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Blood viscosity, coagulation, and activated protein C resistance in central retinal vein occlusion: a population controlled study

BACKGROUND: The role of blood viscosity and haemostasis has been investigated in mixed groups of patients with branch and central retinal vein occlusion (CRVO) with conflicting results. This may have partly been due to the different aetiologies of these two types of vein occlusion. METHODS: In this... Full description

Journal Title: British journal of ophthalmology 1996-03, Vol.80 (3), p.203-208
Main Author: Williamson, T H
Other Authors: Rumley, A , Lowe, G D
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd
ID: ISSN: 0007-1161
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_505429
title: Blood viscosity, coagulation, and activated protein C resistance in central retinal vein occlusion: a population controlled study
format: Article
creator:
  • Williamson, T H
  • Rumley, A
  • Lowe, G D
subjects:
  • Adult
  • Aged
  • Aged, 80 and over
  • Biological and medical sciences
  • Blood Coagulation - physiology
  • Blood Viscosity - physiology
  • Case-Control Studies
  • eye diseases
  • Female
  • Humans
  • Iris - blood supply
  • Male
  • Medical sciences
  • Middle Aged
  • Neovascularization, Pathologic - complications
  • Ophthalmology
  • Protein C - physiology
  • Research Article
  • Retinal Vein Occlusion - blood
  • Retinal Vein Occlusion - complications
  • Retinopathies
ispartof: British journal of ophthalmology, 1996-03, Vol.80 (3), p.203-208
description: BACKGROUND: The role of blood viscosity and haemostasis has been investigated in mixed groups of patients with branch and central retinal vein occlusion (CRVO) with conflicting results. This may have partly been due to the different aetiologies of these two types of vein occlusion. METHODS: In this study viscosity and coagulation (including activated protein C resistance) were examined in 87 patients with CRVO and compared with the results from an age-matched, population based control group. RESULTS: Viscosity variables were higher in CRVO than in controls which suggested that reduced red cell deformability was associated with the occurrence of CRVO. A higher percentage of the patients with CRVO (12%) had activated protein C resistance than controls (5%). Patients who developed the complication of iris neovascularisation had relatively low antithrombin III, factor VII, and tissue plasminogen activator indicating both a tendency to thrombus formation and a reduction in fibrinolytic activity. CONCLUSION: Increased blood viscosity may contribute to the production of CRVO by inducing stasis of blood flow, with thrombus formation in at risk individuals who go on to develop iris neovascularisation.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0007-1161
fulltext: fulltext
issn:
  • 0007-1161
  • 1468-2079
url: Link


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descriptionBACKGROUND: The role of blood viscosity and haemostasis has been investigated in mixed groups of patients with branch and central retinal vein occlusion (CRVO) with conflicting results. This may have partly been due to the different aetiologies of these two types of vein occlusion. METHODS: In this study viscosity and coagulation (including activated protein C resistance) were examined in 87 patients with CRVO and compared with the results from an age-matched, population based control group. RESULTS: Viscosity variables were higher in CRVO than in controls which suggested that reduced red cell deformability was associated with the occurrence of CRVO. A higher percentage of the patients with CRVO (12%) had activated protein C resistance than controls (5%). Patients who developed the complication of iris neovascularisation had relatively low antithrombin III, factor VII, and tissue plasminogen activator indicating both a tendency to thrombus formation and a reduction in fibrinolytic activity. CONCLUSION: Increased blood viscosity may contribute to the production of CRVO by inducing stasis of blood flow, with thrombus formation in at risk individuals who go on to develop iris neovascularisation.
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subjectAdult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Blood Coagulation - physiology ; Blood Viscosity - physiology ; Case-Control Studies ; eye diseases ; Female ; Humans ; Iris - blood supply ; Male ; Medical sciences ; Middle Aged ; Neovascularization, Pathologic - complications ; Ophthalmology ; Protein C - physiology ; Research Article ; Retinal Vein Occlusion - blood ; Retinal Vein Occlusion - complications ; Retinopathies
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descriptionBACKGROUND: The role of blood viscosity and haemostasis has been investigated in mixed groups of patients with branch and central retinal vein occlusion (CRVO) with conflicting results. This may have partly been due to the different aetiologies of these two types of vein occlusion. METHODS: In this study viscosity and coagulation (including activated protein C resistance) were examined in 87 patients with CRVO and compared with the results from an age-matched, population based control group. RESULTS: Viscosity variables were higher in CRVO than in controls which suggested that reduced red cell deformability was associated with the occurrence of CRVO. A higher percentage of the patients with CRVO (12%) had activated protein C resistance than controls (5%). Patients who developed the complication of iris neovascularisation had relatively low antithrombin III, factor VII, and tissue plasminogen activator indicating both a tendency to thrombus formation and a reduction in fibrinolytic activity. CONCLUSION: Increased blood viscosity may contribute to the production of CRVO by inducing stasis of blood flow, with thrombus formation in at risk individuals who go on to develop iris neovascularisation.
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abstractBACKGROUND: The role of blood viscosity and haemostasis has been investigated in mixed groups of patients with branch and central retinal vein occlusion (CRVO) with conflicting results. This may have partly been due to the different aetiologies of these two types of vein occlusion. METHODS: In this study viscosity and coagulation (including activated protein C resistance) were examined in 87 patients with CRVO and compared with the results from an age-matched, population based control group. RESULTS: Viscosity variables were higher in CRVO than in controls which suggested that reduced red cell deformability was associated with the occurrence of CRVO. A higher percentage of the patients with CRVO (12%) had activated protein C resistance than controls (5%). Patients who developed the complication of iris neovascularisation had relatively low antithrombin III, factor VII, and tissue plasminogen activator indicating both a tendency to thrombus formation and a reduction in fibrinolytic activity. CONCLUSION: Increased blood viscosity may contribute to the production of CRVO by inducing stasis of blood flow, with thrombus formation in at risk individuals who go on to develop iris neovascularisation.
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