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Dietary tocopherols inhibit PhIP-induced prostate carcinogenesis in CYP1A-humanized mice

Highlights • Dietary γ-TmT inhibits PhIP-induced prostate mPIN lesion in CYP1A-humanized mice. • γ-TmT reduces PhIP-induced oxidative and nitrosative stress in the mouse prostate. • γ-TmT prevents PhIP-induced dysregulation of p-AKT and PTEN. • δ-T is more effective than γ-T or α-T in inhibiting PhI... Full description

Journal Title: Cancer letters 2015, Vol.371 (1), p.71-78
Main Author: Chen, Jayson X
Other Authors: Li, Guangxun , Wang, Hong , Liu, Anna , Lee, Mao-Jung , Reuhl, Kenneth , Suh, Nanjoo , Bosland, Maarten C , Yang, Chung S
Format: Electronic Article Electronic Article
Language: English
Subjects:
Animals
Anticarcinogenic Agents - administration & dosage
Anticarcinogenic Agents - pharmacology
Article
Cyclooxygenase 2 - metabolism
Cytochrome P-450 CYP1A2 - genetics
Cytochrome P-450 CYP1A2 - metabolism
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - metabolism
Diet
Disease Models, Animal
Hematology, Oncology and Palliative Medicine
Humans
Imidazoles
Ki-67 Antigen - metabolism
Laboratories
Male
Meat
Mice, Transgenic
mPIN
NF-E2-Related Factor 2 - metabolism
p-AKT
PhIP
Phosphorylation
Prostate cancer
Prostate carcinogenesis
Prostatic Intraepithelial Neoplasia - chemically induced
Prostatic Intraepithelial Neoplasia - enzymology
Prostatic Intraepithelial Neoplasia - genetics
Prostatic Intraepithelial Neoplasia - pathology
Prostatic Intraepithelial Neoplasia - prevention & control
Prostatic Neoplasms - chemically induced
Prostatic Neoplasms - enzymology
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Prostatic Neoplasms - prevention & control
Proto-Oncogene Proteins c-akt - metabolism
PTEN Phosphohydrolase - metabolism
Rodents
Signal Transduction - drug effects
Studies
Temperature
Tocopherols
Tocopherols - administration & dosage
Tocopherols - pharmacology
Tyrosine - analogs & derivatives
Tyrosine - metabolism
Vitamin E
Quelle: Alma/SFX Local Collection
Publisher: Ireland: Elsevier Ireland Ltd
ID: ISSN: 0304-3835
Link: https://www.ncbi.nlm.nih.gov/pubmed/26582657
Zum Text:
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4721244
title: Dietary tocopherols inhibit PhIP-induced prostate carcinogenesis in CYP1A-humanized mice
format: Article
creator:
  • Chen, Jayson X
  • Li, Guangxun
  • Wang, Hong
  • Liu, Anna
  • Lee, Mao-Jung
  • Reuhl, Kenneth
  • Suh, Nanjoo
  • Bosland, Maarten C
  • Yang, Chung S
subjects:
  • Animals
  • Anticarcinogenic Agents - administration & dosage
  • Anticarcinogenic Agents - pharmacology
  • Article
  • Cyclooxygenase 2 - metabolism
  • Cytochrome P-450 CYP1A2 - genetics
  • Cytochrome P-450 CYP1A2 - metabolism
  • Deoxyguanosine - analogs & derivatives
  • Deoxyguanosine - metabolism
  • Diet
  • Disease Models, Animal
  • Hematology, Oncology and Palliative Medicine
  • Humans
  • Imidazoles
  • Ki-67 Antigen - metabolism
  • Laboratories
  • Male
  • Meat
  • Mice, Transgenic
  • mPIN
  • NF-E2-Related Factor 2 - metabolism
  • p-AKT
  • PhIP
  • Phosphorylation
  • Prostate cancer
  • Prostate carcinogenesis
  • Prostatic Intraepithelial Neoplasia - chemically induced
  • Prostatic Intraepithelial Neoplasia - enzymology
  • Prostatic Intraepithelial Neoplasia - genetics
  • Prostatic Intraepithelial Neoplasia - pathology
  • Prostatic Intraepithelial Neoplasia - prevention & control
  • Prostatic Neoplasms - chemically induced
  • Prostatic Neoplasms - enzymology
  • Prostatic Neoplasms - genetics
  • Prostatic Neoplasms - pathology
  • Prostatic Neoplasms - prevention & control
  • Proto-Oncogene Proteins c-akt - metabolism
  • PTEN Phosphohydrolase - metabolism
  • Rodents
  • Signal Transduction - drug effects
  • Studies
  • Temperature
  • Tocopherols
  • Tocopherols - administration & dosage
  • Tocopherols - pharmacology
  • Tyrosine - analogs & derivatives
  • Tyrosine - metabolism
  • Vitamin E
ispartof: Cancer letters, 2015, Vol.371 (1), p.71-78
description: Highlights • Dietary γ-TmT inhibits PhIP-induced prostate mPIN lesion in CYP1A-humanized mice. • γ-TmT reduces PhIP-induced oxidative and nitrosative stress in the mouse prostate. • γ-TmT prevents PhIP-induced dysregulation of p-AKT and PTEN. • δ-T is more effective than γ-T or α-T in inhibiting PhIP-induced mPINs and p-AKT.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0304-3835
fulltext: fulltext
issn:
  • 0304-3835
  • 1872-7980
url: Link


