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Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer

Abstract Synthetic oligonucleotides (ODN) that express unmethylated “CpG motifs” trigger cells that express Toll-like receptor 9. In humans this includes plasmacytoid dendritic cells and B cells. CpG ODN induce an innate immune response characterized by the production of Th1 and pro-inflammatory cyt... Full description

Journal Title: Vaccine 2014, Vol.32 (48), p.6377-6389
Main Author: Scheiermann, Julia
Other Authors: Klinman, Dennis M
Format: Electronic Article Electronic Article
Language: English
Subjects:
DNA
Quelle: Alma/SFX Local Collection
Publisher: Kidlington: Elsevier Ltd
ID: ISSN: 0264-410X
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4252359
title: Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer
format: Article
creator:
  • Scheiermann, Julia
  • Klinman, Dennis M
subjects:
  • Adjuvant
  • Adjuvants, Immunologic - pharmacology
  • Allergy and Immunology
  • Applied microbiology
  • Article
  • B cells
  • B-Lymphocytes - immunology
  • Biological and medical sciences
  • Cancer
  • Cancer Vaccines - chemistry
  • Chemokines
  • Clinical trials
  • Clinical Trials as Topic
  • CpG olignucleotide
  • Cytokines - immunology
  • Dendritic cells
  • Dendritic Cells - immunology
  • Deoxyribonucleic acid
  • DNA
  • Fundamental and applied biological sciences. Psychology
  • hemic
  • Humans
  • Immune system
  • immune systems
  • Immunity, Innate
  • Immunology
  • Infection
  • Infectious diseases
  • Ligands
  • Lymphocytes
  • Medical sciences
  • Melanoma
  • Microbiology
  • Oligodeoxyribonucleotides - pharmacology
  • respiratory system
  • Signal Transduction
  • Skin cancer
  • Th1 Cells - immunology
  • Toll-like receptor
  • Toll-Like Receptor 9 - immunology
  • Tumors
  • Vaccines
  • Vaccines - chemistry
  • Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
ispartof: Vaccine, 2014, Vol.32 (48), p.6377-6389
description: Abstract Synthetic oligonucleotides (ODN) that express unmethylated “CpG motifs” trigger cells that express Toll-like receptor 9. In humans this includes plasmacytoid dendritic cells and B cells. CpG ODN induce an innate immune response characterized by the production of Th1 and pro-inflammatory cytokines. Their utility as vaccine adjuvants was evaluated in a number of clinical trials. Results indicate that CpG ODN improve antigen presentation and the generation of vaccine-specific cellular and humoral responses. This work provides an up-to-date overview of the utility of CpG ODN as adjuvants for vaccines targeting infectious agents and cancer.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0264-410X
fulltext: fulltext
issn:
  • 0264-410X
  • 1873-2518
url: Link


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descriptionAbstract Synthetic oligonucleotides (ODN) that express unmethylated “CpG motifs” trigger cells that express Toll-like receptor 9. In humans this includes plasmacytoid dendritic cells and B cells. CpG ODN induce an innate immune response characterized by the production of Th1 and pro-inflammatory cytokines. Their utility as vaccine adjuvants was evaluated in a number of clinical trials. Results indicate that CpG ODN improve antigen presentation and the generation of vaccine-specific cellular and humoral responses. This work provides an up-to-date overview of the utility of CpG ODN as adjuvants for vaccines targeting infectious agents and cancer.
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subjectAdjuvant ; Adjuvants, Immunologic - pharmacology ; Allergy and Immunology ; Applied microbiology ; Article ; B cells ; B-Lymphocytes - immunology ; Biological and medical sciences ; Cancer ; Cancer Vaccines - chemistry ; Chemokines ; Clinical trials ; Clinical Trials as Topic ; CpG olignucleotide ; Cytokines - immunology ; Dendritic cells ; Dendritic Cells - immunology ; Deoxyribonucleic acid ; DNA ; Fundamental and applied biological sciences. Psychology ; hemic ; Humans ; Immune system ; immune systems ; Immunity, Innate ; Immunology ; Infection ; Infectious diseases ; Ligands ; Lymphocytes ; Medical sciences ; Melanoma ; Microbiology ; Oligodeoxyribonucleotides - pharmacology ; respiratory system ; Signal Transduction ; Skin cancer ; Th1 Cells - immunology ; Toll-like receptor ; Toll-Like Receptor 9 - immunology ; Tumors ; Vaccines ; Vaccines - chemistry ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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22Immune system
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24Immunity, Innate
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32Microbiology
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34respiratory system
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37Th1 Cells - immunology
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39Toll-Like Receptor 9 - immunology
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42Vaccines - chemistry
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abstractAbstract Synthetic oligonucleotides (ODN) that express unmethylated “CpG motifs” trigger cells that express Toll-like receptor 9. In humans this includes plasmacytoid dendritic cells and B cells. CpG ODN induce an innate immune response characterized by the production of Th1 and pro-inflammatory cytokines. Their utility as vaccine adjuvants was evaluated in a number of clinical trials. Results indicate that CpG ODN improve antigen presentation and the generation of vaccine-specific cellular and humoral responses. This work provides an up-to-date overview of the utility of CpG ODN as adjuvants for vaccines targeting infectious agents and cancer.
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pmid24975812
doi10.1016/j.vaccine.2014.06.065
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