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Longitudinal changes in pancreatic and adipocyte hormones following Roux-en-Y gastric bypass surgery

Aims/hypothesis Bariatric surgery is an effective treatment for severe obesity, as in addition to dramatic weight loss, co-morbidities such as type 2 diabetes are frequently resolved. Although altered gastrointestinal peptide hormone secretion and its relationship with post-surgical improvements in... Full description

Journal Title: Diabetologia 2008, Vol.51 (10), p.1901-1911
Main Author: Swarbrick, M. M
Other Authors: Stanhope, K. L , Austrheim-Smith, I. T , Van Loan, M. D , Ali, M. R , Wolfe, B. M , Havel, P. J
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
ID: ISSN: 0012-186X
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title: Longitudinal changes in pancreatic and adipocyte hormones following Roux-en-Y gastric bypass surgery
format: Article
creator:
  • Swarbrick, M. M
  • Stanhope, K. L
  • Austrheim-Smith, I. T
  • Van Loan, M. D
  • Ali, M. R
  • Wolfe, B. M
  • Havel, P. J
subjects:
  • 1 Biological
  • Acylation
  • Adipocytes
  • Adipocytes - metabolism
  • adiponectin
  • Adult
  • Article
  • bariatric surgery
  • Binding Proteins
  • Biological and medical sciences
  • blood glucose
  • body fat
  • Body weight
  • C-Reactive Protein - metabolism
  • Chemokine CCL2
  • Chemokine CCL2 - metabolism
  • Cholecystokinin
  • Chorionic gonadotropin
  • Clinical science
  • Clinical Sciences
  • Cytokines
  • Dextrose
  • Diabetes
  • Diabetes. Impaired glucose tolerance
  • Digestive Diseases
  • Endocrine
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinology & Metabolism
  • Endocrinopathies
  • endogenous factors
  • entero pancreatic factors
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Female
  • Gastric Bypass
  • Gastric Bypass - methods
  • gastro
  • Gastro-entero pancreatic factors
  • Gastrointestinal
  • Glucagon
  • Glucagon - metabolism
  • Glucose
  • Glucose - metabolism
  • glycemic control
  • Health Services
  • hormonal regulation
  • hormones
  • Human
  • Human Physiology
  • Humans
  • Insulin
  • Insulin resistance
  • insulin secretion
  • insulin sensitivity
  • Insulin sensitivity and resistance
  • Interleukin
  • Interleukin-6 - metabolism
  • Internal Medicine
  • islets of Langerhans
  • Leptin
  • Leptin - metabolism
  • long term effects
  • Longitudinal Studies
  • Medical colleges
  • Medical sciences
  • Medicine
  • Medicine & Public Health
  • Metabolic
  • Metabolic Diseases
  • Morbid
  • Nutrition
  • Obesity
  • Obesity, Morbid - metabolism
  • Obesity, Morbid - pathology
  • Obesity, Morbid - surgery
  • Oral
  • Other hormones
  • Other islet cells
  • Other islet cells/hormones
  • overweight
  • Paediatrics
  • Pancreas
  • Pancreas - metabolism
  • pancreatic hormones
  • Plasma
  • Prevention
  • Public Health
  • Reactive Protein
  • Reproductive Medicine
  • resistance
  • Retinoids
  • Retinol
  • Retinol-Binding Proteins, Plasma - metabolism
  • Stroke
  • Surgery
  • Time Factors
  • Type 2 diabetes
  • weight control
  • weight loss
  • weight regulation
  • Weight regulation and obesity
ispartof: Diabetologia, 2008, Vol.51 (10), p.1901-1911
description: Aims/hypothesis Bariatric surgery is an effective treatment for severe obesity, as in addition to dramatic weight loss, co-morbidities such as type 2 diabetes are frequently resolved. Although altered gastrointestinal peptide hormone secretion and its relationship with post-surgical improvements in insulin sensitivity has been studied, much less is known about long-term changes in pancreatic and adipose tissue-derived hormones. Our objective was to conduct a comprehensive longitudinal investigation of the endocrine changes following Roux-en-Y gastric bypass surgery (RYGBP), focusing on pancreatic and