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Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: Complete protection of rhesus monkeys from mucosal SHIV challenge

Highlights • We used IgG1 and dimeric IgA2 versions of the V3-loop specific mAb HGN194. • HGN194 IgG1 given iv at a low dose to monkeys: 0% protection from SHIV infection. • Same iv HGN194 IgG1 dose plus mucosally administered dimeric IgA2: 100% protection. • HGN194 dimeric IgA2 given mucosally as s... Full description

Journal Title: Vaccine 2015, Vol.33 (17), p.2086-2095
Main Author: Sholukh, Anton M
Other Authors: Watkins, Jennifer D , Vyas, Hemant K , Gupta, Sandeep , Lakhashe, Samir K , Thorat, Swati , Zhou, Mingkui , Hemashettar, Girish , Bachler, Barbara C , Forthal, Donald N , Villinger, Francois , Sattentau, Quentin J , Weiss, Robin A , Agatic, Gloria , Corti, Davide , Lanzavecchia, Antonio , Heeney, Jonathan L , Ruprecht, Ruth M
Format: Electronic Article Electronic Article
Language: English
Subjects:
HIV
IgA
IgG
Quelle: Alma/SFX Local Collection
Publisher: Netherlands: Elsevier Ltd
ID: ISSN: 0264-410X
Link: https://www.ncbi.nlm.nih.gov/pubmed/25769884
Zum Text:
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4411954
title: Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: Complete protection of rhesus monkeys from mucosal SHIV challenge
format: Article
creator:
  • Sholukh, Anton M
  • Watkins, Jennifer D
  • Vyas, Hemant K
  • Gupta, Sandeep
  • Lakhashe, Samir K
  • Thorat, Swati
  • Zhou, Mingkui
  • Hemashettar, Girish
  • Bachler, Barbara C
  • Forthal, Donald N
  • Villinger, Francois
  • Sattentau, Quentin J
  • Weiss, Robin A
  • Agatic, Gloria
  • Corti, Davide
  • Lanzavecchia, Antonio
  • Heeney, Jonathan L
  • Ruprecht, Ruth M
subjects:
  • 6 max
  • Acquired immune deficiency syndrome
  • Administration, Intravenous
  • Administration, Mucosal
  • AIDS
  • Allergy and Immunology
  • Animals
  • Antibodies, Monoclonal - administration & dosage
  • Antibodies, Monoclonal - immunology
  • Antibodies, Neutralizing - administration & dosage
  • Article
  • C mucosal challenge
  • Complete protection
  • Environmental
  • HIV
  • HIV (Viruses)
  • HIV Antibodies - administration & dosage
  • HIV Antibodies - blood
  • HIV-1 - immunology
  • Human immunodeficiency virus
  • Human immunodeficiency virus 1
  • Humans
  • IgA
  • IgG
  • Immunity, Cellular
  • Immunity, Mucosal
  • Immunization
  • Immunization, Passive
  • Immunoglobulin A
  • Immunoglobulin A - administration & dosage
  • Immunoglobulin A - blood
  • Immunoglobulin A - immunology
  • Immunoglobulin G
  • Immunoglobulin G - administration & dosage
  • Immunoglobulin G - blood
  • Immunoglobulin G - immunology
  • Immunology
  • Infectious Diseases
  • Macaca mulatta
  • Medical research
  • Microbiology(all)
  • Molecular Medicine
  • Mucous Membrane - immunology
  • Occupational Health
  • Passive immunization
  • Public Health
  • Rhesus monkey
  • RNA, Viral - blood
  • SHIV-C mucosal challenge
  • Simian Acquired Immunodeficiency Syndrome - immunology
  • Simian Acquired Immunodeficiency Syndrome - prevention & control
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus - immunology
  • Simian Immunodeficiency Virus - pathogenicity
  • Simian/human immunodeficiency virus
  • Swine influenza virus
  • T-Lymphocytes - immunology
  • Vaccines
  • veterinary(all)
ispartof: Vaccine, 2015, Vol.33 (17), p.2086-2095
description: Highlights • We used IgG1 and dimeric IgA2 versions of the V3-loop specific mAb HGN194. • HGN194 IgG1 given iv at a low dose to monkeys: 0% protection from SHIV infection. • Same iv HGN194 IgG1 dose plus mucosally administered dimeric IgA2: 100% protection. • HGN194 dimeric IgA2 given mucosally as single agent: only 17% protection. • Systemic plus mucosal passive immunization: proof-of-concept for defense-in-depth.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0264-410X
fulltext: fulltext
issn:
  • 0264-410X
  • 1873-2518
url: Link


