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Predictors of change in carotid atherosclerotic plaque inflammation and burden as measured by 18-FDG-PET and MRI, respectively, in the dal-PLAQUE study

Baseline predictors of response to treatment of patients with coronary heart disease (CHD) with respect to vascular inflammation and atherosclerotic plaque burden are poorly understood. From post hoc analysis of the dal-PLAQUE study (NCT00655473), 18F-fluorodeoxyglucose-positron emission tomography... Full description

Journal Title: The International Journal of Cardiovascular Imaging 2014-03, Vol.30 (3), p.571-582
Main Author: Mani, Venkatesh
Other Authors: Woodward, Mark , Samber, Daniel , Bucerius, Jan , Tawakol, Ahmed , Kallend, David , Rudd, James H. F , Abt, Markus , Fayad, Zahi A
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Dordrecht: Springer Netherlands
ID: ISSN: 1569-5794
Link: https://www.ncbi.nlm.nih.gov/pubmed/24458953
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4112486
title: Predictors of change in carotid atherosclerotic plaque inflammation and burden as measured by 18-FDG-PET and MRI, respectively, in the dal-PLAQUE study
format: Article
creator:
  • Mani, Venkatesh
  • Woodward, Mark
  • Samber, Daniel
  • Bucerius, Jan
  • Tawakol, Ahmed
  • Kallend, David
  • Rudd, James H. F
  • Abt, Markus
  • Fayad, Zahi A
subjects:
  • Amides
  • Anticholesteremic Agents - therapeutic use
  • Article
  • Atherosclerotic plaque
  • Cardiac Imaging
  • Cardiac patients
  • Cardiology
  • Coronary Artery Disease - complications
  • Coronary Artery Disease - diagnosis
  • Coronary Artery Disease - drug therapy
  • Coronary heart disease
  • Esters
  • Female
  • Fluorodeoxyglucose
  • Fluorodeoxyglucose F18
  • Fluorodeoxyglucose-positron emission tomography
  • Follow-Up Studies
  • Humans
  • Imaging
  • Inflammation
  • Inflammation - complications
  • Inflammation - diagnosis
  • Inflammation - drug therapy
  • Magnetic resonance imaging
  • Magnetic Resonance Imaging - methods
  • Male
  • Medicine
  • Medicine & Public Health
  • Middle Aged
  • Original Paper
  • PET imaging
  • Phospholipases
  • Plaque burden
  • Plaque, Atherosclerotic - complications
  • Plaque, Atherosclerotic - diagnosis
  • Plaque, Atherosclerotic - drug therapy
  • positron emission tomography
  • Positron-Emission Tomography - methods
  • Predictive Value of Tests
  • Radiology
  • Radiopharmaceuticals
  • Sulfhydryl Compounds - therapeutic use
  • Tomography, X-Ray Computed - methods
  • Treatment Outcome
ispartof: The International Journal of Cardiovascular Imaging, 2014-03, Vol.30 (3), p.571-582
description: Baseline predictors of response to treatment of patients with coronary heart disease (CHD) with respect to vascular inflammation and atherosclerotic plaque burden are poorly understood. From post hoc analysis of the dal-PLAQUE study (NCT00655473), 18F-fluorodeoxyglucose-positron emission tomography (18-FDG-PET) imaging and carotid black blood magnetic resonance imaging (MRI) were used to track changes in these vascular parameters. Baseline demographics, imaging, and biomarkers were collected/measured in 130 patients with CHD or CHD risk-equivalents, and imaging follow-up at 6 months (PET) and 24 months (MRI) was performed. Using stepwise linear regression, predictors of change in carotid plaque inflammation by PET [target-to-background ratio (TBR), n = 92] and plaque burden by MRI [wall area (WA) and total vessel area (TVA), n = 89] were determined. Variables with p  
language: eng
source:
identifier: ISSN: 1569-5794
fulltext: no_fulltext
issn:
  • 1569-5794
  • 1875-8312
  • 1573-0743
url: Link


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titlePredictors of change in carotid atherosclerotic plaque inflammation and burden as measured by 18-FDG-PET and MRI, respectively, in the dal-PLAQUE study
creatorMani, Venkatesh ; Woodward, Mark ; Samber, Daniel ; Bucerius, Jan ; Tawakol, Ahmed ; Kallend, David ; Rudd, James H. F ; Abt, Markus ; Fayad, Zahi A
creatorcontribMani, Venkatesh ; Woodward, Mark ; Samber, Daniel ; Bucerius, Jan ; Tawakol, Ahmed ; Kallend, David ; Rudd, James H. F ; Abt, Markus ; Fayad, Zahi A