adipocyte hormones and systemic markers of inflammation. Methods Nineteen severely obese women (BMI 45.6 ± 1.6 kg/m²) were studied prior to RYGBP, and at 1, 3, 6, and 12 months after RYGBP. Body composition was assessed before surgery and at 1 and 12 months. Results Pre-surgical adiposity was correlated with circulating adipocyte hormones (leptin, visfatin) and inflammatory molecules (IL-6, high sensitivity C-reactive protein [hsCRP], monocyte chemoattractant protein-1). As expected, RYGBP reduced fat mass and fasting insulin and glucose concentrations. In addition, reductions of fasting pancreatic polypeptide (PP) and glucagon concentrations were observed at 1 and 3 months, respectively. In the 12 months following RYGBP, concentrations of most adipocyte hormones (leptin, acylation-stimulating hormone and visfatin, but not retinol-binding hormone-4) and inflammatory molecules (IL-6, hsCRP and soluble intracellular adhesion molecule-1) were significantly reduced. Reductions of insulin resistance (measured by homeostasis model assessment of insulin resistance) were independently associated with changes of glucagon, visfatin and PP. Pre-surgical HMW adiponectin concentrations independently predicted losses of body weight and fat mass. Conclusions/interpretation These results suggest that pancreatic and adipocyte hormones may contribute to the long-term resolution of insulin resistance after RYGBP.
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titleLongitudinal changes in pancreatic and adipocyte hormones following Roux-en-Y gastric bypass surgery
creatorSwarbrick, M. M ; Stanhope, K. L ; Austrheim-Smith, I. T ; Van Loan, M. D ; Ali, M. R ; Wolfe, B. M ; Havel, P. J
creatorcontribSwarbrick, M. M ; Stanhope, K. L ; Austrheim-Smith, I. T ; Van Loan, M. D ; Ali, M. R ; Wolfe, B. M ; Havel, P. J
descriptionAims/hypothesis Bariatric surgery is an effective treatment for severe obesity, as in addition to dramatic weight loss, co-morbidities such as type 2 diabetes are frequently resolved. Although altered gastrointestinal peptide hormone secretion and its relationship with post-surgical improvements in insulin sensitivity has been studied, much less is known about long-term changes in pancreatic and adipose tissue-derived hormones. Our objective was to conduct a comprehensive longitudinal investigation of the endocrine changes following Roux-en-Y gastric bypass surgery (RYGBP), focusing on pancreatic and adipocyte hormones and systemic markers of inflammation. Methods Nineteen severely obese women (BMI 45.6 ± 1.6 kg/m²) were studied prior to RYGBP, and at 1, 3, 6, and 12 months after RYGBP. Body composition was assessed before surgery and at 1 and 12 months. Results Pre-surgical adiposity was correlated with circulating adipocyte hormones (leptin, visfatin) and inflammatory molecules (IL-6, high sensitivity C-reactive protein [hsCRP], monocyte chemoattractant protein-1). As expected, RYGBP reduced fat mass and fasting insulin and glucose concentrations. In addition, reductions of fasting pancreatic polypeptide (PP) and glucagon concentrations were observed at 1 and 3 months, respectively. In the 12 months following RYGBP, concentrations of most adipocyte hormones (leptin, acylation-stimulating hormone and visfatin, but not retinol-binding hormone-4) and inflammatory molecules (IL-6, hsCRP and soluble intracellular adhesion molecule-1) were significantly reduced. Reductions of insulin resistance (measured by homeostasis model assessment of insulin resistance) were independently associated with changes of glucagon, visfatin and PP. Pre-surgical HMW adiponectin concentrations independently predicted losses of body weight and fat mass. Conclusions/interpretation These results suggest that pancreatic and adipocyte hormones may contribute to the long-term resolution of insulin resistance after RYGBP.
