • Sexual Behavior
  • Sexual Partners
  • sexually transmitted infections
  • transmission
  • Uganda
  • Uganda - epidemiology
  • Vagina - microbiology
ispartof: Sexually transmitted infections, 2014-03, Vol.90 (2), p.150-154
description: Objective Previous randomised trial data have demonstrated that male circumcision reduces Mycoplasma genitalium prevalence in men. We assessed whether male circumcision also reduces M genitalium infection in female partners of circumcised men. Methods HIV-negative men were enrolled and randomised to either male circumcision or control. Female partners of male trial participants from the intervention (n=437) and control (n=394) arms provided interview information and self-collected vaginal swabs that were tested for M genitalium by APTIMA transcription-mediated amplification-based assay. Prevalence risk ratios (PRR) and 95% CI of M genitalium prevalence in intervention versus control group were estimated using Poisson regression. Analysis was by intention-to-treat. An as-treated analysis was conducted to account for study-group crossovers. Results Male and female partner enrolment sociodemographic characteristics, sexual behaviours, and symptoms of sexually transmitted infections were similar between study arms. Female M genitalium prevalence at year 2 was 3.2% (14/437) in the intervention arm and 3.6% (14/394) in the control arm (PRR=0.90, 95% CI 0.43 to 1.89, p=0.78). In an as-treated analysis, the prevalence of M genitalium was 3.4% in female partners of circumcised men and 3.3% in female partners of uncircumcised men (PRR=1.01, 95% CI 0.48 to 2.12, p=0.97). Conclusions Contrary to findings in men, male circumcision did not affect M genitalium infection in female partners.
language: eng
source:
identifier: ISSN: 1368-4973
fulltext: no_fulltext
issn:
  • 1368-4973
  • 1472-3263
url: Link


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titleMale circumcision and Mycoplasma genitalium infection in female partners: a randomised trial in Rakai, Uganda
creatorTobian, Aaron A R ; Gaydos, Charlotte ; Gray, Ronald H ; Kigozi, Godfrey ; Serwadda, David ; Quinn, Nicole ; Grabowski, Mary K ; Musoke, Richard ; Ndyanabo, Anthony ; Nalugoda, Fred ; Wawer, Maria J ; Quinn, Thomas C
creatorcontribTobian, Aaron A R ; Gaydos, Charlotte ; Gray, Ronald H ; Kigozi, Godfrey ; Serwadda, David ; Quinn, Nicole ; Grabowski, Mary K ; Musoke, Richard ; Ndyanabo, Anthony ; Nalugoda, Fred ; Wawer, Maria J ; Quinn, Thomas C
descriptionObjective Previous randomised trial data have demonstrated that male circumcision reduces Mycoplasma genitalium prevalence in men. We assessed whether male circumcision also reduces M genitalium infection in female partners of circumcised men. Methods HIV-negative men were enrolled and randomised to either male circumcision or control. Female partners of male trial participants from the intervention (n=437) and control (n=394) arms provided interview information and self-collected vaginal swabs that were tested for M genitalium by APTIMA transcription-mediated amplification-based assay. Prevalence risk ratios (PRR) and 95% CI of M genitalium prevalence in intervention versus control group were estimated using Poisson regression. Analysis was by intention-to-treat. An as-treated analysis was conducted to account for study-group crossovers. Results Male and female partner enrolment sociodemographic characteristics, sexual behaviours, and symptoms of sexually transmitted infections were similar between study arms. Female M genitalium prevalence at year 2 was 3.2% (14/437) in the intervention arm and 3.6% (14/394) in the control arm (PRR=0.90, 95% CI 0.43 to 1.89, p=0.78). In an as-treated analysis, the prevalence of M genitalium was 3.4% in female partners of circumcised men and 3.3% in female partners of uncircumcised men (PRR=1.01, 95% CI 0.48 to 2.12, p=0.97). Conclusions Contrary to findings in men, male circumcision did not affect M genitalium infection in female partners.