descriptionBaseline predictors of response to treatment of patients with coronary heart disease (CHD) with respect to vascular inflammation and atherosclerotic plaque burden are poorly understood. From post hoc analysis of the dal-PLAQUE study (NCT00655473), 18F-fluorodeoxyglucose-positron emission tomography (18-FDG-PET) imaging and carotid black blood magnetic resonance imaging (MRI) were used to track changes in these vascular parameters. Baseline demographics, imaging, and biomarkers were collected/measured in 130 patients with CHD or CHD risk-equivalents, and imaging follow-up at 6 months (PET) and 24 months (MRI) was performed. Using stepwise linear regression, predictors of change in carotid plaque inflammation by PET [target-to-background ratio (TBR), n = 92] and plaque burden by MRI [wall area (WA) and total vessel area (TVA), n = 89] were determined. Variables with p  < 0.05 in multivariable models were considered independently significant. Interleukin-6, systolic blood pressure and standard deviation of wall thickness (WT) at baseline were independently positively associated with 18-FDG uptake (mean of maximum [MeanMax] TBR change over 6 months). Mean of mean TBR, phospholipase A 2 , apolipoprotein A-I, and high-sensitivity C-reactive protein at baseline were independently negatively associated with MeanMax TBR change over 6 months. Mean WT and plasminogen activator inhibitor-1 (PAI-1) activity at baseline, and age, were independently associated with change in WA over 24 months. For TVA changes; mean WA and PAI-1 activity at baseline, age, and female gender were independent predictors. These findings may help determine patients most suitable for clinical trials employing plaque inflammation or burden changes as endpoints.
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subjectAmides ; Anticholesteremic Agents - therapeutic use ; Article ; Atherosclerotic plaque ; Cardiac Imaging ; Cardiac patients ; Cardiology ; Coronary Artery Disease - complications ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - drug therapy ; Coronary heart disease ; Esters ; Female ; Fluorodeoxyglucose ; Fluorodeoxyglucose F18 ; Fluorodeoxyglucose-positron emission tomography ; Follow-Up Studies ; Humans ; Imaging ; Inflammation ; Inflammation - complications ; Inflammation - diagnosis ; Inflammation - drug therapy ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Paper ; PET imaging ; Phospholipases ; Plaque burden ; Plaque, Atherosclerotic - complications ; Plaque, Atherosclerotic - diagnosis ; Plaque, Atherosclerotic - drug therapy ; positron emission tomography ; Positron-Emission Tomography - methods ; Predictive Value of Tests ; Radiology ; Radiopharmaceuticals ; Sulfhydryl Compounds - therapeutic use ; Tomography, X-Ray Computed - methods ; Treatment Outcome
ispartofThe International Journal of Cardiovascular Imaging, 2014-03, Vol.30 (3), p.571-582
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4Tawakol, Ahmed
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7Abt, Markus
8Fayad, Zahi A
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0Predictors of change in carotid atherosclerotic plaque inflammation and burden as measured by 18-FDG-PET and MRI, respectively, in the dal-PLAQUE study
1The International Journal of Cardiovascular Imaging
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descriptionBaseline predictors of response to treatment of patients with coronary heart disease (CHD) with respect to vascular inflammation and atherosclerotic plaque burden are poorly understood. From post hoc analysis of the dal-PLAQUE study (NCT00655473), 18F-fluorodeoxyglucose-positron emission tomography (18-FDG-PET) imaging and carotid black blood magnetic resonance imaging (MRI) were used to track changes in these vascular parameters. Baseline demographics, imaging, and biomarkers were collected/measured in 130 patients with CHD or CHD risk-equivalents, and imaging follow-up at 6 months (PET) and 24 months (MRI) was performed. Using stepwise linear regression, predictors of change in carotid plaque inflammation by PET [target-to-background ratio (TBR), n = 92] and plaque burden by MRI [wall area (WA) and total vessel area (TVA), n = 89] were determined. Variables with p  < 0.05 in multivariable models were considered independently significant. Interleukin-6, systolic blood pressure and standard deviation of wall thickness (WT) at baseline were independently positively associated with 18-FDG uptake (mean of maximum [MeanMax] TBR change over 6 months). Mean of mean TBR, phospholipase A 2 , apolipoprotein A-I, and high-sensitivity C-reactive protein at baseline were independently negatively associated with MeanMax TBR change over 6 months. Mean WT and plasminogen activator inhibitor-1 (PAI-1) activity at baseline, and age, were independently associated with change in WA over 24 months. For TVA changes; mean WA and PAI-1 activity at baseline, age, and female gender were independent predictors. These findings may help determine patients most suitable for clinical trials employing plaque inflammation or burden changes as endpoints.
