High-risk human papillomavirus viral load and persistence among heterosexual HIV-negative and HIV-positive men
| Journal Title: | Sexually transmitted infections 2014-06, Vol.90 (4), p.337-343 |
| Main Author: | Grabowski, Mary K |
| Other Authors: | Gray, Ronald H , Serwadda, David , Kigozi, Godfrey , Gravitt, Patti E , Nalugoda, Fred , Reynolds, Steven J , Wawer, Maria J , Watya, Stephen , Quinn, Thomas C , Tobian, Aaron A R |
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 Electronic Article
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English |
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| Publisher: | London: BMJ Publishing Group |
| ID: | ISSN: 1368-4973 |
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| recordid: | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4030299 |
| title: | High-risk human papillomavirus viral load and persistence among heterosexual HIV-negative and HIV-positive men |
| format: | Article |
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| ispartof: | Sexually transmitted infections, 2014-06, Vol.90 (4), p.337-343 |
| description: | Objectives High-risk human papillomavirus (HR-HPV) viral load is associated with HR-HPV transmission and HR-HPV persistence in women. It is unknown whether HR-HPV viral load is associated with persistence in HIV-negative or HIV-positive men. Methods HR-HPV viral load and persistence were evaluated among 703 HIV-negative and 233 HIV-positive heterosexual men who participated in a male circumcision trial in Rakai, Uganda. Penile swabs were tested at baseline and 6, 12 and 24 months for HR-HPV using the Roche HPV Linear Array, which provides a semiquantitative measure of HPV shedding by hybridisation band intensity (graded: 1–4). Prevalence risk ratios (PRR) were used to estimate the association between HR-HPV viral load and persistent detection of HR-HPV. Results HR-HPV genotypes with high viral load (grade:3–4) at baseline were more likely to persist than HR-HPV genotypes with low viral load (grade: 1–2) among HIV-negative men (month 6: adjPRR=1.83, 95% CI 1.32 to 2.52; month 12: adjPRR=2.01, 95% CI 1.42 to 3.11), and HIV-positive men (month 6: adjPRR=1.33, 95% CI 1.06 to 1.67; month 12: adjPRR=1.73, 95% CI 1.18 to 2.54). Long-term persistence of HR-HPV was more frequent among HIV-positive men compared with HIV-negative men (month 24: adjPRR=2.27, 95% CI 1.47 to 3.51). Persistence of newly detected HR-HPV at the 6-month and 12-month visits with high viral load were also more likely to persist to 24 months than HR-HPV with low viral load among HIV-negative men (adjPRR=1.67, 95% CI 0.88 to 3.16). Conclusions HR-HPV genotypes with high viral load are more likely to persist among HIV-negative and HIV-positive men, though persistence was more common among HIV-positive men overall. The results may explain the association between high HR-HPV viral load and HR-HPV transmission. |
| language: | eng |
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| identifier: | ISSN: 1368-4973 |
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