Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer

Journal Title:	Nature medicine 2016-03, Vol.22 (3), p.250-253
Main Author:	Dominguez-Bello, Maria G
Other Authors:	De Jesus-Laboy, Kassandra M , Shen, Nan , Cox, Laura M , Amir, Amnon , Gonzalez, Antonio , Bokulich, Nicholas A , Song, Se Jin , Hoashi, Marina , Rivera-Vinas, Juana I , Mendez, Keimari , Knight, Rob , Clemente, Jose C
Format:	Electronic Article
Language:	English
Subjects:	Article Bacteroides - genetics Cesarean section Cesarean Section - methods Childbirth Childbirth & labor Delivery, Obstetric Female Gastrointestinal Microbiome Humans Infant, Newborn Infants (Newborn) Lactobacillus - genetics Longitudinal Studies Male Metabolic disorders Metagenome Microbiology Microbiota Microbiota (Symbiotic organisms) Mouth - microbiology Physiological aspects Pilot Projects Pregnancy Research Skin - microbiology Vagina - microbiology
Publisher:	United States: Nature Publishing Group
ID:	ISSN: 1078-8956
Link:	https://www.ncbi.nlm.nih.gov/pubmed/26828196
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title:	Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer
format:	Article
creator:	Dominguez-Bello, Maria G De Jesus-Laboy, Kassandra M Shen, Nan Cox, Laura M Amir, Amnon Gonzalez, Antonio Bokulich, Nicholas A Song, Se Jin Hoashi, Marina Rivera-Vinas, Juana I Mendez, Keimari Knight, Rob Clemente, Jose C
subjects:	Article Bacteroides - genetics Cesarean section Cesarean Section - methods Childbirth Childbirth & labor Delivery, Obstetric Female Gastrointestinal Microbiome Humans Infant, Newborn Infants (Newborn) Lactobacillus - genetics Longitudinal Studies Male Metabolic disorders Metagenome Microbiology Microbiota Microbiota (Symbiotic organisms) Mouth - microbiology Physiological aspects Pilot Projects Pregnancy Research Skin - microbiology Vagina - microbiology
ispartof:	Nature medicine, 2016-03, Vol.22 (3), p.250-253
description:	Exposure of newborns to the maternal vaginal microbiota is interrupted with cesarean birthing. Babies delivered by cesarean section (C-section) acquire a microbiota that differs from that of vaginally delivered infants, and C-section delivery has been associated with increased risk for immune and metabolic disorders. Here we conducted a pilot study in which infants delivered by C-section were exposed to maternal vaginal fluids at birth. Similarly to vaginally delivered babies, the gut, oral and skin bacterial communities of these newborns during the first 30 d of life was enriched in vaginal bacteria--which were underrepresented in unexposed C-section-delivered infants--and the microbiome similarity to those of vaginally delivered infants was greater in oral and skin samples than in anal samples. Although the long-term health consequences of restoring the microbiota of C-section-delivered infants remain unclear, our results demonstrate that vaginal microbes can be partially restored at birth in C-section-delivered babies.
language:	eng
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issn:	1078-8956 1546-170X
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Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer

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Dominguez-Bello, Maria G ; De Jesus-Laboy, Kassandra M ; Shen, Nan ; Cox, Laura M ; Amir, Amnon ; Gonzalez, Antonio ; Bokulich, Nicholas A ; Song, Se Jin ; Hoashi, Marina ; Rivera-Vinas, Juana I ; Mendez, Keimari ; Knight, Rob ; Clemente, Jose C

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description

Exposure of newborns to the maternal vaginal microbiota is interrupted with cesarean birthing. Babies delivered by cesarean section (C-section) acquire a microbiota that differs from that of vaginally delivered infants, and C-section delivery has been associated with increased risk for immune and metabolic disorders. Here we conducted a pilot study in which infants delivered by C-section were exposed to maternal vaginal fluids at birth. Similarly to vaginally delivered babies, the gut, oral and skin bacterial communities of these newborns during the first 30 d of life was enriched in vaginal bacteria--which were underrepresented in unexposed C-section-delivered infants--and the microbiome similarity to those of vaginally delivered infants was greater in oral and skin samples than in anal samples. Although the long-term health consequences of restoring the microbiota of C-section-delivered infants remain unclear, our results demonstrate that vaginal microbes can be partially restored at birth in C-section-delivered babies.

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1	EISSN: 1546-170X
2	DOI: 10.1038/nm.4039
3	PMID: 26828196

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United States: Nature Publishing Group

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Article ; Bacteroides - genetics ; Cesarean section ; Cesarean Section - methods ; Childbirth ; Childbirth & labor ; Delivery, Obstetric ; Female ; Gastrointestinal Microbiome ; Humans ; Infant, Newborn ; Infants (Newborn) ; Lactobacillus - genetics ; Longitudinal Studies ; Male ; Metabolic disorders ; Metagenome ; Microbiology ; Microbiota ; Microbiota (Symbiotic organisms) ; Mouth - microbiology ; Physiological aspects ; Pilot Projects ; Pregnancy ; Research ; Skin - microbiology ; Vagina - microbiology

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creationdate	201603
title	Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer
author	Dominguez-Bello, Maria G ; De Jesus-Laboy, Kassandra M ; Shen, Nan ; Cox, Laura M ; Amir, Amnon ; Gonzalez, Antonio ; Bokulich, Nicholas A ; Song, Se Jin ; Hoashi, Marina ; Rivera-Vinas, Juana I ; Mendez, Keimari ; Knight, Rob ; Clemente, Jose C

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1	De Jesus-Laboy, Kassandra M
2	Shen, Nan
3	Cox, Laura M
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5	Gonzalez, Antonio
6	Bokulich, Nicholas A
7	Song, Se Jin
8	Hoashi, Marina
9	Rivera-Vinas, Juana I
10	Mendez, Keimari
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Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer

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Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer