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Comparative analysis of the relative potential of silver, zinc-oxide and titanium-dioxide nanoparticles against UVB-induced DNA damage for the prevention of skin carcinogenesis

Abstract Sunscreen formulations containing UVB filters, such as Zinc-oxide (ZnO) and titanium-dioxide (TiO2) nanoparticles (NPs) have been developed to limit the exposure of human skin to UV-radiations. Unfortunately, these UVB protective agents have failed in controlling the skin cancer incidence.... Full description

Journal Title: Cancer letters 2016, Vol.383 (1), p.53-61
Main Author: Tyagi, Nikhil
Other Authors: Srivastava, Sanjeev K , Arora, Sumit , Omar, Yousef , Ijaz, Zohaib Mohammad , AL-Ghadhban, Ahmed , Deshmukh, Sachin K , Carter, James E , Singh, Ajay P , Singh, Seema, Ph.D
Format: Electronic Article Electronic Article
Language: English
Subjects:
DNA
Quelle: Alma/SFX Local Collection
Publisher: Ireland: Elsevier B.V
ID: ISSN: 0304-3835
Link: https://www.ncbi.nlm.nih.gov/pubmed/27693632
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5086276
title: Comparative analysis of the relative potential of silver, zinc-oxide and titanium-dioxide nanoparticles against UVB-induced DNA damage for the prevention of skin carcinogenesis
format: Article
creator:
  • Tyagi, Nikhil
  • Srivastava, Sanjeev K
  • Arora, Sumit
  • Omar, Yousef
  • Ijaz, Zohaib Mohammad
  • AL-Ghadhban, Ahmed
  • Deshmukh, Sachin K
  • Carter, James E
  • Singh, Ajay P
  • Singh, Seema, Ph.D
subjects:
  • agriculture
  • Anticarcinogenic Agents - pharmacology
  • Anticarcinogenic Agents - toxicity
  • Antioxidants - pharmacology
  • Article
  • Catalase - metabolism
  • Cell Death - drug effects
  • Cell Line, Tumor
  • Comparative analysis
  • connective tissue diseases
  • Deoxyribonucleic acid
  • DNA
  • DNA damage
  • DNA Damage - drug effects
  • DNA lesions (CPDs, 6-4 PPs)
  • DNA Repair - drug effects
  • Dose-Response Relationship, Drug
  • Enzymes
  • Glutathione Peroxidase - metabolism
  • Hematology, Oncology and Palliative Medicine
  • Humans
  • industry
  • integumentary system
  • Keratinocytes - drug effects
  • Keratinocytes - metabolism
  • Keratinocytes - pathology
  • Keratinocytes - radiation effects
  • Medical colleges
  • Medical research
  • Metal Nanoparticles
  • Nanoparticles
  • Oxidative Stress - drug effects
  • Radiation
  • Reactive oxygen species (ROS)
  • Reactive Oxygen Species - metabolism
  • respiratory system
  • Rodents
  • Silver
  • Silver Compounds - pharmacology
  • Silver nanoparticles (AgNPs)
  • Skin
  • Skin cancer
  • Skin Neoplasms - genetics
  • Skin Neoplasms - metabolism
  • Skin Neoplasms - pathology
  • Skin Neoplasms - prevention & control
  • Sun protection factor (SPF)
  • Sunburn - drug therapy
  • Sunburn - genetics
  • Sunburn - metabolism
  • Sunburn - pathology
  • Sunscreen
  • Sunscreening Agents - pharmacology
  • Sunscreening Agents - toxicity
  • Superoxide Dismutase - metabolism
  • technology
  • Titanium
  • Titanium - pharmacology
  • Titanium - toxicity
  • Titanium dioxide
  • Titanium dioxide nanoparticles (TiO2NPs)
  • Toiletries industry
  • Ultraviolet radiation
  • Ultraviolet Rays - adverse effects
  • Zinc
  • Zinc oxide
  • Zinc Oxide - pharmacology
  • Zinc Oxide - toxicity
  • Zinc oxide nanoparticles (ZnONPs)
ispartof: Cancer letters, 2016, Vol.383 (1), p.53-61