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creatorSholukh, Anton M ; Watkins, Jennifer D ; Vyas, Hemant K ; Gupta, Sandeep ; Lakhashe, Samir K ; Thorat, Swati ; Zhou, Mingkui ; Hemashettar, Girish ; Bachler, Barbara C ; Forthal, Donald N ; Villinger, Francois ; Sattentau, Quentin J ; Weiss, Robin A ; Agatic, Gloria ; Corti, Davide ; Lanzavecchia, Antonio ; Heeney, Jonathan L ; Ruprecht, Ruth M
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descriptionHighlights • We used IgG1 and dimeric IgA2 versions of the V3-loop specific mAb HGN194. • HGN194 IgG1 given iv at a low dose to monkeys: 0% protection from SHIV infection. • Same iv HGN194 IgG1 dose plus mucosally administered dimeric IgA2: 100% protection. • HGN194 dimeric IgA2 given mucosally as single agent: only 17% protection. • Systemic plus mucosal passive immunization: proof-of-concept for defense-in-depth.
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12Weiss, Robin A
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descriptionHighlights • We used IgG1 and dimeric IgA2 versions of the V3-loop specific mAb HGN194. • HGN194 IgG1 given iv at a low dose to monkeys: 0% protection from SHIV infection. • Same iv HGN194 IgG1 dose plus mucosally administered dimeric IgA2: 100% protection. • HGN194 dimeric IgA2 given mucosally as single agent: only 17% protection. • Systemic plus mucosal passive immunization: proof-of-concept for defense-in-depth.
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2Administration, Intravenous
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4AIDS
5Allergy and Immunology
6Animals
7Antibodies, Monoclonal - administration & dosage
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9Antibodies, Neutralizing - administration & dosage
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13Environmental
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19Human immunodeficiency virus
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26Immunization
27Immunization, Passive
28Immunoglobulin A
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30Immunoglobulin A - blood
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32Immunoglobulin G
33Immunoglobulin G - administration & dosage
34Immunoglobulin G - blood
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53Simian Immunodeficiency Virus - pathogenicity
54Simian/human immunodeficiency virus
55Swine influenza virus
56T-Lymphocytes - immunology
57Vaccines
58veterinary(all)
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titleDefense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: Complete protection of rhesus monkeys from mucosal SHIV challenge
authorSholukh, Anton M ; Watkins, Jennifer D ; Vyas, Hemant K ; Gupta, Sandeep ; Lakhashe, Samir K ; Thorat, Swati ; Zhou, Mingkui ; Hemashettar, Girish ; Bachler, Barbara C ; Forthal, Donald N ; Villinger, Francois ; Sattentau, Quentin J ; Weiss, Robin A ; Agatic, Gloria ; Corti, Davide ; Lanzavecchia, Antonio ; Heeney, Jonathan L ; Ruprecht, Ruth M
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6Animals
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8Antibodies, Monoclonal - immunology
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20Human immunodeficiency virus 1
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25Immunity, Mucosal
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34Immunoglobulin G - blood
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49Simian Acquired Immunodeficiency Syndrome - immunology
50Simian Acquired Immunodeficiency Syndrome - prevention & control
51Simian immunodeficiency virus
52Simian Immunodeficiency Virus - immunology
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54Simian/human immunodeficiency virus
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56T-Lymphocytes - immunology
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58veterinary(all)
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abstractHighlights • We used IgG1 and dimeric IgA2 versions of the V3-loop specific mAb HGN194. • HGN194 IgG1 given iv at a low dose to monkeys: 0% protection from SHIV infection. • Same iv HGN194 IgG1 dose plus mucosally administered dimeric IgA2: 100% protection. • HGN194 dimeric IgA2 given mucosally as single agent: only 17% protection. • Systemic plus mucosal passive immunization: proof-of-concept for defense-in-depth.
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