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1EISSN: 1432-0428
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languageeng
publisherBerlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
subject1 Biological ; Acylation ; Adipocytes ; Adipocytes - metabolism ; adiponectin ; Adult ; Article ; bariatric surgery ; Binding Proteins ; Biological and medical sciences ; blood glucose ; body fat ; Body weight ; C-Reactive Protein - metabolism ; Chemokine CCL2 ; Chemokine CCL2 - metabolism ; Cholecystokinin ; Chorionic gonadotropin ; Clinical science ; Clinical Sciences ; Cytokines ; Dextrose ; Diabetes ; Diabetes. Impaired glucose tolerance ; Digestive Diseases ; Endocrine ; Endocrine pancreas. Apud cells (diseases) ; Endocrinology & Metabolism ; Endocrinopathies ; endogenous factors ; entero pancreatic factors ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Gastric Bypass ; Gastric Bypass - methods ; gastro ; Gastro-entero pancreatic factors ; Gastrointestinal ; Glucagon ; Glucagon - metabolism ; Glucose ; Glucose - metabolism ; glycemic control ; Health Services ; hormonal regulation ; hormones ; Human ; Human Physiology ; Humans ; Insulin ; Insulin resistance ; insulin secretion ; insulin sensitivity ; Insulin sensitivity and resistance ; Interleukin ; Interleukin-6 - metabolism ; Internal Medicine ; islets of Langerhans ; Leptin ; Leptin - metabolism ; long term effects ; Longitudinal Studies ; Medical colleges ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic ; Metabolic Diseases ; Morbid ; Nutrition ; Obesity ; Obesity, Morbid - metabolism ; Obesity, Morbid - pathology ; Obesity, Morbid - surgery ; Oral ; Other hormones ; Other islet cells ; Other islet cells/hormones ; overweight ; Paediatrics ; Pancreas ; Pancreas - metabolism ; pancreatic hormones ; Plasma ; Prevention ; Public Health ; Reactive Protein ; Reproductive Medicine ; resistance ; Retinoids ; Retinol ; Retinol-Binding Proteins, Plasma - metabolism ; Stroke ; Surgery ; Time Factors ; Type 2 diabetes ; weight control ; weight loss ; weight regulation ; Weight regulation and obesity
ispartofDiabetologia, 2008, Vol.51 (10), p.1901-1911
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0Swarbrick, M. M
1Stanhope, K. L
2Austrheim-Smith, I. T
3Van Loan, M. D
4Ali, M. R
5Wolfe, B. M
6Havel, P. J
title
0Longitudinal changes in pancreatic and adipocyte hormones following Roux-en-Y gastric bypass surgery
1Diabetologia
addtitle
0Diabetologia
1Diabetologia
descriptionAims/hypothesis Bariatric surgery is an effective treatment for severe obesity, as in addition to dramatic weight loss, co-morbidities such as type 2 diabetes are frequently resolved. Although altered gastrointestinal peptide hormone secretion and its relationship with post-surgical improvements in insulin sensitivity has been studied, much less is known about long-term changes in pancreatic and adipose tissue-derived hormones. Our objective was to conduct a comprehensive longitudinal investigation of the endocrine changes following Roux-en-Y gastric bypass surgery (RYGBP), focusing on pancreatic and adipocyte hormones and systemic markers of inflammation. Methods Nineteen severely obese women (BMI 45.6 ± 1.6 kg/m²) were studied prior to RYGBP, and at 1, 3, 6, and 12 months after RYGBP. Body composition was assessed before surgery and at 1 and 12 months. Results Pre-surgical adiposity was correlated with circulating adipocyte hormones (leptin, visfatin) and inflammatory molecules (IL-6, high sensitivity C-reactive protein [hsCRP], monocyte chemoattractant protein-1). As expected, RYGBP reduced fat mass and fasting insulin and glucose concentrations. In addition, reductions of fasting pancreatic polypeptide (PP) and glucagon concentrations were observed at 1 and 3 months, respectively. In the 12 months following RYGBP, concentrations of most adipocyte hormones (leptin, acylation-stimulating hormone and visfatin, but not retinol-binding hormone-4) and inflammatory molecules (IL-6, hsCRP and soluble intracellular adhesion molecule-1) were significantly reduced. Reductions of insulin resistance (measured by homeostasis model assessment of insulin resistance) were independently associated with changes of glucagon, visfatin and PP. Pre-surgical HMW adiponectin concentrations independently predicted losses of body weight and fat mass. Conclusions/interpretation These results suggest that pancreatic and adipocyte hormones may contribute to the long-term resolution of insulin resistance after RYGBP.
