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Longitudinal changes in insulin sensitivity and beta cell function between women with and without a history of gestational diabetes mellitus

Aims/hypothesis The aim of the study was to compare longitudinal changes in insulin sensitivity (S I ) and beta cell function between women with and without a history of gestational diabetes mellitus (GDM). Methods The prospective follow-up cohort included 235 parous non-diabetic Mexican–American wo... Full description

Journal Title: Diabetologia 2013, Vol.56 (12), p.2753-2760
Main Author: Xiang, Anny H
Other Authors: Takayanagi, Miwa , Black, Mary Helen , Trigo, Enrique , Lawrence, Jean M , Watanabe, Richard M , Buchanan, Thomas A
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0012-186X
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4139094
title: Longitudinal changes in insulin sensitivity and beta cell function between women with and without a history of gestational diabetes mellitus
format: Article
creator:
  • Xiang, Anny H
  • Takayanagi, Miwa
  • Black, Mary Helen
  • Trigo, Enrique
  • Lawrence, Jean M
  • Watanabe, Richard M
  • Buchanan, Thomas A
subjects:
  • Absorptiometry, Photon
  • Adult
  • Article
  • Beta cell function
  • Biological and medical sciences
  • Blood Glucose - metabolism
  • Body Mass Index
  • Body Weight
  • Diabetes in pregnancy
  • Diabetes, Gestational - genetics
  • Diabetes, Gestational - metabolism
  • Diabetes, Gestational - physiopathology
  • Diabetes. Impaired glucose tolerance
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Gestational diabetes mellitus
  • Glucose Tolerance Test
  • Human Physiology
  • Humans
  • Insulin
  • Insulin Resistance - genetics
  • Insulin sensitivity
  • Insulin-Secreting Cells - metabolism
  • Internal Medicine
  • Longitudinal change
  • Medical sciences
  • Medicine
  • Medicine & Public Health
  • Medicine, Preventive
  • Metabolic Diseases
  • Mexican Americans
  • Pancreatic beta cells
  • Pregnancy
  • Pregnant women
  • Preventive health services
  • Prospective Studies
  • Reference Values
  • Risk Factors
  • Womens history
ispartof: Diabetologia, 2013, Vol.56 (12), p.2753-2760
description: Aims/hypothesis The aim of the study was to compare longitudinal changes in insulin sensitivity (S I ) and beta cell function between women with and without a history of gestational diabetes mellitus (GDM). Methods The prospective follow-up cohort included 235 parous non-diabetic Mexican–American women, 93 with and 142 without a history of GDM. The participants underwent dual-energy x-ray absorptiometry, OGTTs and IVGTTs at baseline and at a median of 4.1 years follow-up. The baseline values and rates of change of metabolic measures were compared between groups. Results At baseline, women with prior GDM (mean age 36.3 years) had similar values of S I but higher percentages of body fat and trunk fat ( p  ≤ 0.02), a lower acute insulin response and poorer beta cell compensation (disposition index [DI]) ( p   0.50). Adjustment for baseline age, adiposity, calorie intake, physical activity, age at first pregnancy, additional pregnancies and changes in adiposity during follow-up increased the between-group differences in the rates of change of S I and DI ( p  ≤ 0.003). Conclusions/interpretation Mexican–American women with recent GDM had a faster deterioration in insulin sensitivity and beta cell compensation than their parous counterparts without GDM. The differences were not explained by differences in adiposity, suggesting more deleterious effects of existing fat and/or reduced beta cell robustness in women with GDM.
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titleLongitudinal changes in insulin sensitivity and beta cell function between women with and without a history of gestational diabetes mellitus
creatorXiang, Anny H ; Takayanagi, Miwa ; Black, Mary Helen ; Trigo, Enrique ; Lawrence, Jean M ; Watanabe, Richard M ; Buchanan, Thomas A
creatorcontribXiang, Anny H ; Takayanagi, Miwa ; Black, Mary Helen ; Trigo, Enrique ; Lawrence, Jean M ; Watanabe, Richard M ; Buchanan, Thomas A
descriptionAims/hypothesis The aim of the study was to compare longitudinal changes in insulin sensitivity (S I ) and beta cell function between women with and without a history of gestational diabetes mellitus (GDM). Methods The prospective follow-up cohort included 235 parous non-diabetic Mexican–American women, 93 with and 142 without a history of GDM. The participants underwent dual-energy x-ray absorptiometry, OGTTs and IVGTTs at baseline and at a median of 4.1 years follow-up. The baseline values and rates of change of metabolic measures were compared between groups. Results At baseline, women with prior GDM (mean age 36.3 years) had similar values of S I but higher percentages of body fat and trunk fat ( p  ≤ 0.02), a lower acute insulin response and poorer beta cell compensation (disposition index [DI]) ( p  < 0.0001) than women without GDM (mean age 37.9 years). During the follow-up, women with GDM had a faster decline in S I ( p  = 0.02) and DI ( p  = 0.02) than their counterparts without GDM, with no significant differences in changes of weight or fat ( p  > 0.50). Adjustment for baseline age, adiposity, calorie intake, physical activity, age at first pregnancy, additional pregnancies and changes in adiposity during follow-up increased the between-group differences in the rates of change of S I and DI ( p  ≤ 0.003). Conclusions/interpretation Mexican–American women with recent GDM had a faster deterioration in insulin sensitivity and beta cell compensation than their parous counterparts without GDM. The differences were not explained by differences in adiposity, suggesting more deleterious effects of existing fat and/or reduced beta cell robustness in women with GDM.
