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Understanding immune protection against tuberculosis using RNA expression profiling

Abstract A major limitation in the development and testing of new tuberculosis (TB) vaccines is the current inadequate understanding of the nature of the immune response required for protection against either infection with Mycobacterium tuberculosis (MTB) or progression to disease. Genome wide RNA... Full description

Journal Title: Vaccine 2015, Vol.33 (40), p.5289-5293
Main Author: von Both, Ulrich
Other Authors: Kaforou, Myrsini , Levin, Michael , Newton, Sandra M
Format: Electronic Article Electronic Article
Language: English
Subjects:
RNA
Quelle: Alma/SFX Local Collection
Publisher: Netherlands: Elsevier Ltd
ID: ISSN: 0264-410X
Link: https://www.ncbi.nlm.nih.gov/pubmed/26006085
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title: Understanding immune protection against tuberculosis using RNA expression profiling
format: Article
creator:
  • von Both, Ulrich
  • Kaforou, Myrsini
  • Levin, Michael
  • Newton, Sandra M
subjects:
  • Allergy and Immunology
  • Antigens
  • Article
  • bacille Calmette–Guerin
  • BCG, bacille Calmette–Guerin
  • Biological response modifiers
  • Biomarkers
  • Biomedical research
  • Datasets
  • Defects
  • Development and progression
  • Environmental
  • Female
  • gamma
  • Gene expression
  • Gene Expression Profiling
  • Genomes
  • Humans
  • IFN-γ, interferon-gamma
  • Immunology
  • Infections
  • Infectious Diseases
  • Interferon
  • Interferon-gamma - genetics
  • Interferon-gamma - immunology
  • Interferon-γ
  • Latent Tuberculosis - genetics
  • Latent Tuberculosis - immunology
  • latent tuberculosis infection
  • Long term
  • LTBI, latent tuberculosis infection
  • Male
  • Mendelian susceptibility to mycobacterial disease
  • Microbiology(all)
  • Middle Aged
  • Molecular Medicine
  • MSMD, Mendelian susceptibility to mycobacterial disease
  • MTB, Mycobacterium tuberculosis
  • Mycobacterium tuberculosis
  • Occupational Health
  • Patients
  • PBMC, peripheral blood mononuclear cells
  • peripheral blood mononuclear cells
  • Public Health
  • RNA
  • RNA - genetics
  • RNA expression profiling
  • Scholarships & fellowships
  • TB, tuberculosis
  • Transcriptomics
  • Tuberculosis
  • Tuberculosis - genetics
  • Tuberculosis - immunology
  • Tuberculosis - prevention & control
  • Tuberculosis vaccines
  • Tuberculosis Vaccines - immunology
  • Type I interferon
  • Vaccines
  • veterinary(all)
ispartof: Vaccine, 2015, Vol.33 (40), p.5289-5293
description: Abstract A major limitation in the development and testing of new tuberculosis (TB) vaccines is the current inadequate understanding of the nature of the immune response required for protection against either infection with Mycobacterium tuberculosis (MTB) or progression to disease. Genome wide RNA expression analysis has provided a new tool with which to study the inflammatory and immunological response to mycobacteria. To explore how currently available transcriptomic data might be used to understand the basis of protective immunity to MTB, we analysed and reviewed published RNA expression studies to (1) identify a “susceptible” immune response in patients with acquired defects in the interferon gamma pathway; (2) identify the “failing” transcriptomic response in patients with TB as compared with latent TB infection (LTBI); and (3) identify elements of the “protective” response in healthy latently infected and healthy uninfected individuals.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0264-410X
fulltext: fulltext
issn:
  • 0264-410X
  • 1873-2518
url: Link


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descriptionAbstract A major limitation in the development and testing of new tuberculosis (TB) vaccines is the current inadequate understanding of the nature of the immune response required for protection against either infection with Mycobacterium tuberculosis (MTB) or progression to disease. Genome wide RNA expression analysis has provided a new tool with which to study the inflammatory and immunological response to mycobacteria. To explore how currently available transcriptomic data might be used to understand the basis of protective immunity to MTB, we analysed and reviewed published RNA expression studies to (1) identify a “susceptible” immune response in patients with acquired defects in the interferon gamma pathway; (2) identify the “failing” transcriptomic response in patients with TB as compared with latent TB infection (LTBI); and (3) identify elements of the “protective” response in healthy latently infected and healthy uninfected individuals.
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languageeng
publisherNetherlands: Elsevier Ltd
subjectAllergy and Immunology ; Antigens ; Article ; bacille Calmette–Guerin ; BCG, bacille Calmette–Guerin ; Biological response modifiers ; Biomarkers ; Biomedical research ; Datasets ; Defects ; Development and progression ; Environmental ; Female ; gamma ; Gene expression ; Gene Expression Profiling ; Genomes ; Humans ; IFN-γ, interferon-gamma ; Immunology ; Infections ; Infectious Diseases ; Interferon ; Interferon-gamma - genetics ; Interferon-gamma - immunology ; Interferon-γ ; Latent Tuberculosis - genetics ; Latent Tuberculosis - immunology ; latent tuberculosis infection ; Long term ; LTBI, latent tuberculosis infection ; Male ; Mendelian susceptibility to mycobacterial disease ; Microbiology(all) ; Middle Aged ; Molecular Medicine ; MSMD, Mendelian susceptibility to mycobacterial disease ; MTB, Mycobacterium tuberculosis ; Mycobacterium tuberculosis ; Occupational Health ; Patients ; PBMC, peripheral blood mononuclear cells ; peripheral blood mononuclear cells ; Public Health ; RNA ; RNA - genetics ; RNA expression profiling ; Scholarships & fellowships ; TB, tuberculosis ; Transcriptomics ; Tuberculosis ; Tuberculosis - genetics ; Tuberculosis - immunology ; Tuberculosis - prevention & control ; Tuberculosis vaccines ; Tuberculosis Vaccines - immunology ; Type I interferon ; Vaccines ; veterinary(all)
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descriptionAbstract A major limitation in the development and testing of new tuberculosis (TB) vaccines is the current inadequate understanding of the nature of the immune response required for protection against either infection with Mycobacterium tuberculosis (MTB) or progression to disease. Genome wide RNA expression analysis has provided a new tool with which to study the inflammatory and immunological response to mycobacteria. To explore how currently available transcriptomic data might be used to understand the basis of protective immunity to MTB, we analysed and reviewed published RNA expression studies to (1) identify a “susceptible” immune response in patients with acquired defects in the interferon gamma pathway; (2) identify the “failing” transcriptomic response in patients with TB as compared with latent TB infection (LTBI); and (3) identify elements of the “protective” response in healthy latently infected and healthy uninfected individuals.
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57Vaccines
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abstractAbstract A major limitation in the development and testing of new tuberculosis (TB) vaccines is the current inadequate understanding of the nature of the immune response required for protection against either infection with Mycobacterium tuberculosis (MTB) or progression to disease. Genome wide RNA expression analysis has provided a new tool with which to study the inflammatory and immunological response to mycobacteria. To explore how currently available transcriptomic data might be used to understand the basis of protective immunity to MTB, we analysed and reviewed published RNA expression studies to (1) identify a “susceptible” immune response in patients with acquired defects in the interferon gamma pathway; (2) identify the “failing” transcriptomic response in patients with TB as compared with latent TB infection (LTBI); and (3) identify elements of the “protective” response in healthy latently infected and healthy uninfected individuals.
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