subject
01 Biological
1Acylation
2Adipocytes
3Adipocytes - metabolism
4adiponectin
5Adult
6Article
7bariatric surgery
8Binding Proteins
9Biological and medical sciences
10blood glucose
11body fat
12Body weight
13C-Reactive Protein - metabolism
14Chemokine CCL2
15Chemokine CCL2 - metabolism
16Cholecystokinin
17Chorionic gonadotropin
18Clinical science
19Clinical Sciences
20Cytokines
21Dextrose
22Diabetes
23Diabetes. Impaired glucose tolerance
24Digestive Diseases
25Endocrine
26Endocrine pancreas. Apud cells (diseases)
27Endocrinology & Metabolism
28Endocrinopathies
29endogenous factors
30entero pancreatic factors
31Etiopathogenesis. Screening. Investigations. Target tissue resistance
32Female
33Gastric Bypass
34Gastric Bypass - methods
35gastro
36Gastro-entero pancreatic factors
37Gastrointestinal
38Glucagon
39Glucagon - metabolism
40Glucose
41Glucose - metabolism
42glycemic control
43Health Services
44hormonal regulation
45hormones
46Human
47Human Physiology
48Humans
49Insulin
50Insulin resistance
51insulin secretion
52insulin sensitivity
53Insulin sensitivity and resistance
54Interleukin
55Interleukin-6 - metabolism
56Internal Medicine
57islets of Langerhans
58Leptin
59Leptin - metabolism
60long term effects
61Longitudinal Studies
62Medical colleges
63Medical sciences
64Medicine
65Medicine & Public Health
66Metabolic
67Metabolic Diseases
68Morbid
69Nutrition
70Obesity
71Obesity, Morbid - metabolism
72Obesity, Morbid - pathology
73Obesity, Morbid - surgery
74Oral
75Other hormones
76Other islet cells
77Other islet cells/hormones
78overweight
79Paediatrics
80Pancreas
81Pancreas - metabolism
82pancreatic hormones
83Plasma
84Prevention
85Public Health
86Reactive Protein
87Reproductive Medicine
88resistance
89Retinoids
90Retinol
91Retinol-Binding Proteins, Plasma - metabolism
92Stroke
93Surgery
94Time Factors
95Type 2 diabetes
96weight control
97weight loss
98weight regulation
99Weight regulation and obesity
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1Stanhope, K. L
2Austrheim-Smith, I. T
3Van Loan, M. D
4Ali, M. R
5Wolfe, B. M
6Havel, P. J
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titleLongitudinal changes in pancreatic and adipocyte hormones following Roux-en-Y gastric bypass surgery
authorSwarbrick, M. M ; Stanhope, K. L ; Austrheim-Smith, I. T ; Van Loan, M. D ; Ali, M. R ; Wolfe, B. M ; Havel, P. J
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01 Biological
1Acylation
2Adipocytes
3Adipocytes - metabolism
4adiponectin
5Adult
6Article
7bariatric surgery
8Binding Proteins
9Biological and medical sciences
10blood glucose
11body fat
12Body weight
13C-Reactive Protein - metabolism
14Chemokine CCL2
15Chemokine CCL2 - metabolism
16Cholecystokinin
17Chorionic gonadotropin
18Clinical science
19Clinical Sciences
20Cytokines
21Dextrose
22Diabetes
23Diabetes. Impaired glucose tolerance
24Digestive Diseases
25Endocrine
26Endocrine pancreas. Apud cells (diseases)
27Endocrinology & Metabolism
28Endocrinopathies
29endogenous factors
30entero pancreatic factors
31Etiopathogenesis. Screening. Investigations. Target tissue resistance
32Female
33Gastric Bypass
34Gastric Bypass - methods
35gastro
36Gastro-entero pancreatic factors
37Gastrointestinal
38Glucagon
39Glucagon - metabolism
40Glucose
41Glucose - metabolism
42glycemic control
43Health Services
44hormonal regulation
45hormones
46Human
47Human Physiology
48Humans
49Insulin
50Insulin resistance
51insulin secretion
52insulin sensitivity
53Insulin sensitivity and resistance
54Interleukin
