schliessen

Filtern

 

Bibliotheken

High-risk human papillomavirus viral load and persistence among heterosexual HIV-negative and HIV-positive men

Objectives High-risk human papillomavirus (HR-HPV) viral load is associated with HR-HPV transmission and HR-HPV persistence in women. It is unknown whether HR-HPV viral load is associated with persistence in HIV-negative or HIV-positive men. Methods HR-HPV viral load and persistence were evaluated a... Full description

Journal Title: Sexually transmitted infections 2014, Vol.90 (4), p.337-343
Main Author: Grabowski, Mary K
Other Authors: Gray, Ronald H , Serwadda, David , Kigozi, Godfrey , Gravitt, Patti E , Nalugoda, Fred , Reynolds, Steven J , Wawer, Maria J , Watya, Stephen , Quinn, Thomas C , Tobian, Aaron A R
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: London: BMJ Publishing Group
ID: ISSN: 1368-4973
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4030299
title: High-risk human papillomavirus viral load and persistence among heterosexual HIV-negative and HIV-positive men
format: Article
creator:
  • Grabowski, Mary K
  • Gray, Ronald H
  • Serwadda, David
  • Kigozi, Godfrey
  • Gravitt, Patti E
  • Nalugoda, Fred
  • Reynolds, Steven J
  • Wawer, Maria J
  • Watya, Stephen
  • Quinn, Thomas C
  • Tobian, Aaron A R
subjects:
  • Adolescent
  • Adult
  • Article
  • Biological and medical sciences
  • Case-Control Studies
  • Epidemiology. Vaccinations
  • General aspects
  • Genotype
  • Health aspects
  • Heterosexuality
  • Heterosexuals
  • HIV Infections - complications
  • HIV patients
  • human immunodeficiency virus (HIV)
  • Human infectious diseases. Experimental studies and models
  • Human papillomavirus (HPV)
  • Human papillomavirus 16 - genetics
  • Human papillomavirus 18 - genetics
  • Human papillomavirus 31 - genetics
  • Human viral diseases
  • Humans
  • Infectious diseases
  • linear array band intensity
  • Male
  • male circumcision
  • Medical sciences
  • Papillomaviridae - classification
  • Papillomaviridae - genetics
  • Papillomavirus infections
  • Papillomavirus Infections - complications
  • Papillomavirus Infections - virology
  • penile cancer
  • Penis - virology
  • Risk factors
  • Sexual Behavior
  • sexually transmitted infections
  • Uganda
  • Viral diseases
  • Viral diseases of the lymphoid tissue and the blood. Aids
  • Viral Load
  • viral shedding
  • Young Adult
ispartof: Sexually transmitted infections, 2014, Vol.90 (4), p.337-343
description: Objectives High-risk human papillomavirus (HR-HPV) viral load is associated with HR-HPV transmission and HR-HPV persistence in women. It is unknown whether HR-HPV viral load is associated with persistence in HIV-negative or HIV-positive men. Methods HR-HPV viral load and persistence were evaluated among 703 HIV-negative and 233 HIV-positive heterosexual men who participated in a male circumcision trial in Rakai, Uganda. Penile swabs were tested at baseline and 6, 12 and 24 months for HR-HPV using the Roche HPV Linear Array, which provides a semiquantitative measure of HPV shedding by hybridisation band intensity (graded: 1–4). Prevalence risk ratios (PRR) were used to estimate the association between HR-HPV viral load and persistent detection of HR-HPV. Results HR-HPV genotypes with high viral load (grade:3–4) at baseline were more likely to persist than HR-HPV genotypes with low viral load (grade: 1–2) among HIV-negative men (month 6: adjPRR=1.83, 95% CI 1.32 to 2.52; month 12: adjPRR=2.01, 95% CI 1.42 to 3.11), and HIV-positive men (month 6: adjPRR=1.33, 95% CI 1.06 to 1.67; month 12: adjPRR=1.73, 95% CI 1.18 to 2.54). Long-term persistence of HR-HPV was more frequent among HIV-positive men compared with HIV-negative men (month 24: adjPRR=2.27, 95% CI 1.47 to 3.51). Persistence of newly detected HR-HPV at the 6-month and 12-month visits with high viral load were also more likely to persist to 24 months than HR-HPV with low viral load among HIV-negative men (adjPRR=1.67, 95% CI 0.88 to 3.16). Conclusions HR-HPV genotypes with high viral load are more likely to persist among HIV-negative and HIV-positive men, though persistence was more common among HIV-positive men overall. The results may explain the association between high HR-HPV viral load and HR-HPV transmission.
