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Bovine milk-derived exosomes for drug delivery

Highlights • Bovine milk is a biocompatible and scalable source of exosomes. • Milk exosomes can serve as a vehicle to deliver both hydrophilic and lipophilic small drug molecules. • Exosomal formulations provide enhanced biological efficacy. • Milk exosomes can be functionalized with ligands such a... Full description

Journal Title: Cancer letters 2015, Vol.371 (1), p.48-61
Main Author: Munagala, Radha
Other Authors: Aqil, Farrukh , Jeyabalan, Jeyaprakash , Gupta, Ramesh C
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Ireland: Elsevier Ireland Ltd
ID: ISSN: 0304-3835
Link: https://www.ncbi.nlm.nih.gov/pubmed/26604130
Zum Text:
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4706492
title: Bovine milk-derived exosomes for drug delivery
format: Article
creator:
  • Munagala, Radha
  • Aqil, Farrukh
  • Jeyabalan, Jeyaprakash
  • Gupta, Ramesh C
subjects:
  • Administration, Oral
  • Animals
  • Anticarcinogenic Agents - administration & dosage
  • Anticarcinogenic Agents - pharmacokinetics
  • Antineoplastic Agents - administration & dosage
  • Antineoplastic Agents - pharmacokinetics
  • Article
  • Automation
  • beverages
  • Brownian movements
  • Cattle
  • Cell Line, Tumor
  • Cell Proliferation - drug effects
  • Chemistry, Pharmaceutical
  • Chemopreventive agents
  • Chemotherapeutic drugs
  • Drug Carriers
  • Drug delivery
  • Drug delivery systems
  • Drugs
  • Exosomes - immunology
  • Exosomes - metabolism
  • Female
  • Folic Acid - metabolism
  • food
  • Hematology
  • Hematology, Oncology and Palliative Medicine
  • Humans
  • Immune Tolerance
  • Ligands
  • Lung Neoplasms - drug therapy
  • Lung Neoplasms - metabolism
  • Lung Neoplasms - pathology
  • Male
  • Mice, Nude
  • Milk
  • Milk - immunology
  • Milk - metabolism
  • Milk - toxicity
  • Milk-derived exosomes
  • Nanoparticles
  • Proteins
  • Rodents
  • Software
  • Solubility
  • Statistical analysis
  • Tissue Distribution
  • Tumor-targeting
  • Vehicles
  • Xenograft Model Antitumor Assays
ispartof: Cancer letters, 2015, Vol.371 (1), p.48-61
description: Highlights • Bovine milk is a biocompatible and scalable source of exosomes. • Milk exosomes can serve as a vehicle to deliver both hydrophilic and lipophilic small drug molecules. • Exosomal formulations provide enhanced biological efficacy. • Milk exosomes can be functionalized with ligands such as folic acid to achieve tumor targeting. • Milk exosomes per se exhibit protective effects presumably due to the endogenous cargo of macromolecules.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0304-3835
fulltext: fulltext
issn:
  • 0304-3835
  • 1872-7980
url: Link


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descriptionHighlights • Bovine milk is a biocompatible and scalable source of exosomes. • Milk exosomes can serve as a vehicle to deliver both hydrophilic and lipophilic small drug molecules. • Exosomal formulations provide enhanced biological efficacy. • Milk exosomes can be functionalized with ligands such as folic acid to achieve tumor targeting. • Milk exosomes per se exhibit protective effects presumably due to the endogenous cargo of macromolecules.
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subjectAdministration, Oral ; Animals ; Anticarcinogenic Agents - administration & dosage ; Anticarcinogenic Agents - pharmacokinetics ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - pharmacokinetics ; Article ; Automation ; beverages ; Brownian movements ; Cattle ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Chemistry, Pharmaceutical ; Chemopreventive agents ; Chemotherapeutic drugs ; Drug Carriers ; Drug delivery ; Drug delivery systems ; Drugs ; Exosomes - immunology ; Exosomes - metabolism ; Female ; Folic Acid - metabolism ; food ; Hematology ; Hematology, Oncology and Palliative Medicine ; Humans ; Immune Tolerance ; Ligands ; Lung Neoplasms - drug therapy ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Male ; Mice, Nude ; Milk ; Milk - immunology ; Milk - metabolism ; Milk - toxicity ; Milk-derived exosomes ; Nanoparticles ; Proteins ; Rodents ; Software ; Solubility ; Statistical analysis ; Tissue Distribution ; Tumor-targeting ; Vehicles ; Xenograft Model Antitumor Assays
ispartofCancer letters, 2015, Vol.371 (1), p.48-61
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7Automation
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abstractHighlights • Bovine milk is a biocompatible and scalable source of exosomes. • Milk exosomes can serve as a vehicle to deliver both hydrophilic and lipophilic small drug molecules. • Exosomal formulations provide enhanced biological efficacy. • Milk exosomes can be functionalized with ligands such as folic acid to achieve tumor targeting. • Milk exosomes per se exhibit protective effects presumably due to the endogenous cargo of macromolecules.
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pmid26604130
doi10.1016/j.canlet.2015.10.020
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