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VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer

Most brain tumors oversecrete vascular endothelial growth factor (VEGF), which leads to an abnormally permeable tumor vasculature. This hyperpermeability allows fluid to leak from the intravascular space into the brain parenchyma, which causes vasogenic cerebral edema and increased interstitial flui... Full description

Journal Title: Nature reviews. Clinical oncology 2009-04, Vol.6 (4), p.229-236
Main Author: Batchelor, Tracy T
Other Authors: Gerstner, Elizabeth R , Duda, Dan G , di Tomaso, Emmanuelle , Ryg, Peter A , Loeffler, Jay S , Sorensen, A. Gregory , Ivy, Percy , Jain, Rakesh K
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: Nature Publishing Group
ID: ISSN: 1759-4774
Link: https://www.ncbi.nlm.nih.gov/pubmed/19333229
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4793889
title: VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer
format: Article
creator:
  • Batchelor, Tracy T
  • Gerstner, Elizabeth R
  • Duda, Dan G
  • di Tomaso, Emmanuelle
  • Ryg, Peter A
  • Loeffler, Jay S
  • Sorensen, A. Gregory
  • Ivy, Percy
  • Jain, Rakesh K
subjects:
  • Article
  • Brain Edema - drug therapy
  • Brain Edema - etiology
  • Brain Neoplasms - blood supply
  • Brain Neoplasms - complications
  • Brain Neoplasms - drug therapy
  • Brain tumors
  • Cancer
  • Cerebral edema
  • Chemotherapy
  • Complications and side effects
  • Diagnosis
  • Drug therapy
  • Health aspects
  • Humans
  • Magnetic Resonance Imaging
  • Neovascularization, Pathologic - drug therapy
  • Physiological aspects
  • Quinazolines - administration & dosage
  • Risk factors
  • Vascular endothelial growth factor
  • Vascular Endothelial Growth Factor A - antagonists & inhibitors
ispartof: Nature reviews. Clinical oncology, 2009-04, Vol.6 (4), p.229-236
description: Most brain tumors oversecrete vascular endothelial growth factor (VEGF), which leads to an abnormally permeable tumor vasculature. This hyperpermeability allows fluid to leak from the intravascular space into the brain parenchyma, which causes vasogenic cerebral edema and increased interstitial fluid pressure. Increased interstitial fluid pressure has an important role in treatment resistance by contributing to tumor hypoxia and preventing adequate tumor penetration of chemotherapy agents. In addition, edema and the corticosteroids needed to control cerebral edema cause significant morbidity and mortality. Agents that block the VEGF pathway are able to decrease vascular permeability and, thus, cerebral edema, by restoring the abnormal tumor vasculature to a more normal state. Decreasing cerebral edema minimizes the adverse effects of corticosteroids and could improve clinical outcomes. Anti-VEGF agents might also be useful in other cancer-related conditions that increase vascular permeability, such as malignant pleural effusions or ascites.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1759-4774
fulltext: fulltext
issn:
  • 1759-4774
  • 1759-4782
url: Link


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descriptionMost brain tumors oversecrete vascular endothelial growth factor (VEGF), which leads to an abnormally permeable tumor vasculature. This hyperpermeability allows fluid to leak from the intravascular space into the brain parenchyma, which causes vasogenic cerebral edema and increased interstitial fluid pressure. Increased interstitial fluid pressure has an important role in treatment resistance by contributing to tumor hypoxia and preventing adequate tumor penetration of chemotherapy agents. In addition, edema and the corticosteroids needed to control cerebral edema cause significant morbidity and mortality. Agents that block the VEGF pathway are able to decrease vascular permeability and, thus, cerebral edema, by restoring the abnormal tumor vasculature to a more normal state. Decreasing cerebral edema minimizes the adverse effects of corticosteroids and could improve clinical outcomes. Anti-VEGF agents might also be useful in other cancer-related conditions that increase vascular permeability, such as malignant pleural effusions or ascites.
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subjectArticle ; Brain Edema - drug therapy ; Brain Edema - etiology ; Brain Neoplasms - blood supply ; Brain Neoplasms - complications ; Brain Neoplasms - drug therapy ; Brain tumors ; Cancer ; Cerebral edema ; Chemotherapy ; Complications and side effects ; Diagnosis ; Drug therapy ; Health aspects ; Humans ; Magnetic Resonance Imaging ; Neovascularization, Pathologic - drug therapy ; Physiological aspects ; Quinazolines - administration & dosage ; Risk factors ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - antagonists & inhibitors
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descriptionMost brain tumors oversecrete vascular endothelial growth factor (VEGF), which leads to an abnormally permeable tumor vasculature. This hyperpermeability allows fluid to leak from the intravascular space into the brain parenchyma, which causes vasogenic cerebral edema and increased interstitial fluid pressure. Increased interstitial fluid pressure has an important role in treatment resistance by contributing to tumor hypoxia and preventing adequate tumor penetration of chemotherapy agents. In addition, edema and the corticosteroids needed to control cerebral edema cause significant morbidity and mortality. Agents that block the VEGF pathway are able to decrease vascular permeability and, thus, cerebral edema, by restoring the abnormal tumor vasculature to a more normal state. Decreasing cerebral edema minimizes the adverse effects of corticosteroids and could improve clinical outcomes. Anti-VEGF agents might also be useful in other cancer-related conditions that increase vascular permeability, such as malignant pleural effusions or ascites.
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abstractMost brain tumors oversecrete vascular endothelial growth factor (VEGF), which leads to an abnormally permeable tumor vasculature. This hyperpermeability allows fluid to leak from the intravascular space into the brain parenchyma, which causes vasogenic cerebral edema and increased interstitial fluid pressure. Increased interstitial fluid pressure has an important role in treatment resistance by contributing to tumor hypoxia and preventing adequate tumor penetration of chemotherapy agents. In addition, edema and the corticosteroids needed to control cerebral edema cause significant morbidity and mortality. Agents that block the VEGF pathway are able to decrease vascular permeability and, thus, cerebral edema, by restoring the abnormal tumor vasculature to a more normal state. Decreasing cerebral edema minimizes the adverse effects of corticosteroids and could improve clinical outcomes. Anti-VEGF agents might also be useful in other cancer-related conditions that increase vascular permeability, such as malignant pleural effusions or ascites.
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