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Type 2 diabetes and mammographic breast density among underserved women

Purpose: We conducted a study of women recruited at Meharry Medical College, a historically black medical school, to investigate the relationship between diabetes and mammographic breast density. Methods: A total of 476 women completed in-person interviews, body measurements, and full-field digital... Full description

Journal Title: Cancer causes & control 2015, Vol.26 (2), p.303-309
Main Author: Sanderson, Maureen
Other Authors: O’Hara, Heather , Foderingham, Nia , Dupont, William D , Shu, Xiao-Ou , Peterson, Neeraja , Fair, Alecia M , Disher, Anthony C
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Cham: Springer
ID: ISSN: 0957-5243
Link: https://www.ncbi.nlm.nih.gov/pubmed/25421380
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4301990
title: Type 2 diabetes and mammographic breast density among underserved women
format: Article
creator:
  • Sanderson, Maureen
  • O’Hara, Heather
  • Foderingham, Nia
  • Dupont, William D
  • Shu, Xiao-Ou
  • Peterson, Neeraja
  • Fair, Alecia M
  • Disher, Anthony C
subjects:
  • Adult
  • Aged
  • Algorithms
  • Article
  • Biomedical and Life Sciences
  • Biomedicine
  • Body Mass Index
  • Breast
  • Breast cancer
  • Breast Density
  • Breast Neoplasms - complications
  • Breast Neoplasms - diagnostic imaging
  • Breast Neoplasms - ethnology
  • Brief Report
  • BRIEF REPORTS
  • Cancer Research
  • Complications and side effects
  • Cross-Sectional Studies
  • cross-sectional study
  • Diabetes Mellitus, Type 2 - complications
  • Epidemiology
  • Female
  • general
  • Genetic aspects
  • Health aspects
  • Hematology
  • Humans
  • Insulin - metabolism
  • Mammary Glands, Human - abnormalities
  • Mammary Glands, Human - physiopathology
  • mammographic breast density
  • Mammography
  • Mammography - methods
  • Medically Underserved Area
  • Menopause
  • Middle Aged
  • Oncology
  • Premenopause
  • Prevalence
  • Public Health
  • Risk Factors
  • Type 2 diabetes
  • underserved
  • Usage
ispartof: Cancer causes & control, 2015, Vol.26 (2), p.303-309
description: Purpose: We conducted a study of women recruited at Meharry Medical College, a historically black medical school, to investigate the relationship between diabetes and mammographic breast density. Methods: A total of 476 women completed in-person interviews, body measurements, and full-field digital mammograms on a Hologic mammography unit from December 2011 to February 2014. Average percent breast density for the left and right breasts combined was estimated using Quantra, an automated algorithm for volumetric assessment of breast tissue. The prevalence of type 2 diabetes was determined by self-report. Results: After adjustment for confounding variables, the mean percent breast density among premenopausal women with type 2 diabetes (μ̂ 13.8 %, 95 % confidence interval (CI) 11.6–15.9] was nonsignificantly lower than that of women without type 2 diabetes (μ̂ 15.9 %, 95 % CI 15.0–16.8) (p = 0.07); however, there was no association among postmenopausal women. The effect of type 2 diabetes in severely obese women (BMI ≥ 35) appeared to differ by menopausal status with a reduction in mean percent breast density in premenopausal women, but an increase in mean percent breast density in postmenopausal women which could have been due to chance. Conclusions: Confirmation of our findings in larger studies may assist in clarifying the role of the insulin signaling breast cancer pathway in women with high breast density.
language: eng
source:
identifier: ISSN: 0957-5243
fulltext: no_fulltext
issn:
  • 0957-5243
  • 1573-7225
url: Link


