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Principles of nanoparticle design for overcoming biological barriers to drug delivery

Biological barriers to drug transport prevent successful accumulation of nanotherapeutics specifically at diseased sites, limiting efficacious responses in disease processes ranging from cancer to inflammation. Although substantial research efforts have aimed to incorporate multiple functionalities... Full description

Journal Title: Nature biotechnology 2015, Vol.33 (9), p.941-951
Main Author: Blanco, Elvin
Other Authors: Shen, Haifa , Ferrari, Mauro
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Nature Publishing Group
ID: ISSN: 1087-0156
Link: https://www.ncbi.nlm.nih.gov/pubmed/26348965
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title: Principles of nanoparticle design for overcoming biological barriers to drug delivery
format: Article
creator:
  • Blanco, Elvin
  • Shen, Haifa
  • Ferrari, Mauro
subjects:
  • Article
  • Biocompatible Materials - chemical synthesis
  • Biocompatible Materials - toxicity
  • Biology
  • Biotechnology industry
  • Drug Compounding - methods
  • Drug delivery systems
  • Drug Design
  • Drugs
  • Nanocapsules - chemistry
  • Nanocapsules - toxicity
  • Nanocapsules - ultrastructure
  • Nanomedicine - methods
  • Nanoparticles
  • Production processes
  • Technology application
  • Vehicles
ispartof: Nature biotechnology, 2015, Vol.33 (9), p.941-951
description: Biological barriers to drug transport prevent successful accumulation of nanotherapeutics specifically at diseased sites, limiting efficacious responses in disease processes ranging from cancer to inflammation. Although substantial research efforts have aimed to incorporate multiple functionalities and moieties within the overall nanoparticle design, many of these strategies fail to adequately address these barriers. Obstacles, such as nonspecific distribution and inadequate accumulation of therapeutics, remain formidable challenges to drug developers. A reimagining of conventional nanoparticles is needed to successfully negotiate these impediments to drug delivery. Site-specific delivery of therapeutics will remain a distant reality unless nanocarrier design takes into account the majority, if not all, of the biological barriers that a particle encounters upon intravenous administration. By successively addressing each of these barriers, innovative design features can be rationally incorporated that will create a new generation of nanotherapeutics, realizing a paradigmatic shift in nanoparticle-based drug delivery.
language: eng
source:
identifier: ISSN: 1087-0156
fulltext: no_fulltext
issn:
  • 1087-0156
  • 1546-1696
url: Link


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descriptionBiological barriers to drug transport prevent successful accumulation of nanotherapeutics specifically at diseased sites, limiting efficacious responses in disease processes ranging from cancer to inflammation. Although substantial research efforts have aimed to incorporate multiple functionalities and moieties within the overall nanoparticle design, many of these strategies fail to adequately address these barriers. Obstacles, such as nonspecific distribution and inadequate accumulation of therapeutics, remain formidable challenges to drug developers. A reimagining of conventional nanoparticles is needed to successfully negotiate these impediments to drug delivery. Site-specific delivery of therapeutics will remain a distant reality unless nanocarrier design takes into account the majority, if not all, of the biological barriers that a particle encounters upon intravenous administration. By successively addressing each of these barriers, innovative design features can be rationally incorporated that will create a new generation of nanotherapeutics, realizing a paradigmatic shift in nanoparticle-based drug delivery.
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subjectArticle ; Biocompatible Materials - chemical synthesis ; Biocompatible Materials - toxicity ; Biology ; Biotechnology industry ; Drug Compounding - methods ; Drug delivery systems ; Drug Design ; Drugs ; Nanocapsules - chemistry ; Nanocapsules - toxicity ; Nanocapsules - ultrastructure ; Nanomedicine - methods ; Nanoparticles ; Production processes ; Technology application ; Vehicles
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abstractBiological barriers to drug transport prevent successful accumulation of nanotherapeutics specifically at diseased sites, limiting efficacious responses in disease processes ranging from cancer to inflammation. Although substantial research efforts have aimed to incorporate multiple functionalities and moieties within the overall nanoparticle design, many of these strategies fail to adequately address these barriers. Obstacles, such as nonspecific distribution and inadequate accumulation of therapeutics, remain formidable challenges to drug developers. A reimagining of conventional nanoparticles is needed to successfully negotiate these impediments to drug delivery. Site-specific delivery of therapeutics will remain a distant reality unless nanocarrier design takes into account the majority, if not all, of the biological barriers that a particle encounters upon intravenous administration. By successively addressing each of these barriers, innovative design features can be rationally incorporated that will create a new generation of nanotherapeutics, realizing a paradigmatic shift in nanoparticle-based drug delivery.
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