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Age trajectories of glycaemic traits in non-diabetic South Asian and white individuals: the Whitehall II cohort study

Aims/hypothesis South Asian individuals have an increased prevalence of type 2 diabetes, but little is known about the development of glycaemic traits in this ethnic group. We compared age-related changes in glycaemic traits between non-diabetic South Asian and white participants. Methods In a prosp... Full description

Journal Title: Diabetologia 2014, Vol.58 (3), p.534-542
Main Author: Ikehara, Satoyo
Other Authors: Tabák, Adam G , Akbaraly, Tasnime N , Hulmán, Adam , Kivimäki, Mika , Forouhi, Nita G , Iso, Hiroyasu , Brunner, Eric J
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0012-186X
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4320303
title: Age trajectories of glycaemic traits in non-diabetic South Asian and white individuals: the Whitehall II cohort study
format: Article
creator:
  • Ikehara, Satoyo
  • Tabák, Adam G
  • Akbaraly, Tasnime N
  • Hulmán, Adam
  • Kivimäki, Mika
  • Forouhi, Nita G
  • Iso, Hiroyasu
  • Brunner, Eric J
subjects:
  • Adult
  • Aged
  • Analysis
  • Article
  • Asia
  • Blood Glucose - metabolism
  • Cohort Studies
  • Cohort study
  • Dextrose
  • Diabetes
  • Diabetes Mellitus, Type 2 - blood
  • Diabetes Mellitus, Type 2 - epidemiology
  • Endocrinology
  • Ethnicity
  • Fasting glucose
  • Fasting insulin
  • Female
  • Glucose
  • Glucose metabolism
  • Glycaemic trajectory
  • Human health
  • Human health and pathology
  • Human Physiology
  • Humans
  • Insulin - blood
  • Insulin resistance
  • Insulin Resistance - physiology
  • Insulin secretion
  • Insulin sensitivity
  • Internal Medicine
  • Life Sciences
  • load glucose
  • Male
  • Medicine
  • Medicine & Public Health
  • Metabolic Diseases
  • Metabolism
  • Middle Aged
  • Pancreatic beta cells
  • pathology
  • Post
  • Post-load glucose
  • Prospective Studies
  • Public health
  • South Asian
  • Type 2 diabetes
ispartof: Diabetologia, 2014, Vol.58 (3), p.534-542
description: Aims/hypothesis South Asian individuals have an increased prevalence of type 2 diabetes, but little is known about the development of glycaemic traits in this ethnic group. We compared age-related changes in glycaemic traits between non-diabetic South Asian and white participants. Methods In a prospective British occupational cohort with 5-yearly clinical examinations ( n  = 230/5,749 South Asian/white participants, age 39–79 years at baseline), age-related trajectories of fasting glucose (FG) and 2 h post-load glucose (PLG), log-transformed fasting insulin (FINS) and 2 h post-load insulin (PLINS), HOMA insulin sensitivity (HOMA2-%S) and HOMA insulin secretion (HOMA2-%B) were fitted for South Asian and white individuals who remained free of diabetes between 1991 and 2009. Results In sex-adjusted multilevel models, FG was stable in white participants but increased with age in South Asians (0.12 [SE = 0.04] mmol/l per decade). PLG, FINS and PLINS levels were lower among white participants (by 0.271 [SE = 0.092] mmol/l, 0.306 [SE = 0.046] log pmol/l, 0.707 [SE = 0.059] log pmol/l at age 50, respectively) compared with South Asians, although their age-related trajectories were parallel. HOMA2-%S was higher (0.226 [SE = 0.038] at age 50) and HOMA2-%B lower (by 0.189 [SE = 0.026] at age 50) among white than South Asian participants. The age-related decline in HOMA2-%S was similar in these groups, but the age-related increase in HOMA2-%B was greater in white participants (0.04 [SE = 0.02] per decade). This difference was explained by obesity, lifestyle and social status. Conclusions/interpretation Findings from a diabetes-free population suggest an inadequate pancreatic beta cell reserve in South Asians, as a significantly steeper age-related increase in FG was observed in this ethnic group compared with white individuals.
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titleAge trajectories of glycaemic traits in non-diabetic South Asian and white individuals: the Whitehall II cohort study
creatorIkehara, Satoyo ; Tabák, Adam G ; Akbaraly, Tasnime N ; Hulmán, Adam ; Kivimäki, Mika ; Forouhi, Nita G ; Iso, Hiroyasu ; Brunner, Eric J
creatorcontribIkehara, Satoyo ; Tabák, Adam G ; Akbaraly, Tasnime N ; Hulmán, Adam ; Kivimäki, Mika ; Forouhi, Nita G ; Iso, Hiroyasu ; Brunner, Eric J
descriptionAims/hypothesis South Asian individuals have an increased prevalence of type 2 diabetes, but little is known about the development of glycaemic traits in this ethnic group. We compared age-related changes in glycaemic traits between non-diabetic South Asian and white participants. Methods In a prospective British occupational cohort with 5-yearly clinical examinations ( n  = 230/5,749 South Asian/white participants, age 39–79 years at baseline), age-related trajectories of fasting glucose (FG) and 2 h post-load glucose (PLG), log-transformed fasting insulin (FINS) and 2 h post-load insulin (PLINS), HOMA insulin sensitivity (HOMA2-%S) and HOMA insulin secretion (HOMA2-%B) were fitted for South Asian and white individuals who remained free of diabetes between 1991 and 2009. Results In sex-adjusted multilevel models, FG was stable in white participants but increased with age in South Asians (0.12 [SE = 0.04] mmol/l per decade). PLG, FINS and PLINS levels were lower among white participants (by 0.271 [SE = 0.092] mmol/l, 0.306 [SE = 0.046] log pmol/l, 0.707 [SE = 0.059] log pmol/l at age 50, respectively) compared with South Asians, although their age-related trajectories were parallel. HOMA2-%S was higher (0.226 [SE = 0.038] at age 50) and HOMA2-%B lower (by 0.189 [SE = 0.026] at age 50) among white than South Asian participants. The age-related decline in HOMA2-%S was similar in these groups, but the age-related increase in HOMA2-%B was greater in white participants (0.04 [SE = 0.02] per decade). This difference was explained by obesity, lifestyle and social status. Conclusions/interpretation Findings from a diabetes-free population suggest an inadequate pancreatic beta cell reserve in South Asians, as a significantly steeper age-related increase in FG was observed in this ethnic group compared with white individuals.
