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Erythrocyte saturated fatty acids and systemic inflammation in adults

Abstract Objective The role of saturated fatty acids (SFAs) in chronic disease remains controversial; inflammation is one pathway by which SFAs influence the risk for chronic disease. The aim of this study was to investigate the associations between red blood cell (RBC) phospholipid SFAs and systemi... Full description

Journal Title: Nutrition (Burbank Los Angeles County, Calif.), 2014, Vol.30 (11), p.1404-1408
Main Author: Mu, Lin, B.S., B.A
Other Authors: Mukamal, Kenneth J., M.D., M.P.H., M.A , Naqvi, Asghar Z., M.D., M.P.H., M.N.S
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0899-9007
Link: https://www.ncbi.nlm.nih.gov/pubmed/25280420
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4185280
title: Erythrocyte saturated fatty acids and systemic inflammation in adults
format: Article
creator:
  • Mu, Lin, B.S., B.A
  • Mukamal, Kenneth J., M.D., M.P.H., M.A
  • Naqvi, Asghar Z., M.D., M.P.H., M.N.S
subjects:
  • Adult
  • Adults
  • Analysis
  • Article
  • C-Reactive Protein
  • C-Reactive Protein - metabolism
  • Chronic diseases
  • Dietary Fats - blood
  • Erythrocyte Phospholipid
  • Erythrocytes - metabolism
  • Fatty Acids - blood
  • Female
  • Gastroenterology and Hepatology
  • Humans
  • Inflammation
  • Inflammation - blood
  • Interleukin-6
  • Interleukin-6 - blood
  • Leukocyte Count
  • Male
  • Medical colleges
  • Middle Aged
  • Omega-3 fatty acids
  • Palmitic Acid
  • Palmitic Acid - blood
  • Phospholipids - blood
  • Saturated Fat
  • Saturated fatty acids
  • Stearic Acid
  • Stearic Acids - blood
  • Unsaturated fatty acids
  • White Blood Count
ispartof: Nutrition (Burbank, Los Angeles County, Calif.), 2014, Vol.30 (11), p.1404-1408
description: Abstract Objective The role of saturated fatty acids (SFAs) in chronic disease remains controversial; inflammation is one pathway by which SFAs influence the risk for chronic disease. The aim of this study was to investigate the associations between red blood cell (RBC) phospholipid SFAs and systemic inflammation. Methods As part of a randomized controlled trial, we measured RBC phospholipid FA composition in 55 generally healthy adults twice at 3-mo intervals. We estimated associations of RBC total SFAs and two major SFA subtypes, palmitic and stearic acids, with C-reactive protein (CRP), interleukin (IL)-6, white blood count (WBC), and a composite inflammation measure using generalized estimating equations in multivariable FA substitution models. Results Mean (±SD) SFA level across both visits was 45% ± 3% of the total RBC FAs, mainly palmitic (21% ± 1%) and stearic (17% ± 3%) acids. In models adjusted for age, sex, race, smoking, body mass index, statin use, aspirin use, transunsaturated FAs, and ω-3 FAs, SFAs were significantly associated with IL-6 (20% increase per 1 SD increment; 95% confidence interval [CI], 0.03%–43%; P = 0.05) and the composite inflammation measure ( P = 0.05) and marginally associated with CRP (34% increase; 95% CI, −1% to 81%; P = 0.06), but not associated with WBC. Stearic acid was positively associated with CRP (35% increase; 95% CI, 2%–79%; P = 0.04). Palmitic acid was marginally associated with the composite inflammation measure ( P = 0.06) and, upon additional ω-6 FA adjustment, significantly associated with IL-6 (15% increase; 95% CI, 0.4%–27%; P = 0.006). Conclusions RBC SFAs, which represent longer-term dietary intake, are positively associated with inflammation. In particular, palmitic acid was associated with IL-6, and stearic acid was associated with CRP after multivariable adjustment.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0899-9007
fulltext: fulltext
issn:
  • 0899-9007
  • 1873-1244
url: Link


