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Kruppel-like factors in muscle health and disease

Abstract Kruppel-like factors (KLF) are zinc-finger DNA-binding transcription factors that are critical regulators of tissue homeostasis. Emerging evidence suggests that KLFs are critical regulators of muscle biology in the context of cardiovascular health and disease. The focus of this review is to... Full description

Journal Title: Trends in cardiovascular medicine 2015, Vol.25 (4), p.278-287
Main Author: Prosdocimo, Domenick A., PhD
Other Authors: Sabeh, M. Khaled, MD , Jain, Mukesh K., MD
Format: Electronic Article Electronic Article
Language: English
Subjects:
DNA
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 1050-1738
Link: https://www.ncbi.nlm.nih.gov/pubmed/25528994
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title: Kruppel-like factors in muscle health and disease
format: Article
creator:
  • Prosdocimo, Domenick A., PhD
  • Sabeh, M. Khaled, MD
  • Jain, Mukesh K., MD
subjects:
  • Article
  • Cardiomyocytes
  • Cardiomyopathy
  • Cardiovascular
  • Cardiovascular disease
  • Cardiovascular Diseases - etiology
  • Cardiovascular Diseases - genetics
  • Cardiovascular Diseases - metabolism
  • Deoxyribonucleic acid
  • DNA
  • Genes
  • Heart
  • Homeostasis
  • Hospitals
  • Humans
  • Kruppel-Like Transcription Factors - genetics
  • Kruppel-Like Transcription Factors - metabolism
  • Laboratories
  • Metabolism
  • Mortality
  • Muscle, Skeletal - metabolism
  • Muscle, Smooth - metabolism
  • Mutation
  • Myocardium - metabolism
  • Pathogenesis
  • Physiology
  • Proteins
  • Roles
  • Studies
  • Transcription factors
  • Up-Regulation
ispartof: Trends in cardiovascular medicine, 2015, Vol.25 (4), p.278-287
description: Abstract Kruppel-like factors (KLF) are zinc-finger DNA-binding transcription factors that are critical regulators of tissue homeostasis. Emerging evidence suggests that KLFs are critical regulators of muscle biology in the context of cardiovascular health and disease. The focus of this review is to provide an overview of the current state of knowledge regarding the physiologic and pathologic roles of KLFs in the three lineages of muscle: cardiac, smooth, and skeletal.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1050-1738
fulltext: fulltext
issn:
  • 1050-1738
  • 1873-2615
url: Link


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descriptionAbstract Kruppel-like factors (KLF) are zinc-finger DNA-binding transcription factors that are critical regulators of tissue homeostasis. Emerging evidence suggests that KLFs are critical regulators of muscle biology in the context of cardiovascular health and disease. The focus of this review is to provide an overview of the current state of knowledge regarding the physiologic and pathologic roles of KLFs in the three lineages of muscle: cardiac, smooth, and skeletal.
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subjectArticle ; Cardiomyocytes ; Cardiomyopathy ; Cardiovascular ; Cardiovascular disease ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - metabolism ; Deoxyribonucleic acid ; DNA ; Genes ; Heart ; Homeostasis ; Hospitals ; Humans ; Kruppel-Like Transcription Factors - genetics ; Kruppel-Like Transcription Factors - metabolism ; Laboratories ; Metabolism ; Mortality ; Muscle, Skeletal - metabolism ; Muscle, Smooth - metabolism ; Mutation ; Myocardium - metabolism ; Pathogenesis ; Physiology ; Proteins ; Roles ; Studies ; Transcription factors ; Up-Regulation
ispartofTrends in cardiovascular medicine, 2015, Vol.25 (4), p.278-287
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abstractAbstract Kruppel-like factors (KLF) are zinc-finger DNA-binding transcription factors that are critical regulators of tissue homeostasis. Emerging evidence suggests that KLFs are critical regulators of muscle biology in the context of cardiovascular health and disease. The focus of this review is to provide an overview of the current state of knowledge regarding the physiologic and pathologic roles of KLFs in the three lineages of muscle: cardiac, smooth, and skeletal.
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