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Multifaceted role of prohibitin in cell survival and apoptosis

Human eukaryotic prohibitin (prohibitin-1 and prohibitin-2) is a membrane protein with different cellular localizations. It is involved in multiple cellular functions, including energy metabolism, proliferation, apoptosis, and senescence. The subcellular localization of prohibitin may determine its... Full description

Journal Title: Apoptosis 2015-06-20, Vol.20 (9), p.1135-1149
Main Author: Peng, Ya-Ting
Other Authors: Chen, Ping , Ouyang, Ruo-Yun , Song, Lei
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: New York: Springer US
ID: ISSN: 1360-8185
Link: https://www.ncbi.nlm.nih.gov/pubmed/26091791
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4531144
title: Multifaceted role of prohibitin in cell survival and apoptosis
format: Article
creator:
  • Peng, Ya-Ting
  • Chen, Ping
  • Ouyang, Ruo-Yun
  • Song, Lei
subjects:
  • Active Transport, Cell Nucleus
  • Aging - metabolism
  • Animals
  • Apoptosis
  • Biochemistry
  • Biomedical and Life Sciences
  • Biomedicine
  • Biosynthesis
  • Cancer Research
  • Cell Biology
  • Cell Membrane - metabolism
  • Cell Nucleus - metabolism
  • Cell Proliferation
  • Cell Survival
  • Clinical Biochemistry
  • general
  • Genomics
  • Humans
  • medical
  • Mitochondria - metabolism
  • Mitochondrial DNA
  • Oncology
  • Original Paper
  • Pharmaceutical Science
  • Pharmacology
  • Prohibitin
  • Protein Processing, Post-Translational
  • Repressor Proteins - genetics
  • Repressor Proteins - metabolism
  • Survival
  • Virology
ispartof: Apoptosis, 2015-06-20, Vol.20 (9), p.1135-1149
description: Human eukaryotic prohibitin (prohibitin-1 and prohibitin-2) is a membrane protein with different cellular localizations. It is involved in multiple cellular functions, including energy metabolism, proliferation, apoptosis, and senescence. The subcellular localization of prohibitin may determine its functions. Membrane prohibitin regulate the cellular signaling of membrane transport, nuclear prohibitin control transcription activation and the cell cycle, and mitochondrial prohibitin complex stabilize the mitochondrial genome and modulate mitochondrial dynamics, mitochondrial morphology, mitochondrial biogenesis, and the mitochondrial intrinsic apoptotic pathway. Moreover, prohibitin can translocates into the nucleus or the mitochondria under apoptotic signals and the subcellular shuttling of prohibitin is necessary for apoptosis process. Apoptosis is the process of programmed cell death that is important for the maintenance of normal physiological functions. Consequently, any alteration in the content, post-transcriptional modification (i.e. phosphorylation) or the nuclear or mitochondrial translocation of prohibitin may influence cell fate. Understanding the mechanisms of the expression and regulation of prohibitin may be useful for future research. This review provides an overview of the multifaceted and essential roles played by prohibitin in the regulation of cell survival and apoptosis.
language: eng
source:
identifier: ISSN: 1360-8185
fulltext: no_fulltext
issn:
  • 1360-8185
  • 1573-675X
url: Link


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descriptionHuman eukaryotic prohibitin (prohibitin-1 and prohibitin-2) is a membrane protein with different cellular localizations. It is involved in multiple cellular functions, including energy metabolism, proliferation, apoptosis, and senescence. The subcellular localization of prohibitin may determine its functions. Membrane prohibitin regulate the cellular signaling of membrane transport, nuclear prohibitin control transcription activation and the cell cycle, and mitochondrial prohibitin complex stabilize the mitochondrial genome and modulate mitochondrial dynamics, mitochondrial morphology, mitochondrial biogenesis, and the mitochondrial intrinsic apoptotic pathway. Moreover, prohibitin can translocates into the nucleus or the mitochondria under apoptotic signals and the subcellular shuttling of prohibitin is necessary for apoptosis process. Apoptosis is the process of programmed cell death that is important for the maintenance of normal physiological functions. Consequently, any alteration in the content, post-transcriptional modification (i.e. phosphorylation) or the nuclear or mitochondrial translocation of prohibitin may influence cell fate. Understanding the mechanisms of the expression and regulation of prohibitin may be useful for future research. This review provides an overview of the multifaceted and essential roles played by prohibitin in the regulation of cell survival and apoptosis.
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subjectActive Transport, Cell Nucleus ; Aging - metabolism ; Animals ; Apoptosis ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Biosynthesis ; Cancer Research ; Cell Biology ; Cell Membrane - metabolism ; Cell Nucleus - metabolism ; Cell Proliferation ; Cell Survival ; Clinical Biochemistry ; general ; Genomics ; Humans ; medical ; Mitochondria - metabolism ; Mitochondrial DNA ; Oncology ; Original Paper ; Pharmaceutical Science ; Pharmacology ; Prohibitin ; Protein Processing, Post-Translational ; Repressor Proteins - genetics ; Repressor Proteins - metabolism ; Survival ; Virology
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descriptionHuman eukaryotic prohibitin (prohibitin-1 and prohibitin-2) is a membrane protein with different cellular localizations. It is involved in multiple cellular functions, including energy metabolism, proliferation, apoptosis, and senescence. The subcellular localization of prohibitin may determine its functions. Membrane prohibitin regulate the cellular signaling of membrane transport, nuclear prohibitin control transcription activation and the cell cycle, and mitochondrial prohibitin complex stabilize the mitochondrial genome and modulate mitochondrial dynamics, mitochondrial morphology, mitochondrial biogenesis, and the mitochondrial intrinsic apoptotic pathway. Moreover, prohibitin can translocates into the nucleus or the mitochondria under apoptotic signals and the subcellular shuttling of prohibitin is necessary for apoptosis process. Apoptosis is the process of programmed cell death that is important for the maintenance of normal physiological functions. Consequently, any alteration in the content, post-transcriptional modification (i.e. phosphorylation) or the nuclear or mitochondrial translocation of prohibitin may influence cell fate. Understanding the mechanisms of the expression and regulation of prohibitin may be useful for future research. This review provides an overview of the multifaceted and essential roles played by prohibitin in the regulation of cell survival and apoptosis.
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20Mitochondrial DNA
21Oncology
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30Virology
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abstractHuman eukaryotic prohibitin (prohibitin-1 and prohibitin-2) is a membrane protein with different cellular localizations. It is involved in multiple cellular functions, including energy metabolism, proliferation, apoptosis, and senescence. The subcellular localization of prohibitin may determine its functions. Membrane prohibitin regulate the cellular signaling of membrane transport, nuclear prohibitin control transcription activation and the cell cycle, and mitochondrial prohibitin complex stabilize the mitochondrial genome and modulate mitochondrial dynamics, mitochondrial morphology, mitochondrial biogenesis, and the mitochondrial intrinsic apoptotic pathway. Moreover, prohibitin can translocates into the nucleus or the mitochondria under apoptotic signals and the subcellular shuttling of prohibitin is necessary for apoptosis process. Apoptosis is the process of programmed cell death that is important for the maintenance of normal physiological functions. Consequently, any alteration in the content, post-transcriptional modification (i.e. phosphorylation) or the nuclear or mitochondrial translocation of prohibitin may influence cell fate. Understanding the mechanisms of the expression and regulation of prohibitin may be useful for future research. This review provides an overview of the multifaceted and essential roles played by prohibitin in the regulation of cell survival and apoptosis.
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