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Rates of HIV-1 superinfection and primary HIV-1 infection are similar in female sex workers in Uganda

To determine and compare the rates of HIV superinfection and primary HIV infection in high-risk female sex workers (FSWs) in Kampala, Uganda. A retrospective analysis of individuals who participated in a clinical cohort study among high-risk FSWs in Kampala, Uganda. Plasma samples from HIV-infected... Full description

Journal Title: AIDS (London) 2014, Vol.28 (14), p.2147-2152
Main Author: Redd, Andrew D
Other Authors: Ssemwanga, Deogratius , Vandepitte, Judith , Wendel, Sarah K , Ndembi, Nicaise , Bukenya, Justine , Nakubulwa, Susan , Grosskurth, Heiner , Parry, Chris M , Martens, Craig , Bruno, Daniel , Porcella, Stephen F , Quinn, Thomas C , Kaleebu, Pontiano
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: England
ID: ISSN: 0269-9370
Link: https://www.ncbi.nlm.nih.gov/pubmed/25265078
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title: Rates of HIV-1 superinfection and primary HIV-1 infection are similar in female sex workers in Uganda
format: Article
creator:
  • Redd, Andrew D
  • Ssemwanga, Deogratius
  • Vandepitte, Judith
  • Wendel, Sarah K
  • Ndembi, Nicaise
  • Bukenya, Justine
  • Nakubulwa, Susan
  • Grosskurth, Heiner
  • Parry, Chris M
  • Martens, Craig
  • Bruno, Daniel
  • Porcella, Stephen F
  • Quinn, Thomas C
  • Kaleebu, Pontiano
subjects:
  • Adult
  • Age Factors
  • Cohort Studies
  • Disease Progression
  • Female
  • Follow-Up Studies
  • HIV Infections - epidemiology
  • HIV Infections - immunology
  • HIV-1 - genetics
  • Human immunodeficiency virus 1
  • Humans
  • Incidence
  • Lentivirus
  • Retrospective Studies
  • Retroviridae
  • Sex Workers - statistics & numerical data
  • Sexual Partners
  • Superinfection - epidemiology
  • Superinfection - immunology
  • Uganda - epidemiology
  • Viral Load
ispartof: AIDS (London), 2014, Vol.28 (14), p.2147-2152
description: To determine and compare the rates of HIV superinfection and primary HIV infection in high-risk female sex workers (FSWs) in Kampala, Uganda. A retrospective analysis of individuals who participated in a clinical cohort study among high-risk FSWs in Kampala, Uganda. Plasma samples from HIV-infected FSWs in Kampala, Uganda were examined with next-generation sequencing of the p24 and gp41 HIV genomic regions for the occurrence of superinfection. Primary HIV incidence was determined from initially HIV-uninfected FSWs from the same cohort, and incidence rate ratios were compared. The rate of superinfection in these women (7/85; 3.4/100 person-years) was not significantly different from the rate of primary infection in the same population (3.7/100 person-years; incidence rate ratio = 0.91, P = 0.42). Seven women also entered the study dual-infected (16.5% either dual or superinfected). The women with any presence of dual infection were more likely to report sex work as their only source of income (P = 0.05), and trended to be older and more likely to be widowed (P = 0.07). In this cohort of FSWs, HIV superinfection occurred at a high rate and was similar to that of primary HIV infection. These results differ from a similar study of high-risk female bar workers in Kenya that found the rate of superinfection to be significantly lower than the rate of primary HIV infection.
language: eng
source:
identifier: ISSN: 0269-9370
fulltext: no_fulltext
issn:
  • 0269-9370
  • 1473-5571
url: Link