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languageeng
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subjectAdult ; Aged ; Analysis ; Article ; Asia ; Blood Glucose - metabolism ; Cohort Studies ; Cohort study ; Dextrose ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - epidemiology ; Endocrinology ; Ethnicity ; Fasting glucose ; Fasting insulin ; Female ; Glucose ; Glucose metabolism ; Glycaemic trajectory ; Human health ; Human health and pathology ; Human Physiology ; Humans ; Insulin - blood ; Insulin resistance ; Insulin Resistance - physiology ; Insulin secretion ; Insulin sensitivity ; Internal Medicine ; Life Sciences ; load glucose ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolism ; Middle Aged ; Pancreatic beta cells ; pathology ; Post ; Post-load glucose ; Prospective Studies ; Public health ; South Asian ; Type 2 diabetes
ispartofDiabetologia, 2014, Vol.58 (3), p.534-542
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1Tabák, Adam G
2Akbaraly, Tasnime N
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4Kivimäki, Mika
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6Iso, Hiroyasu
7Brunner, Eric J
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descriptionAims/hypothesis South Asian individuals have an increased prevalence of type 2 diabetes, but little is known about the development of glycaemic traits in this ethnic group. We compared age-related changes in glycaemic traits between non-diabetic South Asian and white participants. Methods In a prospective British occupational cohort with 5-yearly clinical examinations ( n  = 230/5,749 South Asian/white participants, age 39–79 years at baseline), age-related trajectories of fasting glucose (FG) and 2 h post-load glucose (PLG), log-transformed fasting insulin (FINS) and 2 h post-load insulin (PLINS), HOMA insulin sensitivity (HOMA2-%S) and HOMA insulin secretion (HOMA2-%B) were fitted for South Asian and white individuals who remained free of diabetes between 1991 and 2009. Results In sex-adjusted multilevel models, FG was stable in white participants but increased with age in South Asians (0.12 [SE = 0.04] mmol/l per decade). PLG, FINS and PLINS levels were lower among white participants (by 0.271 [SE = 0.092] mmol/l, 0.306 [SE = 0.046] log pmol/l, 0.707 [SE = 0.059] log pmol/l at age 50, respectively) compared with South Asians, although their age-related trajectories were parallel. HOMA2-%S was higher (0.226 [SE = 0.038] at age 50) and HOMA2-%B lower (by 0.189 [SE = 0.026] at age 50) among white than South Asian participants. The age-related decline in HOMA2-%S was similar in these groups, but the age-related increase in HOMA2-%B was greater in white participants (0.04 [SE = 0.02] per decade). This difference was explained by obesity, lifestyle and social status. Conclusions/interpretation Findings from a diabetes-free population suggest an inadequate pancreatic beta cell reserve in South Asians, as a significantly steeper age-related increase in FG was observed in this ethnic group compared with white individuals.
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titleAge trajectories of glycaemic traits in non-diabetic South Asian and white individuals: the Whitehall II cohort study
authorIkehara, Satoyo ; Tabák, Adam G ; Akbaraly, Tasnime N ; Hulmán, Adam ; Kivimäki, Mika ; Forouhi, Nita G ; Iso, Hiroyasu ; Brunner, Eric J
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abstractAims/hypothesis South Asian individuals have an increased prevalence of type 2 diabetes, but little is known about the development of glycaemic traits in this ethnic group. We compared age-related changes in glycaemic traits between non-diabetic South Asian and white participants. Methods In a prospective British occupational cohort with 5-yearly clinical examinations ( n  = 230/5,749 South Asian/white participants, age 39–79 years at baseline), age-related trajectories of fasting glucose (FG) and 2 h post-load glucose (PLG), log-transformed fasting insulin (FINS) and 2 h post-load insulin (PLINS), HOMA insulin sensitivity (HOMA2-%S) and HOMA insulin secretion (HOMA2-%B) were fitted for South Asian and white individuals who remained free of diabetes between 1991 and 2009. Results In sex-adjusted multilevel models, FG was stable in white participants but increased with age in South Asians (0.12 [SE = 0.04] mmol/l per decade). PLG, FINS and PLINS levels were lower among white participants (by 0.271 [SE = 0.092] mmol/l, 0.306 [SE = 0.046] log pmol/l, 0.707 [SE = 0.059] log pmol/l at age 50, respectively) compared with South Asians, although their age-related trajectories were parallel. HOMA2-%S was higher (0.226 [SE = 0.038] at age 50) and HOMA2-%B lower (by 0.189 [SE = 0.026] at age 50) among white than South Asian participants. The age-related decline in HOMA2-%S was similar in these groups, but the age-related increase in HOMA2-%B was greater in white participants (0.04 [SE = 0.02] per decade). This difference was explained by obesity, lifestyle and social status. Conclusions/interpretation Findings from a diabetes-free population suggest an inadequate pancreatic beta cell reserve in South Asians, as a significantly steeper age-related increase in FG was observed in this ethnic group compared with white individuals.
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