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subjectAdolescent ; Adult ; Article ; Biological and medical sciences ; Circumcision ; Circumcision, Male ; Demographic aspects ; Epidemiology. Vaccinations ; Female ; General aspects ; Health aspects ; HIV ; HIV Infections - epidemiology ; HIV Infections - prevention & control ; Human infectious diseases. Experimental studies and models ; Humans ; Incidence ; Infectious diseases ; Male ; Male circumcision ; Medical sciences ; Middle Aged ; Molecular Diagnostic Techniques ; mycoplasma genitalium ; Mycoplasma genitalium - isolation & purification ; Mycoplasma infections ; Mycoplasma Infections - epidemiology ; Mycoplasma Infections - microbiology ; Mycoplasma Infections - prevention & control ; Poisson Distribution ; Prevention ; Risk Factors ; Sexual Behavior ; Sexual Partners ; sexually transmitted infections ; transmission ; Uganda ; Uganda - epidemiology ; Vagina - microbiology
ispartofSexually transmitted infections, 2014-03, Vol.90 (2), p.150-154
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descriptionObjective Previous randomised trial data have demonstrated that male circumcision reduces Mycoplasma genitalium prevalence in men. We assessed whether male circumcision also reduces M genitalium infection in female partners of circumcised men. Methods HIV-negative men were enrolled and randomised to either male circumcision or control. Female partners of male trial participants from the intervention (n=437) and control (n=394) arms provided interview information and self-collected vaginal swabs that were tested for M genitalium by APTIMA transcription-mediated amplification-based assay. Prevalence risk ratios (PRR) and 95% CI of M genitalium prevalence in intervention versus control group were estimated using Poisson regression. Analysis was by intention-to-treat. An as-treated analysis was conducted to account for study-group crossovers. Results Male and female partner enrolment sociodemographic characteristics, sexual behaviours, and symptoms of sexually transmitted infections were similar between study arms. Female M genitalium prevalence at year 2 was 3.2% (14/437) in the intervention arm and 3.6% (14/394) in the control arm (PRR=0.90, 95% CI 0.43 to 1.89, p=0.78). In an as-treated analysis, the prevalence of M genitalium was 3.4% in female partners of circumcised men and 3.3% in female partners of uncircumcised men (PRR=1.01, 95% CI 0.48 to 2.12, p=0.97). Conclusions Contrary to findings in men, male circumcision did not affect M genitalium infection in female partners.
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25Mycoplasma infections
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titleMale circumcision and Mycoplasma genitalium infection in female partners: a randomised trial in Rakai, Uganda
authorTobian, Aaron A R ; Gaydos, Charlotte ; Gray, Ronald H ; Kigozi, Godfrey ; Serwadda, David ; Quinn, Nicole ; Grabowski, Mary K ; Musoke, Richard ; Ndyanabo, Anthony ; Nalugoda, Fred ; Wawer, Maria J ; Quinn, Thomas C
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abstractObjective Previous randomised trial data have demonstrated that male circumcision reduces Mycoplasma genitalium prevalence in men. We assessed whether male circumcision also reduces M genitalium infection in female partners of circumcised men. Methods HIV-negative men were enrolled and randomised to either male circumcision or control. Female partners of male trial participants from the intervention (n=437) and control (n=394) arms provided interview information and self-collected vaginal swabs that were tested for M genitalium by APTIMA transcription-mediated amplification-based assay. Prevalence risk ratios (PRR) and 95% CI of M genitalium prevalence in intervention versus control group were estimated using Poisson regression. Analysis was by intention-to-treat. An as-treated analysis was conducted to account for study-group crossovers. Results Male and female partner enrolment sociodemographic characteristics, sexual behaviours, and symptoms of sexually transmitted infections were similar between study arms. Female M genitalium prevalence at year 2 was 3.2% (14/437) in the intervention arm and 3.6% (14/394) in the control arm (PRR=0.90, 95% CI 0.43 to 1.89, p=0.78). In an as-treated analysis, the prevalence of M genitalium was 3.4% in female partners of circumcised men and 3.3% in female partners of uncircumcised men (PRR=1.01, 95% CI 0.48 to 2.12, p=0.97). Conclusions Contrary to findings in men, male circumcision did not affect M genitalium infection in female partners.
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