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Hypoxia-inducible factor 1 and cardiovascular disease

Cardiac function is required for blood circulation and systemic oxygen delivery. However, the heart has intrinsic oxygen demands that must be met to maintain effective contractility. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostas... Full description

Journal Title: Annual review of physiology 2014, Vol.76 (1), p.39-56
Main Author: Semenza, Gregg L
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Annual Reviews, Inc
ID: ISSN: 0066-4278
Link: https://www.ncbi.nlm.nih.gov/pubmed/23988176
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title: Hypoxia-inducible factor 1 and cardiovascular disease
format: Article
creator:
  • Semenza, Gregg L
subjects:
  • Aging - physiology
  • Angiogenesis
  • Animals
  • Article
  • Cardiovascular Diseases - genetics
  • Cardiovascular Diseases - physiopathology
  • Genetic aspects
  • Glucose
  • Glucose metabolism
  • Health aspects
  • Heart failure
  • Heart Failure - physiopathology
  • Homeostasis
  • Homeostasis - physiology
  • Humans
  • Hypoxia
  • Hypoxia-Inducible Factor 1 - genetics
  • Hypoxia-Inducible Factor 1 - physiology
  • Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
  • Ischemic Preconditioning, Myocardial
  • L heart failure
  • Metabolism
  • myocardial ischemia
  • Myocardial Ischemia - genetics
  • Myocardial Ischemia - physiopathology
  • Oxygen
  • Oxygen Consumption - physiology
  • Physiological aspects
  • preconditioning
  • pressure overload
  • Transcription factors
  • vascular remodeling
ispartof: Annual review of physiology, 2014, Vol.76 (1), p.39-56
description: Cardiac function is required for blood circulation and systemic oxygen delivery. However, the heart has intrinsic oxygen demands that must be met to maintain effective contractility. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species. HIF-1 controls oxygen delivery, by regulating angiogenesis and vascular remodeling, and oxygen utilization, by regulating glucose metabolism and redox homeostasis. Analysis of animal models suggests that by activation of these homeostatic mechanisms, HIF-1 plays a critical protective role in the pathophysiology of ischemic heart disease and pressure-overload heart failure.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0066-4278
fulltext: fulltext
issn:
  • 0066-4278
  • 1545-1585
url: Link


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descriptionCardiac function is required for blood circulation and systemic oxygen delivery. However, the heart has intrinsic oxygen demands that must be met to maintain effective contractility. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species. HIF-1 controls oxygen delivery, by regulating angiogenesis and vascular remodeling, and oxygen utilization, by regulating glucose metabolism and redox homeostasis. Analysis of animal models suggests that by activation of these homeostatic mechanisms, HIF-1 plays a critical protective role in the pathophysiology of ischemic heart disease and pressure-overload heart failure.
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subjectAging - physiology ; Angiogenesis ; Animals ; Article ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - physiopathology ; Genetic aspects ; Glucose ; Glucose metabolism ; Health aspects ; Heart failure ; Heart Failure - physiopathology ; Homeostasis ; Homeostasis - physiology ; Humans ; Hypoxia ; Hypoxia-Inducible Factor 1 - genetics ; Hypoxia-Inducible Factor 1 - physiology ; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism ; Ischemic Preconditioning, Myocardial ; L heart failure ; Metabolism ; myocardial ischemia ; Myocardial Ischemia - genetics ; Myocardial Ischemia - physiopathology ; Oxygen ; Oxygen Consumption - physiology ; Physiological aspects ; preconditioning ; pressure overload ; Transcription factors ; vascular remodeling
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abstractCardiac function is required for blood circulation and systemic oxygen delivery. However, the heart has intrinsic oxygen demands that must be met to maintain effective contractility. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species. HIF-1 controls oxygen delivery, by regulating angiogenesis and vascular remodeling, and oxygen utilization, by regulating glucose metabolism and redox homeostasis. Analysis of animal models suggests that by activation of these homeostatic mechanisms, HIF-1 plays a critical protective role in the pathophysiology of ischemic heart disease and pressure-overload heart failure.
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