language: eng
source:
identifier: ISSN: 1368-4973
fulltext: no_fulltext
issn:
  • 1368-4973
  • 1472-3263
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.441351
LOCALfalse
PrimoNMBib
record
control
sourceidgale_pubme
recordidTN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4030299
sourceformatXML
sourcesystemPC
galeidA379594658
sourcerecordidA379594658
originalsourceidFETCH-LOGICAL-1639t-22737b0f568490eac972d86e2fa9919f7aa4ab4b860b9fd0442c2cebc64a1c0e0
addsrcrecordideNqNkl2L1DAUhoso7rr6D0QKInjT3Xw1abwQlkWdhQVv1Ntwmp7OZGyT2rSD_nszH7vrLIJSaMPp877nJHmz7CUl55RyeRHx5zSCjwUjlBekpIyTR9kpFYoVnEn-OK25rAqhFT_JnsW4JoRIVeqn2QkTomKiqk4zv3DLVTG6-D1fzT34fIDBdV3oYePGOebpDV3eBWhy8E0-4BhdnNBbzKEPfpmvcMIxpGHmxC2uvxUelzC5De74bWEI0e0KPfrn2ZMWuogvDt-z7OvHD1-uFsXN50_XV5c3BZVcTwVjiquatKWshCYIVivWVBJZC1pT3SoAAbWoK0lq3TZECGaZxdpKAdQSJGfZ-73vMNc9NhZ9OqvODKPrYfxlAjhz_Me7lVmGjRGEE6Z1MljsDcKAHtyIR9rG42RCY5hUBpumtVAy4GiJtLpBWWsiiWJIKypJsnp7mGUMP2aMk-ldtNh14DHM0dCSlUpyxUVCXz9A12EefTopQ1Uy00oSek8toUPjfBvSFuzW1FxypUstZFkl6vwvVHoa7J0NHluX6kcCsRfYdJ9xxPZuy5SYbeTMbeTMNnJmH7kke_XnUd-JbjOWgDcHAKKFrk0O1sV7rkrd1a7_uwf9rZtSlML2hlz3ryku9uK6X__f3L8B_TQD5Q
sourcetypeOpen Access Repository
isCDItrue
recordtypearticle
pqid1781697601
display
typearticle
titleHigh-risk human papillomavirus viral load and persistence among heterosexual HIV-negative and HIV-positive men
creatorGrabowski, Mary K ; Gray, Ronald H ; Serwadda, David ; Kigozi, Godfrey ; Gravitt, Patti E ; Nalugoda, Fred ; Reynolds, Steven J ; Wawer, Maria J ; Watya, Stephen ; Quinn, Thomas C ; Tobian, Aaron A R
creatorcontribGrabowski, Mary K ; Gray, Ronald H ; Serwadda, David ; Kigozi, Godfrey ; Gravitt, Patti E ; Nalugoda, Fred ; Reynolds, Steven J ; Wawer, Maria J ; Watya, Stephen ; Quinn, Thomas C ; Tobian, Aaron A R
descriptionObjectives High-risk human papillomavirus (HR-HPV) viral load is associated with HR-HPV transmission and HR-HPV persistence in women. It is unknown whether HR-HPV viral load is associated with persistence in HIV-negative or HIV-positive men. Methods HR-HPV viral load and persistence were evaluated among 703 HIV-negative and 233 HIV-positive heterosexual men who participated in a male circumcision trial in Rakai, Uganda. Penile swabs were tested at baseline and 6, 12 and 24 months for HR-HPV using the Roche HPV Linear Array, which provides a semiquantitative measure of HPV shedding by hybridisation band intensity (graded: 1–4). Prevalence risk ratios (PRR) were used to estimate the association between HR-HPV viral load and persistent detection of HR-HPV. Results HR-HPV genotypes with high viral load (grade:3–4) at baseline were more likely to persist than HR-HPV genotypes with low viral load (grade: 1–2) among HIV-negative men (month 6: adjPRR=1.83, 95% CI 1.32 to 2.52; month 12: adjPRR=2.01, 95% CI 1.42 to 3.11), and HIV-positive men (month 6: adjPRR=1.33, 95% CI 1.06 to 1.67; month 12: adjPRR=1.73, 95% CI 1.18 to 2.54). Long-term persistence of HR-HPV was more frequent among HIV-positive men compared with HIV-negative men (month 24: adjPRR=2.27, 