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Effects of Serum Creatinine Calibration on Estimated Renal Function in African Americans: The Jackson Heart Study

Abstract Background The calibration to isotope dilution mass spectrometry-traceable creatinine is essential for valid use of the new Chronic Kidney Disease Epidemiology Collaboration equation to estimate the glomerular filtration rate. Methods For 5,210 participants in the Jackson Heart study (JHs),... Full description

Journal Title: The American journal of the medical sciences 2015, Vol.349 (5), p.379-384
Main Author: Wang, Wei, PhD
Other Authors: Griswold, Michael E., PhD , Young, Bessie A., MD, MPH , de Boer, Ian H., MD, MS , Katz, Ronit, DPhil , Fülöp, Tibor, MD , Correa, Adolfo, MD, PhD , Ebony Boulware, L., MD, MPH
Format: Electronic Article Electronic Article
Language: English
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Publisher: United States: Elsevier Inc
ID: ISSN: 0002-9629
Link: https://www.ncbi.nlm.nih.gov/pubmed/25806862
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4414728
title: Effects of Serum Creatinine Calibration on Estimated Renal Function in African Americans: The Jackson Heart Study
format: Article
creator:
  • Wang, Wei, PhD
  • Griswold, Michael E., PhD
  • Young, Bessie A., MD, MPH
  • de Boer, Ian H., MD, MS
  • Katz, Ronit, DPhil
  • Fülöp, Tibor, MD
  • Correa, Adolfo, MD, PhD
  • Ebony Boulware, L., MD, MPH
subjects:
  • Abridged Index Medicus
  • Adult
  • African Americans
  • Aged
  • Article
  • Calibration
  • Chronic Kidney Disease
  • CKD-EPI equation
  • Creatinine - analysis
  • Creatinine - blood
  • Deming regression
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Internal Medicine
  • Kidney Function Tests - methods
  • Kidney Function Tests - standards
  • Logistic Models
  • Male
  • Middle Aged
  • Prospective Studies
  • Renal Insufficiency, Chronic - blood
  • Renal Insufficiency, Chronic - ethnology
  • Serum Creatinine
  • Spectrophotometry - methods
  • Spectrophotometry - standards
  • United States
ispartof: The American journal of the medical sciences, 2015, Vol.349 (5), p.379-384
description: Abstract Background The calibration to isotope dilution mass spectrometry-traceable creatinine is essential for valid use of the new Chronic Kidney Disease Epidemiology Collaboration equation to estimate the glomerular filtration rate. Methods For 5,210 participants in the Jackson Heart study (JHs), serum creatinine was measured with a multipoint enzymatic spectrophotometric assay at the baseline visit (2000–2004) and remeasured using the Roche enzymatic method, traceable to isotope dilution mass spectrometry in a subset of 206 subjects. The 200 eligible samples (6 were excluded, 1 for failure of the remeasurement and 5 for outliers) were divided into 3 disjoint sets—training, validation and test—to select a calibration model, estimate true errors and assess performance of the final calibration equation. The calibration equation was applied to serum creatinine measurements of 5,210 participants to estimate glomerular filtration rate and the prevalence of chronic kidney disease (CKD). Results The selected Deming regression model provided a slope of 0.968 (95% confidence interval [CI], 0.904–1.053) and intercept of − 0.0248 (95% CI, − 0.0862 to 0.0366) with R2 value of 0.9527. Calibrated serum creatinine showed high agreement with actual measurements when applying to the unused test set (concordance correlation coefficient 0.934, 95% CI, 0.894–0.960). The baseline prevalence of CKD in the JHS (2000–2004) was 6.30% using calibrated values compared with 8.29% using noncalibrated serum creatinine with the Chronic Kidney Disease Epidemiology Collaboration equation ( P < 0.001). Conclusions A Deming regression model was chosen to optimally calibrate baseline serum creatinine measurements in the JHS, and the calibrated values provide a lower CKD prevalence estimate.
language: eng
source:
identifier: ISSN: 0002-9629
fulltext: no_fulltext
issn:
  • 0002-9629
  • 1538-2990
url: Link