description: Abstract Sunscreen formulations containing UVB filters, such as Zinc-oxide (ZnO) and titanium-dioxide (TiO2) nanoparticles (NPs) have been developed to limit the exposure of human skin to UV-radiations. Unfortunately, these UVB protective agents have failed in controlling the skin cancer incidence. We recently demonstrated that silver nanoparticles (Ag-NPs) could serve as novel protective agents against UVB-radiations. Here our goal was to perform comparative analysis of direct and indirect UVB-protection efficacy of ZnO-, TiO2 - and Ag-NPs. Sun-protection-factor calculated based on their UVB-reflective/absorption abilities was the highest for TiO2 -NPs followed by Ag- and ZnO-NPs. This was further confirmed by studying indirect protection of UVB radiation-induced death of HaCaT cells. However, only Ag-NPs were active in protecting HaCaT cells against direct UVB-induced DNA-damage by repairing bulky-DNA lesions through nucleotide-excision-repair mechanism. Moreover, Ag-NPs were also effective in protecting HaCaT cells from UVB-induced oxidative DNA damage by enhancing SOD/CAT/GPx activity. In contrast, ZnO- and TiO2 -NPs not only failed in providing any direct protection from DNA-damage, but rather enhanced oxidative DNA-damage by increasing ROS production. Together, these findings raise concerns about safety of ZnO- and TiO2-NPs and establish superior protective efficacy of Ag-NPs.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0304-3835
fulltext: fulltext
issn:
  • 0304-3835
  • 1872-7980
url: Link


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titleComparative analysis of the relative potential of silver, zinc-oxide and titanium-dioxide nanoparticles against UVB-induced DNA damage for the prevention of skin carcinogenesis
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creatorTyagi, Nikhil ; Srivastava, Sanjeev K ; Arora, Sumit ; Omar, Yousef ; Ijaz, Zohaib Mohammad ; AL-Ghadhban, Ahmed ; Deshmukh, Sachin K ; Carter, James E ; Singh, Ajay P ; Singh, Seema, Ph.D
creatorcontribTyagi, Nikhil ; Srivastava, Sanjeev K ; Arora, Sumit ; Omar, Yousef ; Ijaz, Zohaib Mohammad ; AL-Ghadhban, Ahmed ; Deshmukh, Sachin K ; Carter, James E ; Singh, Ajay P ; Singh, Seema, Ph.D
descriptionAbstract Sunscreen formulations containing UVB filters, such as Zinc-oxide (ZnO) and titanium-dioxide (TiO2) nanoparticles (NPs) have been developed to limit the exposure of human skin to UV-radiations. Unfortunately, these UVB protective agents have failed in controlling the skin cancer incidence. We recently demonstrated that silver nanoparticles (Ag-NPs) could serve as novel protective agents against UVB-radiations. Here our goal was to perform comparative analysis of direct and indirect UVB-protection efficacy of ZnO-, TiO2 - and Ag-NPs. Sun-protection-factor calculated based on their UVB-reflective/absorption abilities was the highest for TiO2 -NPs followed by Ag- and ZnO-NPs. This was further confirmed by studying indirect protection of UVB radiation-induced death of HaCaT cells. However, only Ag-NPs were active in protecting HaCaT cells against direct UVB-induced DNA-damage by repairing bulky-DNA lesions through nucleotide-excision-repair mechanism. Moreover, Ag-NPs were also effective in protecting HaCaT cells from UVB-induced oxidative DNA damage by enhancing SOD/CAT/GPx activity. In contrast, ZnO- and TiO2 -NPs not only failed in providing any direct protection from DNA-damage, but rather enhanced oxidative DNA-damage by increasing ROS production. Together, these findings raise concerns about safety of ZnO- and TiO2-NPs and establish superior protective efficacy of Ag-NPs.
