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Underweight as a risk factor for respiratory death in the Whitehall cohort study: exploring reverse causality using a 45-year follow-up

Underweight adults have higher rates of respiratory death than the normal weight but it is unclear whether this association is causal or reflects illness-induced weight loss (reverse causality). Evidence from a 45-year follow-up of underweight participants for respiratory mortality in the Whitehall... Full description

Journal Title: Thorax 2016-01, Vol.71 (1), p.84-85
Main Author: Kivimäki, Mika
Other Authors: Shipley, Martin J , Bell, Joshua A , Brunner, Eric J , Batty, G David , Singh-Manoux, Archana
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: BMJ Publishing Group LTD
ID: ISSN: 0040-6376
Link: https://www.ncbi.nlm.nih.gov/pubmed/26253581
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title: Underweight as a risk factor for respiratory death in the Whitehall cohort study: exploring reverse causality using a 45-year follow-up
format: Article
creator:
  • Kivimäki, Mika
  • Shipley, Martin J
  • Bell, Joshua A
  • Brunner, Eric J
  • Batty, G David
  • Singh-Manoux, Archana
subjects:
  • 1506
  • Adult
  • Aged
  • Bias
  • Cardiovascular disease
  • Causality
  • Chronic Disease - mortality
  • Collaboration
  • COPD epidemiology
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Mortality
  • Population Surveillance
  • Research Letter
  • Respiratory diseases
  • Respiratory Tract Diseases - mortality
  • Risk Factors
  • Studies
  • Thinness
ispartof: Thorax, 2016-01, Vol.71 (1), p.84-85
description: Underweight adults have higher rates of respiratory death than the normal weight but it is unclear whether this association is causal or reflects illness-induced weight loss (reverse causality). Evidence from a 45-year follow-up of underweight participants for respiratory mortality in the Whitehall study (N=18 823; 2139 respiratory deaths) suggests that excess risk among the underweight is attributable to reverse causality. The age-adjusted and smoking-adjusted risk was 1.55-fold (95% CI 1.32 to 1.83) higher among underweight compared with normal weight participants, but attenuated in a stepwise manner to 1.14 (95% CI 0.76 to 1.71) after serial exclusions of deaths during the first 5–35 years of follow-up (Ptrend
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0040-6376
fulltext: fulltext
issn:
  • 0040-6376
  • 1468-3296
url: Link


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descriptionUnderweight adults have higher rates of respiratory death than the normal weight but it is unclear whether this association is causal or reflects illness-induced weight loss (reverse causality). Evidence from a 45-year follow-up of underweight participants for respiratory mortality in the Whitehall study (N=18 823; 2139 respiratory deaths) suggests that excess risk among the underweight is attributable to reverse causality. The age-adjusted and smoking-adjusted risk was 1.55-fold (95% CI 1.32 to 1.83) higher among underweight compared with normal weight participants, but attenuated in a stepwise manner to 1.14 (95% CI 0.76 to 1.71) after serial exclusions of deaths during the first 5–35 years of follow-up (Ptrend<0.001).
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subject1506 ; Adult ; Aged ; Bias ; Cardiovascular disease ; Causality ; Chronic Disease - mortality ; Collaboration ; COPD epidemiology ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Mortality ; Population Surveillance ; Research Letter ; Respiratory diseases ; Respiratory Tract Diseases - mortality ; Risk Factors ; Studies ; Thinness
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abstractUnderweight adults have higher rates of respiratory death than the normal weight but it is unclear whether this association is causal or reflects illness-induced weight loss (reverse causality). Evidence from a 45-year follow-up of underweight participants for respiratory mortality in the Whitehall study (N=18 823; 2139 respiratory deaths) suggests that excess risk among the underweight is attributable to reverse causality. The age-adjusted and smoking-adjusted risk was 1.55-fold (95% CI 1.32 to 1.83) higher among underweight compared with normal weight participants, but attenuated in a stepwise manner to 1.14 (95% CI 0.76 to 1.71) after serial exclusions of deaths during the first 5–35 years of follow-up (Ptrend<0.001).
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