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4Cardiac Imaging
5Cardiac patients
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7Coronary Artery Disease - complications
8Coronary Artery Disease - diagnosis
9Coronary Artery Disease - drug therapy
10Coronary heart disease
11Esters
12Female
13Fluorodeoxyglucose
14Fluorodeoxyglucose F18
15Fluorodeoxyglucose-positron emission tomography
16Follow-Up Studies
17Humans
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19Inflammation
20Inflammation - complications
21Inflammation - diagnosis
22Inflammation - drug therapy
23Magnetic resonance imaging
24Magnetic Resonance Imaging - methods
25Male
26Medicine
27Medicine & Public Health
28Middle Aged
29Original Paper
30PET imaging
31Phospholipases
32Plaque burden
33Plaque, Atherosclerotic - complications
34Plaque, Atherosclerotic - diagnosis
35Plaque, Atherosclerotic - drug therapy
36positron emission tomography
37Positron-Emission Tomography - methods
38Predictive Value of Tests
39Radiology
40Radiopharmaceuticals
41Sulfhydryl Compounds - therapeutic use
42Tomography, X-Ray Computed - methods
43Treatment Outcome
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titlePredictors of change in carotid atherosclerotic plaque inflammation and burden as measured by 18-FDG-PET and MRI, respectively, in the dal-PLAQUE study
authorMani, Venkatesh ; Woodward, Mark ; Samber, Daniel ; Bucerius, Jan ; Tawakol, Ahmed ; Kallend, David ; Rudd, James H. F ; Abt, Markus ; Fayad, Zahi A
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1Anticholesteremic Agents - therapeutic use
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7Coronary Artery Disease - complications
8Coronary Artery Disease - diagnosis
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38Predictive Value of Tests
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41Sulfhydryl Compounds - therapeutic use
42Tomography, X-Ray Computed - methods
43Treatment Outcome
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abstractBaseline predictors of response to treatment of patients with coronary heart disease (CHD) with respect to vascular inflammation and atherosclerotic plaque burden are poorly understood. From post hoc analysis of the dal-PLAQUE study (NCT00655473), 18F-fluorodeoxyglucose-positron emission tomography (18-FDG-PET) imaging and carotid black blood magnetic resonance imaging (MRI) were used to track changes in these vascular parameters. Baseline demographics, imaging, and biomarkers were collected/measured in 130 patients with CHD or CHD risk-equivalents, and imaging follow-up at 6 months (PET) and 24 months (MRI) was performed. Using stepwise linear regression, predictors of change in carotid plaque inflammation by PET [target-to-background ratio (TBR), n = 92] and plaque burden by MRI [wall area (WA) and total vessel area (TVA), n = 89] were determined. Variables with p  < 0.05 in multivariable models were considered independently significant. Interleukin-6, systolic blood pressure and standard deviation of wall thickness (WT) at baseline were independently positively associated with 18-FDG uptake (mean of maximum [MeanMax] TBR change over 6 months). Mean of mean TBR, phospholipase A 2 , apolipoprotein A-I, and high-sensitivity C-reactive protein at baseline were independently negatively associated with MeanMax TBR change over 6 months. Mean WT and plasminogen activator inhibitor-1 (PAI-1) activity at baseline, and age, were independently associated with change in WA over 24 months. For TVA changes; mean WA and PAI-1 activity at baseline, age, and female gender were independent predictors. These findings may help determine patients most suitable for clinical trials employing plaque inflammation or burden changes as endpoints.
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