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titleErythrocyte saturated fatty acids and systemic inflammation in adults
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descriptionAbstract Objective The role of saturated fatty acids (SFAs) in chronic disease remains controversial; inflammation is one pathway by which SFAs influence the risk for chronic disease. The aim of this study was to investigate the associations between red blood cell (RBC) phospholipid SFAs and systemic inflammation. Methods As part of a randomized controlled trial, we measured RBC phospholipid FA composition in 55 generally healthy adults twice at 3-mo intervals. We estimated associations of RBC total SFAs and two major SFA subtypes, palmitic and stearic acids, with C-reactive protein (CRP), interleukin (IL)-6, white blood count (WBC), and a composite inflammation measure using generalized estimating equations in multivariable FA substitution models. Results Mean (±SD) SFA level across both visits was 45% ± 3% of the total RBC FAs, mainly palmitic (21% ± 1%) and stearic (17% ± 3%) acids. In models adjusted for age, sex, race, smoking, body mass index, statin use, aspirin use, transunsaturated FAs, and ω-3 FAs, SFAs were significantly associated with IL-6 (20% increase per 1 SD increment; 95% confidence interval [CI], 0.03%–43%; P = 0.05) and the composite inflammation measure ( P = 0.05) and marginally associated with CRP (34% increase; 95% CI, −1% to 81%; P = 0.06), but not associated with WBC. Stearic acid was positively associated with CRP (35% increase; 95% CI, 2%–79%; P = 0.04). Palmitic acid was marginally associated with the composite inflammation measure ( P = 0.06) and, upon additional ω-6 FA adjustment, significantly associated with IL-6 (15% increase; 95% CI, 0.4%–27%; P = 0.006). Conclusions RBC SFAs, which represent longer-term dietary intake, are positively associated with inflammation. In particular, palmitic acid was associated with IL-6, and stearic acid was associated with CRP after multivariable adjustment.
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subjectAdult ; Adults ; Analysis ; Article ; C-Reactive Protein ; C-Reactive Protein - metabolism ; Chronic diseases ; Dietary Fats - blood ; Erythrocyte Phospholipid ; Erythrocytes - metabolism ; Fatty Acids - blood ; Female ; Gastroenterology and Hepatology ; Humans ; Inflammation ; Inflammation - blood ; Interleukin-6 ; Interleukin-6 - blood ; Leukocyte Count ; Male ; Medical colleges ; Middle Aged ; Omega-3 fatty acids ; Palmitic Acid ; Palmitic Acid - blood ; Phospholipids - blood ; Saturated Fat ; Saturated fatty acids ; Stearic Acid ; Stearic Acids - blood ; Unsaturated fatty acids ; White Blood Count
ispartofNutrition (Burbank, Los Angeles County, Calif.), 2014, Vol.30 (11), p.1404-1408
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descriptionAbstract Objective The role of saturated fatty acids (SFAs) in chronic disease remains controversial; inflammation is one pathway by which SFAs influence the risk for chronic disease. The aim of this study was to investigate the associations between red blood cell (RBC) phospholipid SFAs and systemic inflammation. Methods As part of a randomized controlled trial, we measured RBC phospholipid FA composition in 55 generally healthy adults twice at 3-mo intervals. We estimated associations of RBC total SFAs and two major SFA subtypes, palmitic and stearic acids, with C-reactive protein (CRP), interleukin (IL)-6, white blood count (WBC), and a composite inflammation measure using generalized estimating equations in multivariable FA substitution models. Results Mean (±SD) SFA level across both visits was 45% ± 3% of the total RBC FAs, mainly palmitic (21% ± 1%) and stearic (17% ± 3%) acids. In models adjusted for age, sex, race, smoking, body mass index, statin use, aspirin use, transunsaturated FAs, and ω-3 FAs, SFAs were significantly associated with IL-6 (20% increase per 1 SD increment; 95% confidence interval [CI], 0.03%–43%; P = 0.05) and the composite inflammation measure ( P = 0.05) and marginally associated with CRP (34% increase; 95% CI, −1% to 81%; P = 0.06), but not associated with WBC. Stearic acid was positively associated with CRP (35% increase; 95% CI, 2%–79%; P = 0.04). Palmitic acid was marginally associated with the composite inflammation measure ( P = 0.06) and, upon additional ω-6 FA adjustment, significantly associated with IL-6 (15% increase; 95% CI, 0.4%–27%; P = 0.006). Conclusions RBC SFAs, which represent longer-term dietary intake, are positively associated with inflammation. In particular, palmitic acid was associated with IL-6, and stearic acid was associated with CRP after multivariable adjustment.
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titleErythrocyte saturated fatty acids and systemic inflammation in adults
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abstractAbstract Objective The role of saturated fatty acids (SFAs) in chronic disease remains controversial; inflammation is one pathway by which SFAs influence the risk for chronic disease. The aim of this study was to investigate the associations between red blood cell (RBC) phospholipid SFAs and systemic inflammation. Methods As part of a randomized controlled trial, we measured RBC phospholipid FA composition in 55 generally healthy adults twice at 3-mo intervals. We estimated associations of RBC total SFAs and two major SFA subtypes, palmitic and stearic acids, with C-reactive protein (CRP), interleukin (IL)-6, white blood count (WBC), and a composite inflammation measure using generalized estimating equations in multivariable FA substitution models. Results Mean (±SD) SFA level across both visits was 45% ± 3% of the total RBC FAs, mainly palmitic (21% ± 1%) and stearic (17% ± 3%) acids. In models adjusted for age, sex, race, smoking, body mass index, statin use, aspirin use, transunsaturated FAs, and ω-3 FAs, SFAs were significantly associated with IL-6 (20% increase per 1 SD increment; 95% confidence interval [CI], 0.03%–43%; P = 0.05) and the composite inflammation measure ( P = 0.05) and marginally associated with CRP (34% increase; 95% CI, −1% to 81%; P = 0.06), but not associated with WBC. Stearic acid was positively associated with CRP (35% increase; 95% CI, 2%–79%; P = 0.04). Palmitic acid was marginally associated with the composite inflammation measure ( P = 0.06) and, upon additional ω-6 FA adjustment, significantly associated with IL-6 (15% increase; 95% CI, 0.4%–27%; P = 0.006). Conclusions RBC SFAs, which represent longer-term dietary intake, are positively associated with inflammation. In particular, palmitic acid was associated with IL-6, and stearic acid was associated with CRP after multivariable adjustment.
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pmid25280420
doi10.1016/j.nut.2014.04.020
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