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titleEffects of Serum Creatinine Calibration on Estimated Renal Function in African Americans: The Jackson Heart Study
creatorWang, Wei, PhD ; Griswold, Michael E., PhD ; Young, Bessie A., MD, MPH ; de Boer, Ian H., MD, MS ; Katz, Ronit, DPhil ; Fülöp, Tibor, MD ; Correa, Adolfo, MD, PhD ; Ebony Boulware, L., MD, MPH
creatorcontribWang, Wei, PhD ; Griswold, Michael E., PhD ; Young, Bessie A., MD, MPH ; de Boer, Ian H., MD, MS ; Katz, Ronit, DPhil ; Fülöp, Tibor, MD ; Correa, Adolfo, MD, PhD ; Ebony Boulware, L., MD, MPH
descriptionAbstract Background The calibration to isotope dilution mass spectrometry-traceable creatinine is essential for valid use of the new Chronic Kidney Disease Epidemiology Collaboration equation to estimate the glomerular filtration rate. Methods For 5,210 participants in the Jackson Heart study (JHs), serum creatinine was measured with a multipoint enzymatic spectrophotometric assay at the baseline visit (2000–2004) and remeasured using the Roche enzymatic method, traceable to isotope dilution mass spectrometry in a subset of 206 subjects. The 200 eligible samples (6 were excluded, 1 for failure of the remeasurement and 5 for outliers) were divided into 3 disjoint sets—training, validation and test—to select a calibration model, estimate true errors and assess performance of the final calibration equation. The calibration equation was applied to serum creatinine measurements of 5,210 participants to estimate glomerular filtration rate and the prevalence of chronic kidney disease (CKD). Results The selected Deming regression model provided a slope of 0.968 (95% confidence interval [CI], 0.904–1.053) and intercept of − 0.0248 (95% CI, − 0.0862 to 0.0366) with R2 value of 0.9527. Calibrated serum creatinine showed high agreement with actual measurements when applying to the unused test set (concordance correlation coefficient 0.934, 95% CI, 0.894–0.960). The baseline prevalence of CKD in the JHS (2000–2004) was 6.30% using calibrated values compared with 8.29% using noncalibrated serum creatinine with the Chronic Kidney Disease Epidemiology Collaboration equation ( P < 0.001). Conclusions A Deming regression model was chosen to optimally calibrate baseline serum creatinine measurements in the JHS, and the calibrated values provide a lower CKD prevalence estimate.
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subjectAbridged Index Medicus ; Adult ; African Americans ; Aged ; Article ; Calibration ; Chronic Kidney Disease ; CKD-EPI equation ; Creatinine - analysis ; Creatinine - blood ; Deming regression ; Female ; Glomerular Filtration Rate ; Humans ; Internal Medicine ; Kidney Function Tests - methods ; Kidney Function Tests - standards ; Logistic Models ; Male ; Middle Aged ; Prospective Studies ; Renal Insufficiency, Chronic - blood ; Renal Insufficiency, Chronic - ethnology ; Serum Creatinine ; Spectrophotometry - methods ; Spectrophotometry - standards ; United States
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descriptionAbstract Background The calibration to isotope dilution mass spectrometry-traceable creatinine is essential for valid use of the new Chronic Kidney Disease Epidemiology Collaboration equation to estimate the glomerular filtration rate. Methods For 5,210 participants in the Jackson Heart study (JHs), serum creatinine was measured with a multipoint enzymatic spectrophotometric assay at the baseline visit (2000–2004) and remeasured using the Roche enzymatic method, traceable to isotope dilution mass spectrometry in a subset of 206 subjects. The 200 eligible samples (6 were excluded, 1 for failure of the remeasurement and 5 for outliers) were divided into 3 disjoint sets—training, validation and test—to select a calibration model, estimate true errors and assess performance of the final calibration equation. The calibration equation was applied to serum creatinine measurements of 5,210 participants to estimate glomerular filtration rate and the prevalence of chronic kidney disease (CKD). Results The selected Deming regression model provided a slope of 0.968 (95% confidence interval [CI], 0.904–1.053) and intercept of − 0.0248 (95% CI, − 0.0862 to 0.0366) with R2 value of 0.9527. Calibrated serum creatinine showed high agreement with actual measurements when applying to the unused test set (concordance correlation coefficient 0.934, 95% CI, 0.894–0.960). The baseline prevalence of CKD in the JHS (2000–2004) was 6.30% using calibrated values compared with 8.29% using noncalibrated serum creatinine with the Chronic Kidney Disease Epidemiology Collaboration equation ( P < 0.001). Conclusions A Deming regression model was chosen to optimally calibrate baseline serum creatinine measurements in the JHS, and the calibrated values provide a lower CKD prevalence estimate.
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titleEffects of Serum Creatinine Calibration on Estimated Renal Function in African Americans: The Jackson Heart Study
authorWang, Wei, PhD ; Griswold, Michael E., PhD ; Young, Bessie A., MD, MPH ; de Boer, Ian H., MD, MS ; Katz, Ronit, DPhil ; Fülöp, Tibor, MD ; Correa, Adolfo, MD, PhD ; Ebony Boulware, L., MD, MPH
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abstractAbstract Background The calibration to isotope dilution mass spectrometry-traceable creatinine is essential for valid use of the new Chronic Kidney Disease Epidemiology Collaboration equation to estimate the glomerular filtration rate. Methods For 5,210 participants in the Jackson Heart study (JHs), serum creatinine was measured with a multipoint enzymatic spectrophotometric assay at the baseline visit (2000–2004) and remeasured using the Roche enzymatic method, traceable to isotope dilution mass spectrometry in a subset of 206 subjects. The 200 eligible samples (6 were excluded, 1 for failure of the remeasurement and 5 for outliers) were divided into 3 disjoint sets—training, validation and test—to select a calibration model, estimate true errors and assess performance of the final calibration equation. The calibration equation was applied to serum creatinine measurements of 5,210 participants to estimate glomerular filtration rate and the prevalence of chronic kidney disease (CKD). Results The selected Deming regression model provided a slope of 0.968 (95% confidence interval [CI], 0.904–1.053) and intercept of − 0.0248 (95% CI, − 0.0862 to 0.0366) with R2 value of 0.9527. Calibrated serum creatinine showed high agreement with actual measurements when applying to the unused test set (concordance correlation coefficient 0.934, 95% CI, 0.894–0.960). The baseline prevalence of CKD in the JHS (2000–2004) was 6.30% using calibrated values compared with 8.29% using noncalibrated serum creatinine with the Chronic Kidney Disease Epidemiology Collaboration equation ( P < 0.001). Conclusions A Deming regression model was chosen to optimally calibrate baseline serum creatinine measurements in the JHS, and the calibrated values provide a lower CKD prevalence estimate.
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doi10.1097/MAJ.0000000000000446
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