95% CI 1.47 to 3.51). Persistence of newly detected HR-HPV at the 6-month and 12-month visits with high viral load were also more likely to persist to 24 months than HR-HPV with low viral load among HIV-negative men (adjPRR=1.67, 95% CI 0.88 to 3.16). Conclusions HR-HPV genotypes with high viral load are more likely to persist among HIV-negative and HIV-positive men, though persistence was more common among HIV-positive men overall. The results may explain the association between high HR-HPV viral load and HR-HPV transmission.
identifier
0ISSN: 1368-4973
1EISSN: 1472-3263
2DOI: 10.1136/sextrans-2013-051230
3PMID: 24482488
languageeng
publisherLondon: BMJ Publishing Group
subjectAdolescent ; Adult ; Article ; Biological and medical sciences ; Case-Control Studies ; Epidemiology. Vaccinations ; General aspects ; Genotype ; Health aspects ; Heterosexuality ; Heterosexuals ; HIV Infections - complications ; HIV patients ; human immunodeficiency virus (HIV) ; Human infectious diseases. Experimental studies and models ; Human papillomavirus (HPV) ; Human papillomavirus 16 - genetics ; Human papillomavirus 18 - genetics ; Human papillomavirus 31 - genetics ; Human viral diseases ; Humans ; Infectious diseases ; linear array band intensity ; Male ; male circumcision ; Medical sciences ; Papillomaviridae - classification ; Papillomaviridae - genetics ; Papillomavirus infections ; Papillomavirus Infections - complications ; Papillomavirus Infections - virology ; penile cancer ; Penis - virology ; Risk factors ; Sexual Behavior ; sexually transmitted infections ; Uganda ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load ; viral shedding ; Young Adult
ispartofSexually transmitted infections, 2014, Vol.90 (4), p.337-343
rights
0Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions
12015 INIST-CNRS
2Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
3Copyright: 2014 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions
lds50peer_reviewed
oafree_for_read
citedbyFETCH-LOGICAL-1639t-22737b0f568490eac972d86e2fa9919f7aa4ab4b860b9fd0442c2cebc64a1c0e0
citesFETCH-LOGICAL-1639t-22737b0f568490eac972d86e2fa9919f7aa4ab4b860b9fd0442c2cebc64a1c0e0
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28465758$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24482488$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Grabowski, Mary K
1Gray, Ronald H
2Serwadda, David
3Kigozi, Godfrey
4Gravitt, Patti E
5Nalugoda, Fred
6Reynolds, Steven J
7Wawer, Maria J
8Watya, Stephen
9Quinn, Thomas C
10Tobian, Aaron A R
title
0High-risk human papillomavirus viral load and persistence among heterosexual HIV-negative and HIV-positive men
1Sexually transmitted infections
addtitleSex Transm Infect
