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Increased markers of thrombogenesis in chronic atrial fibrillation: effects of warfarin treatment

OBJECTIVE--To determine whether chronic atrial fibrillation is associated with abnormalities in plasma fibrinogen, von Willebrand factor (vWF) (a marker of endothelial disturbance), or fibrin D- dimer (a measure of fibrin turnover); and if so, whether such levels are related to haemodynamic disturba... Full description

Journal Title: British Heart Journal 1995, Vol.73 (6), p.527-533
Main Author: Lip, G. Y
Other Authors: Lowe, G. D , Rumley, A , Dunn, F. G
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: London: BMJ Publishing Group Ltd and British Cardiovascular Society
ID: ISSN: 0007-0769
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_483914
title: Increased markers of thrombogenesis in chronic atrial fibrillation: effects of warfarin treatment
format: Article
creator:
  • Lip, G. Y
  • Lowe, G. D
  • Rumley, A
  • Dunn, F. G
subjects:
  • Abridged Index Medicus
  • Adult
  • Aged
  • Atrial Fibrillation - blood
  • Atrial Fibrillation - drug therapy
  • Biological and medical sciences
  • Biomarkers - blood
  • Blood. Blood coagulation. Reticuloendothelial system
  • Chronic Disease
  • Cross-Sectional Studies
  • Female
  • Fibrin Fibrinogen Degradation Products - metabolism
  • Fibrinogen - metabolism
  • Humans
  • Longitudinal Studies
  • Male
  • Medical sciences
  • Middle Aged
  • Pharmacology. Drug treatments
  • Research Article
  • Thrombosis - blood
  • von Willebrand Factor - metabolism
  • Warfarin - therapeutic use
ispartof: British Heart Journal, 1995, Vol.73 (6), p.527-533
description: OBJECTIVE--To determine whether chronic atrial fibrillation is associated with abnormalities in plasma fibrinogen, von Willebrand factor (vWF) (a marker of endothelial disturbance), or fibrin D- dimer (a measure of fibrin turnover); and if so, whether such levels are related to haemodynamic disturbance (enlarged left atrium, poor left ventricular function) or existing treatment with warfarin or aspirin. To investigate the effects of introducing warfarin in patients with atrial fibrillation on fibrinogen and D- dimer levels. DESIGN--Cross sectional population sample controlled study and longitudinal study of patients undergoing anticoagulation. SETTING--District general hospital. SUBJECTS--87 patients (44 men and 43 women of mean (SEM) age 63.0 (1.0)) with chronic atrial fibrillation. At the time of the study, 37 were taking no antithrombotic medication (group 1), 31 were taking warfarin (including two on warfarin and aspirin) (group 2) and 19 were taking aspirin alone (group 3). They were compared with 158 population controls from a random population sample (the second Glasgow monitoring trends and determinants in cardiovascular disease study). As part of clinical treatment warfarin was introduced in 20 patients with chronic atrial fibrillation (14 men and six women of mean (SEM) (range) age 63.9 (2.35 (32-74) years). RESULTS--Plasma fibrinogen remained significantly increased in patients of group 1 (no antithrombotic medication) compared with that of the population controls (median difference 1.23 g/l; 95% confidence interval (CI) 0.88 to 1.62, P < 0.0001). There was also a significant increase in plasma D-dimer levels (median difference 77 ng/ml; 95% CI 38 to 122, P < 0.01) and vWF (median difference 63 IU/dl; 95% CI 38 to 89, P < 0.0001). There was no significant difference in plasma fibrinogen (median difference 0.14 g/l; 95% CI -0.44 to 0.77, P = 0.65) or vWF (median difference 3.5 IU/dl; 95% CI - 41 to 41, P = not significant in patients of group 2 (warfarin treatment) compared with that of patients in group 1. Levels of D-dimer were significantly lower in group 2 (median difference 90 ng/ml, 95% CI 39 to 150, P < 0.0001) than in group 1. There were no significant differences in plasma fibrinogen (median difference 0.08 g/l; 95% CI - 0.52 to 0.77, P = 0.73), D-dimer (median difference - 34 ng/ml; 95% CI - 114 to 21.0, P = 0.25), or vWF (median difference 2%; 95% CI - 35 to 41, P = not significant) levels between patients of groups 1 and 3. There were
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0007-0769
fulltext: fulltext
issn:
  • 0007-0769
  • 1355-6037
  • 1468-201X
  • 2053-5864
url: Link


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subjectAbridged Index Medicus ; Adult ; Aged ; Atrial Fibrillation - blood ; Atrial Fibrillation - drug therapy ; Biological and medical sciences ; Biomarkers - blood ; Blood. Blood coagulation. Reticuloendothelial system ; Chronic Disease ; Cross-Sectional Studies ; Female ; Fibrin Fibrinogen Degradation Products - metabolism ; Fibrinogen - metabolism ; Humans ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Research Article ; Thrombosis - blood ; von Willebrand Factor - metabolism ; Warfarin - therapeutic use
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