Understanding immune protection against tuberculosis using RNA expression profiling

Journal Title:	Vaccine 2015, Vol.33 (40), p.5289-5293
Main Author:	von Both, Ulrich
Other Authors:	Kaforou, Myrsini , Levin, Michael , Newton, Sandra M
Format:	Electronic Article
Language:	English
Subjects:	Allergy and Immunology Antigens Article bacille Calmette–Guerin BCG, bacille Calmette–Guerin Biological response modifiers Biomarkers Biomedical research Datasets Defects Development and progression Environmental Female gamma Gene expression Gene Expression Profiling Genomes Humans IFN-γ, interferon-gamma Immunology Infections Infectious Diseases Interferon Interferon-gamma - genetics Interferon-gamma - immunology Interferon-γ Latent Tuberculosis - genetics Latent Tuberculosis - immunology latent tuberculosis infection Long term LTBI, latent tuberculosis infection Male Mendelian susceptibility to mycobacterial disease Microbiology(all) Middle Aged Molecular Medicine MSMD, Mendelian susceptibility to mycobacterial disease MTB, Mycobacterium tuberculosis Mycobacterium tuberculosis Occupational Health Patients PBMC, peripheral blood mononuclear cells peripheral blood mononuclear cells Public Health RNA RNA - genetics RNA expression profiling Scholarships & fellowships TB, tuberculosis Transcriptomics Tuberculosis Tuberculosis - genetics Tuberculosis - immunology Tuberculosis - prevention & control Tuberculosis vaccines Tuberculosis Vaccines - immunology Type I interferon Vaccines veterinary(all)
Quelle:	Alma/SFX Local Collection
Publisher:	Netherlands: Elsevier Ltd
ID:	ISSN: 0264-410X
Link:	https://www.ncbi.nlm.nih.gov/pubmed/26006085
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title:	Understanding immune protection against tuberculosis using RNA expression profiling
format:	Article
creator:	von Both, Ulrich Kaforou, Myrsini Levin, Michael Newton, Sandra M
subjects:	Allergy and Immunology Antigens Article bacille Calmette–Guerin BCG, bacille Calmette–Guerin Biological response modifiers Biomarkers Biomedical research Datasets Defects Development and progression Environmental Female gamma Gene expression Gene Expression Profiling Genomes Humans IFN-γ, interferon-gamma Immunology Infections Infectious Diseases Interferon Interferon-gamma - genetics Interferon-gamma - immunology Interferon-γ Latent Tuberculosis - genetics Latent Tuberculosis - immunology latent tuberculosis infection Long term LTBI, latent tuberculosis infection Male Mendelian susceptibility to mycobacterial disease Microbiology(all) Middle Aged Molecular Medicine MSMD, Mendelian susceptibility to mycobacterial disease MTB, Mycobacterium tuberculosis Mycobacterium tuberculosis Occupational Health Patients PBMC, peripheral blood mononuclear cells peripheral blood mononuclear cells Public Health RNA RNA - genetics RNA expression profiling Scholarships & fellowships TB, tuberculosis Transcriptomics Tuberculosis Tuberculosis - genetics Tuberculosis - immunology Tuberculosis - prevention & control Tuberculosis vaccines Tuberculosis Vaccines - immunology Type I interferon Vaccines veterinary(all)
ispartof:	Vaccine, 2015, Vol.33 (40), p.5289-5293
description:	Abstract A major limitation in the development and testing of new tuberculosis (TB) vaccines is the current inadequate understanding of the nature of the immune response required for protection against either infection with Mycobacterium tuberculosis (MTB) or progression to disease. Genome wide RNA expression analysis has provided a new tool with which to study the inflammatory and immunological response to mycobacteria. To explore how currently available transcriptomic data might be used to understand the basis of protective immunity to MTB, we analysed and reviewed published RNA expression studies to (1) identify a “susceptible” immune response in patients with acquired defects in the interferon gamma pathway; (2) identify the “failing” transcriptomic response in patients with TB as compared with latent TB infection (LTBI); and (3) identify elements of the “protective” response in healthy latently infected and healthy uninfected individuals.
language:	eng
source:	Alma/SFX Local Collection
identifier:	ISSN: 0264-410X
fulltext:	fulltext
issn:	0264-410X 1873-2518
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Understanding immune protection against tuberculosis using RNA expression profiling