descriptionObjectives High-risk human papillomavirus (HR-HPV) viral load is associated with HR-HPV transmission and HR-HPV persistence in women. It is unknown whether HR-HPV viral load is associated with persistence in HIV-negative or HIV-positive men. Methods HR-HPV viral load and persistence were evaluated among 703 HIV-negative and 233 HIV-positive heterosexual men who participated in a male circumcision trial in Rakai, Uganda. Penile swabs were tested at baseline and 6, 12 and 24 months for HR-HPV using the Roche HPV Linear Array, which provides a semiquantitative measure of HPV shedding by hybridisation band intensity (graded: 1–4). Prevalence risk ratios (PRR) were used to estimate the association between HR-HPV viral load and persistent detection of HR-HPV. Results HR-HPV genotypes with high viral load (grade:3–4) at baseline were more likely to persist than HR-HPV genotypes with low viral load (grade: 1–2) among HIV-negative men (month 6: adjPRR=1.83, 95% CI 1.32 to 2.52; month 12: adjPRR=2.01, 95% CI 1.42 to 3.11), and HIV-positive men (month 6: adjPRR=1.33, 95% CI 1.06 to 1.67; month 12: adjPRR=1.73, 95% CI 1.18 to 2.54). Long-term persistence of HR-HPV was more frequent among HIV-positive men compared with HIV-negative men (month 24: adjPRR=2.27, 95% CI 1.47 to 3.51). Persistence of newly detected HR-HPV at the 6-month and 12-month visits with high viral load were also more likely to persist to 24 months than HR-HPV with low viral load among HIV-negative men (adjPRR=1.67, 95% CI 0.88 to 3.16). Conclusions HR-HPV genotypes with high viral load are more likely to persist among HIV-negative and HIV-positive men, though persistence was more common among HIV-positive men overall. The results may explain the association between high HR-HPV viral load and HR-HPV transmission.
subject
0Adolescent
1Adult
2Article
3Biological and medical sciences
4Case-Control Studies
5Epidemiology. Vaccinations
6General aspects
7Genotype
8Health aspects
9Heterosexuality
10Heterosexuals
11HIV Infections - complications
12HIV patients
13human immunodeficiency virus (HIV)
14Human infectious diseases. Experimental studies and models
15Human papillomavirus (HPV)
16Human papillomavirus 16 - genetics
17Human papillomavirus 18 - genetics
18Human papillomavirus 31 - genetics
19Human viral diseases
20Humans
21Infectious diseases
22linear array band intensity
23Male
24male circumcision
25Medical sciences
26Papillomaviridae - classification
27Papillomaviridae - genetics
28Papillomavirus infections
29Papillomavirus Infections - complications
30Papillomavirus Infections - virology
31penile cancer
32Penis - virology
33Risk factors
34Sexual Behavior
35sexually transmitted infections
36Uganda
37Viral diseases
38Viral diseases of the lymphoid tissue and the blood. Aids
39Viral Load
40viral shedding
41Young Adult
issn
01368-4973
11472-3263
fulltextfalse
rsrctypearticle
creationdate2014
recordtypearticle
recordideNqNkl2L1DAUhoso7rr6D0QKInjT3Xw1abwQlkWdhQVv1Ntwmp7OZGyT2rSD_nszH7vrLIJSaMPp877nJHmz7CUl55RyeRHx5zSCjwUjlBekpIyTR9kpFYoVnEn-OK25rAqhFT_JnsW4JoRIVeqn2QkTomKiqk4zv3DLVTG6-D1fzT34fIDBdV3oYePGOebpDV3eBWhy8E0-4BhdnNBbzKEPfpmvcMIxpGHmxC2uvxUelzC5De74bWEI0e0KPfrn2ZMWuogvDt-z7OvHD1-uFsXN50_XV5c3BZVcTwVjiquatKWshCYIVivWVBJZC1pT3SoAAbWoK0lq3TZECGaZxdpKAdQSJGfZ-73vMNc9NhZ9OqvODKPrYfxlAjhz_Me7lVmGjRGEE6Z1MljsDcKAHtyIR9rG42RCY5hUBpumtVAy4GiJtLpBWWsiiWJIKypJsnp7mGUMP2aMk-ldtNh14DHM0dCSlUpyxUVCXz9A12EefTopQ1Uy00oSek8toUPjfBvSFuzW1FxypUstZFkl6vwvVHoa7J0NHluX6kcCsRfYdJ9xxPZuy5SYbeTMbeTMNnJmH7kke_XnUd-JbjOWgDcHAKKFrk0O1sV7rkrd1a7_uwf9rZtSlML2hlz3ryku9uK6X__f3L8B_TQD5Q