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languageeng
publisherIreland: Elsevier B.V
subjectagriculture ; Anticarcinogenic Agents - pharmacology ; Anticarcinogenic Agents - toxicity ; Antioxidants - pharmacology ; Article ; Catalase - metabolism ; Cell Death - drug effects ; Cell Line, Tumor ; Comparative analysis ; connective tissue diseases ; Deoxyribonucleic acid ; DNA ; DNA damage ; DNA Damage - drug effects ; DNA lesions (CPDs, 6-4 PPs) ; DNA Repair - drug effects ; Dose-Response Relationship, Drug ; Enzymes ; Glutathione Peroxidase - metabolism ; Hematology, Oncology and Palliative Medicine ; Humans ; industry ; integumentary system ; Keratinocytes - drug effects ; Keratinocytes - metabolism ; Keratinocytes - pathology ; Keratinocytes - radiation effects ; Medical colleges ; Medical research ; Metal Nanoparticles ; Nanoparticles ; Oxidative Stress - drug effects ; Radiation ; Reactive oxygen species (ROS) ; Reactive Oxygen Species - metabolism ; respiratory system ; Rodents ; Silver ; Silver Compounds - pharmacology ; Silver nanoparticles (AgNPs) ; Skin ; Skin cancer ; Skin Neoplasms - genetics ; Skin Neoplasms - metabolism ; Skin Neoplasms - pathology ; Skin Neoplasms - prevention & control ; Sun protection factor (SPF) ; Sunburn - drug therapy ; Sunburn - genetics ; Sunburn - metabolism ; Sunburn - pathology ; Sunscreen ; Sunscreening Agents - pharmacology ; Sunscreening Agents - toxicity ; Superoxide Dismutase - metabolism ; technology ; Titanium ; Titanium - pharmacology ; Titanium - toxicity ; Titanium dioxide ; Titanium dioxide nanoparticles (TiO2NPs) ; Toiletries industry ; Ultraviolet radiation ; Ultraviolet Rays - adverse effects ; Zinc ; Zinc oxide ; Zinc Oxide - pharmacology ; Zinc Oxide - toxicity ; Zinc oxide nanoparticles (ZnONPs)
ispartofCancer letters, 2016, Vol.383 (1), p.53-61
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6Deshmukh, Sachin K
7Carter, James E
8Singh, Ajay P
9Singh, Seema, Ph.D
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descriptionAbstract Sunscreen formulations containing UVB filters, such as Zinc-oxide (ZnO) and titanium-dioxide (TiO2) nanoparticles (NPs) have been developed to limit the exposure of human skin to UV-radiations. Unfortunately, these UVB protective agents have failed in controlling the skin cancer incidence. We recently demonstrated that silver nanoparticles (Ag-NPs) could serve as novel protective agents against UVB-radiations. Here our goal was to perform comparative analysis of direct and indirect UVB-protection efficacy of ZnO-, TiO2 - and Ag-NPs. Sun-protection-factor calculated based on their UVB-reflective/absorption abilities was the highest for TiO2 -NPs followed by Ag- and ZnO-NPs. This was further confirmed by studying indirect protection of UVB radiation-induced death of HaCaT cells. However, only Ag-NPs were active in protecting HaCaT cells against direct UVB-induced DNA-damage by repairing bulky-DNA lesions through nucleotide-excision-repair mechanism. Moreover, Ag-NPs were also effective in protecting HaCaT cells from UVB-induced oxidative DNA damage by enhancing SOD/CAT/GPx activity. In contrast, ZnO- and TiO2 -NPs not only failed in providing any direct protection from DNA-damage, but rather enhanced oxidative DNA-damage by increasing ROS production. Together, these findings raise concerns about safety of ZnO- and TiO2-NPs and establish superior protective efficacy of Ag-NPs.
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1Anticarcinogenic Agents - pharmacology
2Anticarcinogenic Agents - toxicity
3Antioxidants - pharmacology
4Article
5Catalase - metabolism
6Cell Death - drug effects
7Cell Line, Tumor
8Comparative analysis
9connective tissue diseases
10Deoxyribonucleic acid
11DNA
12DNA damage
13DNA Damage - drug effects
14DNA lesions (CPDs, 6-4 PPs)
15DNA Repair - drug effects
16Dose-Response Relationship, Drug
17Enzymes
18Glutathione Peroxidase - metabolism
19Hematology, Oncology and Palliative Medicine
20Humans
21industry
22integumentary system
23Keratinocytes - drug effects
24Keratinocytes - metabolism
25Keratinocytes - pathology
26Keratinocytes - radiation effects
27Medical colleges
28Medical research
29Metal Nanoparticles
30Nanoparticles
31Oxidative Stress - drug effects
32Radiation
33Reactive oxygen species (ROS)
34Reactive Oxygen Species - metabolism
35respiratory system
36Rodents
37Silver
38Silver Compounds - pharmacology
39Silver nanoparticles (AgNPs)
40Skin
41Skin cancer
42Skin Neoplasms - genetics
43Skin Neoplasms - metabolism
44Skin Neoplasms - pathology
45Skin Neoplasms - prevention & control
46Sun protection factor (SPF)
