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Hypoxia-inducible factor 1 and cardiovascular disease

Cardiac function is required for blood circulation and systemic oxygen delivery. However, the heart has intrinsic oxygen demands that must be met to maintain effective contractility. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostas... Full description

Journal Title: Annual review of physiology 2014, Vol.76 (1), p.39-56
Main Author: Semenza, Gregg L
Format: Electronic Article Electronic Article
Language: English
Subjects:
Aging - physiology
Angiogenesis
Animals
Article
Cardiovascular Diseases - genetics
Cardiovascular Diseases - physiopathology
Genetic aspects
Glucose
Glucose metabolism
Health aspects
Heart failure
Heart Failure - physiopathology
Homeostasis
Homeostasis - physiology
Humans
Hypoxia
Hypoxia-Inducible Factor 1 - genetics
Hypoxia-Inducible Factor 1 - physiology
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Ischemic Preconditioning, Myocardial
L heart failure
Metabolism
myocardial ischemia
Myocardial Ischemia - genetics
Myocardial Ischemia - physiopathology
Oxygen
Oxygen Consumption - physiology
Physiological aspects
preconditioning
pressure overload
Transcription factors
vascular remodeling
Quelle: Alma/SFX Local Collection
Publisher: United States: Annual Reviews, Inc
ID: ISSN: 0066-4278
Link: https://www.ncbi.nlm.nih.gov/pubmed/23988176
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title: Hypoxia-inducible factor 1 and cardiovascular disease
format: Article
creator:
  • Semenza, Gregg L
subjects:
  • Aging - physiology
  • Angiogenesis
  • Animals
  • Article
  • Cardiovascular Diseases - genetics
  • Cardiovascular Diseases - physiopathology
  • Genetic aspects
  • Glucose
  • Glucose metabolism
  • Health aspects
  • Heart failure
  • Heart Failure - physiopathology
  • Homeostasis
  • Homeostasis - physiology
  • Humans
  • Hypoxia
  • Hypoxia-Inducible Factor 1 - genetics
  • Hypoxia-Inducible Factor 1 - physiology
  • Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
  • Ischemic Preconditioning, Myocardial
  • L heart failure
  • Metabolism
  • myocardial ischemia
  • Myocardial Ischemia - genetics
  • Myocardial Ischemia - physiopathology
  • Oxygen
  • Oxygen Consumption - physiology
  • Physiological aspects
  • preconditioning
  • pressure overload
  • Transcription factors
  • vascular remodeling
ispartof: Annual review of physiology, 2014, Vol.76 (1), p.39-56
description: Cardiac function is required for blood circulation and systemic oxygen delivery. However, the heart has intrinsic oxygen demands that must be met to maintain effective contractility. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species. HIF-1 controls oxygen delivery, by regulating angiogenesis and vascular remodeling, and oxygen utilization, by regulating glucose metabolism and redox homeostasis. Analysis of animal models suggests that by activation of these homeostatic mechanisms, HIF-1 plays a critical protective role in the pathophysiology of ischemic heart disease and pressure-overload heart failure.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0066-4278
fulltext: fulltext
issn:
  • 0066-4278
  • 1545-1585
url: Link


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descriptionCardiac function is required for blood circulation and systemic oxygen delivery. However, the heart has intrinsic oxygen demands that must be met to maintain effective contractility. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species. HIF-1 controls oxygen delivery, by regulating angiogenesis and vascular remodeling, and oxygen utilization, by regulating glucose metabolism and redox homeostasis. Analysis of animal models suggests that by activation of these homeostatic mechanisms, HIF-1 plays a critical protective role in the pathophysiology of ischemic heart disease and pressure-overload heart failure.
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languageeng
publisherUnited States: Annual Reviews, Inc
subjectAging - physiology ; Angiogenesis ; Animals ; Article ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - physiopathology ; Genetic aspects ; Glucose ; Glucose metabolism ; Health aspects ; Heart failure ; Heart Failure - physiopathology ; Homeostasis ; Homeostasis - physiology ; Humans ; Hypoxia ; Hypoxia-Inducible Factor 1 - genetics ; Hypoxia-Inducible Factor 1 - physiology ; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism ; Ischemic Preconditioning, Myocardial ; L heart failure ; Metabolism ; myocardial ischemia ; Myocardial Ischemia - genetics ; Myocardial Ischemia - physiopathology ; Oxygen ; Oxygen Consumption - physiology ; Physiological aspects ; preconditioning ; pressure overload ; Transcription factors ; vascular remodeling
ispartofAnnual review of physiology, 2014, Vol.76 (1), p.39-56
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descriptionCardiac function is required for blood circulation and systemic oxygen delivery. However, the heart has intrinsic oxygen demands that must be met to maintain effective contractility. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species. HIF-1 controls oxygen delivery, by regulating angiogenesis and vascular remodeling, and oxygen utilization, by regulating glucose metabolism and redox homeostasis. Analysis of animal models suggests that by activation of these homeostatic mechanisms, HIF-1 plays a critical protective role in the pathophysiology of ischemic heart disease and pressure-overload heart failure.
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0Aging - physiology
1Angiogenesis
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4Cardiovascular Diseases - genetics
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abstractCardiac function is required for blood circulation and systemic oxygen delivery. However, the heart has intrinsic oxygen demands that must be met to maintain effective contractility. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species. HIF-1 controls oxygen delivery, by regulating angiogenesis and vascular remodeling, and oxygen utilization, by regulating glucose metabolism and redox homeostasis. Analysis of animal models suggests that by activation of these homeostatic mechanisms, HIF-1 plays a critical protective role in the pathophysiology of ischemic heart disease and pressure-overload heart failure.
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doi10.1146/annurev-physiol-021113-170322
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