startdate201406
enddate201406
creator
0Grabowski, Mary K
1Gray, Ronald H
2Serwadda, David
3Kigozi, Godfrey
4Gravitt, Patti E
5Nalugoda, Fred
6Reynolds, Steven J
7Wawer, Maria J
8Watya, Stephen
9Quinn, Thomas C
10Tobian, Aaron A R
general
0BMJ Publishing Group
1BMJ Publishing Group Ltd
2BMJ Publishing Group LTD
scope
0IQODW
1CGR
2CUY
3CVF
4ECM
5EIF
6NPM
7AAYXX
8CITATION
9BSHEE
103V.
117X7
127XB
1388E
1488I
158AF
168FI
178FJ
188FK
19ABUWG
20AZQEC
21BENPR
22BTHHO
23DWQXO
24FYUFA
25GHDGH
26GNUQQ
27HCIFZ
28K9.
29M0S
30M1P
31M2P
32PQEST
33PQQKQ
34PQUKI
35Q9U
367X8
37BOBZL
38CLFQK
395PM
sort
creationdate201406
titleHigh-risk human papillomavirus viral load and persistence among heterosexual HIV-negative and HIV-positive men
authorGrabowski, Mary K ; Gray, Ronald H ; Serwadda, David ; Kigozi, Godfrey ; Gravitt, Patti E ; Nalugoda, Fred ; Reynolds, Steven J ; Wawer, Maria J ; Watya, Stephen ; Quinn, Thomas C ; Tobian, Aaron A R
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1639t-22737b0f568490eac972d86e2fa9919f7aa4ab4b860b9fd0442c2cebc64a1c0e0
rsrctypearticles
prefilterarticles
languageeng
creationdate2014
topic
0Adolescent
1Adult
2Article
3Biological and medical sciences
4Case-Control Studies
5Epidemiology. Vaccinations
6General aspects
7Genotype
8Health aspects
9Heterosexuality
10Heterosexuals
11HIV Infections - complications
12HIV patients
13human immunodeficiency virus (HIV)
14Human infectious diseases. Experimental studies and models
15Human papillomavirus (HPV)
16Human papillomavirus 16 - genetics
17Human papillomavirus 18 - genetics
18Human papillomavirus 31 - genetics
19Human viral diseases
20Humans
21Infectious diseases
22linear array band intensity
23Male
24male circumcision
25Medical sciences
26Papillomaviridae - classification
27Papillomaviridae - genetics
28Papillomavirus infections
29Papillomavirus Infections - complications
30Papillomavirus Infections - virology
31penile cancer
32Penis - virology
33Risk factors
34Sexual Behavior
35sexually transmitted infections
36Uganda
37Viral diseases
38Viral diseases of the lymphoid tissue and the blood. Aids
39Viral Load
40viral shedding
41Young Adult
toplevelpeer_reviewed
creatorcontrib
0Grabowski, Mary K
1Gray, Ronald H
2Serwadda, David
3Kigozi, Godfrey
4Gravitt, Patti E
5Nalugoda, Fred
6Reynolds, Steven J
7Wawer, Maria J
8Watya, Stephen
9Quinn, Thomas C
10Tobian, Aaron A R
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8Academic OneFile (A&I only)
9ProQuest Central (Corporate)
10Health & Medical Collection
11ProQuest Central (purchase pre-March 2016)
12Medical Database (Alumni Edition)
13Science Database (Alumni Edition)
14STEM Database
15Hospital Premium Collection
16Hospital Premium Collection (Alumni Edition)
17ProQuest Central (Alumni) (purchase pre-March 2016)
18ProQuest Central (Alumni Edition)
19ProQuest Central Essentials