47Sunburn - drug therapy
48Sunburn - genetics
49Sunburn - metabolism
50Sunburn - pathology
51Sunscreen
52Sunscreening Agents - pharmacology
53Sunscreening Agents - toxicity
54Superoxide Dismutase - metabolism
55technology
56Titanium
57Titanium - pharmacology
58Titanium - toxicity
59Titanium dioxide
60Titanium dioxide nanoparticles (TiO2NPs)
61Toiletries industry
62Ultraviolet radiation
63Ultraviolet Rays - adverse effects
64Zinc
65Zinc oxide
66Zinc Oxide - pharmacology
67Zinc Oxide - toxicity
68Zinc oxide nanoparticles (ZnONPs)
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titleComparative analysis of the relative potential of silver, zinc-oxide and titanium-dioxide nanoparticles against UVB-induced DNA damage for the prevention of skin carcinogenesis
authorTyagi, Nikhil ; Srivastava, Sanjeev K ; Arora, Sumit ; Omar, Yousef ; Ijaz, Zohaib Mohammad ; AL-Ghadhban, Ahmed ; Deshmukh, Sachin K ; Carter, James E ; Singh, Ajay P ; Singh, Seema, Ph.D
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6Cell Death - drug effects
7Cell Line, Tumor
8Comparative analysis
9connective tissue diseases
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19Hematology, Oncology and Palliative Medicine
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21industry
22integumentary system
23Keratinocytes - drug effects
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26Keratinocytes - radiation effects
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29Metal Nanoparticles
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31Oxidative Stress - drug effects
32Radiation
33Reactive oxygen species (ROS)
34Reactive Oxygen Species - metabolism
35respiratory system
36Rodents
37Silver
38Silver Compounds - pharmacology
39Silver nanoparticles (AgNPs)
40Skin
41Skin cancer
42Skin Neoplasms - genetics
43Skin Neoplasms - metabolism
44Skin Neoplasms - pathology
45Skin Neoplasms - prevention & control
46Sun protection factor (SPF)
47Sunburn - drug therapy
48Sunburn - genetics
49Sunburn - metabolism
50Sunburn - pathology
51Sunscreen
52Sunscreening Agents - pharmacology
53Sunscreening Agents - toxicity
54Superoxide Dismutase - metabolism
55technology
56Titanium
57Titanium - pharmacology
58Titanium - toxicity
59Titanium dioxide
60Titanium dioxide nanoparticles (TiO2NPs)
61Toiletries industry
62Ultraviolet radiation
63Ultraviolet Rays - adverse effects
64Zinc
65Zinc oxide
66Zinc Oxide - pharmacology
67Zinc Oxide - toxicity
68Zinc oxide nanoparticles (ZnONPs)
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1Srivastava, Sanjeev K
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3Omar, Yousef
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atitleComparative analysis of the relative potential of silver, zinc-oxide and titanium-dioxide nanoparticles against UVB-induced DNA damage for the prevention of skin carcinogenesis
jtitleCancer letters
addtitleCancer Lett
date2016
risdate2016
volume383
issue1
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pages53-61
issn0304-3835
eissn1872-7980
notesCurrent affiliation: Engineering Core Facility, College of Engineering, University of South Alabama, Mobile, Alabama 36688, USA
abstractAbstract Sunscreen formulations containing UVB filters, such as Zinc-oxide (ZnO) and titanium-dioxide (TiO2) nanoparticles (NPs) have been developed to limit the exposure of human skin to UV-radiations. Unfortunately, these UVB protective agents have failed in controlling the skin cancer incidence. We recently demonstrated that silver nanoparticles (Ag-NPs) could serve as novel protective agents against UVB-radiations. Here our goal was to perform comparative analysis of direct and indirect UVB-protection efficacy of ZnO-, TiO2 - and Ag-NPs. Sun-protection-factor calculated based on their UVB-reflective/absorption abilities was the highest for TiO2 -NPs followed by Ag- and ZnO-NPs. This was further confirmed by studying indirect protection of UVB radiation-induced death of HaCaT cells. However, only Ag-NPs were active in protecting HaCaT cells against direct UVB-induced DNA-damage by repairing bulky-DNA lesions through nucleotide-excision-repair mechanism. Moreover, Ag-NPs were also effective in protecting HaCaT cells from UVB-induced oxidative DNA damage by enhancing SOD/CAT/GPx activity. In contrast, ZnO- and TiO2 -NPs not only failed in providing any direct protection from DNA-damage, but rather enhanced oxidative DNA-damage by increasing ROS production. Together, these findings raise concerns about safety of ZnO- and TiO2-NPs and establish superior protective efficacy of Ag-NPs.
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