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Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer

Exposure of newborns to the maternal vaginal microbiota is interrupted with cesarean birthing. Babies delivered by cesarean section (C-section) acquire a microbiota that differs from that of vaginally delivered infants, and C-section delivery has been associated with increased risk for immune and me... Full description

Journal Title: Nature medicine 2016, Vol.22 (3), p.250-253
Main Author: Dominguez-Bello, Maria G
Other Authors: De Jesus-Laboy, Kassandra M , Shen, Nan , Cox, Laura M , Amir, Amnon , Gonzalez, Antonio , Bokulich, Nicholas A , Song, Se Jin , Hoashi, Marina , Rivera-Vinas, Juana I , Mendez, Keimari , Knight, Rob , Clemente, Jose C
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Nature Publishing Group
ID: ISSN: 1078-8956
Link: https://www.ncbi.nlm.nih.gov/pubmed/26828196
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5062956
title: Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer
format: Article
creator:
  • Dominguez-Bello, Maria G
  • De Jesus-Laboy, Kassandra M
  • Shen, Nan
  • Cox, Laura M
  • Amir, Amnon
  • Gonzalez, Antonio
  • Bokulich, Nicholas A
  • Song, Se Jin
  • Hoashi, Marina
  • Rivera-Vinas, Juana I
  • Mendez, Keimari
  • Knight, Rob
  • Clemente, Jose C
subjects:
  • Article
  • Bacteroides - genetics
  • Cesarean section
  • Cesarean Section - methods
  • Childbirth
  • Childbirth & labor
  • Delivery, Obstetric
  • Female
  • Gastrointestinal Microbiome
  • Humans
  • Infant, Newborn
  • Infants (Newborn)
  • Lactobacillus - genetics
  • Longitudinal Studies
  • Male
  • Metabolic disorders
  • Metagenome
  • Microbiology
  • Microbiota
  • Microbiota (Symbiotic organisms)
  • Mouth - microbiology
  • Physiological aspects
  • Pilot Projects
  • Pregnancy
  • Skin - microbiology
  • Vagina - microbiology
ispartof: Nature medicine, 2016, Vol.22 (3), p.250-253
description: Exposure of newborns to the maternal vaginal microbiota is interrupted with cesarean birthing. Babies delivered by cesarean section (C-section) acquire a microbiota that differs from that of vaginally delivered infants, and C-section delivery has been associated with increased risk for immune and metabolic disorders. Here we conducted a pilot study in which infants delivered by C-section were exposed to maternal vaginal fluids at birth. Similarly to vaginally delivered babies, the gut, oral and skin bacterial communities of these newborns during the first 30 d of life was enriched in vaginal bacteria--which were underrepresented in unexposed C-section-delivered infants--and the microbiome similarity to those of vaginally delivered infants was greater in oral and skin samples than in anal samples. Although the long-term health consequences of restoring the microbiota of C-section-delivered infants remain unclear, our results demonstrate that vaginal microbes can be partially restored at birth in C-section-delivered babies.
language: eng
source:
identifier: ISSN: 1078-8956
fulltext: no_fulltext
issn:
  • 1078-8956
  • 1546-170X
url: Link


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titlePartial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer
creatorDominguez-Bello, Maria G ; De Jesus-Laboy, Kassandra M ; Shen, Nan ; Cox, Laura M ; Amir, Amnon ; Gonzalez, Antonio ; Bokulich, Nicholas A ; Song, Se Jin ; Hoashi, Marina ; Rivera-Vinas, Juana I ; Mendez, Keimari ; Knight, Rob ; Clemente, Jose C
creatorcontribDominguez-Bello, Maria G ; De Jesus-Laboy, Kassandra M ; Shen, Nan ; Cox, Laura M ; Amir, Amnon ; Gonzalez, Antonio ; Bokulich, Nicholas A ; Song, Se Jin ; Hoashi, Marina ; Rivera-Vinas, Juana I ; Mendez, Keimari ; Knight, Rob ; Clemente, Jose C
descriptionExposure of newborns to the maternal vaginal microbiota is interrupted with cesarean birthing. Babies delivered by cesarean section (C-section) acquire a microbiota that differs from that of vaginally delivered infants, and C-section delivery has been associated with increased risk for immune and metabolic disorders. Here we conducted a pilot study in which infants delivered by C-section were exposed to maternal vaginal fluids at birth. Similarly to vaginally delivered babies, the gut, oral and skin bacterial communities of these newborns during the first 30 d of life was enriched in vaginal bacteria--which were underrepresented in unexposed C-section-delivered infants--and the microbiome similarity to those of vaginally delivered infants was greater in oral and skin samples than in anal samples. Although the long-term health consequences of restoring the microbiota of C-section-delivered infants remain unclear, our results demonstrate that vaginal microbes can be partially restored at birth in C-section-delivered babies.
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subjectArticle ; Bacteroides - genetics ; Cesarean section ; Cesarean Section - methods ; Childbirth ; Childbirth & labor ; Delivery, Obstetric ; Female ; Gastrointestinal Microbiome ; Humans ; Infant, Newborn ; Infants (Newborn) ; Lactobacillus - genetics ; Longitudinal Studies ; Male ; Metabolic disorders ; Metagenome ; Microbiology ; Microbiota ; Microbiota (Symbiotic organisms) ; Mouth - microbiology ; Physiological aspects ; Pilot Projects ; Pregnancy ; Skin - microbiology ; Vagina - microbiology
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descriptionExposure of newborns to the maternal vaginal microbiota is interrupted with cesarean birthing. Babies delivered by cesarean section (C-section) acquire a microbiota that differs from that of vaginally delivered infants, and C-section delivery has been associated with increased risk for immune and metabolic disorders. Here we conducted a pilot study in which infants delivered by C-section were exposed to maternal vaginal fluids at birth. Similarly to vaginally delivered babies, the gut, oral and skin bacterial communities of these newborns during the first 30 d of life was enriched in vaginal bacteria--which were underrepresented in unexposed C-section-delivered infants--and the microbiome similarity to those of vaginally delivered infants was greater in oral and skin samples than in anal samples. Although the long-term health consequences of restoring the microbiota of C-section-delivered infants remain unclear, our results demonstrate that vaginal microbes can be partially restored at birth in C-section-delivered babies.
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titlePartial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer
authorDominguez-Bello, Maria G ; De Jesus-Laboy, Kassandra M ; Shen, Nan ; Cox, Laura M ; Amir, Amnon ; Gonzalez, Antonio ; Bokulich, Nicholas A ; Song, Se Jin ; Hoashi, Marina ; Rivera-Vinas, Juana I ; Mendez, Keimari ; Knight, Rob ; Clemente, Jose C
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10Mendez, Keimari
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issn1078-8956
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abstractExposure of newborns to the maternal vaginal microbiota is interrupted with cesarean birthing. Babies delivered by cesarean section (C-section) acquire a microbiota that differs from that of vaginally delivered infants, and C-section delivery has been associated with increased risk for immune and metabolic disorders. Here we conducted a pilot study in which infants delivered by C-section were exposed to maternal vaginal fluids at birth. Similarly to vaginally delivered babies, the gut, oral and skin bacterial communities of these newborns during the first 30 d of life was enriched in vaginal bacteria--which were underrepresented in unexposed C-section-delivered infants--and the microbiome similarity to those of vaginally delivered infants was greater in oral and skin samples than in anal samples. Although the long-term health consequences of restoring the microbiota of C-section-delivered infants remain unclear, our results demonstrate that vaginal microbes can be partially restored at birth in C-section-delivered babies.
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