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Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies

Highlights • Baicalin and baicalein display therapeutic potentials for hematological malignancies. • They are associated with diverse cancer targets and signaling pathways. • Potential biological mechanisms in various hematological malignancies are discussed. • Biotransformation and approaches to im... Full description

Journal Title: Cancer letters 2014, Vol.354 (1), p.5-11
Main Author: Chen, Haijun
Other Authors: Gao, Yu , Wu, Jianlei , Chen, Yingyu , Chen, Buyuan , Hu, Jianda , Zhou, Jia
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Ireland: Elsevier Ireland Ltd
ID: ISSN: 0304-3835
Link: https://www.ncbi.nlm.nih.gov/pubmed/25128647
Zum Text:
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4179973
title: Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies
format: Article
creator:
  • Chen, Haijun
  • Gao, Yu
  • Wu, Jianlei
  • Chen, Yingyu
  • Chen, Buyuan
  • Hu, Jianda
  • Zhou, Jia
subjects:
  • Antineoplastic Agents - chemistry
  • Antineoplastic Agents - therapeutic use
  • Article
  • Baicalein
  • Baicalin
  • Biological Availability
  • Biotransformation
  • Cancer
  • Cancer targets
  • Chemotherapy
  • Diet
  • Drug Discovery
  • Flavanones - chemistry
  • Flavanones - therapeutic use
  • Flavonoids
  • Flavonoids - chemistry
  • Flavonoids - therapeutic use
  • Health aspects
  • Hematologic Neoplasms - drug therapy
  • Hematological malignancies
  • Hematology, Oncology and Palliative Medicine
  • Herbal medicine
  • Humans
  • Kinases
  • Pharmaceutical industry
  • Plant Extracts - therapeutic use
  • Polyphenols - chemistry
  • Signal Transduction
ispartof: Cancer letters, 2014, Vol.354 (1), p.5-11
description: Highlights • Baicalin and baicalein display therapeutic potentials for hematological malignancies. • They are associated with diverse cancer targets and signaling pathways. • Potential biological mechanisms in various hematological malignancies are discussed. • Biotransformation and approaches to improve their bioavailability are summarized. • Combination with baicalin or baicalein offers promise as chemotherapeutic adjuvants.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0304-3835
fulltext: fulltext
issn:
  • 0304-3835
  • 1872-7980
url: Link


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descriptionHighlights • Baicalin and baicalein display therapeutic potentials for hematological malignancies. • They are associated with diverse cancer targets and signaling pathways. • Potential biological mechanisms in various hematological malignancies are discussed. • Biotransformation and approaches to improve their bioavailability are summarized. • Combination with baicalin or baicalein offers promise as chemotherapeutic adjuvants.
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subjectAntineoplastic Agents - chemistry ; Antineoplastic Agents - therapeutic use ; Article ; Baicalein ; Baicalin ; Biological Availability ; Biotransformation ; Cancer ; Cancer targets ; Chemotherapy ; Diet ; Drug Discovery ; Flavanones - chemistry ; Flavanones - therapeutic use ; Flavonoids ; Flavonoids - chemistry ; Flavonoids - therapeutic use ; Health aspects ; Hematologic Neoplasms - drug therapy ; Hematological malignancies ; Hematology, Oncology and Palliative Medicine ; Herbal medicine ; Humans ; Kinases ; Pharmaceutical industry ; Plant Extracts - therapeutic use ; Polyphenols - chemistry ; Signal Transduction
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abstractHighlights • Baicalin and baicalein display therapeutic potentials for hematological malignancies. • They are associated with diverse cancer targets and signaling pathways. • Potential biological mechanisms in various hematological malignancies are discussed. • Biotransformation and approaches to improve their bioavailability are summarized. • Combination with baicalin or baicalein offers promise as chemotherapeutic adjuvants.
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pmid25128647
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