20ProQuest Central
21BMJ Journals
22ProQuest Central Korea
23Health Research Premium Collection
24Health Research Premium Collection (Alumni)
25ProQuest Central Student
26SciTech Premium Collection
27ProQuest Health & Medical Complete (Alumni)
28Health & Medical Collection (Alumni Edition)
29Medical Database
30Science Database
31ProQuest One Academic Eastern Edition
32ProQuest One Academic
33ProQuest One Academic UKI Edition
34ProQuest Central Basic
35MEDLINE - Academic
36OpenAIRE (Open Access)
37OpenAIRE
38PubMed Central (Full Participant titles)
jtitleSexually transmitted infections
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Grabowski, Mary K
1Gray, Ronald H
2Serwadda, David
3Kigozi, Godfrey
4Gravitt, Patti E
5Nalugoda, Fred
6Reynolds, Steven J
7Wawer, Maria J
8Watya, Stephen
9Quinn, Thomas C
10Tobian, Aaron A R
formatjournal
genrearticle
ristypeJOUR
atitleHigh-risk human papillomavirus viral load and persistence among heterosexual HIV-negative and HIV-positive men
jtitleSexually transmitted infections
addtitleSex Transm Infect
date2014-06
risdate2014
volume90
issue4
spage337
epage343
pages337-343
issn1368-4973
eissn1472-3263
abstractObjectives High-risk human papillomavirus (HR-HPV) viral load is associated with HR-HPV transmission and HR-HPV persistence in women. It is unknown whether HR-HPV viral load is associated with persistence in HIV-negative or HIV-positive men. Methods HR-HPV viral load and persistence were evaluated among 703 HIV-negative and 233 HIV-positive heterosexual men who participated in a male circumcision trial in Rakai, Uganda. Penile swabs were tested at baseline and 6, 12 and 24 months for HR-HPV using the Roche HPV Linear Array, which provides a semiquantitative measure of HPV shedding by hybridisation band intensity (graded: 1–4). Prevalence risk ratios (PRR) were used to estimate the association between HR-HPV viral load and persistent detection of HR-HPV. Results HR-HPV genotypes with high viral load (grade:3–4) at baseline were more likely to persist than HR-HPV genotypes with low viral load (grade: 1–2) among HIV-negative men (month 6: adjPRR=1.83, 95% CI 1.32 to 2.52; month 12: adjPRR=2.01, 95% CI 1.42 to 3.11), and HIV-positive men (month 6: adjPRR=1.33, 95% CI 1.06 to 1.67; month 12: adjPRR=1.73, 95% CI 1.18 to 2.54). Long-term persistence of HR-HPV was more frequent among HIV-positive men compared with HIV-negative men (month 24: adjPRR=2.27, 95% CI 1.47 to 3.51). Persistence of newly detected HR-HPV at the 6-month and 12-month visits with high viral load were also more likely to persist to 24 months than HR-HPV with low viral load among HIV-negative men (adjPRR=1.67, 95% CI 0.88 to 3.16). Conclusions HR-HPV genotypes with high viral load are more likely to persist among HIV-negative and HIV-positive men, though persistence was more common among HIV-positive men overall. The results may explain the association between high HR-HPV viral load and HR-HPV transmission.
copLondon
pubBMJ Publishing Group
pmid24482488
doi10.1136/sextrans-2013-051230
oafree_for_read