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descriptionPurpose: We conducted a study of women recruited at Meharry Medical College, a historically black medical school, to investigate the relationship between diabetes and mammographic breast density. Methods: A total of 476 women completed in-person interviews, body measurements, and full-field digital mammograms on a Hologic mammography unit from December 2011 to February 2014. Average percent breast density for the left and right breasts combined was estimated using Quantra, an automated algorithm for volumetric assessment of breast tissue. The prevalence of type 2 diabetes was determined by self-report. Results: After adjustment for confounding variables, the mean percent breast density among premenopausal women with type 2 diabetes (μ̂ 13.8 %, 95 % confidence interval (CI) 11.6–15.9] was nonsignificantly lower than that of women without type 2 diabetes (μ̂ 15.9 %, 95 % CI 15.0–16.8) (p = 0.07); however, there was no association among postmenopausal women. The effect of type 2 diabetes in severely obese women (BMI ≥ 35) appeared to differ by menopausal status with a reduction in mean percent breast density in premenopausal women, but an increase in mean percent breast density in postmenopausal women which could have been due to chance. Conclusions: Confirmation of our findings in larger studies may assist in clarifying the role of the insulin signaling breast cancer pathway in women with high breast density.
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subjectAdult ; Aged ; Algorithms ; Article ; Biomedical and Life Sciences ; Biomedicine ; Body Mass Index ; Breast ; Breast cancer ; Breast Density ; Breast Neoplasms - complications ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - ethnology ; Brief Report ; BRIEF REPORTS ; Cancer Research ; Complications and side effects ; Cross-Sectional Studies ; cross-sectional study ; Diabetes Mellitus, Type 2 - complications ; Epidemiology ; Female ; general ; Genetic aspects ; Health aspects ; Hematology ; Humans ; Insulin - metabolism ; Mammary Glands, Human - abnormalities ; Mammary Glands, Human - physiopathology ; mammographic breast density ; Mammography ; Mammography - methods ; Medically Underserved Area ; Menopause ; Middle Aged ; Oncology ; Premenopause ; Prevalence ; Public Health ; Risk Factors ; Type 2 diabetes ; underserved ; Usage
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5Peterson, Neeraja
6Fair, Alecia M
7Disher, Anthony C
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descriptionPurpose: We conducted a study of women recruited at Meharry Medical College, a historically black medical school, to investigate the relationship between diabetes and mammographic breast density. Methods: A total of 476 women completed in-person interviews, body measurements, and full-field digital mammograms on a Hologic mammography unit from December 2011 to February 2014. Average percent breast density for the left and right breasts combined was estimated using Quantra, an automated algorithm for volumetric assessment of breast tissue. The prevalence of type 2 diabetes was determined by self-report. Results: After adjustment for confounding variables, the mean percent breast density among premenopausal women with type 2 diabetes (μ̂ 13.8 %, 95 % confidence interval (CI) 11.6–15.9] was nonsignificantly lower than that of women without type 2 diabetes (μ̂ 15.9 %, 95 % CI 15.0–16.8) (p = 0.07); however, there was no association among postmenopausal women. The effect of type 2 diabetes in severely obese women (BMI ≥ 35) appeared to differ by menopausal status with a reduction in mean percent breast density in premenopausal women, but an increase in mean percent breast density in postmenopausal women which could have been due to chance. Conclusions: Confirmation of our findings in larger studies may assist in clarifying the role of the insulin signaling breast cancer pathway in women with high breast density.
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abstractPurpose: We conducted a study of women recruited at Meharry Medical College, a historically black medical school, to investigate the relationship between diabetes and mammographic breast density. Methods: A total of 476 women completed in-person interviews, body measurements, and full-field digital mammograms on a Hologic mammography unit from December 2011 to February 2014. Average percent breast density for the left and right breasts combined was estimated using Quantra, an automated algorithm for volumetric assessment of breast tissue. The prevalence of type 2 diabetes was determined by self-report. Results: After adjustment for confounding variables, the mean percent breast density among premenopausal women with type 2 diabetes (μ̂ 13.8 %, 95 % confidence interval (CI) 11.6–15.9] was nonsignificantly lower than that of women without type 2 diabetes (μ̂ 15.9 %, 95 % CI 15.0–16.8) (p = 0.07); however, there was no association among postmenopausal women. The effect of type 2 diabetes in severely obese women (BMI ≥ 35) appeared to differ by menopausal status with a reduction in mean percent breast density in premenopausal women, but an increase in mean percent breast density in postmenopausal women which could have been due to chance. Conclusions: Confirmation of our findings in larger studies may assist in clarifying the role of the insulin signaling breast cancer pathway in women with high breast density.
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