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titleRates of HIV-1 superinfection and primary HIV-1 infection are similar in female sex workers in Uganda
creatorRedd, Andrew D ; Ssemwanga, Deogratius ; Vandepitte, Judith ; Wendel, Sarah K ; Ndembi, Nicaise ; Bukenya, Justine ; Nakubulwa, Susan ; Grosskurth, Heiner ; Parry, Chris M ; Martens, Craig ; Bruno, Daniel ; Porcella, Stephen F ; Quinn, Thomas C ; Kaleebu, Pontiano
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descriptionTo determine and compare the rates of HIV superinfection and primary HIV infection in high-risk female sex workers (FSWs) in Kampala, Uganda. A retrospective analysis of individuals who participated in a clinical cohort study among high-risk FSWs in Kampala, Uganda. Plasma samples from HIV-infected FSWs in Kampala, Uganda were examined with next-generation sequencing of the p24 and gp41 HIV genomic regions for the occurrence of superinfection. Primary HIV incidence was determined from initially HIV-uninfected FSWs from the same cohort, and incidence rate ratios were compared. The rate of superinfection in these women (7/85; 3.4/100 person-years) was not significantly different from the rate of primary infection in the same population (3.7/100 person-years; incidence rate ratio = 0.91, P = 0.42). Seven women also entered the study dual-infected (16.5% either dual or superinfected). The women with any presence of dual infection were more likely to report sex work as their only source of income (P = 0.05), and trended to be older and more likely to be widowed (P = 0.07). In this cohort of FSWs, HIV superinfection occurred at a high rate and was similar to that of primary HIV infection. These results differ from a similar study of high-risk female bar workers in Kenya that found the rate of superinfection to be significantly lower than the rate of primary HIV infection.
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descriptionTo determine and compare the rates of HIV superinfection and primary HIV infection in high-risk female sex workers (FSWs) in Kampala, Uganda. A retrospective analysis of individuals who participated in a clinical cohort study among high-risk FSWs in Kampala, Uganda. Plasma samples from HIV-infected FSWs in Kampala, Uganda were examined with next-generation sequencing of the p24 and gp41 HIV genomic regions for the occurrence of superinfection. Primary HIV incidence was determined from initially HIV-uninfected FSWs from the same cohort, and incidence rate ratios were compared. The rate of superinfection in these women (7/85; 3.4/100 person-years) was not significantly different from the rate of primary infection in the same population (3.7/100 person-years; incidence rate ratio = 0.91, P = 0.42). Seven women also entered the study dual-infected (16.5% either dual or superinfected). The women with any presence of dual infection were more likely to report sex work as their only source of income (P = 0.05), and trended to be older and more likely to be widowed (P = 0.07). In this cohort of FSWs, HIV superinfection occurred at a high rate and was similar to that of primary HIV infection. These results differ from a similar study of high-risk female bar workers in Kenya that found the rate of superinfection to be significantly lower than the rate of primary HIV infection.
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titleRates of HIV-1 superinfection and primary HIV-1 infection are similar in female sex workers in Uganda
authorRedd, Andrew D ; Ssemwanga, Deogratius ; Vandepitte, Judith ; Wendel, Sarah K ; Ndembi, Nicaise ; Bukenya, Justine ; Nakubulwa, Susan ; Grosskurth, Heiner ; Parry, Chris M ; Martens, Craig ; Bruno, Daniel ; Porcella, Stephen F ; Quinn, Thomas C ; Kaleebu, Pontiano
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abstractTo determine and compare the rates of HIV superinfection and primary HIV infection in high-risk female sex workers (FSWs) in Kampala, Uganda. A retrospective analysis of individuals who participated in a clinical cohort study among high-risk FSWs in Kampala, Uganda. Plasma samples from HIV-infected FSWs in Kampala, Uganda were examined with next-generation sequencing of the p24 and gp41 HIV genomic regions for the occurrence of superinfection. Primary HIV incidence was determined from initially HIV-uninfected FSWs from the same cohort, and incidence rate ratios were compared. The rate of superinfection in these women (7/85; 3.4/100 person-years) was not significantly different from the rate of primary infection in the same population (3.7/100 person-years; incidence rate ratio = 0.91, P = 0.42). Seven women also entered the study dual-infected (16.5% either dual or superinfected). The women with any presence of dual infection were more likely to report sex work as their only source of income (P = 0.05), and trended to be older and more likely to be widowed (P = 0.07). In this cohort of FSWs, HIV superinfection occurred at a high rate and was similar to that of primary HIV infection. These results differ from a similar study of high-risk female bar workers in Kenya that found the rate of superinfection to be significantly lower than the rate of primary HIV infection.
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