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descriptionHighlights • Dietary γ-TmT inhibits PhIP-induced prostate mPIN lesion in CYP1A-humanized mice. • γ-TmT reduces PhIP-induced oxidative and nitrosative stress in the mouse prostate. • γ-TmT prevents PhIP-induced dysregulation of p-AKT and PTEN. • δ-T is more effective than γ-T or α-T in inhibiting PhIP-induced mPINs and p-AKT.
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title
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descriptionHighlights • Dietary γ-TmT inhibits PhIP-induced prostate mPIN lesion in CYP1A-humanized mice. • γ-TmT reduces PhIP-induced oxidative and nitrosative stress in the mouse prostate. • γ-TmT prevents PhIP-induced dysregulation of p-AKT and PTEN. • δ-T is more effective than γ-T or α-T in inhibiting PhIP-induced mPINs and p-AKT.
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37PTEN Phosphohydrolase - metabolism
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39Signal Transduction - drug effects
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titleDietary tocopherols inhibit PhIP-induced prostate carcinogenesis in CYP1A-humanized mice
authorChen, Jayson X ; Li, Guangxun ; Wang, Hong ; Liu, Anna ; Lee, Mao-Jung ; Reuhl, Kenneth ; Suh, Nanjoo ; Bosland, Maarten C ; Yang, Chung S
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1Anticarcinogenic Agents - administration & dosage
2Anticarcinogenic Agents - pharmacology
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5Cytochrome P-450 CYP1A2 - genetics
6Cytochrome P-450 CYP1A2 - metabolism
7Deoxyguanosine - analogs & derivatives
8Deoxyguanosine - metabolism
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10Disease Models, Animal
11Hematology, Oncology and Palliative Medicine
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13Imidazoles
14Ki-67 Antigen - metabolism
15Laboratories
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17Meat
18Mice, Transgenic
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21p-AKT
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27Prostatic Intraepithelial Neoplasia - enzymology
28Prostatic Intraepithelial Neoplasia - genetics
29Prostatic Intraepithelial Neoplasia - pathology
30Prostatic Intraepithelial Neoplasia - prevention & control
31Prostatic Neoplasms - chemically induced
32Prostatic Neoplasms - enzymology
33Prostatic Neoplasms - genetics
34Prostatic Neoplasms - pathology
35Prostatic Neoplasms - prevention & control
36Proto-Oncogene Proteins c-akt - metabolism
37PTEN Phosphohydrolase - metabolism
38Rodents
39Signal Transduction - drug effects
40Studies
41Temperature
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43Tocopherols - administration & dosage
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45Tyrosine - analogs & derivatives
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47Vitamin E
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atitleDietary tocopherols inhibit PhIP-induced prostate carcinogenesis in CYP1A-humanized mice
jtitleCancer letters
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date2015
risdate2015
volume371
issue1
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pages71-78
issn0304-3835
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abstractHighlights • Dietary γ-TmT inhibits PhIP-induced prostate mPIN lesion in CYP1A-humanized mice. • γ-TmT reduces PhIP-induced oxidative and nitrosative stress in the mouse prostate. • γ-TmT prevents PhIP-induced dysregulation of p-AKT and PTEN. • δ-T is more effective than γ-T or α-T in inhibiting PhIP-induced mPINs and p-AKT.
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pubElsevier Ireland Ltd
pmid26582657
doi10.1016/j.canlet.2015.11.010
oafree_for_read