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Alma/SFX Local Collection

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von Both, Ulrich ; Kaforou, Myrsini ; Levin, Michael ; Newton, Sandra M

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von Both, Ulrich ; Kaforou, Myrsini ; Levin, Michael ; Newton, Sandra M

description

Abstract A major limitation in the development and testing of new tuberculosis (TB) vaccines is the current inadequate understanding of the nature of the immune response required for protection against either infection with Mycobacterium tuberculosis (MTB) or progression to disease. Genome wide RNA expression analysis has provided a new tool with which to study the inflammatory and immunological response to mycobacteria. To explore how currently available transcriptomic data might be used to understand the basis of protective immunity to MTB, we analysed and reviewed published RNA expression studies to (1) identify a “susceptible” immune response in patients with acquired defects in the interferon gamma pathway; (2) identify the “failing” transcriptomic response in patients with TB as compared with latent TB infection (LTBI); and (3) identify elements of the “protective” response in healthy latently infected and healthy uninfected individuals.

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1	EISSN: 1873-2518
2	DOI: 10.1016/j.vaccine.2015.05.025
3	PMID: 26006085

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eng

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Netherlands: Elsevier Ltd

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Allergy and Immunology ; Antigens ; Article ; bacille Calmette–Guerin ; BCG, bacille Calmette–Guerin ; Biological response modifiers ; Biomarkers ; Biomedical research ; Datasets ; Defects ; Development and progression ; Environmental ; Female ; gamma ; Gene expression ; Gene Expression Profiling ; Genomes ; Humans ; IFN-γ, interferon-gamma ; Immunology ; Infections ; Infectious Diseases ; Interferon ; Interferon-gamma - genetics ; Interferon-gamma - immunology ; Interferon-γ ; Latent Tuberculosis - genetics ; Latent Tuberculosis - immunology ; latent tuberculosis infection ; Long term ; LTBI, latent tuberculosis infection ; Male ; Mendelian susceptibility to mycobacterial disease ; Microbiology(all) ; Middle Aged ; Molecular Medicine ; MSMD, Mendelian susceptibility to mycobacterial disease ; MTB, Mycobacterium tuberculosis ; Mycobacterium tuberculosis ; Occupational Health ; Patients ; PBMC, peripheral blood mononuclear cells ; peripheral blood mononuclear cells ; Public Health ; RNA ; RNA - genetics ; RNA expression profiling ; Scholarships & fellowships ; TB, tuberculosis ; Transcriptomics ; Tuberculosis ; Tuberculosis - genetics ; Tuberculosis - immunology ; Tuberculosis - prevention & control ; Tuberculosis vaccines ; Tuberculosis Vaccines - immunology ; Type I interferon ; Vaccines ; veterinary(all)

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Vaccine, 2015, Vol.33 (40), p.5289-5293

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title	Understanding immune protection against tuberculosis using RNA expression profiling
author	von Both, Ulrich ; Kaforou, Myrsini ; Levin, Michael ; Newton, Sandra M

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4	BCG, bacille Calmette–Guerin
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6	Biomarkers
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1	Kaforou, Myrsini
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Understanding immune protection against tuberculosis using RNA expression profiling

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notes

These authors contributed equally to this work.

abstract

cop

Netherlands

pub

Elsevier Ltd

pmid

26006085

doi

10.1016/j.vaccine.2015.05.025

orcidid

https://orcid.org/0000-0001-9878-4007

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Understanding immune protection against tuberculosis using RNA expression profiling