55Interleukin-6 - metabolism
56Internal Medicine
57islets of Langerhans
58Leptin
59Leptin - metabolism
60long term effects
61Longitudinal Studies
62Medical colleges
63Medical sciences
64Medicine
65Medicine & Public Health
66Metabolic
67Metabolic Diseases
68Morbid
69Nutrition
70Obesity
71Obesity, Morbid - metabolism
72Obesity, Morbid - pathology
73Obesity, Morbid - surgery
74Oral
75Other hormones
76Other islet cells
77Other islet cells/hormones
78overweight
79Paediatrics
80Pancreas
81Pancreas - metabolism
82pancreatic hormones
83Plasma
84Prevention
85Public Health
86Reactive Protein
87Reproductive Medicine
88resistance
89Retinoids
90Retinol
91Retinol-Binding Proteins, Plasma - metabolism
92Stroke
93Surgery
94Time Factors
95Type 2 diabetes
96weight control
97weight loss
98weight regulation
99Weight regulation and obesity
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1Stanhope, K. L
2Austrheim-Smith, I. T
3Van Loan, M. D
4Ali, M. R
5Wolfe, B. M
6Havel, P. J
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1Stanhope, K. L
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3Van Loan, M. D
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jtitleDiabetologia
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date2008
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0http://dx.doi.org/10.1007/s00125-008-1118-5
1http://hdl.handle.net/10113/27226
abstractAims/hypothesis Bariatric surgery is an effective treatment for severe obesity, as in addition to dramatic weight loss, co-morbidities such as type 2 diabetes are frequently resolved. Although altered gastrointestinal peptide hormone secretion and its relationship with post-surgical improvements in insulin sensitivity has been studied, much less is known about long-term changes in pancreatic and adipose tissue-derived hormones. Our objective was to conduct a comprehensive longitudinal investigation of the endocrine changes following Roux-en-Y gastric bypass surgery (RYGBP), focusing on pancreatic and adipocyte hormones and systemic markers of inflammation. Methods Nineteen severely obese women (BMI 45.6 ± 1.6 kg/m²) were studied prior to RYGBP, and at 1, 3, 6, and 12 months after RYGBP. Body composition was assessed before surgery and at 1 and 12 months. Results Pre-surgical adiposity was correlated with circulating adipocyte hormones (leptin, visfatin) and inflammatory molecules (IL-6, high sensitivity C-reactive protein [hsCRP], monocyte chemoattractant protein-1). As expected, RYGBP reduced fat mass and fasting insulin and glucose concentrations. In addition, reductions of fasting pancreatic polypeptide (PP) and glucagon concentrations were observed at 1 and 3 months, respectively. In the 12 months following RYGBP, concentrations of most adipocyte hormones (leptin, acylation-stimulating hormone and visfatin, but not retinol-binding hormone-4) and inflammatory molecules (IL-6, hsCRP and soluble intracellular adhesion molecule-1) were significantly reduced. Reductions of insulin resistance (measured by homeostasis model assessment of insulin resistance) were independently associated with changes of glucagon, visfatin and PP. Pre-surgical HMW adiponectin concentrations independently predicted losses of body weight and fat mass. Conclusions/interpretation These results suggest that pancreatic and adipocyte hormones may contribute to the long-term resolution of insulin resistance after RYGBP.
copBerlin/Heidelberg
pubBerlin/Heidelberg : Springer-Verlag
pmid18704364
doi10.1007/s00125-008-1118-5
oafree_for_read