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subjectAbsorptiometry, Photon ; Adult ; Article ; Beta cell function ; Biological and medical sciences ; Blood Glucose - metabolism ; Body Mass Index ; Body Weight ; Diabetes in pregnancy ; Diabetes, Gestational - genetics ; Diabetes, Gestational - metabolism ; Diabetes, Gestational - physiopathology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Follow-Up Studies ; Genetic Predisposition to Disease ; Genetic Variation ; Gestational diabetes mellitus ; Glucose Tolerance Test ; Human Physiology ; Humans ; Insulin ; Insulin Resistance - genetics ; Insulin sensitivity ; Insulin-Secreting Cells - metabolism ; Internal Medicine ; Longitudinal change ; Medical sciences ; Medicine ; Medicine & Public Health ; Medicine, Preventive ; Metabolic Diseases ; Mexican Americans ; Pancreatic beta cells ; Pregnancy ; Pregnant women ; Preventive health services ; Prospective Studies ; Reference Values ; Risk Factors ; Womens history
ispartofDiabetologia, 2013, Vol.56 (12), p.2753-2760
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2Black, Mary Helen
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5Watanabe, Richard M
6Buchanan, Thomas A
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descriptionAims/hypothesis The aim of the study was to compare longitudinal changes in insulin sensitivity (S I ) and beta cell function between women with and without a history of gestational diabetes mellitus (GDM). Methods The prospective follow-up cohort included 235 parous non-diabetic Mexican–American women, 93 with and 142 without a history of GDM. The participants underwent dual-energy x-ray absorptiometry, OGTTs and IVGTTs at baseline and at a median of 4.1 years follow-up. The baseline values and rates of change of metabolic measures were compared between groups. Results At baseline, women with prior GDM (mean age 36.3 years) had similar values of S I but higher percentages of body fat and trunk fat ( p  ≤ 0.02), a lower acute insulin response and poorer beta cell compensation (disposition index [DI]) ( p  < 0.0001) than women without GDM (mean age 37.9 years). During the follow-up, women with GDM had a faster decline in S I ( p  = 0.02) and DI ( p  = 0.02) than their counterparts without GDM, with no significant differences in changes of weight or fat ( p  > 0.50). Adjustment for baseline age, adiposity, calorie intake, physical activity, age at first pregnancy, additional pregnancies and changes in adiposity during follow-up increased the between-group differences in the rates of change of S I and DI ( p  ≤ 0.003). Conclusions/interpretation Mexican–American women with recent GDM had a faster deterioration in insulin sensitivity and beta cell compensation than their parous counterparts without GDM. The differences were not explained by differences in adiposity, suggesting more deleterious effects of existing fat and/or reduced beta cell robustness in women with GDM.
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15Female
16Follow-Up Studies
17Genetic Predisposition to Disease
18Genetic Variation
19Gestational diabetes mellitus
20Glucose Tolerance Test
21Human Physiology
22Humans
23Insulin
24Insulin Resistance - genetics
25Insulin sensitivity
26Insulin-Secreting Cells - metabolism
27Internal Medicine
28Longitudinal change
29Medical sciences
30Medicine
31Medicine & Public Health
32Medicine, Preventive
33Metabolic Diseases
34Mexican Americans
35Pancreatic beta cells
36Pregnancy
37Pregnant women
38Preventive health services
39Prospective Studies
40Reference Values
41Risk Factors
42Womens history
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titleLongitudinal changes in insulin sensitivity and beta cell function between women with and without a history of gestational diabetes mellitus
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6Body Mass Index
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8Diabetes in pregnancy
9Diabetes, Gestational - genetics
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13Endocrine pancreas. Apud cells (diseases)
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39Prospective Studies
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42Womens history
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1Takayanagi, Miwa
2Black, Mary Helen
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atitleLongitudinal changes in insulin sensitivity and beta cell function between women with and without a history of gestational diabetes mellitus
jtitleDiabetologia
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abstractAims/hypothesis The aim of the study was to compare longitudinal changes in insulin sensitivity (S I ) and beta cell function between women with and without a history of gestational diabetes mellitus (GDM). Methods The prospective follow-up cohort included 235 parous non-diabetic Mexican–American women, 93 with and 142 without a history of GDM. The participants underwent dual-energy x-ray absorptiometry, OGTTs and IVGTTs at baseline and at a median of 4.1 years follow-up. The baseline values and rates of change of metabolic measures were compared between groups. Results At baseline, women with prior GDM (mean age 36.3 years) had similar values of S I but higher percentages of body fat and trunk fat ( p  ≤ 0.02), a lower acute insulin response and poorer beta cell compensation (disposition index [DI]) ( p  < 0.0001) than women without GDM (mean age 37.9 years). During the follow-up, women with GDM had a faster decline in S I ( p  = 0.02) and DI ( p  = 0.02) than their counterparts without GDM, with no significant differences in changes of weight or fat ( p  > 0.50). Adjustment for baseline age, adiposity, calorie intake, physical activity, age at first pregnancy, additional pregnancies and changes in adiposity during follow-up increased the between-group differences in the rates of change of S I and DI ( p  ≤ 0.003). Conclusions/interpretation Mexican–American women with recent GDM had a faster deterioration in insulin sensitivity and beta cell compensation than their parous counterparts without GDM. The differences were not explained by differences in adiposity, suggesting more deleterious effects of existing fat and/or reduced beta cell robustness in women with GDM.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
pmid24030069
doi10.1007/s00125-013-3048-0
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