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Nomograms in oncology: more than meets the eye

Summary Nomograms are widely used as prognostic devices in oncology and medicine. With the ability to generate an individual probability of a clinical event by integrating diverse prognostic and determinant variables, nomograms meet our desire for biologically and clinically integrated models and fu... Full description

Journal Title: The lancet oncology 2015, Vol.16 (4), p.e173-e180
Main Author: Balachandran, Vinod P, Dr
Other Authors: Gonen, Mithat, PhD , Smith, J Joshua, MD , DeMatteo, Ronald P, MD
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: Elsevier Ltd
ID: ISSN: 1470-2045
Link: https://www.ncbi.nlm.nih.gov/pubmed/25846097
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title: Nomograms in oncology: more than meets the eye
format: Article
creator:
  • Balachandran, Vinod P, Dr
  • Gonen, Mithat, PhD
  • Smith, J Joshua, MD
  • DeMatteo, Ronald P, MD
subjects:
  • Article
  • Cancer therapies
  • Decision making
  • Disease
  • Disease-Free Survival
  • genetic structures
  • Hematology, Oncology and Palliative Medicine
  • Humans
  • male genital diseases
  • Mathematical models
  • Medical prognosis
  • Metastasis
  • Neoplasms - diagnosis
  • Neoplasms - pathology
  • Nomograms
  • Oncology
  • outcome
  • Population
  • Prognosis
  • staging
  • Surgery
  • Tumors
  • urologic
  • Variables
ispartof: The lancet oncology, 2015, Vol.16 (4), p.e173-e180
description: Summary Nomograms are widely used as prognostic devices in oncology and medicine. With the ability to generate an individual probability of a clinical event by integrating diverse prognostic and determinant variables, nomograms meet our desire for biologically and clinically integrated models and fulfill our drive towards personalised medicine. Rapid computation through user-friendly digital interfaces, together with increased accuracy, and more easily understood prognoses compared with conventional staging, allow for seamless incorporation of nomogram-derived prognosis to aid clinical decision making. This has led to the appearance of many nomograms on the internet and in medical journals, and an increase in nomogram use by patients and physicians alike. However, the statistical foundations of nomogram construction, their precise interpretation, and evidence supporting their use are generally misunderstood. This issue is leading to an under-appreciation of the inherent uncertainties regarding nomogram use. We provide a systematic, practical approach to evaluating and comprehending nomogram-derived prognoses, with particular emphasis on clarifying common misconceptions and highlighting limitations.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1470-2045
fulltext: fulltext
issn:
  • 1470-2045
  • 1474-5488
url: Link


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descriptionSummary Nomograms are widely used as prognostic devices in oncology and medicine. With the ability to generate an individual probability of a clinical event by integrating diverse prognostic and determinant variables, nomograms meet our desire for biologically and clinically integrated models and fulfill our drive towards personalised medicine. Rapid computation through user-friendly digital interfaces, together with increased accuracy, and more easily understood prognoses compared with conventional staging, allow for seamless incorporation of nomogram-derived prognosis to aid clinical decision making. This has led to the appearance of many nomograms on the internet and in medical journals, and an increase in nomogram use by patients and physicians alike. However, the statistical foundations of nomogram construction, their precise interpretation, and evidence supporting their use are generally misunderstood. This issue is leading to an under-appreciation of the inherent uncertainties regarding nomogram use. We provide a systematic, practical approach to evaluating and comprehending nomogram-derived prognoses, with particular emphasis on clarifying common misconceptions and highlighting limitations.
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subjectArticle ; Cancer therapies ; Decision making ; Disease ; Disease-Free Survival ; genetic structures ; Hematology, Oncology and Palliative Medicine ; Humans ; male genital diseases ; Mathematical models ; Medical prognosis ; Metastasis ; Neoplasms - diagnosis ; Neoplasms - pathology ; Nomograms ; Oncology ; outcome ; Population ; Prognosis ; staging ; Surgery ; Tumors ; urologic ; Variables
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abstractSummary Nomograms are widely used as prognostic devices in oncology and medicine. With the ability to generate an individual probability of a clinical event by integrating diverse prognostic and determinant variables, nomograms meet our desire for biologically and clinically integrated models and fulfill our drive towards personalised medicine. Rapid computation through user-friendly digital interfaces, together with increased accuracy, and more easily understood prognoses compared with conventional staging, allow for seamless incorporation of nomogram-derived prognosis to aid clinical decision making. This has led to the appearance of many nomograms on the internet and in medical journals, and an increase in nomogram use by patients and physicians alike. However, the statistical foundations of nomogram construction, their precise interpretation, and evidence supporting their use are generally misunderstood. This issue is leading to an under-appreciation of the inherent uncertainties regarding nomogram use. We provide a systematic, practical approach to evaluating and comprehending nomogram-derived prognoses, with particular emphasis on clarifying common misconceptions and highlighting limitations.
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